Arctigenen (BioDeep_00000859725)

PANOMIX_OTCML-2023

代谢物信息卡片

2(3H)-furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-

化学式: C21H24O6 (372.1572804)
中文名称: 牛蒡子苷元
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC
InChI: InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1

描述信息

Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3].
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3].

同义名列表

23 个代谢物同义名

2(3H)-furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxy-phenyl)methyl]tetrahydrofuran-2-one; (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-tetrahydrofuranone; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxy-phenyl)methyl]oxolan-2-one; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one; (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxy-benzyl)tetrahydrofuran-2-one; NCGC00025291-01; (−)-Arctigenin; (-)-Arctigenin; MEGxp0_001799; ACon1_000416; A1854_SIGMA; AIDS-002466; Tocris-1777; Arctigenen; AIDS002466; Arctigenin; 41328-87-4; 26687-78-5; 7770-78-7; C10545

数据库引用编号

6 个数据库交叉引用编号

ChEBI: CHEBI:79
PubChem: 64981
ChEMBL: CHEMBL435734
CAS: 144901-91-7
CAS: 7770-78-7
medchemexpress: HY-N0035

分类词条

苯丙素类

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

88 个相关的物种来源信息

33090 了哥王根: -
4217 牛蒡子: -
33090 络石藤: -
33090 连翘: -
2565749 Centaurea regia: 10.1016/0031-9422(88)83055-3
41511 Centaurea calcitrapa:
199751 Bupleurum salicifolium:
363423 Centaurea deflexa: 10.1016/J.EJMECH.2011.03.011
2753873 Daphne feddei: 10.1021/NP8004166
205692 Forsythia koreana:
205691 Forsythia viridissima:
137893 Saussurea medusa:
205694 Forsythia ovata: 10.1248/CPB.36.3667
1486496 Centaurea arenaria: 10.1002/PTR.3187
196747 Onopordum acaulon: 10.1016/0031-9422(92)83742-H
48027 Anthriscus sylvestris: 10.1055/S-2001-18849
351316 Centaurea paui: 10.1002/JLAC.199719970313
147277 Torreya jackii: 10.1016/S0021-9673(99)00050-3
29760 Vitis vinifera: 10.1016/S0308-8146(03)00222-X
446849 Saussurea salicifolia:
2072395 Centaurea scoparia: 10.1055/S-2006-959378
4217 Arctium lappa:
238949 Saussurea parviflora: 10.1016/S0031-9422(02)00758-6
4265 Cynara cardunculus: 10.1016/S0367-326X(99)00007-6
41526 Centaurea dealbata: 10.1016/0031-9422(91)83195-Q
124926 Centaurea cineraria: 10.1016/0031-9422(91)83195-Q
347529 Centaurea solstitialis:
886941 Saussurea candicans: 10.1016/0031-9422(88)80305-4
452780 Haplophyllum patavinum: 10.3987/COM-01-S(K)71
50187 Taiwania cryptomerioides: 10.1016/S0031-9422(00)00275-2
4222 Carthamus tinctorius:
200489 Saussurea involucrata: 10.1080/10286020.2010.499856
254913 Saussurea laniceps: 10.1016/S1875-5364(11)60016-2
129201 Ipomoea cairica:
429296 Trachelospermum axillare: 10.1016/0031-9422(93)85183-R
126418 Forsythia suspensa:
910632 Centaurea phrygia: 10.1016/0031-9422(91)85119-K
41503 Centaurea: 10.1016/S0305-1978(01)00042-4
50189 Torreya nucifera:
41506 Plectocephalus americanus: 10.1016/J.PHYTOCHEM.2006.08.012
41536 Centaurea melitensis: 10.1016/J.PHYTOCHEM.2006.08.012
41535 Centaurea macrocephala: 10.1016/S0305-1978(02)00046-7
75633 Centaurea nigra: 10.1016/S0305-1978(02)00227-2
145517 Centaurea scabiosa: 10.1016/S0305-1978(02)00143-6
305795 Oenanthe aquatica: 10.1016/0731-7085(87)80060-2
2565749 Centaurea regia: 10.1016/0031-9422(88)83055-3
41511 Centaurea calcitrapa:
199751 Bupleurum salicifolium:
363423 Centaurea deflexa: 10.1016/J.EJMECH.2011.03.011
2753873 Daphne feddei: 10.1021/NP8004166
205692 Forsythia koreana:
205691 Forsythia viridissima:
137893 Saussurea medusa:
205694 Forsythia ovata: 10.1248/CPB.36.3667
1486496 Centaurea arenaria: 10.1002/PTR.3187
196747 Onopordum acaulon: 10.1016/0031-9422(92)83742-H
48027 Anthriscus sylvestris: 10.1055/S-2001-18849
351316 Centaurea paui: 10.1002/JLAC.199719970313
147277 Torreya jackii: 10.1016/S0021-9673(99)00050-3
29760 Vitis vinifera: 10.1016/S0308-8146(03)00222-X
446849 Saussurea salicifolia:
2072395 Centaurea scoparia: 10.1055/S-2006-959378
4217 Arctium lappa:
238949 Saussurea parviflora: 10.1016/S0031-9422(02)00758-6
4265 Cynara cardunculus: 10.1016/S0367-326X(99)00007-6
41526 Centaurea dealbata: 10.1016/0031-9422(91)83195-Q
124926 Centaurea cineraria: 10.1016/0031-9422(91)83195-Q
347529 Centaurea solstitialis:
886941 Saussurea candicans: 10.1016/0031-9422(88)80305-4
452780 Haplophyllum patavinum: 10.3987/COM-01-S(K)71
50187 Taiwania cryptomerioides: 10.1016/S0031-9422(00)00275-2
4222 Carthamus tinctorius:
200489 Saussurea involucrata: 10.1080/10286020.2010.499856
254913 Saussurea laniceps: 10.1016/S1875-5364(11)60016-2
129201 Ipomoea cairica:
429296 Trachelospermum axillare: 10.1016/0031-9422(93)85183-R
126418 Forsythia suspensa:
910632 Centaurea phrygia: 10.1016/0031-9422(91)85119-K
41503 Centaurea: 10.1016/S0305-1978(01)00042-4
50189 Torreya nucifera:
41506 Plectocephalus americanus: 10.1016/J.PHYTOCHEM.2006.08.012
41536 Centaurea melitensis: 10.1016/J.PHYTOCHEM.2006.08.012
41535 Centaurea macrocephala: 10.1016/S0305-1978(02)00046-7
75633 Centaurea nigra: 10.1016/S0305-1978(02)00227-2
145517 Centaurea scabiosa: 10.1016/S0305-1978(02)00143-6
305795 Oenanthe aquatica: 10.1016/0731-7085(87)80060-2
4217 Arctium lappa L.: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Mengjia Lv, Shiyi Chen, Mengwen Shan, Yuan Si, Chenggang Huang, Jing Chen, Likun Gong. Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice. European journal of pharmacology. 2024 Jul; 974(?):176629. doi: 10.1016/j.ejphar.2024.176629. [PMID: 38679116]
Zhuoqun Li, Lixing Cao, Kai Han, Lihong Fan, Chong Zhao, Shutao Yin, Hongbo Hu. Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis. Biochemical and biophysical research communications. 2024 May; 710(?):149895. doi: 10.1016/j.bbrc.2024.149895. [PMID: 38593620]
Xueling Li, Jue Wang, Jiayi Yan, John Cijiang He, Yi Li, Yifei Zhong. Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 171(?):116107. doi: 10.1016/j.biopha.2023.116107. [PMID: 38215692]
Shunfang Liu, Yaozhen He, Minding Feng, Yongtong Huang, Wenhao Wu, Jiu Wang. Targeted Delivery of Arctigenin Using Sialic Acid Conjugate-Modified Liposomes for the Treatment of Breast Cancer. Molecules (Basel, Switzerland). 2024 Jan; 29(1):. doi: 10.3390/molecules29010278. [PMID: 38202860]
Zekrayat J H Medras, Yasser M Mostafa, Amal A M Ahmed, Norhan M El-Sayed. Arctigenin improves neuropathy via ameliorating apoptosis and modulating autophagy in streptozotocin-induced diabetic mice. CNS neuroscience & therapeutics. 2023 May; ?(?):. doi: 10.1111/cns.14249. [PMID: 37170684]
Yi-Fan Chen, Run-Zhi Liu, Wen-Wen Ying, Yue-Ning Yang, Sen-Feng Xiang, Xue-Jing Shao, Ji Cao, Yan-Qi Zhang, Bo Yang, Qiao-Jun He, Mei-Dan Ying. Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells. Acta pharmacologica Sinica. 2023 Mar; 44(3):661-669. doi: 10.1038/s41401-022-00992-6. [PMID: 36138144]
Peter Kiplangʼat Koech, Gergely Jócsák, Imre Boldizsár, Kinga Moldován, Sándor Borbély, Ildikó Világi, Arpád Dobolyi, Petra Varró. Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin - An ex vivo Study on Rat Brain Slices. Planta medica. 2023 Feb; ?(?):. doi: 10.1055/a-2005-5497. [PMID: 36592636]
Xingyue Jin, Suyi Liu, Shujing Chen, Lirong Wang, Yan Cui, Jun He, Shiming Fang, Jin Li, Yanxu Chang. A systematic review on botany, ethnopharmacology, quality control, phytochemistry, pharmacology and toxicity of Arctium lappa L. fruit. Journal of ethnopharmacology. 2023 Feb; ?(?):116223. doi: 10.1016/j.jep.2023.116223. [PMID: 36781057]
Guanming Wang, Li Ge, Tongyu Liu, Zhihui Zheng, Lijun Chen. The therapeutic potential of arctigenin against multiple human diseases: A mechanistic review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Feb; 110(?):154647. doi: 10.1016/j.phymed.2023.154647. [PMID: 36628833]
Yuyan Zhou, Lina Liu, Ruoxuan Xiang, Xiaoyang Bu, Guozheng Qin, Jiajia Dai, Zhigang Zhao, Xue Fang, Shuo Yang, Jun Han, Guodong Wang. Arctigenin mitigates insulin resistance by modulating the IRS2/GLUT4 pathway via TLR4 in type 2 diabetes mellitus mice. International immunopharmacology. 2023 Jan; 114(?):109529. doi: 10.1016/j.intimp.2022.109529. [PMID: 36481528]
Quan Yuan, Yiran Wu, Gang Wang, Xiang Zhou, Xiaohui Dong, Zihan Lou, Sanqiang Li, Dongmei Wang. Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice. Metabolic brain disease. 2022 08; 37(6):2039-2052. doi: 10.1007/s11011-022-01031-3. [PMID: 35731324]
Yu Tao, Si-Miao Qiao, Chang-Jun Lv, Xin-Ming Yun, Meng-Fan Yue, Yu-Lai Fang, Zhi-Feng Wei, Yue Dai, Yu-Feng Xia. Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ERβ/TRIM21/PHB1 pathway. Phytotherapy research : PTR. 2022 Aug; 36(8):3248-3264. doi: 10.1002/ptr.7495. [PMID: 35599350]
Jia-Cheng Qin, Bo-Yang Li, Yu-Feng Shen, Tao Wang, Gao-Xue Wang. In vitro and in vivo inhibition of a novel arctigenin derivative on aquatic rhabdovirus. Virus research. 2022 07; 316(?):198798. doi: 10.1016/j.virusres.2022.198798. [PMID: 35562080]
Nguyen Duy Phan, Ashraf M Omar, Sijia Sun, Juthamart Maneenet, Dya Fita Dibwe, Mao Sato, Surya Kant Kalauni, Naoki Toyooka, Tsutomu Fujii, Suresh Awale. Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line. Bioorganic & medicinal chemistry letters. 2022 06; 66(?):128723. doi: 10.1016/j.bmcl.2022.128723. [PMID: 35395369]
Xin Zhang, Mengjun Zou, Yue Liang, Yonghong Yang, Lina Jing, Minghui Sun, Zhilin Dong, Xinyuan Zhang, Huabao Xiong, Guanjun Dong. Arctigenin inhibits abnormal germinal center reactions and attenuates murine lupus by inhibiting IFN-I pathway. European journal of pharmacology. 2022 Mar; 919(?):174808. doi: 10.1016/j.ejphar.2022.174808. [PMID: 35151645]
Lijun Wu, Jie Chen, Danna Zhou, Runshan Chen, Xiabing Chen, Zhiyong Shao, Wenhai Yang, Bin He. Anti-inflammatory activity of arctigenin against PCV2 infection in a mouse model. Veterinary medicine and science. 2022 03; 8(2):700-709. doi: 10.1002/vms3.693. [PMID: 34914190]
Mingzhuo Cao, Changda Liu, Kamal D Srivastava, Adora Lin, Christopher Lazarski, Lu Wang, Anish Maskey, Ying Song, Xiaoke Chen, Nan Yang, Linda Zambrano, Renna Bushko, Anna Nowak-Wegrzyn, Amanda Cox, Zhigang Liu, Weihua Huang, David Dunkin, Mingsan Miao, Xiu-Min Li. Anti-IgE effect of small-molecule-compound arctigenin on food allergy in association with a distinct transcriptome profile. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2022 02; 52(2):250-264. doi: 10.1111/cea.14048. [PMID: 34757674]
Sayeh Mottaghi, Hassan Abbaszadeh. A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives. Critical reviews in food science and nutrition. 2022; 62(26):7301-7318. doi: 10.1080/10408398.2021.1913568. [PMID: 33905270]
Samir A Salama, Ahmed M Mohamadin, Mohamed S Abdel-Bakky. Arctigenin alleviates cadmium-induced nephrotoxicity: Targeting endoplasmic reticulum stress, Nrf2 signaling, and the associated inflammatory response. Life sciences. 2021 Dec; 287(?):120121. doi: 10.1016/j.lfs.2021.120121. [PMID: 34742745]
Arezoo Gowhari Shabgah, Wanich Suksatan, Muhammad Harun Achmad, Dmitry O Bokov, Walid Kamal Abdelbasset, Fatemeh Ezzatifar, Sasan Hemmati, Hamed Mohammadi, Davood Soleimani, Farhad Jadidi-Niaragh, Majid Ahmadi, Jamshid Gholizadeh Navashenaq. Arctigenin, an anti-tumor agent; a cutting-edge topic and up-to-the-minute approach in cancer treatment. European journal of pharmacology. 2021 Oct; 909(?):174419. doi: 10.1016/j.ejphar.2021.174419. [PMID: 34391770]
Ashraf M Omar, Sijia Sun, Min Jo Kim, Nguyen Duy Phan, Ahmed M Tawila, Suresh Awale. Benzophenones from Betula alnoides with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of natural products. 2021 05; 84(5):1607-1616. doi: 10.1021/acs.jnatprod.1c00150. [PMID: 34008971]
Yosuke Suzuki, Michiko Sato, Takuya Awazuhara, Yusuke Nukui, Airi Yoshida, Tomoka Terashima, Keita Watanabe, Rumi Fujioka, Katsuya Tsuchihara, Satoshi Kishino, Keiko Ohno. Simultaneous quantification of arctigenin and its glucuronide conjugate in mouse plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry. Journal of separation science. 2021 Apr; 44(7):1299-1306. doi: 10.1002/jssc.202001078. [PMID: 33387366]
Shaimaa Fayez, Alessia Cacciatore, Sijia Sun, Minjo Kim, Laurent Aké Assi, Doris Feineis, Suresh Awale, Gerhard Bringmann. Ancistrobrevidines A-C and related naphthylisoquinoline alkaloids with cytotoxic activities against HeLa and pancreatic cancer cells, from the liana Ancistrocladus abbreviatus. Bioorganic & medicinal chemistry. 2021 01; 30(?):115950. doi: 10.1016/j.bmc.2020.115950. [PMID: 33383442]
Xueying Liu, Jian Wang, Peiyuan Dou, Xu Zhang, Xiaoku Ran, Linlin Liu, Deqiang Dou. The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-β Signaling Pathway. Oxidative medicine and cellular longevity. 2021; 2021(?):5598980. doi: 10.1155/2021/5598980. [PMID: 34336106]
Liangpeng Wei, Zhenyi Xue, Baihui Lan, Shiyang Yuan, Yuanyuan Li, Cunle Guo, Rongxin Zhang, Ran Ding, Hui Shen. Arctigenin Exerts Neuroprotective Effect by Ameliorating Cortical Activities in Experimental Autoimmune Encephalomyelitis In Vivo. Frontiers in immunology. 2021; 12(?):691590. doi: 10.3389/fimmu.2021.691590. [PMID: 34349758]
Eman Al-Sayed, Tzu-Yi Ke, Tsong-Long Hwang, Shu-Rong Chen, Michal Korinek, Shu-Li Chen, Yuan-Bin Cheng. Cytotoxic and anti-inflammatory effects of lignans and diterpenes from Cupressus macrocarpa. Bioorganic & medicinal chemistry letters. 2020 05; 30(10):127127. doi: 10.1016/j.bmcl.2020.127127. [PMID: 32223924]
Mostafa Alilou, Dya Fita Dibwe, Stefan Schwaiger, Mojtaba Khodami, Jakob Troppmair, Suresh Awale, Hermann Stuppner. Antiausterity Activity of Secondary Metabolites from the Roots of Ferula hezarlalehzarica against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of natural products. 2020 04; 83(4):1099-1106. doi: 10.1021/acs.jnatprod.9b01109. [PMID: 32163286]
Hongbo Li, Chunli Yang, Min Lan, Xingen Liao, Zhiming Tang. Arctigenin promotes bone formation involving PI3K/Akt/PPARγ signaling pathway. Chemical biology & drug design. 2020 04; 95(4):451-459. doi: 10.1111/cbdd.13659. [PMID: 31883507]
Shi-Hao Ni, Shu-Ning Sun, Zheng Zhou, Yue Li, Yu-Sheng Huang, Huan Li, Jia-Jia Wang, Wei Xiao, Shao-Xiang Xian, Zhong-Qi Yang, Ling-Jun Wang, Lu Lu. Arctigenin alleviates myocardial infarction injury through inhibition of the NFAT5-related inflammatory phenotype of cardiac macrophages/monocytes in mice. Laboratory investigation; a journal of technical methods and pathology. 2020 04; 100(4):527-541. doi: 10.1038/s41374-019-0340-8. [PMID: 31792391]
Yu Tao, Mengfan Yue, Changjun Lv, Xinming Yun, Simiao Qiao, Yulai Fang, Zhifeng Wei, Yufeng Xia, Yue Dai. Pharmacological activation of ERβ by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 02; 34(2):3069-3090. doi: 10.1096/fj.201901638rr. [PMID: 31908053]
Gang Jin, Yanjin Su, Qianlan Dong, Xiaohong Zhao, Linping Zhang, Xiaohui Yan. Arctigenin alleviates TGF-β1-induced epithelial-mesenchymal transition and PAI-1 expression via AMPK/NF-κB pathway in peritoneal mesothelial cells. Biochemical and biophysical research communications. 2019 12; 520(2):413-419. doi: 10.1016/j.bbrc.2019.09.130. [PMID: 31607474]
Jing Hu, Yun Shi, Bing Yang, Zibo Dong, Xinxin Si, Kunming Qin. Changes in chemical components and antitumor activity during the heating process of Fructus Arctii. Pharmaceutical biology. 2019 Dec; 57(1):363-368. doi: 10.1080/13880209.2019.1616778. [PMID: 31295042]
Dieudonné Tshitenge Tshitenge, Torsten Bruhn, Doris Feineis, David Schmidt, Virima Mudogo, Marcel Kaiser, Reto Brun, Frank Würthner, Suresh Awale, Gerhard Bringmann. Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells. Journal of natural products. 2019 11; 82(11):3150-3164. doi: 10.1021/acs.jnatprod.9b00755. [PMID: 31630523]
Yifei Zhong, Kyung Lee, Yueyi Deng, Yueming Ma, Yiping Chen, Xueling Li, Chengguo Wei, Shumin Yang, Tianming Wang, Nicholas J Wong, Alecia N Muwonge, Evren U Azeloglu, Weijia Zhang, Bhaskar Das, John Cijiang He, Ruijie Liu. Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes. Nature communications. 2019 10; 10(1):4523. doi: 10.1038/s41467-019-12433-w. [PMID: 31586053]
Yang Hu, Wei-Chao Chen, Yu-Feng Shen, Bin Zhu, Gao-Xue Wang. Synthesis and antiviral activity of a new arctigenin derivative against IHNV in vitro and in vivo. Fish & shellfish immunology. 2019 Sep; 92(?):736-745. doi: 10.1016/j.fsi.2019.07.006. [PMID: 31284045]
Yuzhou Song, Xiao Li, Yunyun Liu, Yingjie Hu, Ruiyi Yang. Arctigenin improves lipid metabolism by regulating AMP-activated protein kinase and downstream signaling pathways. Journal of cellular biochemistry. 2019 08; 120(8):13275-13288. doi: 10.1002/jcb.28602. [PMID: 30891825]
Ning Ke, Qing Liu, Lianhong Pi, Jing Fang, Lin Chen, Xinke Chen. The antitumor function of arctigenin in human retinoblastoma cells is mediated by jagged‑1. Molecular medicine reports. 2019 May; 19(5):3642-3648. doi: 10.3892/mmr.2019.10026. [PMID: 30896794]
Jing Zhang, Peng Cao, Jingjing Gui, Xin Wang, Jun Han, Yuwei Wang, Guodong Wang. Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice. Life sciences. 2019 Apr; 223(?):194-201. doi: 10.1016/j.lfs.2019.03.037. [PMID: 30898648]
Yuru Du, Wenjing Li, Yiming Li, Juxiang Yang, Xinhao Wang, Shuo Yin, Xi Wang, Omar Israel Velez de-la-Paz, Yuan Gao, Haiying Chen, Xi Yin, Haishui Shi. Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice. Brain research bulletin. 2019 03; 146(?):79-86. doi: 10.1016/j.brainresbull.2018.12.005. [PMID: 30597190]
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Feng Han, Xin-Xin Xia, Meng Dou, Yu-Xiang Wang, Wu-Jun Xue, Xiao-Ming Ding, Jin Zheng, Chen-Guang Ding, Pu-Xun Tian. Arctigenin: A two-edged sword in ischemia/reperfusion induced acute kidney injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jul; 103(?):1127-1136. doi: 10.1016/j.biopha.2018.04.169. [PMID: 29715756]
Guo Feng, Yun-Long Chen, Wei Li, Lai-Lai Li, Zeng-Guang Wu, Zi-Jun Wu, Yue Hai, Si-Chao Zhang, Chuan-Qi Zheng, Chang-Xiao Liu, Xin He. Exploring the Q-marker of "sweat soaking method" processed radix Wikstroemia indica: Based on the "effect-toxicity-chemicals" study. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jun; 45(?):49-58. doi: 10.1016/j.phymed.2018.03.063. [PMID: 29691116]
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Kung-Yen Chen, Jui-An Lin, Han-Yun Yao, An-Chih Hsu, Yu-Ting Tai, Jui-Tai Chen, Mao-Chih Hsieh, Tang-Long Shen, Ren-Yi Hsu, Hong-Tan Wu, Guey Horng Wang, Bing-Ying Ho, Yu-Pei Chen. Arctigenin protects against steatosis in WRL68 hepatocytes through activation of phosphoinositide 3-kinase/protein kinase B and AMP-activated protein kinase pathways. Nutrition research (New York, N.Y.). 2018 04; 52(?):87-97. doi: 10.1016/j.nutres.2018.02.004. [PMID: 29525610]
See-Hyoung Park, Jae Youl Cho, Sae Woong Oh, Mingyeong Kang, Seung Eun Lee, Ju Ah Yoo, Kwangseon Jung, Jienny Lee, Sang Yeol Lee, Jongsung Lee. Arctigenin protects against ultraviolet-A-induced damage to stemness through inhibition of the NF-κB/MAPK pathway. Chemico-biological interactions. 2018 Feb; 282(?):63-68. doi: 10.1016/j.cbi.2018.01.005. [PMID: 29317250]
Yusuke Baba, Zenpei Shigemi, Naoko Hara, Misato Moriguchi, Marina Ikeda, Tadashi Watanabe, Masahiro Fujimuro. Arctigenin induces the apoptosis of primary effusion lymphoma cells under conditions of glucose deprivation. International journal of oncology. 2018 Feb; 52(2):505-517. doi: 10.3892/ijo.2017.4215. [PMID: 29207179]
Enbo Cai, Shijie Guo, Limin Yang, Mei Han, Jing Xia, Yan Zhao, Xiaorui Gao, Yu Wang. Synthesis and antitumour activity of arctigenin amino acid ester derivatives against H22 hepatocellular carcinoma. Natural product research. 2018 Feb; 32(4):406-411. doi: 10.1080/14786419.2017.1314279. [PMID: 28415847]
Rumi Fujioka, Nobuo Mochizuki, Masafumi Ikeda, Akihiro Sato, Shogo Nomura, Satoshi Owada, Satoshi Yomoda, Katsuya Tsuchihara, Satoshi Kishino, Hiroyasu Esumi. Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer. PloS one. 2018; 13(6):e0198219. doi: 10.1371/journal.pone.0198219. [PMID: 29856804]
Qin Feng, Jingchun Yao, Ge Zhou, Wenkai Xia, Jingang Lyu, Xin Li, Tao Zhao, Guimin Zhang, Ningwei Zhao, Jie Yang. Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy. Frontiers in immunology. 2018; 9(?):1881. doi: 10.3389/fimmu.2018.01881. [PMID: 30177931]
Ji-Ye Kee, Seung-Heon Hong. Inhibition of Mast Cell-Mediated Allergic Responses by Arctii Fructus Extracts and Its Main Compound Arctigenin. Journal of agricultural and food chemistry. 2017 Nov; 65(43):9443-9452. doi: 10.1021/acs.jafc.7b02965. [PMID: 28976750]
Jun Li, Raina Seupel, Torsten Bruhn, Doris Feineis, Marcel Kaiser, Reto Brun, Virima Mudogo, Suresh Awale, Gerhard Bringmann. Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of natural products. 2017 10; 80(10):2807-2817. doi: 10.1021/acs.jnatprod.7b00650. [PMID: 29043798]
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Chang-Ling Hu, Juan Xiong, Peng Xu, Ke-Jun Cheng, Guo-Xun Yang, Jin-Feng Hu. Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities. Natural product research. 2017 Jun; 31(12):1358-1364. doi: 10.1080/14786419.2016.1247082. [PMID: 27774796]
Ye Wang, Fei Yu, Ming-Yue Liu, Yi-Kai Zhao, Dong-Ming Wang, Qing-Hong Hao, Xiu-Ling Wang. Isolation and Characterization of a Human Intestinal Bacterium Eggerthella sp. AUH-JLD49s for the Conversion of (-)-3'-Desmethylarctigenin. Journal of agricultural and food chemistry. 2017 May; 65(20):4051-4056. doi: 10.1021/acs.jafc.7b00114. [PMID: 28493688]
Jihye Lee, Jee-Young Imm, Seong-Ho Lee. β-Catenin Mediates Anti-adipogenic and Anticancer Effects of Arctigenin in Preadipocytes and Breast Cancer Cells. Journal of agricultural and food chemistry. 2017 Mar; 65(12):2513-2520. doi: 10.1021/acs.jafc.7b00112. [PMID: 28279068]
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Yue Qi, De-Qiang Dou, Hong Jiang, Bing-Bing Zhang, Wen-Yan Qin, Kai Kang, Na Zhang, Dong Jia. Arctigenin Attenuates Learning and Memory Deficits through PI3k/Akt/GSK-3β Pathway Reducing Tau Hyperphosphorylation in Aβ-Induced AD Mice. Planta medica. 2017 Jan; 83(1-02):51-56. doi: 10.1055/s-0042-107471. [PMID: 27224270]
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Hai Xuan Nguyen, Truong Nhat Van Do, Tho Huu Le, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Hiroyasu Esumi, Suresh Awale. Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of natural products. 2016 08; 79(8):2053-9. doi: 10.1021/acs.jnatprod.6b00381. [PMID: 27466882]
Hui Zhang, Zhenying Zhao, Tao Wang, Yijia Wang, Xiao Cui, Huijuan Zhang, Zhong-Ze Fang. Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Arctiin and Arctigenin. Phytotherapy research : PTR. 2016 Jul; 30(7):1189-96. doi: 10.1002/ptr.5627. [PMID: 27145339]
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Jie Chen, Wentao Li, Erguang Jin, Qigai He, Weidong Yan, Hanchun Yang, Shiyu Gong, Yi Guo, Shulin Fu, Xiabing Chen, Shengqiang Ye, Yunguo Qian. The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2. Research in veterinary science. 2016 Jun; 106(?):159-64. doi: 10.1016/j.rvsc.2015.10.012. [PMID: 27234554]
Haitao Lü, Zhaoyun Sun, Hu Shan, Jiying Song. Microwave-Assisted Extraction and Purification of Arctiin and Arctigenin from Fructus Arctii by High-Speed Countercurrent Chromatography. Journal of chromatographic science. 2016 Mar; 54(3):472-8. doi: 10.1093/chromsci/bmv168. [PMID: 26590235]
Qing-chun Li, Yun Liang, Yuan Tian, Guang-rui Hu. Arctigenin induces apoptosis in colon cancer cells through ROS/p38MAPK pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2016 Jan; 21(1):87-94. doi: . [PMID: 27061535]
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Hong Xin, Yang-Liu Xia, Jie Hou, Ping Wang, Wei He, Ling Yang, Guang-Bo Ge, Wei Xu. Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin. The Journal of pharmacy and pharmacology. 2015 Dec; 67(12):1673-81. doi: 10.1111/jphp.12483. [PMID: 26407805]
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Xin Wu, Yannong Dou, Yan Yang, Difei Bian, Jinque Luo, Bei Tong, Yufeng Xia, Yue Dai. Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway. Biochemical pharmacology. 2015 Aug; 96(4):323-36. doi: 10.1016/j.bcp.2015.06.008. [PMID: 26074264]
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