Elemicin (BioDeep_00000859518)

Main id: BioDeep_00000008097

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Benzene, 1,2,3-trimethoxy-5-(2-propenyl)- (9CI)

化学式: C12H16O3 (208.1099)
中文名称: 榄香素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCC1=CC(OC)=C(OC)C(OC)=C1
InChI: InChI=1S/C12H16O3/c1-5-6-9-7-10(13-2)12(15-4)11(8-9)14-3/h5,7-8H,1,6H2,2-4H3

描述信息

Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity[1][2][3][4].
Elemicin is a alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin is one of the main components in aromatic food and has antimicrobial, antioxidant, and antiviral activities. Elemicin possesses genotoxicity and carcinogenicity[1].
Elemicin is a alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin is one of the main components in aromatic food and has antimicrobial, antioxidant, and antiviral activities. Elemicin possesses genotoxicity and carcinogenicity[1].

同义名列表

21 个代谢物同义名

Benzene, 1,2,3-trimethoxy-5-(2-propenyl)- (9CI); 4-06-00-07478 (Beilstein Handbook Reference); Benzene, 1,2,3-trimethoxy-5-(2-propenyl)-; 1,2,3-trimethoxy-5-prop-2-enyl-benzene; 1,2,3-Trimethoxy-5-(2-propenyl)benzene; 1,2,3-trimethoxy-5-prop-2-enylbenzene; BENZENE, 5-ALLYL-1,2,3-TRIMETHOXY-; 5-allyl-1,2,3-trimethoxy-benzene; 5-Allyl-1,2,3-trimethoxybenzene; 3,4,5-Trimethoxyallylbenzene; EINECS 207-649-0; BRN 1912664; CCRIS 6783; AI3-20815; NSC 16704; NSC16704; Elemicin; 487-11-6; C10451; Elemicin; Elemicin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

429 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CAT, CYP1A1, CYP3A4, FASN, HPGDS, INMT, SLC6A3
Peripheral membrane protein 2 ACHE, CYP1A1
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 3 CYP1A1, CYP1A2, CYP3A4
Nucleus 1 ACHE
cytosol 7 CAT, FASN, GPT, HPGDS, IL1B, INMT, LEP
dendrite 1 MAOB
nucleoplasm 1 HPGDS
Cell membrane 5 ACHE, SLC6A2, SLC6A3, SLC6A4, TNF
Cytoplasmic side 1 MAOB
Cell projection, axon 1 SLC6A3
Multi-pass membrane protein 3 SLC6A2, SLC6A3, SLC6A4
Synapse 2 ACHE, SLC6A4
cell surface 5 ACHE, ADIPOQ, SLC6A2, SLC6A3, TNF
Golgi apparatus 3 ACHE, ATRN, FASN
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
neuronal cell body 3 MAOB, SLC6A3, TNF
presynaptic membrane 3 SLC6A2, SLC6A3, SLC6A4
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
Presynapse 1 SLC6A4
plasma membrane 7 ACHE, ATRN, FASN, SLC6A2, SLC6A3, SLC6A4, TNF
synaptic vesicle membrane 1 SLC6A2
Membrane 7 ACHE, CAT, CYP3A4, FASN, SLC6A2, SLC6A3, SLC6A4
axon 2 SLC6A2, SLC6A3
extracellular exosome 4 ATRN, CAT, FASN, GPT
endoplasmic reticulum 1 ADIPOQ
extracellular space 7 ACHE, ADIPOQ, ATRN, IL1B, IL6, LEP, TNF
perinuclear region of cytoplasm 1 ACHE
mitochondrion 3 CAT, CYP1A1, MAOB
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 5 CAT, CYP1A1, CYP1A2, CYP3A4, HPGDS
Microsome membrane 3 CYP1A1, CYP1A2, CYP3A4
Single-pass type I membrane protein 1 ATRN
Secreted 5 ACHE, ADIPOQ, IL1B, IL6, LEP
extracellular region 8 ACHE, ADIPOQ, CAT, DNAH9, IL1B, IL6, LEP, TNF
Mitochondrion outer membrane 1 MAOB
mitochondrial outer membrane 1 MAOB
neuronal cell body membrane 2 SLC6A2, SLC6A3
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
motile cilium 1 DNAH9
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 2 SLC6A3, SLC6A4
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 3 SLC6A3, SLC6A4, TNF
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 2 CAT, SLC6A4
microtubule 1 DNAH9
flotillin complex 1 SLC6A3
Peroxisome 1 CAT
basement membrane 1 ACHE
collagen trimer 1 ADIPOQ
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ADIPOQ
secretory granule 1 IL1B
axoneme 1 DNAH9
Cell projection, neuron projection 2 SLC6A3, SLC6A4
neuron projection 2 SLC6A3, SLC6A4
phagocytic cup 1 TNF
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
Endomembrane system 1 SLC6A4
Melanosome 1 FASN
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 IL6
axon terminus 1 SLC6A3
Secreted, extracellular exosome 1 IL1B
mitochondrial envelope 1 MAOB
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
Single-pass type IV membrane protein 1 MAOB
synaptic cleft 1 ACHE
[Isoform 1]: Cell membrane 1 ATRN
dopaminergic synapse 1 SLC6A3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[Isoform H]: Cell membrane 1 ACHE
serotonergic synapse 1 SLC6A4
glycogen granule 1 FASN
outer dynein arm 1 DNAH9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
distal portion of axoneme 1 DNAH9


文献列表

  • Ly Thi Huong Nguyen, Nhi Phuc Khanh Nguyen, Khoa Nguyen Tran, Heung-Mook Shin, In-Jun Yang. Intranasal administration of the essential oil from Perillae Folium ameliorates social defeat stress-induced behavioral impairments in mice. Journal of ethnopharmacology. 2024 Jan; 324(?):117775. doi: 10.1016/j.jep.2024.117775. [PMID: 38224793]
  • Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang. Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice. Toxicology. 2022 02; 467(?):153088. doi: 10.1016/j.tox.2021.153088. [PMID: 34979169]
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  • Xiao-Nan Yang, Yi-Kun Wang, Xu Zhu, Xue-Rong Xiao, Man-Yun Dai, Ting Zhang, Yan Qu, Xiu-Wei Yang, Hong-Bo Qin, Frank J Gonzalez, Fei Li. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chemical research in toxicology. 2019 10; 32(10):1965-1976. doi: 10.1021/acs.chemrestox.9b00112. [PMID: 31468958]
  • Yi-Kun Wang, Xiao-Nan Yang, Xu Zhu, Xue-Rong Xiao, Xiu-Wei Yang, Hong-Bo Qin, Frank J Gonzalez, Fei Li. Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity. Journal of agricultural and food chemistry. 2019 Jul; 67(29):8243-8252. doi: 10.1021/acs.jafc.9b02137. [PMID: 31271289]
  • Emmanuelle Dorla, Anne Gauvin-Bialecki, Zoé Deuscher, Agathe Allibert, Isabelle Grondin, Jean-Philippe Deguine, Philippe Laurent. Insecticidal Activity of the Leaf Essential Oil of Peperomia borbonensis Miq. (Piperaceae) and Its Major Components against the Melon Fly Bactrocera cucurbitae (Diptera: Tephritidae). Chemistry & biodiversity. 2017 Jun; 14(6):. doi: 10.1002/cbdv.201600493. [PMID: 28273402]
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