Clorgiline (BioDeep_00000858685)

Main id: BioDeep_00000008801

 


代谢物信息卡片


Clorgiline

化学式: C13H15Cl2NO (271.0531)
中文名称: 氯吉灵, 氯精氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C#CCN(C)CCCOc1ccc(cc1Cl)Cl
InChI: InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
Same as: D03248

同义名列表

4 个代谢物同义名

Clorgiline; Clorgyline; Clorgyline; Clorgiline



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AOC3, AR, CAT, CTNNB1, DDC, HIF1A, SLC6A3, TH
Peripheral membrane protein 2 ACHE, AOC1
Endoplasmic reticulum membrane 1 DRD1
Mitochondrion membrane 1 MAOA
Nucleus 6 ACHE, AR, CTNNB1, DRD1, HIF1A, TH
cytosol 8 AR, CAT, COMT, CTNNB1, DDC, HIF1A, MAOA, TH
dendrite 7 COMT, DRD2, HTR1A, HTR1B, HTR2A, MAOB, TH
nuclear body 1 HIF1A
centrosome 1 CTNNB1
nucleoplasm 3 AR, CTNNB1, HIF1A
RNA polymerase II transcription regulator complex 1 HIF1A
Cell membrane 12 ACHE, ADRB3, AOC1, AOC3, COMT, CTNNB1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, SLC6A3
Cytoplasmic side 2 MAOA, MAOB
lamellipodium 1 CTNNB1
Cell projection, axon 3 HTR2A, SLC6A3, TH
Multi-pass membrane protein 7 ADRB3, DRD1, DRD2, HTR1A, HTR1B, HTR2A, SLC6A3
Golgi apparatus membrane 1 DRD2
Synapse 5 ACHE, COMT, CTNNB1, DRD2, HTR1A
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 3 ACHE, AOC3, SLC6A3
dendritic shaft 1 HTR2A
glutamatergic synapse 4 CTNNB1, DRD1, DRD2, HTR2A
Golgi apparatus 2 ACHE, AOC3
Golgi membrane 2 DRD2, INS
neuromuscular junction 1 ACHE
neuronal cell body 3 HTR2A, MAOB, SLC6A3
presynaptic membrane 6 CTNNB1, DRD1, DRD2, HTR1B, HTR2A, SLC6A3
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Presynapse 1 HTR2A
acrosomal vesicle 1 DRD2
plasma membrane 13 ACHE, ADRB3, AOC1, AOC3, AR, COMT, CTNNB1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, SLC6A3
synaptic vesicle membrane 1 DRD2
terminal bouton 1 TH
Membrane 8 ACHE, AOC3, AR, CAT, COMT, CTNNB1, MAOA, SLC6A3
axon 5 COMT, DRD2, HTR2A, SLC6A3, TH
basolateral plasma membrane 1 CTNNB1
caveola 1 HTR2A
extracellular exosome 5 AOC1, CAT, COMT, CTNNB1, DDC
endoplasmic reticulum 2 AOC3, HTR1B
extracellular space 3 ACHE, AOC1, INS
perinuclear region of cytoplasm 3 ACHE, CTNNB1, TH
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 AOC1, CTNNB1
mitochondrion 4 CAT, MAOA, MAOB, TH
protein-containing complex 4 AR, CAT, CTNNB1, HIF1A
intracellular membrane-bounded organelle 2 CAT, COMT
Secreted 2 ACHE, INS
extracellular region 4 ACHE, AOC1, CAT, INS
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 2 MAOA, MAOB
Single-pass membrane protein 1 MAOA
mitochondrial outer membrane 2 MAOA, MAOB
neuronal cell body membrane 1 SLC6A3
mitochondrial matrix 1 CAT
Extracellular side 3 ACHE, AOC1, COMT
transcription regulator complex 1 CTNNB1
ciliary membrane 2 DRD1, DRD2
motile cilium 1 HIF1A
dendritic spine 2 DRD1, DRD2
perikaryon 2 DRD2, TH
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
cytoplasmic vesicle 2 HTR2A, TH
Wnt signalosome 1 CTNNB1
axon cytoplasm 1 HIF1A
Melanosome membrane 1 TH
Early endosome 1 AOC3
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
Single-pass type II membrane protein 2 AOC3, COMT
postsynaptic membrane 5 CTNNB1, DRD1, DRD2, HTR2A, SLC6A3
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 SLC6A3
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CAT, CTNNB1
GABA-ergic synapse 2 DRD1, DRD2
Cell junction, adherens junction 1 CTNNB1
flotillin complex 2 CTNNB1, SLC6A3
Peroxisome 2 AOC1, CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Cell projection, dendritic spine 1 DRD1
fascia adherens 1 CTNNB1
lateral plasma membrane 2 CTNNB1, DRD2
nuclear speck 2 AR, HIF1A
receptor complex 1 ADRB3
Cell projection, neuron projection 1 SLC6A3
neuron projection 2 SLC6A3, TH
cilium 2 DRD1, DRD2
chromatin 2 AR, HIF1A
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Secreted, extracellular space 1 AOC1
spindle pole 1 CTNNB1
non-motile cilium 2 DRD1, DRD2
postsynaptic density, intracellular component 1 CTNNB1
Lipid-anchor, GPI-anchor 1 ACHE
microvillus membrane 1 CTNNB1
sperm flagellum 1 DRD2
Endomembrane system 1 CTNNB1
endosome lumen 1 INS
microvillus 1 AOC3
Membrane, caveola 1 HTR2A
cell body fiber 1 HTR2A
Cell projection, dendrite 3 DRD1, HTR1A, HTR2A
Nucleus speckle 1 HIF1A
euchromatin 2 CTNNB1, HIF1A
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
axon terminus 2 DRD2, SLC6A3
specific granule lumen 1 AOC1
endocytic vesicle 1 DRD2
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
mitochondrial envelope 1 MAOB
Single-pass type IV membrane protein 2 MAOA, MAOB
neurofilament 1 HTR2A
presynaptic active zone cytoplasmic component 1 CTNNB1
calyx of Held 1 HTR1B
synaptic cleft 1 ACHE
protein-DNA complex 1 CTNNB1
dopaminergic synapse 2 DRD2, SLC6A3
catenin complex 1 CTNNB1
Cell projection, cilium membrane 1 DRD1
catalase complex 1 CAT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
G protein-coupled receptor complex 2 DRD1, DRD2
beta-catenin-TCF7L2 complex 1 CTNNB1
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
[Isoform H]: Cell membrane 1 ACHE
G protein-coupled serotonin receptor complex 2 HTR1B, HTR2A
serotonergic synapse 1 HTR1B
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1


文献列表

  • Guohui Zhong, Jie Guo, Chengyun Pang, Di Su, Chunli Tang, Lin Jing, Fengling Zhang, Ping He, Yaqian Yan, Zongji Chen, Jing Liu, Neng Jiang. Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. Bioorganic chemistry. 2023 01; 130(?):106224. doi: 10.1016/j.bioorg.2022.106224. [PMID: 36332315]
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  • Sai-Sai Xie, Jing Liu, Chunli Tang, Chengyun Pang, Qing Li, Yuelian Qin, Xiaojie Nong, Zhipeng Zhang, Jie Guo, Maojun Cheng, Weizhong Tang, Ningsheng Liang, Neng Jiang. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease. European journal of medicinal chemistry. 2020 Sep; 202(?):112475. doi: 10.1016/j.ejmech.2020.112475. [PMID: 32652406]
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  • Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):718-722. doi: 10.1016/j.bmcl.2017.01.050. [PMID: 28131710]
  • Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Deng. Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2017 Jan; 126(?):762-775. doi: 10.1016/j.ejmech.2016.12.009. [PMID: 27951485]
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  • Juliana Maria de Mello Andrade, Carolina Dos Santos Passos, Maria Angélica Kieling Rubio, Jacqueline Nakau Mendonça, Norberto Peporine Lopes, Amélia Teresinha Henriques. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chemico-biological interactions. 2016 Jul; 254(?):135-45. doi: 10.1016/j.cbi.2016.06.005. [PMID: 27270453]
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