trimetrexate (BioDeep_00000858453)

Main id: BioDeep_00000008521

 


代谢物信息卡片


trimetrexate

化学式: C19H23N5O3 (369.1801)
中文名称: 三甲曲沙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC
InChI: InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)

描述信息

P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
Same as: D06238

同义名列表

2 个代谢物同义名

trimetrexate; Trimetrexate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, ALB, CD34, CDKN2A, DHFR, FANCC, IKZF3, TYMS, YTHDF2
Peripheral membrane protein 1 PRTN3
Endoplasmic reticulum membrane 1 FOLR1
Nucleus 8 ALB, CDKN2A, FANCC, FOLR1, IKZF3, RFC1, TYMS, YTHDF2
cytosol 10 ALB, B2M, CDKN2A, DHFR, FANCC, GART, IKZF3, PRTN3, TYMS, YTHDF2
centrosome 1 ALB
nucleoplasm 5 CD2, CDKN2A, FANCC, IKZF3, RFC1
Cell membrane 7 ABCB1, B2M, CD2, FOLR1, PRTN3, RFC1, TNF
Cytoplasmic granule 1 PRTN3
Early endosome membrane 1 B2M
Multi-pass membrane protein 3 ABCB1, CACNA1I, RFC1
cell surface 5 ABCB1, B2M, CD2, FOLR1, TNF
Golgi apparatus 3 ALB, B2M, CD2
Golgi membrane 2 B2M, FOLR1
lysosomal membrane 1 B2M
mitochondrial inner membrane 1 TYMS
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 YTHDF2
Lysosome 1 CD34
endosome 1 FOLR1
plasma membrane 11 ABCB1, B2M, CACNA1I, CD2, CD34, FOLR1, IFNLR1, IL2RA, PRTN3, RFC1, TNF
Membrane 7 ABCB1, B2M, CACNA1I, CD34, FOLR1, IFNLR1, IL2RA
apical plasma membrane 4 ABCB1, CD34, FOLR1, RFC1
basolateral plasma membrane 2 FOLR1, RFC1
extracellular exosome 7 ABCB1, ALB, B2M, FOLR1, GART, PRTN3, RFC1
endoplasmic reticulum 2 ALB, B2M
extracellular space 5 ALB, B2M, IL2, PRTN3, TNF
perinuclear region of cytoplasm 1 CD34
mitochondrion 3 CDKN2A, DHFR, TYMS
protein-containing complex 3 ALB, CD2, CDKN2A
intracellular membrane-bounded organelle 1 PRTN3
Single-pass type I membrane protein 4 CD2, CD34, IFNLR1, IL2RA
Secreted 5 ALB, B2M, FOLR1, IL2, PRTN3
extracellular region 7 ALB, B2M, CD2, CD34, IL2, PRTN3, TNF
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion matrix 1 TYMS
mitochondrial matrix 2 CDKN2A, TYMS
Extracellular side 1 PRTN3
anchoring junction 1 ALB
centriolar satellite 1 YTHDF2
external side of plasma membrane 6 B2M, CD2, CD34, FOLR1, IL2RA, TNF
cytoplasmic vesicle 1 FOLR1
nucleolus 1 CDKN2A
Cytoplasm, P-body 1 YTHDF2
P-body 1 YTHDF2
cell-cell junction 1 CD2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 3 ABCB1, FOLR1, RFC1
Mitochondrion inner membrane 1 TYMS
Membrane raft 2 PRTN3, TNF
focal adhesion 1 B2M
ciliary basal body 1 ALB
chromatin 1 FANCC
Late endosome membrane 1 B2M
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 B2M
[Isoform 3]: Nucleus 1 IKZF3
centriole 1 ALB
cytoplasmic ribonucleoprotein granule 1 YTHDF2
brush border membrane 2 FOLR1, RFC1
Nucleus, nucleolus 1 CDKN2A
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 2 FOLR1, RFC1
Lipid-anchor, GPI-anchor 1 FOLR1
intercellular bridge 1 CD34
Recycling endosome membrane 1 B2M
Fanconi anaemia nuclear complex 1 FANCC
Nucleus, nucleoplasm 1 CDKN2A
Cytoplasm, Stress granule 1 YTHDF2
cytoplasmic stress granule 1 YTHDF2
basal plasma membrane 1 CD34
clathrin-coated vesicle 1 FOLR1
plasma membrane raft 1 PRTN3
HFE-transferrin receptor complex 1 B2M
endoplasmic reticulum lumen 2 ALB, B2M
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 1 B2M
tertiary granule lumen 1 B2M
Cytoplasmic vesicle, clathrin-coated vesicle 1 FOLR1
transport vesicle 1 FOLR1
azurophil granule lumen 1 PRTN3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 FOLR1
ER to Golgi transport vesicle membrane 2 B2M, FOLR1
[Isoform 1]: Nucleus 1 IKZF3
external side of apical plasma membrane 1 ABCB1
MHC class I peptide loading complex 1 B2M
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-2 receptor complex 1 IL2RA
MHC class I protein complex 1 B2M
MHC class II protein complex 1 B2M
Lipid-anchor, GPI-like-anchor 1 FOLR1
senescence-associated heterochromatin focus 1 CDKN2A
glomerular endothelium fenestra 1 CD34
DNA replication factor C complex 1 RFC1
Elg1 RFC-like complex 1 RFC1
[Isoform 12]: Cytoplasm 1 IKZF3
ciliary transition fiber 1 ALB
early endosome lumen 1 B2M
[Isoform 11]: Nucleus 1 IKZF3
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform smARF]: Mitochondrion 1 CDKN2A
[Isoform 14]: Nucleus 1 IKZF3


文献列表

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  • Allen T Hopper, Adam Brockman, Andy Wise, Julie Gould, Jennifer Barks, Joshua B Radke, L David Sibley, Yongmao Zou, Stephen Thomas. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. Journal of medicinal chemistry. 2019 02; 62(3):1562-1576. doi: 10.1021/acs.jmedchem.8b01754. [PMID: 30624926]
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