Guaiacol (BioDeep_00000000836)

 

Secondary id: BioDeep_00000861900

human metabolite Endogenous blood metabolite PANOMIX_OTCML-2023


代谢物信息卡片


Guaiacol, Pharmaceutical Secondary Standard; Certified Reference Material

化学式: C7H8O2 (124.05242679999999)
中文名称: 木材防腐油, 愈创木酚, 蜂胶黄酮
谱图信息: 最多检出来源 Homo sapiens(blood) 0.08%

分子结构信息

SMILES: COC1=C(O)C=CC=C1
InChI: InChI=1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3

描述信息

O-methoxyphenol appears as colorless to amber crystals or liquid. Density (of solid) 1.129 g / cm3. Solidifies at 28 °C (82.4 °F), but may remain liquid for a long time even at a much lower temperature. Slightly water soluble. Soluble in aqueous sodium hydroxide. Used medicinally as an expectorant. Used, because of its anti-oxidant properties, as an anti-skinning agent for paints.
Guaiacol is a monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position. It has a role as an expectorant, a disinfectant, a plant metabolite and an EC 1.1.1.25 (shikimate dehydrogenase) inhibitor. It is functionally related to a catechol.
Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma.
Guaiacol is a natural product found in Verbascum lychnitis, Castanopsis cuspidata, and other organisms with data available.
Guaiacol is a phenolic compound with a methoxy group and is the monomethyl ether of catechol. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes. It therefore serves as a reducing co-substrate for COX reactions. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a yellowish aromatic oil that is now commonly derived from guaiacum or wood creosote. It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a potent scavenger of reactive oxygen radicals and its radical scavenging activity may be associated with its effect on cell proliferation. Guaiacol is also used in the preparation of synthetic vanillin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma. (A3556, A3559).
2-methoxyphenol is a metabolite found in or produced by Saccharomyces cerevisiae.
An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
See also: Wood Creosote (part of); Tolu balsam (USP) (part of).
Guaiacol is a phenolic compound with a methoxy group and is the monomethyl ether of catechol. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes. It therefore serves as a reducing co-substrate for COX reactions. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a yellowish aromatic oil that is now commonly derived from guaiacum or wood creosote. It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a potent scavenger of reactive oxygen radicals and its radical scavenging activity may be associated with its effect on cell proliferation. Guaiacol is also used in the preparation of synthetic vanillin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma. (PMID 4344880, 16152729).
Present in Parmesan cheese, tea and soybean. Flavouring ingredient. 2-Methoxyphenol is found in many foods, some of which are milk and milk products, asparagus, pepper (c. annuum), and wild celery.
R - Respiratory system > R05 - Cough and cold preparations > R05C - Expectorants, excl. combinations with cough suppressants > R05CA - Expectorants
A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
C78273 - Agent Affecting Respiratory System > C29767 - Expectorant
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1].
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1].

同义名列表

103 个代谢物同义名

Guaiacol, Pharmaceutical Secondary Standard; Certified Reference Material; Guaiacol, United States Pharmacopeia (USP) Reference Standard; Guaiacol, European Pharmacopoeia (EP) Reference Standard; 2-Methoxyphenol;o-Methoxyphenol;2-Hydroxyanisole; InChI=1/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H; Guaiacol, Vetec(TM) reagent grade, 98\\%; GUAIFENESIN IMPURITY A [EP IMPURITY]; GUAIFENESIN IMPURITY A (EP IMPURITY); Guaiacol, SAJ first grade, >=98.0\\%; Guaiacol, natural, >=99\\%, FG; Pyrocatechol monomethyl ether; 2-Methoxyphenol-3,4,5,6-d4,OD; Guaiacol, oxidation indicator; guaiacol (liquid) extra pure; 3-methoxy-4-hydroxy benzene; 1-Hydroxy-2-methoxybenzene; 2-methoxyphenol (guaiacol); Catechol mono methyl ether; Pyrocatechol methyl ester; Catechol monomethyl ether; 2-methoxyl-4-vinylphenol; ghl.PD_Mitscher_leg0.900; GUAIACOL [EP MONOGRAPH]; GUAIACOL (USP IMPURITY); Guaiacol, puriss., 99\\%; 2-Methoxy-d3-phenol--d4; GUAIACOL [USP IMPURITY]; GUAIACOL (EP MONOGRAPH); ortho-methoxyphenol; 2-(methyloxy)phenol; Guaiacol (natural); (mu)-methoxyphenol; Phenol, 2-methoxy-; orthomethoxyphenol; Phenol, o-methoxy-; O-METHOXY CATECHOL; GUAIACOL (USP-RS); O-HYDROXYANIOSOLE; GUAIACOL [USP-RS]; O-Methyl catechol; 2-Methyloxyphenol; 2-Hydroxy-Anisole; Guaiacol [JAN:NF]; GUAIACOL [WHO-DD]; GUAIACOL [VANDF]; hydroxyl anisole; o--methoxyphenol; 2-Methoxy-Phenol; Catechol, Methyl; GUAIACOL (MART.); o-methoxy-Phenol; Phenol, methoxy-; 2-Hydroxyanisole; Guajakol [Czech]; o-Hydroxyanisole; O-methylcatechol; GUAIACOL [MART.]; 2-methoxy phenol; 6-methoxyphenol; 2-Methoxyphenol; o-Methoxyphenol; GUAIACOL [HSDB]; Pyroguaiac acid; UNII-6JKA7MAH9C; GUAIACOL [FHFI]; Methyl Catechol; Methylcatachol; CREOSOTE, WOOD; Methylcatechol; methoxy phenol; Guaiacol (JAN); Guaiacol [JAN]; ortho-Guaiacol; Methoxyphenol; GUAIACOL [MI]; Creosote wood; Wood creosote; Tox21_202990; Tox21_201136; Tox21_111031; Creodon (TN); Guaiacol,(S); Tox21_400004; WLN: QR BO1; CAS-90-05-1; o-Guaiacol; 6JKA7MAH9C; Guaicolina; AI3-05615; Guaiastil; o-Guiacol; Guajacol; Creasote; Guajakol; Creosote; Guaiacol; Guaicol; guiacol; Creodon; Anastil; Guajol; Guasol; JZ3



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(11)

PlantCyc(2)

代谢反应

31 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

  • guaiacylglycerol-β-guaiacyl ether degradation: (2R)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one + glutathione ⟶ (2R)-2-(glutathion-S-yl)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one + guaiacol

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(6)

COVID-19 Disease Map(0)

PathBank(24)

PharmGKB(0)

76 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Weilai Yu, Boyang Li, Luxi Chen, Qiu Chen, QingQing Song, Xiaosheng Jin, Yandan Yin, Haibin Tong, Liwei Xue. Gigantol ameliorates DSS-induced colitis via suppressing β2 integrin mediated adhesion and chemotaxis of macrophage. Journal of ethnopharmacology. 2024 Jun; 328(?):118123. doi: 10.1016/j.jep.2024.118123. [PMID: 38554854]
  • Maksimiljan Adamek, Anja Kavčič, Marta Debeljak, Martin Šala, Jože Grdadolnik, Katarina Vogel-Mikuš, Ana Kroflič. Toxicity of nitrophenolic pollutant 4-nitroguaiacol to terrestrial plants and comparison with its non-nitro analogue guaiacol (2-methoxyphenol). Scientific reports. 2024 01; 14(1):2198. doi: 10.1038/s41598-024-52610-6. [PMID: 38272996]
  • Shahrzad Molavinia, Mehrad Nikravesh, Marzieh Pashmforoosh, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar. Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation. Neurochemical research. 2023 Oct; ?(?):. doi: 10.1007/s11064-023-04043-2. [PMID: 37864024]
  • Delong Wang, Min Li, Chunxia Yuan, Yali Fang, Zhijia Zhang. Guaiacol as a natural melanin biosynthesis inhibitor to control northern corn leaf blight. Pest management science. 2022 Nov; 78(11):4557-4568. doi: 10.1002/ps.7075. [PMID: 35833811]
  • Natalia Mikołajczak, Małgorzata Tańska, Dorota Ogrodowska, Sylwester Czaplicki. Efficacy of canolol and guaiacol in the protection of cold-pressed oils being a dietary source linoleic acid against oxidative deterioration. Food chemistry. 2022 Nov; 393(?):133390. doi: 10.1016/j.foodchem.2022.133390. [PMID: 35688088]
  • Ngouana Moffo A Ivane, Fopa Kue Roméo Elysé, Suleiman A Haruna, Ngwasiri Pride, Ejoh Richard, Anuanwen Claris Foncha, Munir Abba Dandago. The anti-oxidative potential of ginger extract and its constituent on meat protein isolate under induced Fenton oxidation. Journal of proteomics. 2022 10; 269(?):104723. doi: 10.1016/j.jprot.2022.104723. [PMID: 36096434]
  • Soukaina Hrichi, Raja Chaâbane-Banaoues, Filippo Alibrando, Ammar B Altemimi, Oussama Babba, Yassine Oulad El Majdoub, Habib Nasri, Luigi Mondello, Hamouda Babba, Zine Mighri, Francesco Cacciola. Chemical Composition, Antifungal and Anti-Biofilm Activities of Volatile Fractions of Convolvulus althaeoides L. Roots from Tunisia. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206834. [PMID: 36296427]
  • Maryam Ramtin, Fariba Sharifniya, Mohaddeseh Larypoor, Mirsasan Mirpour, Saeid Zarrabi. Evaluation of the Active Ingredient of Campsis radicans Essential Oils and its Antimicrobial Evaluation Against Pathogenic Bacteria. Current microbiology. 2022 Oct; 79(11):338. doi: 10.1007/s00284-022-03042-w. [PMID: 36201048]
  • Wei-Hao Zhang, Han-Yan Luo, Jing Fang, Chen-Liang Zhao, Kam-Chun Chan, Yui-Man Chan, Cai-Xia Dong, Hu-Biao Chen, Zhong-Zhen Zhao, Song-Lin Li, Jun Xu. Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence. Journal of agricultural and food chemistry. 2022 Oct; 70(39):12577-12586. doi: 10.1021/acs.jafc.2c05710. [PMID: 36130944]
  • Surabhi Mangal, Sanjay Chhibber, Vasundhara Singh, Kusum Harjai. Guaiacol augments quorum quenching potential of ciprofloxacin against Pseudomonas aeruginosa. Journal of applied microbiology. 2022 Oct; 133(4):2235-2254. doi: 10.1111/jam.15787. [PMID: 35984044]
  • Sania Ashrafi, Safaet Alam, Nazim Uddin Emon, Monira Ahsan. Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from Glycosmis cyanocarpa (Blume) Spreng. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185972. [PMID: 36144708]
  • Kumud Upadhyaya, Priya Kumari Sharma, Ansab Akhtar, Sangeeta Pilkhwal Sah. Protective Effects of Zingerone Against Depression-Like Behavior and Biochemical Changes in Chronic Stressed Rats: Antioxidant Effects. Journal of medicinal food. 2022 Jun; 25(6):576-587. doi: 10.1089/jmf.2021.k.0141. [PMID: 35639359]
  • Erdinç Türk, Mehmet Güvenç, Mustafa Cellat, Ahmet Uyar, Müslüm Kuzu, Ahmet Gökhan Ağgül, Akın Kırbaş. Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats. Drug and chemical toxicology. 2022 May; 45(3):1054-1065. doi: 10.1080/01480545.2020.1804397. [PMID: 32781857]
  • Walaa H El-Maadawy, Marwa Hassan, Rabab M Abdou, Riham S El-Dine, Tarek Aboushousha, Nebal D El-Tanbouly, Aly M El-Sayed. 6-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways. Environmental toxicology and pharmacology. 2022 Apr; 91(?):103817. doi: 10.1016/j.etap.2022.103817. [PMID: 35091105]
  • Xinwen Zhang, Delphis F Levia, Elvis Osamudiamhen Ebikade, Jeffrey Chang, Dionisios G Vlachos, Changqing Wu. The impact of differential lignin S/G ratios on mutagenicity and chicken embryonic toxicity. Journal of applied toxicology : JAT. 2022 03; 42(3):423-435. doi: 10.1002/jat.4229. [PMID: 34448506]
  • Nasiru Muhammad, Busisani W Lembede, Kennedy H Erlwanger. Neonatal administration of zingerone prevents the subsequent development of high dietary fructose-induced early features of nephropathy in rats. General physiology and biophysics. 2022 Mar; 41(2):141-150. doi: 10.4149/gpb_2022008. [PMID: 35416177]
  • Gabriel S Vignoli Muniz, Evandro L Duarte, Esteban N Lorenzón, Eduardo M Cilli, M Teresa Lamy. What different physical techniques can disclose about disruptions on membrane structure caused by the antimicrobial peptide Hylin a1 and a more positively charged analogue. Chemistry and physics of lipids. 2022 03; 243(?):105173. doi: 10.1016/j.chemphyslip.2022.105173. [PMID: 34995561]
  • Gehad M Elnagar, Mohamed M Elseweidy, Yasmin K Mahmoud, Nesreen M I M Elkomy, Ziyad M Althafar, Sultan F Alnomasy, Naif A Al-Gabri, Mohamed Shawky. 10-Dehydrogingerdione Attenuates Tramadol-Induced Nephrotoxicity by Modulating Renal Oxidative Stress, Inflammation and Apoptosis in Experimental Rats: Role of HO-1 Activation and TLR4/NF-κB/ERK Inhibition. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031384. [PMID: 35163308]
  • Shujie Li, Hualing Li, Dandan Yin, Xiaojing Xue, Xiaoling Chen, Xiaoyue Li, Junwei Li, Yongxiang Yi. Effect of gigantol on the proliferation of hepatocellular carcinoma cells tested by a network-based pharmacological approach and experiments. Frontiers in bioscience (Landmark edition). 2022 01; 27(1):25. doi: 10.31083/j.fbl2701025. [PMID: 35090330]
  • Huanan Kang, Yiming Sun, Xijiao Hu, Li Liu. Gigantol inhibits proliferation and enhanced oxidative stress-mediated apoptosis through modulating of Wnt/β-catenin signaling pathway in HeLa cells. Journal of biochemical and molecular toxicology. 2022 Jan; 36(1):e22944. doi: 10.1002/jbt.22944. [PMID: 34729850]
  • Nazirah Bashir, Sheikh Bilal Ahmad, Muneeb U Rehman, Showkeen Muzamil, Rahil Razak Bhat, Manzoor Ur Rahman Mir, Gamal A Shazly, Mohamed A Ibrahim, Gehan M Elossaily, Abdelrahman Y Sherif, Mohsin Kazi. Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants. Redox report : communications in free radical research. 2021 Dec; 26(1):62-70. doi: 10.1080/13510002.2021.1907518. [PMID: 33784959]
  • Tamilvelan Manjunathan, Ajay Guru, Jesu Arokiaraj, Pushparathinam Gopinath. 6-Gingerol and Semisynthetic 6-Gingerdione Counteract Oxidative Stress Induced by ROS in Zebrafish. Chemistry & biodiversity. 2021 Dec; 18(12):e2100650. doi: 10.1002/cbdv.202100650. [PMID: 34599795]
  • Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Basil Roufogalis, Amir Hossein Abdolghaffari, Amirhossein Sahebkar. Ginger: A complementary approach for management of cardiovascular diseases. BioFactors (Oxford, England). 2021 Nov; 47(6):933-951. doi: 10.1002/biof.1777. [PMID: 34388275]
  • X Geng, H Liu, Q Yuwen, J Wang, S Zhang, X Zhang, J Sun. Protective effects of zingerone on high cholesterol diet-induced atherosclerosis through lipid regulatory signaling pathway. Human & experimental toxicology. 2021 Oct; 40(10):1732-1745. doi: 10.1177/09603271211006170. [PMID: 33845646]
  • Giovanni Schepici, Valentina Contestabile, Andrea Valeri, Emanuela Mazzon. Ginger, a Possible Candidate for the Treatment of Dementias?. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185700. [PMID: 34577171]
  • Nasiru Muhammad, Busisani Wiseman Lembede, Kennedy Honey Erlwanger. Zingerone Administered Neonatally Prevents the Subsequent Development of High Dietary Fructose-Induced Fatty Liver in Sprague Dawley Rats. Journal of medicinal food. 2021 Sep; 24(9):944-952. doi: 10.1089/jmf.2020.0189. [PMID: 33512269]
  • Gehad M Elnagar, Mohamed M Elseweidy, Nesreen M I M Elkomy, Naif A Al-Gabri, Mohamed Shawky. 10-Dehydrogingerdione ameliorates renal endoplasmic reticulum/oxidative stress and apoptosis in alcoholic nephropathy induced in experimental rats. Life sciences. 2021 Aug; 279(?):119673. doi: 10.1016/j.lfs.2021.119673. [PMID: 34081991]
  • Tarique Anwer, Zafar Ali Alkarbi, Ali Hassan Najmi, Saeed Alshahrani, Rahimullah Siddiqui, Gyas Khan, Mohammad Firoz Alam. Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats. Archives of physiology and biochemistry. 2021 Aug; 127(4):304-310. doi: 10.1080/13813455.2019.1637436. [PMID: 31389247]
  • N Muhammad, B W Lembede, K H Erlwanger. Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats. Journal of developmental origins of health and disease. 2021 08; 12(4):671-679. doi: 10.1017/s2040174420000525. [PMID: 32500848]
  • Hiroyuki Hattori, Takashi Mori, Takahiro Shibata, Masaki Kita, Tohru Mitsunaga. 6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise. Molecular nutrition & food research. 2021 08; 65(16):e2100185. doi: 10.1002/mnfr.202100185. [PMID: 33793045]
  • Niramon Utama-Ang, Sirinapa Sida, Phenphichar Wanachantararak, Arthitaya Kawee-Ai. Development of edible Thai rice film fortified with ginger extract using microwave-assisted extraction for oral antimicrobial properties. Scientific reports. 2021 07; 11(1):14870. doi: 10.1038/s41598-021-94430-y. [PMID: 34290338]
  • Naoki Kitaoka, Taiji Nomura, Shinjiro Ogita, Yasuo Kato. Bioproduction of 4-Vinylphenol and 4-Vinylguaiacol β-Primeverosides Using Transformed Bamboo Cells Expressing Bacterial Phenolic Acid Decarboxylase. Applied biochemistry and biotechnology. 2021 Jul; 193(7):2061-2075. doi: 10.1007/s12010-021-03522-y. [PMID: 33544364]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Fei Zhou, Robert L Last, Eran Pichersky. Degradation of salicylic acid to catechol in Solanaceae by SA 1-hydroxylase. Plant physiology. 2021 04; 185(3):876-891. doi: 10.1093/plphys/kiaa096. [PMID: 33793924]
  • Nedra Slama, Houda Mankai, Ferid Limam. Streptomyces tunisiensis DSM 42037 mediated bioconversion of ferulic acid released from barley bran. World journal of microbiology & biotechnology. 2021 Mar; 37(4):70. doi: 10.1007/s11274-021-03031-4. [PMID: 33748917]
  • Insha Amin, Ishraq Hussain, Muneeb U Rehman, Bilal Ahmad Mir, Showkat Ahmad Ganaie, Sheikh Bilal Ahmad, Manzoor Ur Rahman Mir, Syed Shanaz, Showkeen Muzamil, Azher Arafah, Parvaiz Ahmad. Zingerone prevents lead-induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats. Journal of food biochemistry. 2021 03; 45(3):e13241. doi: 10.1111/jfbc.13241. [PMID: 32515504]
  • Saeed Mehrzadi, Hamidreza Khalili, Iman Fatemi, Alireza Malayeri, Amir Siahpoosh, Mehdi Goudarzi. Zingerone Mitigates Carrageenan-Induced Inflammation Through Antioxidant and Anti-inflammatory Activities. Inflammation. 2021 Feb; 44(1):186-193. doi: 10.1007/s10753-020-01320-y. [PMID: 32803664]
  • Misbahuddin Rafeeq, Hussam Aly Sayed Murad, Hossam Mohammed Abdallah, Ali M El-Halawany. Protective effect of 6-paradol in acetic acid-induced ulcerative colitis in rats. BMC complementary medicine and therapies. 2021 Jan; 21(1):28. doi: 10.1186/s12906-021-03203-7. [PMID: 33441125]
  • Rishab Marahatha, Saroj Basnet, Bibek Raj Bhattarai, Prakriti Budhathoki, Babita Aryal, Bikash Adhikari, Ganesh Lamichhane, Darbin Kumar Poudel, Niranjan Parajuli. Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis. BMC complementary medicine and therapies. 2021 Jan; 21(1):1. doi: 10.1186/s12906-020-03162-5. [PMID: 33386071]
  • Shengqiang Qian, Huiying Fang, Lu Zheng, Mei Liu. Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC-3 cells. Journal of biochemical and molecular toxicology. 2021 Jan; 35(1):e22611. doi: 10.1002/jbt.22611. [PMID: 32905641]
  • Karuna Sharma, Sunil Kumar Bose, Sanjay Chhibber, Kusum Harjai. Exploring the Therapeutic Efficacy of Zingerone Nanoparticles in Treating Biofilm-Associated Pyelonephritis Caused by Pseudomonas aeruginosa in the Murine Model. Inflammation. 2020 Dec; 43(6):2344-2356. doi: 10.1007/s10753-020-01304-y. [PMID: 32948964]
  • Kaho Yamaguchi, Tohru Mitsunaga, Kosei Yamauchi. 6-Paradol and its glucoside improve memory disorder in mice. Food & function. 2020 Nov; 11(11):9892-9902. doi: 10.1039/d0fo01975e. [PMID: 33094793]
  • Adil Farooq Wali, Muneeb U Rehman, Mohammad Raish, Mohsin Kazi, Padma G M Rao, Osamah Alnemer, Parvaiz Ahmad, Ajaz Ahmad. Zingerone [4-(3-Methoxy-4-hydroxyphenyl)-butan-2] Attenuates Lipopolysaccharide-Induced Inflammation and Protects Rats from Sepsis Associated Multi Organ Damage. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215127. [PMID: 33158114]
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