Mequinol (BioDeep_00000017462)

 

Secondary id: BioDeep_00000615816, BioDeep_00000863185

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs


代谢物信息卡片


4-Methoxybenzyl S-(4,6-dimethylpyrimidin-2-yl)thiocarbonate

化学式: C7H8O2 (124.05242679999999)
中文名称: 4-甲氧基苯酚,对羟基苯甲醚, 4-甲氧基苯酚(MEHQ), 4-甲氧基苯酚
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: c1c(ccc(c1)OC)O
InChI: InChI=1S/C7H8O2/c1-9-7-4-2-6(8)3-5-7/h2-5,8H,1H3

描述信息

Hydroquinone monomethyl ether appears as pink crystals or white waxy solid. (NTP, 1992)
P-methoxyphenol is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.
Mequinol is a phenol used in various applications. It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture of antioxidants, pharmaceuticals, plasticizers, and dyestuffs. It is found as an active ingredient in topical drugs used for skin depigmentation indicated for the treatment of solar lentigines.
Mequinol is a Skin Lightening Agent. The mechanism of action of mequinol is as a Melanin Synthesis Inhibitor. The physiologic effect of mequinol is by means of Depigmenting Activity.
4-Methoxyphenol is a natural product found in Origanum majorana, Ascia monuste, and other organisms with data available.
Mequinol is a synthetic derivate of hydroquinone and depigmenting agent. Although the exact mechanism of the depigmenting effects of mequinol remains unclear, it may exert its effect by oxidation of tyrosinase to cytotoxic products in melanocytes. Mequinol may also act by competitively inhibiting the formation of melanin precursors.
See also: Anoxomer (monomer of).
Mequinol is a drug used in combination with the drug tretinoin in the treatment of liver spots. Mequinol used alone and in higher doses is used as a topical drug for medical depigmentation. Mequinol is found in sweet marjoram and anise.
Mequinol is found in anise. Mequinol is a drug used in combination with the drug tretinoin in the treatment of liver spots. Mequinol used alone and in higher doses is used as a topical drug for medical depigmentation. (Wikipedia
D020011 - Protective Agents > D000975 - Antioxidants
A natural product found in Cordyceps sinensis.
C78284 - Agent Affecting Integumentary System
D000970 - Antineoplastic Agents
D - Dermatologicals
Mequinol (4-Methoxyphenol) is one of bioactive components in Mercurialis. Mequinol is used for skin depigmentation[1]
Mequinol (4-Methoxyphenol) is one of bioactive components in Mercurialis. Mequinol is used for skin depigmentation[1]

同义名列表

86 个代谢物同义名

4-Methoxybenzyl S-(4,6-dimethylpyrimidin-2-yl)thiocarbonate; InChI=1/C7H8O2/c1-9-7-4-2-6(8)3-5-7/h2-5,8H,1H; 4-Methoxyphenol, SAJ first grade, >=97.0\\%; 4-Methoxyphenol, purum, >=98.0\\% (HPLC); 4-Methoxyphenol, ReagentPlus(R), 99\\%; 4-Methoxyphenol, analytical standard; HQMME; HYDROXYQUINONE METHYL ETHER; 4-hydroxyanisole, potassium salt; Mono methyl ether hydroquinone; hydroquinone mono methyl ether; hydroquinone monomethyl ether; Monomethyl ether hydroquinone; 4-hydroxyanisole, sodium salt; MEQUINOL COMPONENT OF SOLAGE; hydroquinone monomethylether; hydroxyquinone methyl ether; 1-Hydroxy-4-methoxybenzene; hydroquinone methyl ether; SOLAGE COMPONENT MEQUINOL; Menthyl anthranilic acid; p-Hydroxymethoxybenzene; Mequinol [USAN:INN:DCF]; P-HYDROXYANISOLE [INCI]; Mequinolum [INN-Latin]; MEQUINOL [ORANGE BOOK]; para- hydroxyanisole; BMS-181158P-Guaiacol; Menthyl anthranilate; Mequinol, INN, USAN; para-hydroxyanisole; Mequinol (USAN/INN); 4-(methyloxy)phenol; Phenol, p-methoxy-; Phenol, 4-methoxy-; para-methoxyphenol; 4-(methoxy)phenol; PMF (antioxidant); paramethoxyphenol; MEQUINOL [WHO-DD]; Novo-Dermoquinona; 4-Methoxy-phenol; MEQUINOL [MART.]; PHENOL,4-METHOXY; 4-hydroxyanisole; MEQUINOL [VANDF]; MEQUINOL (MART.); p- methoxyphenol; p-hydroxyanisole; p-methoxy-phenol; Mechinolo [DCIT]; p-methoxy phenol; 4-methoxy phenol; MEQUINOL [USAN]; UNII-6HT8U7K3AM; MEQUINOL [HSDB]; p-Methoxyphenol; 4-methoxyphenol; Mequinol (INN); Hydroxyanisole; 4methoxyphenol; Tox21_111125_1; MEQUINOL [INN]; Methoxyphenol; Eastman HQMME; Leucodinine B; NCI60_004190; Tox21_302876; Tox21_202367; Tox21_111125; WLN: QR DO1; Leucodine B; Mechinolum; Leucobasal; P-Guaiacol; Mequinolum; 6HT8U7K3AM; AI3-00841; Mechinolo; USAF AN-7; Mequinol; D11AX06; HQMME; MEHQ; HQME; 4KS; 4HA



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Sylvain Valère Tanemossu Sob, Hippolyte Kamdem Wabo, Chun-Ping Tang, Pierre Tane, Bonaventure Tchaleu Ngadjui, Yang Ye. Phenol esters and other constituents from the stem barks of Stereospermum acuminatissimum. Journal of Asian natural products research. 2011 Dec; 13(12):1128-34. doi: 10.1080/10286020.2011.619182. [PMID: 22008010]
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  • Horacio Riojas-Rodriguez, Astrid Schilmann, Adriana Teresa Marron-Mares, Omar Masera, Zheng Li, Lovisa Romanoff, Andreas Sjödin, Leonora Rojas-Bracho, Larry L Needham, Isabelle Romieu. Impact of the improved patsari biomass stove on urinary polycyclic aromatic hydrocarbon biomarkers and carbon monoxide exposures in rural Mexican women. Environmental health perspectives. 2011 Sep; 119(9):1301-7. doi: 10.1289/ehp.1002927. [PMID: 21622083]
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  • Jan-Willem de Kraker, Maurice C R Franssen, Maaike Joerink, Aede de Groot, Harro J Bouwmeester. Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory. Plant physiology. 2002 May; 129(1):257-68. doi: 10.1104/pp.010957. [PMID: 12011356]
  • Carol A Lapp, George S Schuster. Effects of DMAEMA and 4-methoxyphenol on gingival fibroblast growth, metabolism, and response to interleukin-1. Journal of biomedical materials research. 2002 Apr; 60(1):30-5. doi: 10.1002/jbm.10057. [PMID: 11835156]
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