Guajol (BioDeep_00000861900)
Main id: BioDeep_00000000836
PANOMIX_OTCML-2023 BioNovoGene_Lab2019
描述信息
R - Respiratory system > R05 - Cough and cold preparations > R05C - Expectorants, excl. combinations with cough suppressants > R05CA - Expectorants
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
C78273 - Agent Affecting Respiratory System > C29767 - Expectorant
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1].
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1].
同义名列表
62 个代谢物同义名
InChI=1\C7H8O2\c1-9-7-5-3-2-4-6(7)8\h2-5,8H,1H; Pyrocatechol monomethyl ether; 1-Hydroxy-2-methoxybenzene; Pyrocatechol methyl ester; Catechol monomethyl ether; ghl.PD_Mitscher_leg0.900; Guaiacol (natural); Phenol, 2-methoxy-; Phenol, o-methoxy-; O-Methyl catechol; EINECS 201-964-7; Phenol, methoxy-; 2-Hydroxyanisole; Guajakol [Czech]; o-Hydroxyanisole; 2-Methoxyphenol; NCGC00090827-02; o-Methoxyphenol; W253200_ALDRICH; Pyroguaiac acid; NCGC00090827-03; NCGC00090827-01; CREOSOTE, WOOD; Methylcatechol; Guaiacol (JAN); Guaiacol [JAN]; FEMA No. 2532; Methoxyphenol; Creosote wood; Creodon (TN); ZINC00001521; AIDS-107096; 50880_FLUKA; WLN: QR BO1; CHEBI:28591; G5502_SIGMA; o-Guaiacol; Guaicolina; CCRIS 2943; 26638-03-9; AIDS107096; HSDB 4241; ST5214385; AI3-05615; Guaiastil; 8021-39-4; NSC 3815; Guajacol; Guaiacol; CPD-400; Guaicol; 90-05-1; NSC3815; Creodon; Anastil; C15572; Guajol; D00117; Guasol; C01502; Phenol, 2-methoxy-; o-Methoxyphenol
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:28591
- KEGG: C01502
- PubChem: 460
- DrugBank: DB11359
- ChEMBL: CHEMBL13766
- MeSH: Guaiacol
- CAS: 20189-11-1
- CAS: 9009-62-5
- CAS: 8021-39-4
- CAS: 90-05-1
- PubChem: 4671
- KNApSAcK: C00002654
- PDB-CCD: JZ3
- 3DMET: B00308
- NIKKAJI: J3.217D
- RefMet: Methylcatechol
- medchemexpress: HY-N1380
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-431
- KNApSAcK: 28591
- LOTUS: LTS0066913
- wikidata: Q2862455
分类词条
相关代谢途径
Reactome(0)
BioCyc(11)
- superpathway of N-acetylneuraminate degradation
- mixed acid fermentation
- superpathway of pyrimidine deoxyribonucleosides degradation
- superpathway of purine deoxyribonucleosides degradation
- superpathway of L-threonine metabolism
- 2'-deoxy-α-D-ribose 1-phosphate degradation
- ethanol degradation I
- ethanolamine utilization
- guaiacylglycerol-β-guaiacyl ether degradation
- L-threonine degradation IV
- pyruvate fermentation to ethanol I
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
61 个相关的物种来源信息
- 501610 - Agathosma betulina: 10.1021/JF60201A021
- 85712 - Angelica gigas: 10.1021/JF802820D
- 661339 - Aronia melanocarpa: 10.1002/JSFA.2740360908
- 155124 - Aspalathus linearis: 10.1021/JF00062A024
- 339519 - Astragalus pycnocephalus: 10.1021/NP0102051
- 124943 - Azadirachta indica: 10.1246/CL.1979.1137
- 375214 - Blepharocalyx salicifolius: 10.1021/NP50035A036
- 260124 - Blepharocalyx tweediei: 10.1021/NP50035A036
- 4072 - Capsicum annuum: 10.1006/JFCA.1997.0535
- 114816 - Castanopsis cuspidata: 10.1021/JF60224A025
- 13442 - Coffea: 10.1021/JF060460X
- 13443 - Coffea arabica: 10.1021/JF60160A010
- 329675 - Daphne odora: 10.1271/BBB1961.47.483
- 2715869 - Daphne papyracea: 10.1271/BBB1961.47.483
- 148894 - Geum heterocarpum: 10.1080/10412905.1994.9698398
- 49827 - Glycyrrhiza glabra: 10.1021/JF60214A042
- 3635 - Gossypium hirsutum: 10.1007/BF00575737
- 124774 - Illicium fargesii: 10.1248/CPB.56.1201
- 1202800 - Illicium simonsii: 10.1248/CPB.56.1201
- 85864 - Magnolia Officinalis Rehd Et Wils\uff0e: -
- 306395 - Micromeria juliana: 10.1080/10412905.1991.9697971
- 49558 - Osmorhiza aristata: 10.1248/YAKUSHI1947.99.11_1116
- 53809 - Oxalis pes-caprae: 10.1002/CBDV.200800179
- 35924 - Paeonia lactiflora:
- 45171 - Paeonia suffruticosa: 10.1080/00021369.1983.10866058
- 4054 - Panax ginseng: 10.1002/BMC.969
- 48386 - Perilla Frutescens: -
- 146781 - Phallus impudicus: 10.1248/CPB.32.797
- 5791 - Physarum polycephalum: 10.1248/CPB.32.797
- 271192 - Pimpinella anisum: 10.1016/S0031-9422(03)00179-1
- 33090 - Plants: -
- 3755 - Prunus dulcis: 10.1021/JF60228A025
- 65409 - Scutellaria baicalensis: 10.1271/BBB1961.51.1449
- 4182 - Sesamum indicum: 10.1021/JF970172O
- 1765318 - Thalia multiflora: 10.1002/PTR.1731
- 432920 - Uloma: 10.1007/BF00989557
- 1000433 - Verbascum lychnitis: 10.1007/BF00564831
- 54477 - Vitex agnus-castus: 10.1002/RCM.1290091307
- 29760 - Vitis vinifera: 10.3389/FMICB.2017.00457
- 137456 - 乌梅: -
- 83936 - 凌霄花: -
- 3440 - 升麻: -
- 85864 - 厚朴: -
- 33090 - 威灵仙: -
- 33090 - 当归: -
- 33090 - 柴胡: -
- 13428 - 桂枝: -
- 3498 - 桑叶: -
- 33090 - 梅花: -
- 33090 - 洋金花: -
- 33090 - 矮地茶: -
- 33090 - 竹沥: -
- 33090 - 紫苏: -
- 33090 - 绞股蓝: -
- 33090 - 罗汉果: -
- 33090 - 芦根: -
- 4047 - 芫荽: -
- 3311 - 银杏叶: -
- 33090 - 降香: -
- 33090 - 黄柏: -
- 33090 - 黑豆: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Weilai Yu, Boyang Li, Luxi Chen, Qiu Chen, QingQing Song, Xiaosheng Jin, Yandan Yin, Haibin Tong, Liwei Xue. Gigantol ameliorates DSS-induced colitis via suppressing β2 integrin mediated adhesion and chemotaxis of macrophage.
Journal of ethnopharmacology.
2024 Jun; 328(?):118123. doi:
10.1016/j.jep.2024.118123
. [PMID: 38554854] - Maksimiljan Adamek, Anja Kavčič, Marta Debeljak, Martin Šala, Jože Grdadolnik, Katarina Vogel-Mikuš, Ana Kroflič. Toxicity of nitrophenolic pollutant 4-nitroguaiacol to terrestrial plants and comparison with its non-nitro analogue guaiacol (2-methoxyphenol).
Scientific reports.
2024 01; 14(1):2198. doi:
10.1038/s41598-024-52610-6
. [PMID: 38272996] - Shahrzad Molavinia, Mehrad Nikravesh, Marzieh Pashmforoosh, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar. Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation.
Neurochemical research.
2023 Oct; ?(?):. doi:
10.1007/s11064-023-04043-2
. [PMID: 37864024] - Delong Wang, Min Li, Chunxia Yuan, Yali Fang, Zhijia Zhang. Guaiacol as a natural melanin biosynthesis inhibitor to control northern corn leaf blight.
Pest management science.
2022 Nov; 78(11):4557-4568. doi:
10.1002/ps.7075
. [PMID: 35833811] - Natalia Mikołajczak, Małgorzata Tańska, Dorota Ogrodowska, Sylwester Czaplicki. Efficacy of canolol and guaiacol in the protection of cold-pressed oils being a dietary source linoleic acid against oxidative deterioration.
Food chemistry.
2022 Nov; 393(?):133390. doi:
10.1016/j.foodchem.2022.133390
. [PMID: 35688088] - Ngouana Moffo A Ivane, Fopa Kue Roméo Elysé, Suleiman A Haruna, Ngwasiri Pride, Ejoh Richard, Anuanwen Claris Foncha, Munir Abba Dandago. The anti-oxidative potential of ginger extract and its constituent on meat protein isolate under induced Fenton oxidation.
Journal of proteomics.
2022 10; 269(?):104723. doi:
10.1016/j.jprot.2022.104723
. [PMID: 36096434] - Soukaina Hrichi, Raja Chaâbane-Banaoues, Filippo Alibrando, Ammar B Altemimi, Oussama Babba, Yassine Oulad El Majdoub, Habib Nasri, Luigi Mondello, Hamouda Babba, Zine Mighri, Francesco Cacciola. Chemical Composition, Antifungal and Anti-Biofilm Activities of Volatile Fractions of Convolvulus althaeoides L. Roots from Tunisia.
Molecules (Basel, Switzerland).
2022 Oct; 27(20):. doi:
10.3390/molecules27206834
. [PMID: 36296427] - Maryam Ramtin, Fariba Sharifniya, Mohaddeseh Larypoor, Mirsasan Mirpour, Saeid Zarrabi. Evaluation of the Active Ingredient of Campsis radicans Essential Oils and its Antimicrobial Evaluation Against Pathogenic Bacteria.
Current microbiology.
2022 Oct; 79(11):338. doi:
10.1007/s00284-022-03042-w
. [PMID: 36201048] - Wei-Hao Zhang, Han-Yan Luo, Jing Fang, Chen-Liang Zhao, Kam-Chun Chan, Yui-Man Chan, Cai-Xia Dong, Hu-Biao Chen, Zhong-Zhen Zhao, Song-Lin Li, Jun Xu. Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence.
Journal of agricultural and food chemistry.
2022 Oct; 70(39):12577-12586. doi:
10.1021/acs.jafc.2c05710
. [PMID: 36130944] - Surabhi Mangal, Sanjay Chhibber, Vasundhara Singh, Kusum Harjai. Guaiacol augments quorum quenching potential of ciprofloxacin against Pseudomonas aeruginosa.
Journal of applied microbiology.
2022 Oct; 133(4):2235-2254. doi:
10.1111/jam.15787
. [PMID: 35984044] - Sania Ashrafi, Safaet Alam, Nazim Uddin Emon, Monira Ahsan. Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from Glycosmis cyanocarpa (Blume) Spreng.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185972
. [PMID: 36144708] - Kumud Upadhyaya, Priya Kumari Sharma, Ansab Akhtar, Sangeeta Pilkhwal Sah. Protective Effects of Zingerone Against Depression-Like Behavior and Biochemical Changes in Chronic Stressed Rats: Antioxidant Effects.
Journal of medicinal food.
2022 Jun; 25(6):576-587. doi:
10.1089/jmf.2021.k.0141
. [PMID: 35639359] - Erdinç Türk, Mehmet Güvenç, Mustafa Cellat, Ahmet Uyar, Müslüm Kuzu, Ahmet Gökhan Ağgül, Akın Kırbaş. Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats.
Drug and chemical toxicology.
2022 May; 45(3):1054-1065. doi:
10.1080/01480545.2020.1804397
. [PMID: 32781857] - Walaa H El-Maadawy, Marwa Hassan, Rabab M Abdou, Riham S El-Dine, Tarek Aboushousha, Nebal D El-Tanbouly, Aly M El-Sayed. 6-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways.
Environmental toxicology and pharmacology.
2022 Apr; 91(?):103817. doi:
10.1016/j.etap.2022.103817
. [PMID: 35091105] - Xinwen Zhang, Delphis F Levia, Elvis Osamudiamhen Ebikade, Jeffrey Chang, Dionisios G Vlachos, Changqing Wu. The impact of differential lignin S/G ratios on mutagenicity and chicken embryonic toxicity.
Journal of applied toxicology : JAT.
2022 03; 42(3):423-435. doi:
10.1002/jat.4229
. [PMID: 34448506] - Nasiru Muhammad, Busisani W Lembede, Kennedy H Erlwanger. Neonatal administration of zingerone prevents the subsequent development of high dietary fructose-induced early features of nephropathy in rats.
General physiology and biophysics.
2022 Mar; 41(2):141-150. doi:
10.4149/gpb_2022008
. [PMID: 35416177] - Gabriel S Vignoli Muniz, Evandro L Duarte, Esteban N Lorenzón, Eduardo M Cilli, M Teresa Lamy. What different physical techniques can disclose about disruptions on membrane structure caused by the antimicrobial peptide Hylin a1 and a more positively charged analogue.
Chemistry and physics of lipids.
2022 03; 243(?):105173. doi:
10.1016/j.chemphyslip.2022.105173
. [PMID: 34995561] - Gehad M Elnagar, Mohamed M Elseweidy, Yasmin K Mahmoud, Nesreen M I M Elkomy, Ziyad M Althafar, Sultan F Alnomasy, Naif A Al-Gabri, Mohamed Shawky. 10-Dehydrogingerdione Attenuates Tramadol-Induced Nephrotoxicity by Modulating Renal Oxidative Stress, Inflammation and Apoptosis in Experimental Rats: Role of HO-1 Activation and TLR4/NF-κB/ERK Inhibition.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031384
. [PMID: 35163308] - Shujie Li, Hualing Li, Dandan Yin, Xiaojing Xue, Xiaoling Chen, Xiaoyue Li, Junwei Li, Yongxiang Yi. Effect of gigantol on the proliferation of hepatocellular carcinoma cells tested by a network-based pharmacological approach and experiments.
Frontiers in bioscience (Landmark edition).
2022 01; 27(1):25. doi:
10.31083/j.fbl2701025
. [PMID: 35090330] - Huanan Kang, Yiming Sun, Xijiao Hu, Li Liu. Gigantol inhibits proliferation and enhanced oxidative stress-mediated apoptosis through modulating of Wnt/β-catenin signaling pathway in HeLa cells.
Journal of biochemical and molecular toxicology.
2022 Jan; 36(1):e22944. doi:
10.1002/jbt.22944
. [PMID: 34729850] - Nazirah Bashir, Sheikh Bilal Ahmad, Muneeb U Rehman, Showkeen Muzamil, Rahil Razak Bhat, Manzoor Ur Rahman Mir, Gamal A Shazly, Mohamed A Ibrahim, Gehan M Elossaily, Abdelrahman Y Sherif, Mohsin Kazi. Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants.
Redox report : communications in free radical research.
2021 Dec; 26(1):62-70. doi:
10.1080/13510002.2021.1907518
. [PMID: 33784959] - Tamilvelan Manjunathan, Ajay Guru, Jesu Arokiaraj, Pushparathinam Gopinath. 6-Gingerol and Semisynthetic 6-Gingerdione Counteract Oxidative Stress Induced by ROS in Zebrafish.
Chemistry & biodiversity.
2021 Dec; 18(12):e2100650. doi:
10.1002/cbdv.202100650
. [PMID: 34599795] - Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Basil Roufogalis, Amir Hossein Abdolghaffari, Amirhossein Sahebkar. Ginger: A complementary approach for management of cardiovascular diseases.
BioFactors (Oxford, England).
2021 Nov; 47(6):933-951. doi:
10.1002/biof.1777
. [PMID: 34388275] - X Geng, H Liu, Q Yuwen, J Wang, S Zhang, X Zhang, J Sun. Protective effects of zingerone on high cholesterol diet-induced atherosclerosis through lipid regulatory signaling pathway.
Human & experimental toxicology.
2021 Oct; 40(10):1732-1745. doi:
10.1177/09603271211006170
. [PMID: 33845646] - Giovanni Schepici, Valentina Contestabile, Andrea Valeri, Emanuela Mazzon. Ginger, a Possible Candidate for the Treatment of Dementias?.
Molecules (Basel, Switzerland).
2021 Sep; 26(18):. doi:
10.3390/molecules26185700
. [PMID: 34577171] - Nasiru Muhammad, Busisani Wiseman Lembede, Kennedy Honey Erlwanger. Zingerone Administered Neonatally Prevents the Subsequent Development of High Dietary Fructose-Induced Fatty Liver in Sprague Dawley Rats.
Journal of medicinal food.
2021 Sep; 24(9):944-952. doi:
10.1089/jmf.2020.0189
. [PMID: 33512269] - Gehad M Elnagar, Mohamed M Elseweidy, Nesreen M I M Elkomy, Naif A Al-Gabri, Mohamed Shawky. 10-Dehydrogingerdione ameliorates renal endoplasmic reticulum/oxidative stress and apoptosis in alcoholic nephropathy induced in experimental rats.
Life sciences.
2021 Aug; 279(?):119673. doi:
10.1016/j.lfs.2021.119673
. [PMID: 34081991] - Tarique Anwer, Zafar Ali Alkarbi, Ali Hassan Najmi, Saeed Alshahrani, Rahimullah Siddiqui, Gyas Khan, Mohammad Firoz Alam. Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats.
Archives of physiology and biochemistry.
2021 Aug; 127(4):304-310. doi:
10.1080/13813455.2019.1637436
. [PMID: 31389247] - N Muhammad, B W Lembede, K H Erlwanger. Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats.
Journal of developmental origins of health and disease.
2021 08; 12(4):671-679. doi:
10.1017/s2040174420000525
. [PMID: 32500848] - Hiroyuki Hattori, Takashi Mori, Takahiro Shibata, Masaki Kita, Tohru Mitsunaga. 6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise.
Molecular nutrition & food research.
2021 08; 65(16):e2100185. doi:
10.1002/mnfr.202100185
. [PMID: 33793045] - Niramon Utama-Ang, Sirinapa Sida, Phenphichar Wanachantararak, Arthitaya Kawee-Ai. Development of edible Thai rice film fortified with ginger extract using microwave-assisted extraction for oral antimicrobial properties.
Scientific reports.
2021 07; 11(1):14870. doi:
10.1038/s41598-021-94430-y
. [PMID: 34290338] - Naoki Kitaoka, Taiji Nomura, Shinjiro Ogita, Yasuo Kato. Bioproduction of 4-Vinylphenol and 4-Vinylguaiacol β-Primeverosides Using Transformed Bamboo Cells Expressing Bacterial Phenolic Acid Decarboxylase.
Applied biochemistry and biotechnology.
2021 Jul; 193(7):2061-2075. doi:
10.1007/s12010-021-03522-y
. [PMID: 33544364] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Fei Zhou, Robert L Last, Eran Pichersky. Degradation of salicylic acid to catechol in Solanaceae by SA 1-hydroxylase.
Plant physiology.
2021 04; 185(3):876-891. doi:
10.1093/plphys/kiaa096
. [PMID: 33793924] - Nedra Slama, Houda Mankai, Ferid Limam. Streptomyces tunisiensis DSM 42037 mediated bioconversion of ferulic acid released from barley bran.
World journal of microbiology & biotechnology.
2021 Mar; 37(4):70. doi:
10.1007/s11274-021-03031-4
. [PMID: 33748917] - Insha Amin, Ishraq Hussain, Muneeb U Rehman, Bilal Ahmad Mir, Showkat Ahmad Ganaie, Sheikh Bilal Ahmad, Manzoor Ur Rahman Mir, Syed Shanaz, Showkeen Muzamil, Azher Arafah, Parvaiz Ahmad. Zingerone prevents lead-induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats.
Journal of food biochemistry.
2021 03; 45(3):e13241. doi:
10.1111/jfbc.13241
. [PMID: 32515504] - Saeed Mehrzadi, Hamidreza Khalili, Iman Fatemi, Alireza Malayeri, Amir Siahpoosh, Mehdi Goudarzi. Zingerone Mitigates Carrageenan-Induced Inflammation Through Antioxidant and Anti-inflammatory Activities.
Inflammation.
2021 Feb; 44(1):186-193. doi:
10.1007/s10753-020-01320-y
. [PMID: 32803664] - Misbahuddin Rafeeq, Hussam Aly Sayed Murad, Hossam Mohammed Abdallah, Ali M El-Halawany. Protective effect of 6-paradol in acetic acid-induced ulcerative colitis in rats.
BMC complementary medicine and therapies.
2021 Jan; 21(1):28. doi:
10.1186/s12906-021-03203-7
. [PMID: 33441125] - Rishab Marahatha, Saroj Basnet, Bibek Raj Bhattarai, Prakriti Budhathoki, Babita Aryal, Bikash Adhikari, Ganesh Lamichhane, Darbin Kumar Poudel, Niranjan Parajuli. Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis.
BMC complementary medicine and therapies.
2021 Jan; 21(1):1. doi:
10.1186/s12906-020-03162-5
. [PMID: 33386071] - Shengqiang Qian, Huiying Fang, Lu Zheng, Mei Liu. Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC-3 cells.
Journal of biochemical and molecular toxicology.
2021 Jan; 35(1):e22611. doi:
10.1002/jbt.22611
. [PMID: 32905641] - Karuna Sharma, Sunil Kumar Bose, Sanjay Chhibber, Kusum Harjai. Exploring the Therapeutic Efficacy of Zingerone Nanoparticles in Treating Biofilm-Associated Pyelonephritis Caused by Pseudomonas aeruginosa in the Murine Model.
Inflammation.
2020 Dec; 43(6):2344-2356. doi:
10.1007/s10753-020-01304-y
. [PMID: 32948964] - Kaho Yamaguchi, Tohru Mitsunaga, Kosei Yamauchi. 6-Paradol and its glucoside improve memory disorder in mice.
Food & function.
2020 Nov; 11(11):9892-9902. doi:
10.1039/d0fo01975e
. [PMID: 33094793] - Adil Farooq Wali, Muneeb U Rehman, Mohammad Raish, Mohsin Kazi, Padma G M Rao, Osamah Alnemer, Parvaiz Ahmad, Ajaz Ahmad. Zingerone [4-(3-Methoxy-4-hydroxyphenyl)-butan-2] Attenuates Lipopolysaccharide-Induced Inflammation and Protects Rats from Sepsis Associated Multi Organ Damage.
Molecules (Basel, Switzerland).
2020 Nov; 25(21):. doi:
10.3390/molecules25215127
. [PMID: 33158114] - Ya-Ru Xue, Sheng Yao, Qian Liu, Zhao-Liang Peng, Qiang-Qiang Deng, Bo Liu, Zheng-Hua Ma, Le Wang, Hu Zhou, Yang Ye, Guo-Yu Pan. Dihydro-stilbene gigantol relieves CCl4-induced hepatic oxidative stress and inflammation in mice via inhibiting C5b-9 formation in the liver.
Acta pharmacologica Sinica.
2020 Nov; 41(11):1433-1445. doi:
10.1038/s41401-020-0406-6
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Life sciences.
2020 Oct; 259(?):118382. doi:
10.1016/j.lfs.2020.118382
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Scientific reports.
2020 09; 10(1):15004. doi:
10.1038/s41598-020-72209-x
. [PMID: 32929156] - Huseyin Gungor, Mehmet Ekici, Mehmet Onder Karayigit, Nergiz Hacer Turgut, Haki Kara, Emre Arslanbas. Zingerone ameliorates oxidative stress and inflammation in bleomycin-induced pulmonary fibrosis: modulation of the expression of TGF-β1 and iNOS.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 09; 393(9):1659-1670. doi:
10.1007/s00210-020-01881-7
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Natural product research.
2020 Aug; 34(16):2372-2377. doi:
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ChemMedChem.
2020 07; 15(13):1187-1199. doi:
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Biotechnology journal.
2020 Jul; 15(7):e1900571. doi:
10.1002/biot.201900571
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Molecules (Basel, Switzerland).
2020 Jun; 25(12):. doi:
10.3390/molecules25122877
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Journal of cellular and molecular medicine.
2020 05; 24(9):5122-5134. doi:
10.1111/jcmm.15153
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Nutrients.
2020 Jan; 12(2):. doi:
10.3390/nu12020324
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PloS one.
2020; 15(9):e0238509. doi:
10.1371/journal.pone.0238509
. [PMID: 32870935] - Ping Su, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Wang Lu. A ginger derivative, zingerone-a phenolic compound-induces ROS-mediated apoptosis in colon cancer cells (HCT-116).
Journal of biochemical and molecular toxicology.
2019 Dec; 33(12):e22403. doi:
10.1002/jbt.22403
. [PMID: 31714660] - Hongyu Rao, Peibo Li, Hao Wu, Chong Liu, Wei Peng, Weiwei Su. Simultaneous Determination of Six Compounds in Destructive Distillation Extracts of Hawthorn Seed by GC-MS and Evaluation of Their Antimicrobial Activity.
Molecules (Basel, Switzerland).
2019 Nov; 24(23):. doi:
10.3390/molecules24234328
. [PMID: 31783502] - Jing Wu, Yuqing Duan, Jie Cui, Yinping Dong, Hongyan Li, Meifang Wang, Saijun Fan, Deguan Li, Yiliang Li. Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury.
Journal of radiation research.
2019 Nov; 60(6):740-746. doi:
10.1093/jrr/rrz065
. [PMID: 31665488] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
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Journal of biochemical and molecular toxicology.
2019 Oct; 33(10):e22387. doi:
10.1002/jbt.22387
. [PMID: 31476248] - Cüneyt Çağlayan, Parham Taslimi, Yeliz Demir, Sefa Küçükler, Fatih Mehmet Kandemir, İlhami Gulçin. The effects of zingerone against vancomycin-induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes.
Journal of biochemical and molecular toxicology.
2019 Oct; 33(10):e22381. doi:
10.1002/jbt.22381
. [PMID: 31454121] - Zeinab Rafiee, Layasadat Khorsandi, Fereshteh Nejad-Dehbashi. Protective effect of Zingerone against mouse testicular damage induced by zinc oxide nanoparticles.
Environmental science and pollution research international.
2019 Sep; 26(25):25814-25824. doi:
10.1007/s11356-019-05818-3
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Journal of bioscience and bioengineering.
2019 Sep; 128(3):316-322. doi:
10.1016/j.jbiosc.2019.02.012
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Pesticide biochemistry and physiology.
2019 Sep; 159(?):127-135. doi:
10.1016/j.pestbp.2019.06.006
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Fitoterapia.
2019 Sep; 137(?):104251. doi:
10.1016/j.fitote.2019.104251
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Molecular biology reports.
2019 Aug; 46(4):3921-3928. doi:
10.1007/s11033-019-04836-1
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Food chemistry.
2019 Aug; 288(?):86-95. doi:
10.1016/j.foodchem.2019.02.075
. [PMID: 30902319] - Fatih Mehmet Kandemir, Serkan Yildirim, Cuneyt Caglayan, Sefa Kucukler, Gizem Eser. Protective effects of zingerone on cisplatin-induced nephrotoxicity in female rats.
Environmental science and pollution research international.
2019 Aug; 26(22):22562-22574. doi:
10.1007/s11356-019-05505-3
. [PMID: 31165450] - Muneeb U Rehman, Shahzada Mudasir Rashid, Saiema Rasool, Sheeba Shakeel, Bilal Ahmad, Sheikh Bilal Ahmad, Hassan Madkhali, Majid Ahmad Ganaie, Sabiya Majid, Showkat Ahmad Bhat. Zingerone (4-(4-hydroxy-3-methylphenyl)butan-2-one) ameliorates renal function via controlling oxidative burst and inflammation in experimental diabetic nephropathy.
Archives of physiology and biochemistry.
2019 Jul; 125(3):201-209. doi:
10.1080/13813455.2018.1448422
. [PMID: 29537332] - Kiran George, Nisha Susan Thomas, Raman Malathi. Modulatory Effect of Selected Dietary Phytochemicals on Delayed Rectifier K+ Current in Human Prostate Cancer Cells.
The Journal of membrane biology.
2019 06; 252(2-3):195-206. doi:
10.1007/s00232-019-00070-9
. [PMID: 31165179] - Wan-Xin Zhang, In-Cheng Chao, De-Jun Hu, Farid Shakerian, Liya Ge, Xiao Liang, Ying Wang, Jing Zhao, Shao-Ping Li. Comparison of Antioxidant Activity and Main Active Compounds Among Different Parts of Alpinia officinarum Hance Using High-Performance Thin Layer Chromatography-Bioautography.
Journal of AOAC International.
2019 May; 102(3):726-733. doi:
10.5740/jaoacint.18-0307
. [PMID: 30388970] - Majid Ahmad Ganaie, Abdulaziz Al Saeedan, Hassan Madhkali, Basit Lateef Jan, Tanvir Khatlani, Ishfaq Ahmad Sheikh, Muneeb U Rehman, Khalida Wani. Chemopreventive efficacy zingerone (4-[4-hydroxy-3-methylphenyl] butan-2-one) in experimental colon carcinogenesis in Wistar rats.
Environmental toxicology.
2019 May; 34(5):610-625. doi:
10.1002/tox.22727
. [PMID: 30720227] - Bong-Seon Lee, Changhun Lee, Sumin Yang, Sae-Kwang Ku, Jong-Sup Bae. Renal protective effects of zingerone in a mouse model of sepsis.
BMB reports.
2019 Apr; 52(4):271-276. doi:
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- Neda Sistani Karampour, Ardeshir Arzi, Anahita Rezaie, Marzieh Pashmforoosh, Fatemeh Kordi. Gastroprotective Effect of Zingerone on Ethanol-Induced Gastric Ulcers in Rats.
Medicina (Kaunas, Lithuania).
2019 Mar; 55(3):. doi:
10.3390/medicina55030064
. [PMID: 30862060] - Chong Wang, Ting Yu, Tsugumi Fujita, Eiichi Kumamoto. Moieties of plant-derived compounds responsible for outward current production and TRPA1 activation in rat spinal substantia gelatinosa.
Pharmacological reports : PR.
2019 Feb; 71(1):67-72. doi:
10.1016/j.pharep.2018.09.003
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Molecules (Basel, Switzerland).
2018 Dec; 24(1):. doi:
10.3390/molecules24010080
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Applied biochemistry and biotechnology.
2018 Dec; 186(4):805-815. doi:
10.1007/s12010-018-2776-5
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European journal of medicinal chemistry.
2018 Oct; 158(?):91-105. doi:
10.1016/j.ejmech.2018.09.009
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Journal of the science of food and agriculture.
2018 Sep; 98(12):4742-4748. doi:
10.1002/jsfa.9009
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Sep; 105(?):225-232. doi:
10.1016/j.biopha.2018.05.085
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Sep; 105(?):981-991. doi:
10.1016/j.biopha.2018.06.048
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Naunyn-Schmiedeberg's archives of pharmacology.
2018 08; 391(8):819-832. doi:
10.1007/s00210-018-1506-4
. [PMID: 29736620] - Mohammad Firoz Alam, Mohammed M Safhi, Tarique Anwer, Rahimullah Siddiqui, Gyas Khan, Sivakumar Sivagurunathan Moni. Therapeutic potential of Vanillylacetone against CCl4 induced hepatotoxicity by suppressing the serum marker, oxidative stress, inflammatory cytokines and apoptosis in Swiss albino mice.
Experimental and molecular pathology.
2018 08; 105(1):81-88. doi:
10.1016/j.yexmp.2018.06.001
. [PMID: 29909158] - Suk-Ling Wee, Thelma Peek, Anthony R Clarke. The responsiveness of Bactrocera jarvisi (Diptera: Tephritidae) to two naturally occurring phenylbutaonids, zingerone and raspberry ketone.
Journal of insect physiology.
2018 Aug; 109(?):41-46. doi:
10.1016/j.jinsphys.2018.06.004
. [PMID: 29890169] - Ali Ghasemzadeh, Hawa Z E Jaafar, Ali Baghdadi, Amin Tayebi-Meigooni. Formation of 6-, 8- and 10-Shogaol in Ginger through Application of Different Drying Methods: Altered Antioxidant and Antimicrobial Activity.
Molecules (Basel, Switzerland).
2018 07; 23(7):. doi:
10.3390/molecules23071646
. [PMID: 29976903] - Vivian Boesso Oriani, Izabela Dutra Alvim, Bruno Nicolau Paulino, Fernanda Ramalho Procópio, Glaucia Maria Pastore, Míriam Dupas Hubinger. The influence of the storage temperature on the stability of lipid microparticles containing ginger oleoresin.
Food research international (Ottawa, Ont.).
2018 Jul; 109(?):472-480. doi:
10.1016/j.foodres.2018.04.066
. [PMID: 29803473] - Erdal Kaygusuzoglu, Cuneyt Caglayan, Fatih Mehmet Kandemir, Serkan Yıldırım, Sefa Kucukler, Mehmet Akif Kılınc, Yavuz Selim Saglam. Zingerone ameliorates cisplatin-induced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jun; 102(?):517-530. doi:
10.1016/j.biopha.2018.03.119
. [PMID: 29587238] - Yan Cui, Yan Shi, Yan Bao, Shulong Wang, Qiuju Hua, Yun Liu. Zingerone attenuates diabetic nephropathy through inhibition of nicotinamide adenine dinucleotide phosphate oxidase 4.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Mar; 99(?):422-430. doi:
10.1016/j.biopha.2018.01.051
. [PMID: 29367111] - Shubin Yu, Zhongyuan Wang, Zijie Su, Jiaxing Song, Liang Zhou, Qi Sun, Shanshan Liu, Shiyue Li, Ying Li, Meina Wang, Guo-Qiang Zhang, Xue Zhang, Zhong-Jian Liu, Desheng Lu. Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells.
BMC complementary and alternative medicine.
2018 Feb; 18(1):59. doi:
10.1186/s12906-018-2108-x
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Journal of plant physiology.
2018 Feb; 221(?):101-106. doi:
10.1016/j.jplph.2017.12.010
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Food chemistry.
2018 Feb; 240(?):679-685. doi:
10.1016/j.foodchem.2017.08.007
. [PMID: 28946329] - Wonhwa Lee, Mi-Hye Hwang, Yuri Lee, Jong-Sup Bae. Protective effects of zingerone on lipopolysaccharide-induced hepatic failure through the modulation of inflammatory pathways.
Chemico-biological interactions.
2018 Feb; 281(?):106-110. doi:
10.1016/j.cbi.2017.12.031
. [PMID: 29289488] - Jienny Lee, Sae Woong Oh, Seoung Woo Shin, Kyung-Woo Lee, Jae-Youl Cho, Jongsung Lee. Zingerone protects keratinocyte stem cells from UVB-induced damage.
Chemico-biological interactions.
2018 Jan; 279(?):27-33. doi:
10.1016/j.cbi.2017.11.004
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Oxidative medicine and cellular longevity.
2018; 2018(?):2474831. doi:
10.1155/2018/2474831
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Free radical research.
2017 Dec; 51(11-12):943-953. doi:
10.1080/10715762.2017.1395025
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Journal of plant physiology.
2017 Dec; 219(?):22-27. doi:
10.1016/j.jplph.2017.09.005
. [PMID: 28961464] - Hyun Hwa Lee, Eun-Kyung Ahn, Seong-Su Hong, Joa Sub Oh. Anti-inflammatory effect of tribulusamide D isolated from Tribulus terrestris in lipopolysaccharide-stimulated RAW264.7 macrophages.
Molecular medicine reports.
2017 Oct; 16(4):4421-4428. doi:
10.3892/mmr.2017.7208
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Fungal biology.
2017 09; 121(9):763-774. doi:
10.1016/j.funbio.2017.05.006
. [PMID: 28800848] - Hisashi Nishiwaki, Shoko Nakazaki, Koichi Akiyama, Satoshi Yamauchi. Structure-Antifungal Activity Relationship of Fluorinated Dihydroguaiaretic Acid Derivatives and Preventive Activity against Alternaria alternata Japanese Pear Pathotype.
Journal of agricultural and food chemistry.
2017 Aug; 65(31):6701-6707. doi:
10.1021/acs.jafc.7b01896
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Food research international (Ottawa, Ont.).
2017 08; 98(?):40-49. doi:
10.1016/j.foodres.2017.01.004
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