Kokusaginine (BioDeep_00000008264)

   

natural product


代谢物信息卡片


Furo(2,3-b)quinoline, 4,6,7-trimethoxy-

化学式: C14H13NO4 (259.0845)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)C(=C3C=COC3=N2)OC)OC
InChI: InChI=1S/C14H13NO4/c1-16-11-6-9-10(7-12(11)17-2)15-14-8(4-5-19-14)13(9)18-3/h4-7H,1-3H3

描述信息

同义名列表

3 个代谢物同义名

Furo(2,3-b)quinoline, 4,6,7-trimethoxy-; Kokusaginine; Kokusaginine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

148 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, AKT1, ANXA5, BCL2, BCL2L1, CASP9, HSP90AA1, TUBB4B, TYR, UBA5
Peripheral membrane protein 2 ACHE, ANXA5
Endoplasmic reticulum membrane 3 BCL2, TRPM8, UBA5
Mitochondrion membrane 1 BCL2L1
Nucleus 9 ACHE, AKT1, BCL2, CASP9, HSP90AA1, PARP1, PPARA, TUBB4B, UBA5
cytosol 9 AKT1, ANXA5, BCL2, BCL2L1, CASP9, HSP90AA1, PARP1, TUBB4B, UBA5
dendrite 1 TRPM5
nuclear body 1 PARP1
centrosome 1 BCL2L1
nucleoplasm 4 AKT1, HSP90AA1, PARP1, PPARA
Cell membrane 9 ABCB1, ACHE, AKT1, HSP90AA1, TNF, TRPA1, TRPM5, TRPM8, TRPV1
Cytoplasmic side 1 BCL2L1
lamellipodium 1 AKT1
Multi-pass membrane protein 6 ABCB1, TAS2R20, TRPA1, TRPM5, TRPM8, TRPV1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 4 ABCB1, ACHE, HSP90AA1, TNF
glutamatergic synapse 1 AKT1
Golgi apparatus 2 ACHE, UBA5
mitochondrial inner membrane 1 BCL2L1
neuromuscular junction 1 ACHE
neuronal cell body 4 HSP90AA1, TNF, TRPM5, TRPV1
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 2 BCL2L1, PARP1
Lysosome 1 TYR
plasma membrane 11 ABCB1, ACHE, AKT1, HSP90AA1, TAS2R10, TAS2R20, TNF, TRPA1, TRPM5, TRPM8, TRPV1
synaptic vesicle membrane 1 BCL2L1
Membrane 13 ABCB1, ACHE, AKT1, ANXA5, BCL2, HSP90AA1, PARP1, TAS2R10, TAS2R20, TRPA1, TRPM5, TRPM8, TRPV1
apical plasma membrane 2 ABCB1, HSP90AA1
basolateral plasma membrane 1 HSP90AA1
extracellular exosome 4 ABCB1, ANXA5, HSP90AA1, TUBB4B
endoplasmic reticulum 2 BCL2, BCL2L1
extracellular space 2 ACHE, TNF
lysosomal lumen 1 HSP90AA1
perinuclear region of cytoplasm 3 ACHE, HSP90AA1, TYR
mitochondrion 5 BCL2, BCL2L1, CASP9, HSP90AA1, PARP1
protein-containing complex 5 AKT1, BCL2, CASP9, HSP90AA1, PARP1
intracellular membrane-bounded organelle 2 TYR, UBA5
Single-pass type I membrane protein 1 TYR
Secreted 1 ACHE
extracellular region 5 ACHE, ANXA5, HSP90AA1, TNF, TUBB4B
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 2 BCL2, BCL2L1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
Extracellular side 1 ACHE
transcription regulator complex 1 PARP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 2 BCL2, BCL2L1
external side of plasma membrane 4 ANXA5, TNF, TRPM8, TRPV1
Extracellular vesicle 1 TUBB4B
microtubule cytoskeleton 2 AKT1, TUBB4B
nucleolus 1 PARP1
Melanosome membrane 1 TYR
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 TRPV1
Apical cell membrane 1 ABCB1
Membrane raft 2 TNF, TRPM8
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TUBB4B
focal adhesion 1 ANXA5
microtubule 1 TUBB4B
spindle 1 AKT1
GABA-ergic synapse 1 TRPV1
basement membrane 1 ACHE
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ANXA5, HSP90AA1
Postsynaptic cell membrane 1 TRPV1
Cell projection, neuron projection 1 TRPV1
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 AKT1
chromatin 2 PARP1, PPARA
axonal growth cone 1 HSP90AA1
stereocilium bundle 1 TRPA1
phagocytic cup 1 TNF
mitotic spindle 1 TUBB4B
Chromosome 1 PARP1
cytoskeleton 1 TUBB4B
brush border membrane 1 HSP90AA1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 PARP1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 1 PARP1
axonemal microtubule 1 TUBB4B
monoatomic ion channel complex 1 TRPM5
Melanosome 2 HSP90AA1, TYR
side of membrane 1 ACHE
dendritic growth cone 1 HSP90AA1
myelin sheath 2 BCL2, HSP90AA1
sperm mitochondrial sheath 1 HSP90AA1
sperm plasma membrane 1 HSP90AA1
plasma membrane raft 1 TRPM8
ficolin-1-rich granule lumen 1 HSP90AA1
secretory granule lumen 1 HSP90AA1
azurophil granule lumen 1 TUBB4B
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCB1
site of DNA damage 1 PARP1
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
endocytic vesicle lumen 1 HSP90AA1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Zhihong Liu, Dane Huang, Shuangjia Zheng, Ying Song, Bingdong Liu, Jingyuan Sun, Zhangming Niu, Qiong Gu, Jun Xu, Liwei Xie. Deep learning enables discovery of highly potent anti-osteoporosis natural products. European journal of medicinal chemistry. 2021 Jan; 210(?):112982. doi: 10.1016/j.ejmech.2020.112982. [PMID: 33158578]
  • Blaise Kemajou Nganou, Armelle T Mbaveng, Serge A T Fobofou, Aimé G Fankam, Gabin Thierry M Bitchagno, James D Simo Mpetga, Ludger A Wessjohann, Victor Kuete, Thomas Efferth, Pierre Tane. Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii. Fitoterapia. 2019 Mar; 133(?):193-199. doi: 10.1016/j.fitote.2019.01.003. [PMID: 30654126]
  • Hugues Fouotsa, Armelle T Mbaveng, Celine D Mbazoa, Augustin E Nkengfack, Shaheen Farzana, Choudhary M Iqbal, Jacobus J Marion Meyer, Namrita Lall, Victor Kuete. Antibacterial constituents of three Cameroonian medicinal plants: Garcinia nobilis, Oricia suaveolens and Balsamocitrus camerunensis. BMC complementary and alternative medicine. 2013 Apr; 13(?):81. doi: 10.1186/1472-6882-13-81. [PMID: 23574627]
  • Jean Duplex Wansi, Hidayat Hussain, Alain Tadjong Tcho, Simeon F Kouam, Sabine Specht, Salem Ramadan Sarite, Achim Hoerauf, Karsten Krohn. Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii. Phytotherapy research : PTR. 2010 May; 24(5):775-7. doi: 10.1002/ptr.2894. [PMID: 19496062]
  • Anna Oliva, Kumudini M Meepagala, David E Wedge, Dewayne Harries, Amber L Hale, Giovanni Aliotta, Stephen O Duke. Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. Journal of agricultural and food chemistry. 2003 Feb; 51(4):890-6. doi: 10.1021/jf0259361. [PMID: 12568545]
  • I S Chen, H F Chen, M J Cheng, Y L Chang, C M Teng, I Tsutomu, J J Chen, I L Tsai. Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity. Journal of natural products. 2001 Sep; 64(9):1143-7. doi: 10.1021/np010122k. [PMID: 11575945]