Mimosine (BioDeep_00000000787)

 

Secondary id: BioDeep_00000398734

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


1(4H)-Pyridinepropanoic acid, .alpha.-amino-3-hydroxy-4-oxo-, (.alpha.S)-

化学式: C8H10N2O4 (198.0641)
中文名称: 含羞草碱
谱图信息: 最多检出来源 Homo sapiens(otcml) 45.07%

分子结构信息

SMILES: C1=CN(C=C(C1=O)O)CC(C(=O)O)N
InChI: InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1

描述信息

Mimosine is only found in individuals that have used or taken this drug. It is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca. [PubChem]Mimosine causes inhibition of DNA replication, changes in the progression of the cells in the cell cycle, and apoptosis. Mimosine appears to introduce breaks into DNA. Mimosine is an iron/zinc chelator. Iron depletion induces DNA double-strand breaks in treated cells, and activates a DNA damage response that results in focal phosphorylation of histones. This leads to inhibition of DNA replication and/or DNA elongation. Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT). Inhibition of serine hydroxymethyltransferase is moderated by a zinc responsive unit located in front of the SHMT gene.
L-mimosine is an L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor and a plant metabolite. It is a non-proteinogenic L-alpha-amino acid and a member of 4-pyridones. It is functionally related to a propionic acid. It is a conjugate acid of a L-mimosine(1-). It is a tautomer of a L-mimosine zwitterion.
Mimosine is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.
3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.
An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.

同义名列表

40 个代谢物同义名

1(4H)-Pyridinepropanoic acid, .alpha.-amino-3-hydroxy-4-oxo-, (.alpha.S)-; (2S)-2-amino-3-(3-hydroxy-4-oxo-1,4-dihydropyridin-1-yl)propanoic acid; 1(4H)-Pyridinepropanoic acid, alpha-amino-3-hydroxy-4-oxo-, (alphaS)-; 1(4H)-Pyridinepropanoic acid, alpha-amino-3-hydroxy-4-oxo-, (S)-; (2S)-2-azaniumyl-3-(4-hydroxy-3-oxidopyridinium-1-yl)propanoate; (2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid; (S)-2-Amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid; (S)-2-Amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoic acid; (2S)-2-Amino-3-[3-hydroxy-4-oxo-1(4H)-pyridyl]propanoic acid; (S)-alpha-Amino-3-hydroxy-4-oxo-1(4H)-pyridylpropionic acid; (2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1-yl)propanoic acid; (S)-2-Amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate; (2S)-2-amino-3-(3-hydroxy-4-oxo-1-pyridyl)propanoic acid; 3-(3-hydroxy-4-oxopyridin-1(4H)-yl)-L-alanine; L-Mimosine from Koa hoale seeds, >=98\\%; L-Mimosine from Koa hoale seeds; WZNJWVWKTVETCG-YFKPBYRVSA-N; MIMOSINE [WHO-DD]; Prestwick3_000379; UNII-Z46B1LUI5N; BPBio1_000591; MIMOSINE [MI]; Minosine, L-; (L)-MIMOSINE; Tox21_501238; Bio1_001334; Bio1_000845; Bio1_000356; L-Leucinine; L-mimosine; Leucaenine; Z46B1LUI5N; 1-mimosine; Leucaenol; AI3-51821; Leucenine; Leucenol; Mimosine; Mimosin; L-Mimosine



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ANG, CASP3, CAT, CCND1, CDK2, CDKN1B, CDKN3, HIF1A, MAPK14, MAPK8, PRKX, TP53, TYR, VEGFA
Nucleus 13 ANG, CASP3, CCND1, CDK2, CDKN1B, CDKN3, HIF1A, JUN, MAPK14, MAPK8, PRKX, TP53, VEGFA
cytosol 11 ANG, CASP3, CAT, CCND1, CDK2, CDKN1B, CDKN3, HIF1A, MAPK14, MAPK8, TP53
nuclear body 1 HIF1A
centrosome 3 CCND1, CDK2, TP53
nucleoplasm 10 CASP3, CCND1, CDK2, CDKN1B, HIF1A, JUN, MAPK14, MAPK8, PRKX, TP53
RNA polymerase II transcription regulator complex 2 HIF1A, JUN
Cell membrane 1 TNF
Synapse 1 MAPK8
cell surface 2 TNF, VEGFA
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 1 VEGFA
growth cone 1 ANG
neuronal cell body 3 ANG, CASP3, TNF
Lysosome 1 TYR
endosome 2 CDK2, CDKN1B
plasma membrane 1 TNF
Membrane 3 CAT, TP53, VEGFA
axon 1 MAPK8
extracellular exosome 1 CAT
endoplasmic reticulum 2 TP53, VEGFA
extracellular space 5 ANG, CXCL8, IL6, TNF, VEGFA
perinuclear region of cytoplasm 2 CDKN3, TYR
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
mitochondrion 3 CAT, MAPK14, TP53
protein-containing complex 4 CAT, CDKN1B, HIF1A, TP53
intracellular membrane-bounded organelle 3 CAT, CDKN1B, TYR
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TYR
Secreted 4 ANG, CXCL8, IL6, VEGFA
extracellular region 7 ANG, CAT, CXCL8, IL6, MAPK14, TNF, VEGFA
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 3 CDK2, JUN, TP53
motile cilium 1 HIF1A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK2, TP53
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 2 ANG, TP53
axon cytoplasm 1 HIF1A
Melanosome membrane 1 TYR
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 CDKN3
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
secretory granule 1 VEGFA
nuclear speck 2 HIF1A, MAPK14
chromatin 3 HIF1A, JUN, TP53
phagocytic cup 1 TNF
Chromosome 1 ANG
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
chromosome, telomeric region 1 CDK2
nuclear chromosome 1 JUN
site of double-strand break 1 TP53
nuclear envelope 1 CDK2
Melanosome 1 TYR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
Nucleus speckle 1 HIF1A
euchromatin 2 HIF1A, JUN
germ cell nucleus 1 TP53
replication fork 1 TP53
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
endoplasmic reticulum lumen 1 IL6
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
male germ cell nucleus 1 CDK2
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
Cajal body 1 CDK2
[Isoform 1]: Nucleus 1 TP53
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
condensed chromosome 1 CDK2
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 3 CCND1, CDK2, CDKN3
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin A2-CDK2 complex 1 CDK2
cyclin D1-CDK6 complex 1 CCND1
cyclin A1-CDK2 complex 1 CDK2
Cul4A-RING E3 ubiquitin ligase complex 1 CDKN1B
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Mizael Machado, Cintia R R Queiroz-Machado, Dale R Gardner, Márcio B Castro, Antônio Carlos L Câmara, Luciano A Pimentel, Glauco J N Galiza, Franklin Riet-Correa. Leucaena leucocephala toxicity in Brazilian horses. Toxicon : official journal of the International Society on Toxinology. 2024 Mar; 240(?):107655. doi: 10.1016/j.toxicon.2024.107655. [PMID: 38382883]
  • Isis Machado Hueza, Vanius Vinicius Dipe, André Tadeu Gotardo, Dale R Gardner, Elaine Renata Motta de Almeida, Silvana Lima Górniak. Potential immunomodulatory response associated with L-mimosine in male Wistar rats. Toxicon : official journal of the International Society on Toxinology. 2023 Apr; 226(?):107084. doi: 10.1016/j.toxicon.2023.107084. [PMID: 36905965]
  • Einar Artiles-Ortega, Pedro Yoelvys de la Fé-Rodríguez, Beydis Reguera-Barreto, Raciel Lima-Orozco, Veerle Fievez. In vitro rumen degradability of tropical legumes and their secondary metabolites depends on inoculum source. Tropical animal health and production. 2022 Sep; 54(5):330. doi: 10.1007/s11250-022-03327-z. [PMID: 36173493]
  • Amal Widaad, Ihsan Nazurah Zulkipli, Mark I R Petalcorin. Anthelmintic Effect of Leucaena leucocephala Extract and Its Active Compound, Mimosine, on Vital Behavioral Activities in Caenorhabditis elegans. Molecules (Basel, Switzerland). 2022 Mar; 27(6):. doi: 10.3390/molecules27061875. [PMID: 35335240]
  • Kelly Cristine da Silva Rodrigues-Honda, Michael David Hideo Honda, Dulal Borthakur, Arthur G Fett-Neto. Methods of Mimosine Extraction from Leucaena leucocephala (Lam.) de Wit Leaves. Methods in molecular biology (Clifton, N.J.). 2022; 2469(?):231-237. doi: 10.1007/978-1-0716-2185-1_19. [PMID: 35508843]
  • André Tadeu Gotardo, Vânius Vinicius Dipe, Elaine Renata Motta de Almeida, Isis Machado Hueza, James Alan Pfister, Silvana Lima Górniak. Potential toxic effects produced by L-mimosine in the thyroid and reproductive systems. Evaluation in male rats. Toxicon : official journal of the International Society on Toxinology. 2021 Nov; 203(?):121-128. doi: 10.1016/j.toxicon.2021.10.003. [PMID: 34662629]
  • Sotiris Kyriakou, William Cheung, Theodora Mantso, Melina Mitsiogianni, Ioannis Anestopoulos, Stephany Veuger, Dimitris T Trafalis, Rodrigo Franco, Aglaia Pappa, David Tetard, Mihalis I Panayiotidis. A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma. Investigational new drugs. 2021 08; 39(4):971-986. doi: 10.1007/s10637-021-01087-5. [PMID: 33624234]
  • Jaime N Wertman, Nicole Melong, Matthew R Stoyek, Olivia Piccolo, Stewart Langley, Benno Orr, Shelby L Steele, Babak Razaghi, Jason N Berman. The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model. eLife. 2020 07; 9(?):. doi: 10.7554/elife.56235. [PMID: 32720645]
  • Michael D H Honda, Dulal Borthakur. Mimosine facilitates metallic cation uptake by plants through formation of mimosine-cation complexes. Plant molecular biology. 2020 Mar; 102(4-5):431-445. doi: 10.1007/s11103-019-00956-1. [PMID: 31907707]
  • Md Harun-Ur-Rashid, Shigeki Oogai, Shahanaz Parveen, Masashi Inafuku, Hironori Iwasaki, Masakazu Fukuta, Md Amzad Hossain, Hirosuke Oku. Molecular cloning of putative chloroplastic cysteine synthase in Leucaena leucocephala. Journal of plant research. 2020 Jan; 133(1):95-108. doi: 10.1007/s10265-019-01158-y. [PMID: 31828681]
  • Akm Moyeenul Huq, Lam Kok Wai, Kamal Rullah, Mohd Fadhlizil Fasihi Mohd Aluwi, Johnson Stanslas, Jamia Azdina Jamal. Oestrogenic activity of mimosine on MCF-7 breast cancer cell line through the ERα-mediated pathway. Chemical biology & drug design. 2019 03; 93(3):222-231. doi: 10.1111/cbdd.13404. [PMID: 30251480]
  • Naoto Sano, Mitsunori Seo. Cell cycle inhibitors improve seed storability after priming treatments. Journal of plant research. 2019 Mar; 132(2):263-271. doi: 10.1007/s10265-018-01084-5. [PMID: 30637553]
  • Kelly Cristine da Silva Rodrigues-Corrêa, Michael D H Honda, Dulal Borthakur, Arthur Germano Fett-Neto. Mimosine accumulation in Leucaena leucocephala in response to stress signaling molecules and acute UV exposure. Plant physiology and biochemistry : PPB. 2019 Feb; 135(?):432-440. doi: 10.1016/j.plaphy.2018.11.018. [PMID: 30482504]
  • Md Harun-Ur-Rashid, Hironori Iwasaki, Shahanaz Parveen, Shigeki Oogai, Masakazu Fukuta, Md Amzad Hossain, Toyoaki Anai, Hirosuke Oku. Cytosolic Cysteine Synthase Switch Cysteine and Mimosine Production in Leucaena leucocephala. Applied biochemistry and biotechnology. 2018 Nov; 186(3):613-632. doi: 10.1007/s12010-018-2745-z. [PMID: 29691793]
  • Yiwen Xu, Lin Cai. L‑mimosine induces caspase‑9‑mediated apoptosis in human osteosarcoma cells. Molecular medicine reports. 2018 03; 17(3):4695-4701. doi: 10.3892/mmr.2018.8403. [PMID: 29328422]
  • Md Harun-Ur- Rashid, Hironori Iwasaki, Shigeki Oogai, Masakazu Fukuta, Shahanaz Parveen, Md Amzad Hossain, Toyoaki Anai, Hirosuke Oku. Molecular characterization of cytosolic cysteine synthase in Mimosa pudica. Journal of plant research. 2018 Mar; 131(2):319-329. doi: 10.1007/s10265-017-0986-5. [PMID: 29181648]
  • Anna Sonja Müller, Klara Janjić, Gunpreet Oberoi, Manuela Pensch, Christoph Kurzmann, Andreas Moritz, Hermann Agis. Deferoxamine but Not Dimethyloxalylglycine, L-Mimosine, or Cobalt Dichloride Can Interfere with the MTT Assay. BioMed research international. 2018; 2018(?):5872865. doi: 10.1155/2018/5872865. [PMID: 30581861]
  • Gen Kuroyanagi, Haruhiko Tokuda, Naohiro Yamamoto, Shingo Kainuma, Kazuhiko Fujita, Reou Ohguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka. Attenuation of prostaglandin E1‑induced osteoprotegerin synthesis in osteoblasts by normoxic HIF inducers. Molecular medicine reports. 2017 Apr; 15(4):1847-1852. doi: 10.3892/mmr.2017.6177. [PMID: 28259984]
  • S Retana-Márquez, L Juárez-Rojas, A Hernández, C Romero, G López, L Miranda, A Guerrero-Aguilera, F Solano, E Hernández, P Chemineau, M Keller, J A Delgadillo. Comparison of the effects of mesquite pod and Leucaena extracts with phytoestrogens on the reproductive physiology and sexual behavior in the male rat. Physiology & behavior. 2016 10; 164(Pt A):1-10. doi: 10.1016/j.physbeh.2016.05.004. [PMID: 27163522]
  • Yi Fang, Hui Zhang, Yihong Zhong, Xiaoqiang Ding. Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury. Oncotarget. 2016 08; 7(34):54317-54328. doi: 10.18632/oncotarget.11104. [PMID: 27527871]
  • Gen Kuroyanagi, Takanobu Otsuka, Naohiro Yamamoto, Shingo Kainuma, Reou Ohguchi, Kazuhiko Fujita, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda. Mimosine suppresses the PGF2α-induced synthesis of osteoprotegerin but not interleukin-6 in osteoblasts. International journal of molecular medicine. 2016 Feb; 37(2):533-41. doi: 10.3892/ijmm.2016.2452. [PMID: 26744072]
  • Vishal Singh Negi, Dulal Borthakur. Heterologous Expression and Characterization of Mimosinase from Leucaena leucocephala. Methods in molecular biology (Clifton, N.J.). 2016; 1405(?):59-77. doi: 10.1007/978-1-4939-3393-8_7. [PMID: 26843166]
  • Maria Bottini-Luzardo, Carlos Aguilar-Perez, Fernando Centurion-Castro, Francisco Solorio-Sanchez, Armin Ayala-Burgos, Ruben Montes-Perez, David Muñoz-Rodriguez, Juan Ku-Vera. Ovarian activity and estrus behavior in early postpartum cows grazing Leucaena leucocephala in the tropics. Tropical animal health and production. 2015 Dec; 47(8):1481-6. doi: 10.1007/s11250-015-0887-3. [PMID: 26210396]
  • Ann M Fallon. Effects of mimosine on Wolbachia in mosquito cells: cell cycle suppression reduces bacterial abundance. In vitro cellular & developmental biology. Animal. 2015 Oct; 51(9):958-63. doi: 10.1007/s11626-015-9918-7. [PMID: 26019119]
  • Binh Cao Quan Nguyen, Jamnian Chompoo, Shinkichi Tawata. Insecticidal and Nematicidal Activities of Novel Mimosine Derivatives. Molecules (Basel, Switzerland). 2015 Sep; 20(9):16741-56. doi: 10.3390/molecules200916741. [PMID: 26389870]
  • Graham Crawford, Birgit Puschner, Verena Affolter, Ilse Stalis, Autumn Davidson, Tomas Baker, John Tahara, Alison Jolly, Susan Ostapak. Systemic effects of Leucaena leucocephala ingestion on ringtailed lemurs (Lemur catta) at Berenty Reserve, Madagascar. American journal of primatology. 2015 Jun; 77(6):633-41. doi: 10.1002/ajp.22386. [PMID: 25809223]
  • Mogher Khamaisi, Hala Toukan, Jonathan H Axelrod, Christian Rosenberger, Galia Skarzinski, Ahuva Shina, Rina Meidan, Robert Koesters, Seymour Rosen, Gail Walkinshaw, Imari Mimura, Masaomi Nangaku, Samuel N Heyman. Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. Kidney international. 2015 Apr; 87(4):761-70. doi: 10.1038/ki.2014.362. [PMID: 25469848]
  • Hiroki Yasuhara, Kazuki Kitamoto. Aphidicolin-induced nuclear elongation in tobacco BY-2 cells. Plant & cell physiology. 2014 May; 55(5):913-27. doi: 10.1093/pcp/pcu026. [PMID: 24492257]
  • Shinjiro Ogita, Misako Kato, Shin Watanabe, Hiroshi Ashihara. The co-occurrence of two pyridine alkaloids, mimosine and trigonelline, in Leucaena leucocephala. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2014 Mar; 69(3-4):124-32. doi: 10.5560/znc.2013-0137. [PMID: 24873033]
  • Vishal Singh Negi, Jon-Paul Bingham, Qing X Li, Dulal Borthakur. A carbon-nitrogen lyase from Leucaena leucocephala catalyzes the first step of mimosine degradation. Plant physiology. 2014 Feb; 164(2):922-34. doi: 10.1104/pp.113.230870. [PMID: 24351687]
  • Yosra A Soltan, Amr S Morsy, Sobhy M A Sallam, Ronaldo C Lucas, Helder Louvandini, Michael Kreuzer, Adibe L Abdalla. Contribution of condensed tannins and mimosine to the methane mitigation caused by feeding Leucaena leucocephala. Archives of animal nutrition. 2013 Jun; 67(3):169-84. doi: 10.1080/1745039x.2013.801139. [PMID: 23742642]
  • Yi Fang, Xiaofang Yu, Yong Liu, Alison J Kriegel, Yanyan Heng, Xialian Xu, Mingyu Liang, Xiaoqiang Ding. miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation. American journal of physiology. Renal physiology. 2013 May; 304(10):F1274-82. doi: 10.1152/ajprenal.00287.2012. [PMID: 23467423]
  • Marcos Barros-Rodríguez, Javier Solorio-Sánchez, Juan Ku-Vera, Armín Ayala-Burgos, Carlos Sandoval-Castro, Georgina Solís-Pérez. Productive performance and urinary excretion of mimosine metabolites by hair sheep grazing in a silvopastoral system with high densities of Leucaena leucocephala. Tropical animal health and production. 2012 Dec; 44(8):1873-8. doi: 10.1007/s11250-012-0150-0. [PMID: 22528536]
  • Xiaofang Yu, Yi Fang, Hong Liu, Jiaming Zhu, Jianzhou Zou, Xunhui Xu, Suhua Jiang, Xiaoqiang Ding. The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 Aug; 27(8):3110-9. doi: 10.1093/ndt/gfr754. [PMID: 22399494]
  • Kiyoshi Nokihara, Akiyoshi Hirata, Tetsuya Sogon, Takafumi Ohyama. Preparative scale isolation, purification and derivatization of mimosine, a non-proteinogenic amino acid. Amino acids. 2012 Jul; 43(1):475-82. doi: 10.1007/s00726-011-1104-y. [PMID: 21993536]
  • Thongsuk Jetana, Sirima Thongruay, Sawong Uswang, Runchuan Hengtrakulsin. A comparative study on mimosine, 3,4-dihydroxy pyridone (3,4-DHP) and 2,3-dihydroxy pyridone (2,3-DHP), purine derivatives (PD) excretion in the urine, thyroid hormone and blood metabolites profiles of Thai swamp buffalo (Bubalus bubalis) and Murrah buffalo (Bubalus bubalis). Tropical animal health and production. 2012 Apr; 44(4):887-97. doi: 10.1007/s11250-011-9983-1. [PMID: 21928129]
  • Soon-Young Park, Jun-Sub Im, Sung-Rye Park, Sang-Eun Kim, Hoe-Jeong Wang, Joon-Kyu Lee. Mimosine arrests the cell cycle prior to the onset of DNA replication by preventing the binding of human Ctf4/And-1 to chromatin via Hif-1α activation in HeLa cells. Cell cycle (Georgetown, Tex.). 2012 Feb; 11(4):761-6. doi: 10.4161/cc.11.4.19209. [PMID: 22374673]
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