Cirsiliol (BioDeep_00000007762)
Main id: BioDeep_00000270028
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-chromen-4-one
化学式: C17H14O7 (330.0739494)
中文名称: 条叶蓟素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(OC)=CC2OC(C3C=CC(O)=C(O)C=3)=CC(=O)C=2C(O)=C1OC
InChI: InChI=1S/C17H14O7/c1-22-14-7-13-15(16(21)17(14)23-2)11(20)6-12(24-13)8-3-4-9(18)10(19)5-8/h3-7,18-19,21H,1-2H3
描述信息
Cirsiliol, also known as 3,4,5-trihydroxy-6,7-dimethoxyflavone or 6,7-dimethoxy-5,3,4-trihydroxyflavone, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, cirsiliol is considered to be a flavonoid lipid molecule. Cirsiliol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Cirsiliol can be found in common sage and lemon verbena, which makes cirsiliol a potential biomarker for the consumption of these food products.
Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:3719
- KEGG: C10033
- PubChem: 160237
- HMDB: HMDB0250275
- Metlin: METLIN49652
- ChEMBL: CHEMBL72637
- LipidMAPS: LMPK12111227
- KNApSAcK: C00001033
- foodb: FDB016700
- CAS: 34334-69-5
- PMhub: MS000021233
- PubChem: 12219
- 3DMET: B03476
- NIKKAJI: J94.517J
- RefMet: Cirsiliol
- medchemexpress: HY-110399
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
114 个相关的物种来源信息
- 196581 Passiflora menispermifolia: 10.1021/NP50015A025
- 1571166 Salvia macrosiphon:
- 202612 Salvia stenophylla:
- 268912 Salvia verbenaca:
- 204224 Salvia guaranitica:
- 207754 Salvia dorrii:
- 95165 Salvia columbariae:
- 1294397 Salvia hypoleuca:
- 1241420 Lantana fucata: 10.1021/NP9002383
- 155258 Sideritis pungens:
- 21880 Salvia:
- 1132409 Teucrium divaricatum: 10.1016/S0031-9422(00)90415-1
- 282767 Achillea setacea: 10.1016/0305-1978(88)90071-3
- 1685713 Salvia limbata: 10.1080/14786411003766912
- 359922 Achillea formosa: 10.1515/ZNC-1989-3-423
- 301871 Leucocyclus formosus: 10.1515/ZNC-1989-3-423
- 312798 Ferula aucheri: 10.1016/0031-9422(94)00840-P
- 1241423 Lantana montevidensis:
- 1209876 Teucrium nudicaule: 10.1080/10575639608044893
- 1117157 Teucrium polium:
- 925377 Aloysia citrodora: 10.1055/S-2006-962505
- 35608 Artemisia annua: 10.1016/S0031-9422(00)97776-8
- 1550814 Brickellia dentata: 10.1016/0031-9422(80)85136-3
- 1209878 Teucrium oliverianum: 10.1021/NP50096A005
- 482483 Achillea millefolium var. millefolium: 10.1016/0031-9422(90)85371-L
- 282720 Achillea aspleniifolia: 10.1016/0031-9422(90)85371-L
- 13329 Achillea millefolium: 10.1016/0031-9422(90)85371-L
- 282770 Achillea virescens: 10.1016/0031-9422(90)85371-L
- 1715998 Baccharis genistelloides: 10.1248/CPB.33.5075
- 1654448 Baccharis sagittalis: 10.1248/CPB.33.5075
- 145513 Centaurea raphanina: 10.1021/NP50021A025
- 76707 Wilkesia hobdyi: 10.1016/0031-9422(90)85423-D
- 401941 Artemisia xanthochroa: 10.1007/BF00580042
- 1107925 Thymus herba-barona: 10.1016/0031-9422(95)00217-U
- 353935 Fridericia platyphylla: 10.1016/S0305-1978(01)00149-1
- 1209865 Teucrium kotschyanum: 10.1016/S0031-9422(00)98084-1
- 1391945 Sideritis leucantha:
- 155232 Sideritis algarviensis: 10.1016/0305-1978(90)90068-Q
- 1000430 Teucrium montanum: 10.1016/S0031-9422(00)97579-4
- 1224218 Ocimum kilimandscharicum: 10.1016/S0031-9422(00)00439-8
- 587669 Isodon rubescens: 10.1007/BFB0119198
- 2039521 Salvia lineata: 10.1016/S0031-9422(00)81700-8
- 2494293 Isodon tenuifolius: 10.3987/COM-07-11140
- 2026527 Salvia rhyacophila: 10.1016/S0040-4020(01)89722-2
- 53176 Teucrium chamaedrys: 10.1016/S0031-9422(00)97033-X
- 282717 Achillea ageratum: 10.1016/S0031-9422(96)00774-1
- 1933739 Salvia montbretii: 10.1016/S0031-9422(00)97086-9
- 191155 Calanticaria greggii: 10.1016/0305-1978(88)90036-1
- 1209892 Teucrium stocksianum: 10.1300/J044V03N01_03
- 2707421 Baccharis flabellata: 10.1016/0031-9422(88)80471-0
- 2494283 Isodon angustifolius: 10.1021/NP970302N
- 260603 Lycopus europaeus: 10.1055/S-2006-958121
- 425908 Isodon japonicus: 10.1055/S-2002-32080
- 38868 Salvia officinalis: 10.1002/ARDP.19713040802
- 222877 Phyla nodiflora: 10.1155/2014/528653
- 196581 Passiflora menispermifolia: 10.1021/NP50015A025
- 1571166 Salvia macrosiphon:
- 202612 Salvia stenophylla:
- 268912 Salvia verbenaca:
- 204224 Salvia guaranitica:
- 207754 Salvia dorrii:
- 95165 Salvia columbariae:
- 1294397 Salvia hypoleuca:
- 1241420 Lantana fucata: 10.1021/NP9002383
- 155258 Sideritis pungens:
- 21880 Salvia:
- 1132409 Teucrium divaricatum: 10.1016/S0031-9422(00)90415-1
- 282767 Achillea setacea: 10.1016/0305-1978(88)90071-3
- 1685713 Salvia limbata: 10.1080/14786411003766912
- 359922 Achillea formosa: 10.1515/ZNC-1989-3-423
- 301871 Leucocyclus formosus: 10.1515/ZNC-1989-3-423
- 312798 Ferula aucheri: 10.1016/0031-9422(94)00840-P
- 1241423 Lantana montevidensis:
- 1209876 Teucrium nudicaule: 10.1080/10575639608044893
- 1117157 Teucrium polium:
- 925377 Aloysia citrodora: 10.1055/S-2006-962505
- 35608 Artemisia annua: 10.1016/S0031-9422(00)97776-8
- 1550814 Brickellia dentata: 10.1016/0031-9422(80)85136-3
- 1209878 Teucrium oliverianum: 10.1021/NP50096A005
- 482483 Achillea millefolium var. millefolium: 10.1016/0031-9422(90)85371-L
- 282720 Achillea aspleniifolia: 10.1016/0031-9422(90)85371-L
- 13329 Achillea millefolium: 10.1016/0031-9422(90)85371-L
- 282770 Achillea virescens: 10.1016/0031-9422(90)85371-L
- 1715998 Baccharis genistelloides: 10.1248/CPB.33.5075
- 1654448 Baccharis sagittalis: 10.1248/CPB.33.5075
- 145513 Centaurea raphanina: 10.1021/NP50021A025
- 76707 Wilkesia hobdyi: 10.1016/0031-9422(90)85423-D
- 401941 Artemisia xanthochroa: 10.1007/BF00580042
- 1107925 Thymus herba-barona: 10.1016/0031-9422(95)00217-U
- 353935 Fridericia platyphylla: 10.1016/S0305-1978(01)00149-1
- 1209865 Teucrium kotschyanum: 10.1016/S0031-9422(00)98084-1
- 1391945 Sideritis leucantha:
- 155232 Sideritis algarviensis: 10.1016/0305-1978(90)90068-Q
- 1000430 Teucrium montanum: 10.1016/S0031-9422(00)97579-4
- 1224218 Ocimum kilimandscharicum: 10.1016/S0031-9422(00)00439-8
- 587669 Isodon rubescens: 10.1007/BFB0119198
- 2039521 Salvia lineata: 10.1016/S0031-9422(00)81700-8
- 2494293 Isodon tenuifolius: 10.3987/COM-07-11140
- 2026527 Salvia rhyacophila: 10.1016/S0040-4020(01)89722-2
- 53176 Teucrium chamaedrys: 10.1016/S0031-9422(00)97033-X
- 282717 Achillea ageratum: 10.1016/S0031-9422(96)00774-1
- 1933739 Salvia montbretii: 10.1016/S0031-9422(00)97086-9
- 191155 Calanticaria greggii: 10.1016/0305-1978(88)90036-1
- 1209892 Teucrium stocksianum: 10.1300/J044V03N01_03
- 2707421 Baccharis flabellata: 10.1016/0031-9422(88)80471-0
- 2494283 Isodon angustifolius: 10.1021/NP970302N
- 260603 Lycopus europaeus: 10.1055/S-2006-958121
- 425908 Isodon japonicus: 10.1055/S-2002-32080
- 38868 Salvia officinalis: 10.1002/ARDP.19713040802
- 222877 Phyla nodiflora: 10.1155/2014/528653
- 9606 Homo sapiens: -
- 35608 Artemisia Annua L.: -
- 146995 Chrysanthemum indicum: -
- 33090 Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Benedetta Fois, Angela Corona, Enzo Tramontano, Simona Distinto, Elias Maccioni, Rita Meleddu, Pierluigi Caboni, Costantino Floris, Filippo Cottiglia. Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase-associated RNase H function.
Journal of enzyme inhibition and medicinal chemistry.
2021 Dec; 36(1):749-757. doi:
10.1080/14756366.2021.1887170. [PMID: 33715562] - Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer.
Bioorganic & medicinal chemistry.
2020 01; 28(1):115180. doi:
10.1016/j.bmc.2019.115180. [PMID: 31784199] - Wael A Elmasri, Tianjiao Yang, Phat Tran, Mohamed-Elamir F Hegazy, Abdul N Hamood, Yehia Mechref, Paul W Paré. Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus.
Journal of natural products.
2015 Jan; 78(1):2-9. doi:
10.1021/np5004092. [PMID: 25524452] - Peter Forgo, István Zupkó, Judit Molnár, Andrea Vasas, György Dombi, Judit Hohmann. Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L.
Fitoterapia.
2012 Jul; 83(5):921-5. doi:
10.1016/j.fitote.2012.04.006. [PMID: 22537643] - Jun Li, Frank R Fronczek, Daneel Ferreira, Charles L Burandt, Vincent Setola, Bryan L Roth, Jordan K Zjawiony. Bis-spirolabdane diterpenoids from Leonotis nepetaefolia.
Journal of natural products.
2012 Apr; 75(4):728-34. doi:
10.1021/np3000156. [PMID: 22475308] - Shuangqing Wu, Qun Sun, Chunjun Chu, Jian Zhang. [Chemical constituents of Eupatorium lindleyanum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Apr; 37(7):937-40. doi:
. [PMID: 22792793] - Anat Elmann, Sharon Mordechay, Hilla Erlank, Alona Telerman, Miriam Rindner, Rivka Ofir. Anti-neuroinflammatory effects of the extract of Achillea fragrantissima.
BMC complementary and alternative medicine.
2011 Oct; 11(?):98. doi:
10.1186/1472-6882-11-98. [PMID: 22018032] - Gjoshe Stefkov, Svetlana Kulevanova, Biljana Miova, Suzana Dinevska-Kjovkarovska, Per Mølgaard, Anna K Jäger, Knud Josefsen. Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats.
Pharmaceutical biology.
2011 Sep; 49(9):885-92. doi:
10.3109/13880209.2011.552187. [PMID: 21619454] - Seed Niazmand, Maryam Esparham, Tahereh Hassannia, Mohammad Derakhshan. Cardiovascular effects of Teucrium polium L. extract in rabbit.
Pharmacognosy magazine.
2011 Jul; 7(27):260-4. doi:
10.4103/0973-1296.84244. [PMID: 21969799] - Ahmad R Gohari, Soodabeh Saeidnia, Maryam Malmir, Abbass Hadjiakhoondi, Yousef Ajani. Flavones and rosmarinic acid from Salvia limbata.
Natural product research.
2010 Dec; 24(20):1902-6. doi:
10.1080/14786411003766912. [PMID: 21108116] - Ai-Hua Zhao, Rong-Tao Li, Bei Jiang, Ji-Xia Zhang, Qin-Shi Zhao, Han-Dong Sun. Three new compounds from Isodon melissoides.
Journal of Asian natural products research.
2005 Apr; 7(2):151-6. doi:
10.1080/1028602042000204108. [PMID: 15621618] - Sheng Lin, Qi-Wei Zhang, Ning-Ning Zhang, Yong-Xin Zhang. [Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2005 Apr; 30(8):591-4. doi:
. [PMID: 16011282] - Tsuneatsu Nagao, Fumiko Abe, Junei Kinjo, Hikaru Okabe. Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.
Biological & pharmaceutical bulletin.
2002 Jul; 25(7):875-9. doi:
10.1248/bpb.25.875. [PMID: 12132661] - Qi-wei Zhang, Yong-xi Zhang, Ying Zhang, Yong-qing Xiao, Zhi-min Wang. [Studies on chemical constituents in buds of Artemisia scoparia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2002 Mar; 27(3):202-4. doi:
. [PMID: 12774401] - H Blomgren, G Kling-Andersson. Growth inhibition of human malignant glioma cells in vitro by agents which interfere with biosynthesis of eicosanoids.
Anticancer research.
1992 May; 12(3):981-6. doi:
NULL. [PMID: 1622156]