Xanthochymol (BioDeep_00000007723)

   

human metabolite Endogenous natural product


代谢物信息卡片


3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-[5-methyl-2-(prop-1-en-2-yl)hex-5-en-1-yl]-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione

化学式: C38H50O6 (602.3607)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(=C([C@]2(C(=O)[C@@](C1=O)(C([C@H](C2)CC=C(C)C)(C)C)CC=C(C)C)C[C@@H](CC=C(C)C)C(=C)C)O)C(=O)c1cc(c(cc1)O)O
InChI: InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,37+,38-/m1/s1

描述信息

Xanthochymol is found in fruits. Xanthochymol is a constituent of the famine food Garcinia xanthochymus

同义名列表

3 个代谢物同义名

3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-[5-methyl-2-(prop-1-en-2-yl)hex-5-en-1-yl]-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione; Xanthochymol; Xanthochymol



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

56 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 BCL2, BIRC5, CASP3, CASP8, CAT, CCND1, EP300, ERBB2, GATA2, ITPR3, JAK2, MCL1, MTOR, PGR, PTGS2
Peripheral membrane protein 3 JAK2, MTOR, PTGS2
Endosome membrane 1 ERBB2
Endoplasmic reticulum membrane 4 BCL2, ITPR3, MTOR, PTGS2
Nucleus 15 BCL2, BIRC5, CASP3, CASP8, CCND1, CIITA, DNTT, EP300, ERBB2, GATA2, JAK2, MCL1, MTOR, PCNA, PGR
cytosol 15 BCL2, BIRC5, CASP3, CASP8, CAT, CCND1, CIITA, DNTT, EP300, ERBB2, JAK2, LIPE, MCL1, MTOR, PGR
dendrite 1 MTOR
nuclear body 1 PCNA
phagocytic vesicle 1 MTOR
centrosome 2 CCND1, PCNA
nucleoplasm 15 BIRC5, CASP3, CASP8, CCND1, CIITA, DNTT, EP300, ERBB2, GATA2, ITPR3, JAK2, MCL1, MTOR, PCNA, PGR
Cell membrane 3 ERBB2, HLA-E, LIPE
Cytoplasmic side 1 MTOR
lamellipodium 1 CASP8
ruffle membrane 1 ERBB2
Early endosome membrane 1 HLA-E
Multi-pass membrane protein 1 ITPR3
Golgi apparatus membrane 2 HLA-E, MTOR
cell surface 2 CIITA, HLA-E
glutamatergic synapse 2 CASP3, JAK2
Golgi membrane 2 HLA-E, MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ERBB2
neuronal cell body 2 CASP3, ITPR3
postsynapse 1 JAK2
presynaptic membrane 1 ERBB2
Cytoplasm, cytosol 1 LIPE
Lysosome 1 MTOR
plasma membrane 5 ERBB2, HLA-E, ITPR3, JAK2, PGR
Membrane 9 BCL2, CAT, ERBB2, HLA-E, ITPR3, JAK2, LIPE, MCL1, MTOR
apical plasma membrane 1 ERBB2
basolateral plasma membrane 1 ERBB2
brush border 1 ITPR3
caveola 3 JAK2, LIPE, PTGS2
extracellular exosome 3 CAT, HLA-E, PCNA
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, ITPR3, PTGS2
extracellular space 1 HLA-E
perinuclear region of cytoplasm 1 ERBB2
bicellular tight junction 1 CCND1
mitochondrion 4 BCL2, CASP8, CAT, MCL1
protein-containing complex 5 BCL2, BIRC5, CASP8, CAT, PTGS2
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 ERBB2
extracellular region 2 CAT, ERBB2
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 3 BCL2, HLA-E, MCL1
mitochondrial outer membrane 5 BCL2, CASP8, MCL1, MTOR, PGR
mitochondrial matrix 1 CAT
transcription regulator complex 2 EP300, GATA2
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 2 BCL2, MCL1
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 HLA-E
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 1 BIRC5
nucleolus 1 ITPR3
midbody 1 BIRC5
Early endosome 1 ERBB2
apical part of cell 1 ITPR3
Cell projection, lamellipodium 1 CASP8
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 1 JAK2
pore complex 1 BCL2
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 2 CAT, JAK2
microtubule 1 BIRC5
spindle 1 BIRC5
Peroxisome 1 CAT
sarcoplasmic reticulum 1 ITPR3
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 CIITA, MTOR
PML body 2 CIITA, MTOR
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 2 ITPR3, PTGS2
receptor complex 2 ERBB2, ITPR3
neuron projection 1 PTGS2
chromatin 3 EP300, PCNA, PGR
phagocytic vesicle membrane 1 HLA-E
Chromosome 2 BIRC5, EP300
cytoskeleton 2 CASP8, JAK2
centriole 1 BIRC5
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
nuclear chromosome 1 BIRC5
nuclear envelope 1 MTOR
Recycling endosome membrane 1 HLA-E
Endomembrane system 2 JAK2, MTOR
endosome lumen 1 JAK2
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
myosin complex 1 MCL1
Nucleus, nucleoplasm 1 MCL1
euchromatin 2 DNTT, JAK2
cell body 1 CASP8
replication fork 1 PCNA
myelin sheath 2 BCL2, ERBB2
basal plasma membrane 1 ERBB2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
secretory granule membrane 1 ITPR3
endoplasmic reticulum lumen 1 PTGS2
nuclear matrix 1 DNTT
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
kinetochore 1 BIRC5
ER to Golgi transport vesicle membrane 1 HLA-E
chromosome, centromeric region 1 BIRC5
semaphorin receptor complex 1 ERBB2
nuclear lamina 1 PCNA
chromosome passenger complex 1 BIRC5
platelet dense tubular network membrane 1 ITPR3
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
cytoplasmic microtubule 1 BIRC5
histone acetyltransferase complex 1 EP300
protein-DNA complex 1 EP300
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
lumenal side of endoplasmic reticulum membrane 1 HLA-E
[Isoform 1]: Cell membrane 1 ERBB2
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
MHC class I protein complex 1 HLA-E
transport vesicle membrane 1 ITPR3
catalase complex 1 CAT
ERBB3:ERBB2 complex 1 ERBB2
[Isoform 4]: Mitochondrion outer membrane 1 PGR
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted 1 HLA-E
MHC class Ib protein complex 1 HLA-E
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
cyclin D1-CDK6 complex 1 CCND1


文献列表

  • Jing Xu, Shan Jin, Fei Gan, Hui Xiong, Zhinan Mei, Yu Chen, Guangzhong Yang. Polycyclic polyprenylated acylphloroglucinols from Garcinia xanthochymus fruits exhibit antitumor effects through inhibition of the STAT3 signaling pathway. Food & function. 2020 Dec; 11(12):10568-10579. doi: 10.1039/d0fo02535f. [PMID: 33185634]
  • Azazahemad A Kureshi, Chirag Dholakiya, Tabaruk Hussain, Amit Mirgal, Siddhesh P Salvi, Pritam C Barua, Madhumita Talukdar, Chekunnath Beena, Ashish Kar, Thondiath John Zachariah, Premlata Kumari, Tushar Dhanani, Raghuraj Singh, Ponnuchamy Manivel, Satyanshu Kumar. Simultaneous Identification and Quantification of Three Xanthones and Two Polyisoprenylated Benzophenones in Eight Indian Garcinia Species Using a Validated UHPLC-PDA Method. Journal of AOAC International. 2019 Sep; 102(5):1423-1434. doi: 10.5740/jaoacint.18-0335. [PMID: 30808434]
  • Xin Lin, Dongsong Tian, Yanhui Fu, Yanan Li, Liejun Huang, Wei Gu, Jialei Song, Yanmei Li, Yaacov Ben-David, Min Wen, Chunmao Yuan, Xiaojiang Hao. Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase. European journal of medicinal chemistry. 2019 Jan; 162(?):765-780. doi: 10.1016/j.ejmech.2018.11.046. [PMID: 30500683]
  • Jun Li, Ruixi Gao, Dan Zhao, Xianju Huang, Yu Chen, Fei Gan, Hui Liu, Guangzhong Yang. Separation and preparation of xanthochymol and guttiferone E by high performance liquid chromatography and high speed counter-current chromatography combined with silver nitrate coordination reaction. Journal of chromatography. A. 2017 Aug; 1511(?):143-148. doi: 10.1016/j.chroma.2017.07.010. [PMID: 28688721]
  • Desmond N Jackson, Lin Yang, ShiBiao Wu, Edward J Kennelly, Peter N Lipke. Garcinia xanthochymus Benzophenones Promote Hyphal Apoptosis and Potentiate Activity of Fluconazole against Candida albicans Biofilms. Antimicrobial agents and chemotherapy. 2015 Oct; 59(10):6032-8. doi: 10.1128/aac.00820-15. [PMID: 26195512]
  • Satyanshu Kumar, Sunil K Chattopadhyay. High-performance liquid chromatography and LC-ESI-MS method for the identification and quantification of two biologically active polyisoprenylated benzophenones xanthochymol and isoxanthochymol in different parts of Garcinia indica. Biomedical chromatography : BMC. 2007 Feb; 21(2):139-63. doi: 10.1002/bmc.726. [PMID: 17120303]