Fagaronine (BioDeep_00000007374)
代谢物信息卡片
化学式: C21H20NO4+ (350.1392)
中文名称:
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: C[N+]1=CC2=CC(=C(C=C2C3=C1C4=CC(=C(C=C4C=C3)O)OC)OC)OC
InChI: InChI=1S/C21H19NO4/c1-22-11-13-8-19(25-3)20(26-4)9-15(13)14-6-5-12-7-17(23)18(24-2)10-16(12)21(14)22/h5-11H,1-4H3/p+1
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:28954
- KEGG: C09438
- PubChem: 40305
- ChEMBL: CHEMBL121087
- CAS: 52259-65-1
- MetaboLights: MTBLC28954
- PubChem: 11629
- KNApSAcK: C00001857
- 3DMET: B02967
- NIKKAJI: J34.247E
- KNApSAcK: 28954
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Farid Ouchani, Albin Jeanne, Jessica Thevenard, Jean-Jacques Helesbeux, Amandine Wahart, Isabelle Letinois, Olivier Duval, Laurent Martiny, Emmanuelle Charpentier, Jérôme Devy. Ethoxyfagaronine, a synthetic analogue of fagaronine that inhibits vascular endothelial growth factor-1, as a new anti-angiogeneic agent.
Investigational new drugs.
2015 Feb; 33(1):75-85. doi:
10.1007/s10637-014-0184-4
. [PMID: 25404487] - F Ouchani, J Devy, A Rusciani, J J Helesbeux, S Salesse, I Letinois, D Gras-Billart, L Duca, O Duval, L Martiny, E Charpentier. Targeting focal adhesion assembly by ethoxyfagaronine prevents lymphoblastic cell adhesion to fibronectin.
Analytical cellular pathology (Amsterdam).
2012; 35(4):267-84. doi:
10.3233/acp-2012-0055
. [PMID: 22407353] - Motilal Maiti, Gopinatha Suresh Kumar. Polymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer.
Journal of nucleic acids.
2010; 2010(?):. doi:
10.4061/2010/593408
. [PMID: 20814427] - Claude Dupont, Eric Couillerot, Reynald Gillet, Catherine Caron, Monique Zeches-Hanrot, Jean-François Riou, Chantal Trentesaux. The benzophenanthridine alkaloid fagaronine induces erythroleukemic cell differentiation by gene activation.
Planta medica.
2005 Jun; 71(6):489-94. doi:
10.1055/s-2005-864147
. [PMID: 15971117] - Olakunle O Kassim, Mark Loyevsky, Biaffra Elliott, Andrew Geall, Henrietta Amonoo, Victor R Gordeuk. Effects of root extracts of Fagara zanthoxyloides on the in vitro growth and stage distribution of Plasmodium falciparum.
Antimicrobial agents and chemotherapy.
2005 Jan; 49(1):264-8. doi:
10.1128/aac.49.1.264-268.2005
. [PMID: 15616304] - Patoomratana Tuchinda, Aroonchai Saiai, Manat Pohmakotr, Chalobon Yoosook, Jittra Kasisit, Chanita Napaswat, Thawatchai Santisuk, Vichai Reutrakul. Anti-HIV-1 cycloartanes from leaves and twigs of Gardenia thailandica.
Planta medica.
2004 Apr; 70(4):366-70. doi:
10.1055/s-2004-818951
. [PMID: 15095155] - A Sedo, R Malík, J Vicar, V Simánek, J Ulrichová. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of dipeptidyl peptidase IV-like activity baring enzymes in human blood plasma and glioma cell lines.
Physiological research.
2003; 52(3):367-72. doi:
. [PMID: 12790770]
- Aleksi Sedo, Kvetoslava Vlasicová, Petr Barták, Radim Vespalec, Jaroslav Vicar, Vilim Simánek, Jitka Ulrichová. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV.
Phytotherapy research : PTR.
2002 Feb; 16(1):84-7. doi:
10.1002/ptr.969
. [PMID: 11807974] - J Ulrichová, Z Dvorák, J Vicar, J Lata, J Smrzová, A Sedo, V Simánek. Cytotoxicity of natural compounds in hepatocyte cell culture models. The case of quaternary benzo[c]phenanthridine alkaloids.
Toxicology letters.
2001 Dec; 125(1-3):125-32. doi:
10.1016/s0378-4274(01)00430-1
. [PMID: 11701231] - B S Falch, G M König, A D Wright, O Sticher, C K Angerhofer, J M Pezzuto, H Bachmann. Biological activities of cyanobacteria: evaluation of extracts and pure compounds.
Planta medica.
1995 Aug; 61(4):321-8. doi:
10.1055/s-2006-958092
. [PMID: 7480178] - G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal of natural products.
1991 Jan; 54(1):143-54. doi:
10.1021/np50073a012
. [PMID: 1710653]