Fagaronine (BioDeep_00000007374)

   


代谢物信息卡片


Fagaronine

化学式: C21H20NO4+ (350.1392)
中文名称:
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: C[N+]1=CC2=CC(=C(C=C2C3=C1C4=CC(=C(C=C4C=C3)O)OC)OC)OC
InChI: InChI=1S/C21H19NO4/c1-22-11-13-8-19(25-3)20(26-4)9-15(13)14-6-5-12-7-17(23)18(24-2)10-16(12)21(14)22/h5-11H,1-4H3/p+1

描述信息

D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

Fagaronine; Fagaronine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ANG, ANPEP, CYP1A1, DNPEP, HMBS, MMP14, NFE2, VEGFA
Peripheral membrane protein 2 CYP1A1, CYP1B1
Endosome membrane 1 TFRC
Endoplasmic reticulum membrane 2 CYP1A1, CYP1B1
Nucleus 8 ANG, DNPEP, GATA1, MKI67, MMP14, NFE2, TOP1, VEGFA
cytosol 4 ANG, DNPEP, HMBS, MMP14
nuclear body 1 MKI67
trans-Golgi network 1 FUT4
nucleoplasm 4 GATA1, MKI67, NFE2, TOP1
RNA polymerase II transcription regulator complex 1 NFE2
Cell membrane 6 ANPEP, DPP4, EPOR, MMP14, PROKR2, TFRC
lamellipodium 1 DPP4
Multi-pass membrane protein 1 PROKR2
cell junction 1 DPP4
cell surface 5 DPP4, FUT4, PLG, TFRC, VEGFA
glutamatergic synapse 2 PLG, TFRC
Golgi apparatus 3 ATRN, FUT4, VEGFA
Golgi membrane 1 FUT4
growth cone 1 ANG
lysosomal membrane 2 ANPEP, DPP4
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 1 ANG
endosome 1 TFRC
plasma membrane 8 ANPEP, ATRN, DPP4, EPOR, MMP14, PLG, PROKR2, TFRC
Membrane 8 CYP1B1, DPP4, EPOR, FUT4, MKI67, MMP14, TFRC, VEGFA
apical plasma membrane 1 DPP4
basolateral plasma membrane 1 TFRC
extracellular exosome 5 ANPEP, ATRN, DPP4, PLG, TFRC
endoplasmic reticulum 2 PRAP1, VEGFA
extracellular space 7 ANG, ANPEP, ATRN, MMP14, PLG, TFRC, VEGFA
perinuclear region of cytoplasm 1 TFRC
Schaffer collateral - CA1 synapse 1 PLG
adherens junction 1 VEGFA
intercellular canaliculus 1 DPP4
mitochondrion 2 CYP1A1, CYP1B1
intracellular membrane-bounded organelle 3 CYP1A1, CYP1B1, TFRC
Microsome membrane 2 CYP1A1, CYP1B1
Single-pass type I membrane protein 3 ATRN, EPOR, MMP14
Secreted 5 ANG, DPP4, PLG, PRAP1, VEGFA
extracellular region 7 ANG, DPP4, EPOR, PLG, PRAP1, TFRC, VEGFA
Single-pass membrane protein 2 DPP4, EPOR
[Isoform 2]: Secreted 1 ATRN
anchoring junction 1 DPP4
transcription regulator complex 1 GATA1
external side of plasma membrane 4 ANPEP, EPOR, PLG, TFRC
Extracellular vesicle 1 TFRC
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
perikaryon 1 TOP1
cytoplasmic vesicle 2 MMP14, TFRC
nucleolus 3 ANG, MKI67, TOP1
P-body 1 TOP1
Early endosome 1 TFRC
clathrin-coated pit 1 TFRC
recycling endosome 1 TFRC
Single-pass type II membrane protein 3 ANPEP, DPP4, TFRC
Apical cell membrane 1 DPP4
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 DPP4
focal adhesion 2 DPP4, MMP14
extracellular matrix 2 MMP14, VEGFA
basement membrane 1 ANG
PML body 1 NFE2
collagen-containing extracellular matrix 1 PLG
secretory granule 1 VEGFA
nuclear speck 1 EPOR
chromatin 2 GATA1, NFE2
cell periphery 1 FUT4
Chromosome 3 ANG, MKI67, TOP1
Nucleus, nucleolus 3 ANG, MKI67, TOP1
blood microparticle 3 DNPEP, PLG, TFRC
[Isoform 3]: Secreted 1 ATRN
fibrillar center 1 TOP1
Recycling endosome membrane 1 TFRC
Endomembrane system 1 DPP4
Nucleus, nucleoplasm 1 TOP1
Melanosome 2 MMP14, TFRC
Golgi cisterna membrane 1 FUT4
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
intermediate filament cytoskeleton 1 MMP14
HFE-transferrin receptor complex 1 TFRC
secretory granule membrane 1 ANPEP
Golgi lumen 1 MMP14
transcription repressor complex 1 GATA1
male germ cell nucleus 1 TOP1
platelet alpha granule lumen 2 PLG, VEGFA
endocytic vesicle 2 ANG, DPP4
clathrin-coated endocytic vesicle membrane 1 TFRC
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
protein-DNA complex 3 GATA1, NFE2, TOP1
[Isoform 1]: Cell membrane 1 ATRN
postsynaptic recycling endosome membrane 1 TFRC
lamellipodium membrane 1 DPP4
[Transferrin receptor protein 1, serum form]: Secreted 1 TFRC
angiogenin-PRI complex 1 ANG
Cell projection, lamellipodium membrane 1 DPP4
Cell projection, invadopodium membrane 1 DPP4
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform EPOR-S]: Secreted 1 EPOR
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4
macropinosome 1 MMP14


文献列表

  • Farid Ouchani, Albin Jeanne, Jessica Thevenard, Jean-Jacques Helesbeux, Amandine Wahart, Isabelle Letinois, Olivier Duval, Laurent Martiny, Emmanuelle Charpentier, Jérôme Devy. Ethoxyfagaronine, a synthetic analogue of fagaronine that inhibits vascular endothelial growth factor-1, as a new anti-angiogeneic agent. Investigational new drugs. 2015 Feb; 33(1):75-85. doi: 10.1007/s10637-014-0184-4. [PMID: 25404487]
  • F Ouchani, J Devy, A Rusciani, J J Helesbeux, S Salesse, I Letinois, D Gras-Billart, L Duca, O Duval, L Martiny, E Charpentier. Targeting focal adhesion assembly by ethoxyfagaronine prevents lymphoblastic cell adhesion to fibronectin. Analytical cellular pathology (Amsterdam). 2012; 35(4):267-84. doi: 10.3233/acp-2012-0055. [PMID: 22407353]
  • Motilal Maiti, Gopinatha Suresh Kumar. Polymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer. Journal of nucleic acids. 2010; 2010(?):. doi: 10.4061/2010/593408. [PMID: 20814427]
  • Claude Dupont, Eric Couillerot, Reynald Gillet, Catherine Caron, Monique Zeches-Hanrot, Jean-François Riou, Chantal Trentesaux. The benzophenanthridine alkaloid fagaronine induces erythroleukemic cell differentiation by gene activation. Planta medica. 2005 Jun; 71(6):489-94. doi: 10.1055/s-2005-864147. [PMID: 15971117]
  • Olakunle O Kassim, Mark Loyevsky, Biaffra Elliott, Andrew Geall, Henrietta Amonoo, Victor R Gordeuk. Effects of root extracts of Fagara zanthoxyloides on the in vitro growth and stage distribution of Plasmodium falciparum. Antimicrobial agents and chemotherapy. 2005 Jan; 49(1):264-8. doi: 10.1128/aac.49.1.264-268.2005. [PMID: 15616304]
  • Patoomratana Tuchinda, Aroonchai Saiai, Manat Pohmakotr, Chalobon Yoosook, Jittra Kasisit, Chanita Napaswat, Thawatchai Santisuk, Vichai Reutrakul. Anti-HIV-1 cycloartanes from leaves and twigs of Gardenia thailandica. Planta medica. 2004 Apr; 70(4):366-70. doi: 10.1055/s-2004-818951. [PMID: 15095155]
  • A Sedo, R Malík, J Vicar, V Simánek, J Ulrichová. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of dipeptidyl peptidase IV-like activity baring enzymes in human blood plasma and glioma cell lines. Physiological research. 2003; 52(3):367-72. doi: . [PMID: 12790770]
  • Aleksi Sedo, Kvetoslava Vlasicová, Petr Barták, Radim Vespalec, Jaroslav Vicar, Vilim Simánek, Jitka Ulrichová. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV. Phytotherapy research : PTR. 2002 Feb; 16(1):84-7. doi: 10.1002/ptr.969. [PMID: 11807974]
  • J Ulrichová, Z Dvorák, J Vicar, J Lata, J Smrzová, A Sedo, V Simánek. Cytotoxicity of natural compounds in hepatocyte cell culture models. The case of quaternary benzo[c]phenanthridine alkaloids. Toxicology letters. 2001 Dec; 125(1-3):125-32. doi: 10.1016/s0378-4274(01)00430-1. [PMID: 11701231]
  • B S Falch, G M König, A D Wright, O Sticher, C K Angerhofer, J M Pezzuto, H Bachmann. Biological activities of cyanobacteria: evaluation of extracts and pure compounds. Planta medica. 1995 Aug; 61(4):321-8. doi: 10.1055/s-2006-958092. [PMID: 7480178]
  • G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products. 1991 Jan; 54(1):143-54. doi: 10.1021/np50073a012. [PMID: 1710653]