mafenide (BioDeep_00000006423)
Secondary id: BioDeep_00001868383
human metabolite blood metabolite Chemicals and Drugs Antibiotics
代谢物信息卡片
化学式: C7H10N2O2S (186.0463)
中文名称: 4-氨基甲基苯磺酰胺
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C1=CC(=CC=C1CN)S(=O)(=O)N
InChI: InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
描述信息
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BA - Sulfonamides
D004791 - Enzyme Inhibitors > D002257 - Carbonic Anhydrase Inhibitors
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
21 个代谢物同义名
Sanofi winthrop brand OF mafenide acetate; 4-(Aminomethyl)benzene-1-sulphonamide; 4-(aminomethyl)benzene-1-sulfonamide; Bertek brand OF mafenide acetate; 4-HOMOsulphanilamide; 4 Homosulfanilamide; 4-Homosulfanilamide; Acetate, mafenide; Mafenide Acetate; Sulfabenzamine; Bensulfamide; Sulphamylon; Sulfamylon; Marfanil; Maphenid; mafenide; Napaltan; Mafylon; emilene; Mafenide; Mafenide
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:6633
- KEGG: C07106
- KEGGdrug: D02351
- PubChem: 3998
- HMDB: HMDB0254296
- Metlin: METLIN43232
- DrugBank: DB06795
- ChEMBL: CHEMBL419
- Wikipedia: Mafenide
- MeSH: Mafenide
- CAS: 138-39-6
- PMhub: MS000019460
- PubChem: 9317
- PDB-CCD: 6LH
- NIKKAJI: J812E
- RefMet: Mafenide
- KNApSAcK: 6633
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ramazan Demirdağ, Veysel Çomaklı, Murat Şentürk, Deniz Ekinci, Ö İrfan Küfrevioğlu, Claudiu T Supuran. Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.
Bioorganic & medicinal chemistry.
2013 Mar; 21(6):1522-5. doi:
10.1016/j.bmc.2012.08.018. [PMID: 22974493] - Rachel A Pendleton, James H Holmes. Systemic absorption of amphotericin B with topical 5\% mafenide acetate/amphotericin B solution for grafted burn wounds: is it clinically relevant?.
Burns : journal of the International Society for Burn Injuries.
2010 Feb; 36(1):38-41. doi:
10.1016/j.burns.2009.04.009. [PMID: 19481350] - Rajeev B Ahuja, Amit Gupta, Renu Gur. A prospective double-blinded comparative analysis of framycetin and silver sulphadiazine as topical agents for burns: a pilot study.
Burns : journal of the International Society for Burn Injuries.
2009 Aug; 35(5):672-6. doi:
10.1016/j.burns.2008.08.015. [PMID: 19443125] - Mika Hilvo, Anna Maria Salzano, Alessio Innocenti, Markku S Kulomaa, Andrea Scozzafava, Andrea Scaloni, Seppo Parkkila, Claudiu T Supuran. Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Journal of medicinal chemistry.
2009 Feb; 52(3):646-54. doi:
10.1021/jm801267c. [PMID: 19193158] - Jonna M Lehtonen, Seppo Parkkila, Daniela Vullo, Angela Casini, Andrea Scozzafava, Claudiu T Supuran. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.
Bioorganic & medicinal chemistry letters.
2004 Jul; 14(14):3757-62. doi:
10.1016/j.bmcl.2004.04.106. [PMID: 15203157] - A Scozzafava, F Briganti, M A Ilies, C T Supuran. Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
Journal of medicinal chemistry.
2000 Jan; 43(2):292-300. doi:
10.1021/jm990479+. [PMID: 10649985] - A Scozzafava, F Briganti, G Mincione, L Menabuoni, F Mincione, C T Supuran. Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
Journal of medicinal chemistry.
1999 Sep; 42(18):3690-700. doi:
10.1021/jm9901879. [PMID: 10479300] - A Scozzafava, L Menabuoni, F Mincione, F Briganti, G Mincione, C T Supuran. Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?.
Journal of medicinal chemistry.
1999 Jul; 42(14):2641-50. doi:
10.1021/jm9900523. [PMID: 10411484] - G L Klein, D N Herndon, T C Rutan, J R Barnett, N L Miller, A C Alfrey. Risk of aluminum accumulation in patients with burns and ways to reduce it.
The Journal of burn care & rehabilitation.
1994 Jul; 15(4):354-8. doi:
10.1097/00004630-199407000-00011. [PMID: 7929518] - R L McCauley, Y Y Li, B Poole, M J Evans, M C Robson, J P Heggers, D N Herndon. Differential inhibition of human basal keratinocyte growth to silver sulfadiazine and mafenide acetate.
The Journal of surgical research.
1992 Mar; 52(3):276-85. doi:
10.1016/0022-4804(92)90086-f. [PMID: 1538606] - M L Cooper, S T Boyce, J F Hansbrough, T J Foreman, D H Frank. Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents.
The Journal of surgical research.
1990 Mar; 48(3):190-5. doi:
10.1016/0022-4804(90)90212-k. [PMID: 2314091] - D J Weisdorf, J H Aldridge. Mafenide (Sulfamylon) inhibits plasmin fibrinolytic activity.
Thrombosis and haemostasis.
1988 Jun; 59(3):440-4. doi:
. [PMID: 2973151] - P R Liebman, M M Kennelly, E F Hirsch. Hypercarbia and acidosis associated with carbonic anhydrase inhibition: a hazard of topical mafenide acetate use in renal failure.
Burns, including thermal injury.
1982 Jul; 8(6):395-8. doi:
10.1016/0305-4179(82)90109-7. [PMID: 6809230] - G Erbs, F E Müller, W Opferkuch. [The effect of burns on the complement system].
Fortschritte der Medizin.
1980 Mar; 98(11):397-9. doi:
NULL. [PMID: 6154634] - J M Steyn. Thin-layer chromatographic determination of mafenide [(p-aminomethyl) benzenesulphonamide] in human serum.
Journal of chromatography.
1977 Mar; 143(2):210-3. doi:
10.1016/s0378-4347(00)81827-7. [PMID: 838834] - W L Brown, E G Bowler, A D Mason, B A pruitt. Protein metabolism in burned rats.
The American journal of physiology.
1976 Aug; 231(2):476-82. doi:
10.1152/ajplegacy.1976.231.2.476. [PMID: 961900] - G STUTTGEN. [Marfanil in the serum following peroral administration].
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie.
1950; 210(4-5):431-6. doi:
NULL. [PMID: 14777503] - R C RUTLEDGE, W G KLINGBERG, M L HEIDEMAN. Nephrocalcinosis and Pseudomonas aeruginosa pyelonephritis; treatment with p-aminomethylbenzene-sulfonamide (sulfamylon).
The Journal of pediatrics.
1949 Jul; 35(1):88-93. doi:
10.1016/s0022-3476(49)80036-9. [PMID: 18132990]
