D-1,5-Anhydrofructose (BioDeep_00000006168)

 

Secondary id: BioDeep_00001868750

human metabolite natural product


代谢物信息卡片


4,5-dihydroxy-6-(hydroxymethyl)oxan-3-one

化学式: C6H10O5 (162.0528)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 9.74%

分子结构信息

SMILES: C1C(=O)C(C(C(O1)CO)O)O
InChI: InChI=1S/C6H10O5/c7-1-4-6(10)5(9)3(8)2-11-4/h4-7,9-10H,1-2H2

描述信息

D-1,5-Anhydrofructose is found in fruits. D-1,5-Anhydrofructose is isolated from Morchella vulgaris (morel).
Isolated from Morchella vulgaris (morel). D-1,5-Anhydrofructose is found in fruits.

同义名列表

7 个代谢物同义名

4,5-dihydroxy-6-(hydroxymethyl)oxan-3-one; 1:5-anhydro-D-Fructose; 1,5-anhydro-D-Fructose; 15-anhydro-D-FRUCTOSE; D-1,5-Anhydrofructose; 1,5-Anhydrofructose; 1,5-Anhydro-D-fructose



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKR1B1, AKR1E2, BDNF, GCK, NFKB1, NLRP3, PPARG
Peripheral membrane protein 4 GBA1, GCK, GORASP1, HSD17B6
Nucleus 7 FOS, GCK, NFKB1, NLRP3, PPARG, PPARGC1A, RFC2
cytosol 8 AKR1B1, AKR1E2, FOS, GCK, NFKB1, NLRP3, PPARG, PPARGC1A
dendrite 1 BDNF
trans-Golgi network 1 GBA1
nucleoplasm 7 AKR1B1, FOS, GCK, NFKB1, PPARG, PPARGC1A, RFC2
RNA polymerase II transcription regulator complex 2 FOS, PPARG
Cell membrane 2 SLC5A9, TNF
Cytoplasmic side 1 GORASP1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 SLC5A9
Golgi apparatus membrane 3 GCK, GORASP1, NLRP3
cell surface 1 TNF
Golgi apparatus 2 GBA1, GORASP1
Golgi membrane 4 GCK, GORASP1, INS, NLRP3
lysosomal membrane 2 GAA, GBA1
neuronal cell body 1 TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 NLRP3
Lysosome 2 GAA, GBA1
plasma membrane 5 F2, GAA, GCG, SLC5A9, TNF
Membrane 4 BDNF, GAA, NLRP3, SLC5A9
axon 1 BDNF
basolateral plasma membrane 1 GCK
extracellular exosome 5 AKR1B1, F2, GAA, GBA1, SLC5A9
Lysosome membrane 2 GAA, GBA1
Lumenal side 2 GBA1, HSD17B6
endoplasmic reticulum 4 FOS, GBA1, HSD17B6, NLRP3
extracellular space 7 AKR1B1, BDNF, F2, GCG, IL10, INS, TNF
lysosomal lumen 2 GAA, GBA1
perinuclear region of cytoplasm 2 BDNF, PPARG
mitochondrion 4 AKR1B1, GCK, NFKB1, NLRP3
intracellular membrane-bounded organelle 3 GAA, HSD17B6, PPARG
Microsome membrane 1 HSD17B6
Secreted 7 BDNF, F2, GAA, GCG, IL10, INS, NLRP3
extracellular region 9 BDNF, F2, GAA, GCG, IL10, INS, NFKB1, NLRP3, TNF
transcription regulator complex 1 NFKB1
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
cis-Golgi network 1 GORASP1
Nucleus, PML body 1 PPARGC1A
PML body 1 PPARGC1A
collagen-containing extracellular matrix 1 F2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
receptor complex 1 PPARG
chromatin 4 FOS, NFKB1, PPARG, PPARGC1A
phagocytic cup 1 TNF
blood microparticle 1 F2
Basolateral cell membrane 1 GCK
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
tertiary granule membrane 1 GAA
secretory granule lumen 3 GCG, INS, NFKB1
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 4 BDNF, F2, GCG, INS
nuclear matrix 1 FOS
specific granule lumen 1 NFKB1
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
[Isoform 1]: Nucleus 1 PPARGC1A
protein-DNA complex 1 FOS
ficolin-1-rich granule membrane 1 GAA
transcription factor AP-1 complex 1 FOS
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
autolysosome lumen 1 GAA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
Ctf18 RFC-like complex 1 RFC2
DNA replication factor C complex 1 RFC2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Akiko Sakasai-Sakai, Takanobu Takata, Hirokazu Suzuki, Ikuro Maruyama, Yoshihiro Motomiya, Masayoshi Takeuchi. Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite. Scientific reports. 2019 07; 9(1):10194. doi: 10.1038/s41598-019-46333-2. [PMID: 31308400]
  • Akiko Kojima-Yuasa, Yohei Deguchi, Yotaro Konishi, Isao Matsui-Yuasa. Effect of 1,5-anhydro-D-fructose on the inhibition of adipogenesis in 3T3-L1 adipocytes. Natural product communications. 2012 Nov; 7(11):1501-6. doi: . [PMID: 23285817]
  • Xiaojie Meng, Ko-ichi Kawahara, Kenji Matsushita, Yuko Nawa, Binita Shrestha, Kiyoshi Kikuchi, Hisayo Sameshima, Teruto Hashiguchi, Ikuro Maruyama. Attenuation of LPS-induced iNOS expression by 1,5-anhydro-d-fructose. Biochemical and biophysical research communications. 2009 Sep; 387(1):42-6. doi: 10.1016/j.bbrc.2009.06.108. [PMID: 19559007]
  • Yongbing Yuan, Shuxia Mo, Rong Cao, Birgitte Claudi Westh, Shukun Yu. Examination of 1,5-anhydro-D-fructose and the enolone ascopyrone P, metabolites of the anhydrofructose pathway of glycogen and starch degradation, for their possible application in fruits, vegetables, and beverages as antibrowning agents. Journal of agricultural and food chemistry. 2005 Nov; 53(24):9491-7. doi: 10.1021/jf0515274. [PMID: 16302767]
  • Shukun Yu, Jie Mei, Bo Ahrén. Basic toxicology and metabolism studies of 1,5-anhydro-D-fructose using bacteria, cultured mammalian cells, and rodents. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2004 Oct; 42(10):1677-86. doi: 10.1016/j.fct.2004.06.004. [PMID: 15354319]
  • Kazuhiro Yoshinaga, Jun-ichi Abe, Toshiko Tanimoto, Kyoko Koizumi, Susumu Hizukuri. Preparation and reactivity of a novel disaccharide, glucosyl 1,5-anhydro-D-fructose (1,5-anhydro-3-O-alpha-glucopyranosyl-D-fructose). Carbohydrate research. 2003 Oct; 338(21):2221-5. doi: 10.1016/s0008-6215(03)00341-0. [PMID: 14553983]
  • Kazuyo Yamaji, Krishna Pada Sarker, Ikuro Maruyama, Susumu Hizukuri. Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro. Planta medica. 2002 Jan; 68(1):16-9. doi: 10.1055/s-2002-20050. [PMID: 11842320]
  • B Ahrén, J J Holst, S Yu. 1,5-Anhydro-D-fructose increases glucose tolerance by increasing glucagon-like peptide-1 and insulin in mice. European journal of pharmacology. 2000 May; 397(1):219-25. doi: 10.1016/s0014-2999(00)00261-2. [PMID: 10844116]
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