Rhapontin (BioDeep_00000600340)

Main id: BioDeep_00000008001

 

PANOMIX_OTCML-2023


代谢物信息卡片


Rhapontin

化学式: C21H24O9 (420.142)
中文名称: 土大黄苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)C=CC2=CC(=CC(=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O
InChI: InChI=1S/C21H24O9/c1-28-16-5-4-11(8-15(16)24)2-3-12-6-13(23)9-14(7-12)29-21-20(27)19(26)18(25)17(10-22)30-21/h2-9,17-27H,10H2,1H3/b3-2-

描述信息

Rhapontin is a member of the class of compounds known as stilbene glycosides. Stilbene glycosides are compounds structurally characterized by the presence of a carbohydrate moiety glycosidically linked to the stilbene skeleton. Rhapontin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Rhapontin can be found in garden rhubarb, which makes rhapontin a potential biomarker for the consumption of this food product. Rhapontin has beneficial effects on diabetic mice, and in vitro results suggest it may be relevant to Alzheimers disease with an action on beta amyloid .
Rhapontin (Rhaponiticin), a component of rhubarb (Rheum officinale Baill), induces apoptosis resulting in suppression of proliferation of human stomach cancer KATO III cells[1].
Rhapontin (Rhaponiticin), a component of rhubarb (Rheum officinale Baill), induces apoptosis resulting in suppression of proliferation of human stomach cancer KATO III cells[1].

同义名列表

3 个代谢物同义名

Rhapontin; Rhaponiticin; Rhaponticin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

32 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANG, BCL2, CASP9, CAT, KEAP1, MAPK14, PRKAA2, PTGS2, TP53, TYR, XDH
Peripheral membrane protein 3 CYP1B1, GORASP1, PTGS2
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, HMOX1, PTGS2
Nucleus 11 ANG, BCL2, CASP9, GABPA, HMOX1, KEAP1, MAPK14, PARP1, PCNA, PRKAA2, TP53
cytosol 11 ANG, BCL2, CASP9, CAT, HMOX1, KEAP1, MAPK14, PARP1, PRKAA2, TP53, XDH
dendrite 1 PRKAA2
nuclear body 2 PARP1, PCNA
centrosome 2 PCNA, TP53
nucleoplasm 8 GABPA, HMOX1, KEAP1, MAPK14, PARP1, PCNA, PRKAA2, TP53
Cell membrane 1 TNF
Cytoplasmic side 2 GORASP1, HMOX1
Golgi apparatus membrane 1 GORASP1
cell surface 1 TNF
glutamatergic synapse 1 MAPK14
Golgi apparatus 2 GORASP1, PRKAA2
Golgi membrane 2 GORASP1, INS
growth cone 1 ANG
neuronal cell body 3 ANG, PRKAA2, TNF
Cytoplasm, cytosol 1 PARP1
Lysosome 1 TYR
plasma membrane 1 TNF
Membrane 7 BCL2, CAT, CYP1B1, HMOX1, PARP1, PRKAA2, TP53
axon 1 PRKAA2
caveola 1 PTGS2
extracellular exosome 2 CAT, PCNA
endoplasmic reticulum 5 BCL2, HMOX1, KEAP1, PTGS2, TP53
extracellular space 6 ANG, HMOX1, IL6, INS, TNF, XDH
perinuclear region of cytoplasm 2 HMOX1, TYR
mitochondrion 7 BCL2, CASP9, CAT, CYP1B1, MAPK14, PARP1, TP53
protein-containing complex 6 BCL2, CASP9, CAT, PARP1, PTGS2, TP53
intracellular membrane-bounded organelle 3 CAT, CYP1B1, TYR
Microsome membrane 2 CYP1B1, PTGS2
Single-pass type I membrane protein 1 TYR
Secreted 3 ANG, IL6, INS
extracellular region 6 ANG, CAT, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 2 PARP1, TP53
centriolar satellite 1 KEAP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
actin cytoskeleton 1 ANG
nucleolus 3 ANG, PARP1, TP53
Melanosome membrane 1 TYR
midbody 1 KEAP1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
cis-Golgi network 1 GORASP1
Peroxisome 2 CAT, XDH
basement membrane 1 ANG
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 4 GABPA, PARP1, PCNA, TP53
phagocytic cup 1 TNF
Chromosome 2 ANG, PARP1
Nucleus, nucleolus 2 ANG, PARP1
spindle pole 1 MAPK14
nuclear replication fork 2 PARP1, PCNA
chromosome, telomeric region 2 PARP1, PCNA
actin filament 1 KEAP1
site of double-strand break 2 PARP1, TP53
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 1 PARP1
endosome lumen 1 INS
Melanosome 1 TYR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
germ cell nucleus 1 TP53
replication fork 2 PCNA, TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
male germ cell nucleus 1 PCNA
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
nuclear lamina 1 PCNA
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 PARP1
nucleotide-activated protein kinase complex 1 PRKAA2
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Oleksandra Liudvytska, Michał B Ponczek, Oskar Ciesielski, Justyna Krzyżanowska-Kowalczyk, Mariusz Kowalczyk, Aneta Balcerczyk, Joanna Kolodziejczyk-Czepas. Rheum rhaponticum and Rheum rhabarbarum Extracts as Modulators of Endothelial Cell Inflammatory Response. Nutrients. 2023 Feb; 15(4):. doi: 10.3390/nu15040949. [PMID: 36839307]
  • Bon-Hyeock Koo, Jonghoon Lee, Younghyun Jin, Hyun Kyo Lim, Sungwoo Ryoo. Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation. BMB reports. 2021 Oct; 54(10):516-521. doi: . [PMID: 34078530]
  • Tiansong Yang, Qingyong Wang, Yuanyuan Qu, Chuwen Feng, Chaoran Li, Yan Yang, Zhongren Sun, Tahani A Alahmadi, Sulaiman A Alharbi, Shengyong Bao. Protective effect of rhaponticin on ovariectomy-induced osteoporosis in rats. Journal of biochemical and molecular toxicology. 2021 Sep; 35(9):e22837. doi: 10.1002/jbt.22837. [PMID: 34227182]
  • Rougang Li, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H M Shair, Vishnu Priya Veeraraghavan, Krishna Mohan Surapaneni, Thamaraiselvan Rengarajan. Anti-inflammatory effects of rhaponticin on LPS-induced human endothelial cells through inhibition of MAPK/NF-κβ signaling pathways. Journal of biochemical and molecular toxicology. 2021 May; 35(5):e22733. doi: 10.1002/jbt.22733. [PMID: 33605003]
  • Manh Tuan Ha, Minji Kim, Chung Sub Kim, Se-Eun Park, Jeong Ah Kim, Mi Hee Woo, Jae Sue Choi, Byung Sun Min. Tetra-aryl cyclobutane and stilbenes from the rhizomes of Rheum undulatum and their α-glucosidase inhibitory activity: Biological evaluation, kinetic analysis, and molecular docking simulation. Bioorganic & medicinal chemistry letters. 2020 04; 30(8):127049. doi: 10.1016/j.bmcl.2020.127049. [PMID: 32111435]
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  • Yang Sun, Zhen Ji, Xuehua Liang, Guobo Li, Shengyong Yang, Song Wei, Yingyong Zhao, Xiaoyun Hu, Jun Fan. Studies on the binding of rhaponticin with human serum albumin by molecular spectroscopy, modeling and equilibrium dialysis. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Feb; 87(?):171-8. doi: 10.1016/j.saa.2011.11.033. [PMID: 22169567]
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