Gomisin G (BioDeep_00000000569)

Main id: BioDeep_00000230410

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


[(9S,10S,11S)-10-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-11-yl] benzoate

化学式: C30H32O9 (536.2046)
中文名称: 戈米辛G, 戈米辛 G
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2=CC(=C(C(=C2C3=C(C4=C(C=C3C(C1(C)O)OC(=O)C5=CC=CC=C5)OCO4)OC)OC)OC)OC
InChI: InChI=1S/C30H32O9/c1-16-12-18-13-20(33-3)24(34-4)26(35-5)22(18)23-19(14-21-25(27(23)36-6)38-15-37-21)28(30(16,2)32)39-29(31)17-10-8-7-9-11-17/h7-11,13-14,16,28,32H,12,15H2,1-6H3/t16-,28-,30-/m0/s1

描述信息

Gomisin G is a natural product found in Kadsura heteroclita, Schisandra henryi, and other organisms with data available.
See also: Schisandra chinensis fruit (part of).
Gomisin G is an ethanolic extract of the stems of Kadsura interior; exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively.
Gomisin G is an ethanolic extract of the stems of Kadsura interior; exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively.

同义名列表

10 个代谢物同义名

Gomisin G; [(9S,10S,11S)-10-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-11-yl] benzoate; Benzo[3,4]cycloocta[1,2:4,5]benzo[1,2-d][1,3]dioxole-7,8-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 8-benzoate, (6S,7S,8S)-; Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole-7,8-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 8-benzoate, (6S,7S,8S,13aS)-; (hydroxy-tetramethoxy-dimethyl-[?]yl) benzoate; UNII-6B4CV8T31X; (-)-Gomisin G; 6B4CV8T31X; FT-0701664; GOMISING



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ANXA5, CASP3, CCND1, CYP3A4, EGFR, EIF4EBP1, MTOR, PGR, PIK3CA, TYR
Peripheral membrane protein 3 ACHE, ANXA5, MTOR
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 6 CYP3A4, CYP3A5, EGFR, HMOX1, MTOR, NRF1
Nucleus 11 ACHE, CASP3, CCND1, EGFR, EIF4EBP1, HMOX1, MTOR, NRF1, PGR, PPARGC1A, TFAM
cytosol 12 ANXA5, CASP3, CCND1, EIF4EBP1, HMOX1, LIPE, MTOR, NRF1, PGR, PIK3CA, PPARGC1A, TFAM
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 CCND1
nucleoplasm 7 CASP3, CCND1, HMOX1, MTOR, NRF1, PGR, PPARGC1A
Cell membrane 3 ACHE, EGFR, LIPE
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 MTOR
Synapse 1 ACHE
cell junction 1 EGFR
cell surface 2 ACHE, EGFR
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 1 ACHE
Golgi membrane 2 EGFR, MTOR
lysosomal membrane 2 GAA, MTOR
neuromuscular junction 1 ACHE
neuronal cell body 1 CASP3
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 LIPE
Lysosome 3 GAA, MTOR, TYR
endosome 1 EGFR
plasma membrane 5 ACHE, EGFR, GAA, PGR, PIK3CA
Membrane 9 ACHE, ANXA5, CYP3A4, CYP3A5, EGFR, GAA, HMOX1, LIPE, MTOR
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 1 LIPE
extracellular exosome 3 ANXA5, GAA, NRF1
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 1 HMOX1
extracellular space 5 ACHE, EGFR, HMOX1, IL6, MSTN
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 5 ACHE, EGFR, HMOX1, PIK3CA, TYR
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 1 TFAM
protein-containing complex 2 EGFR, TFAM
intracellular membrane-bounded organelle 4 CYP3A4, CYP3A5, GAA, TYR
Microsome membrane 3 CYP3A4, CYP3A5, MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 EGFR, TYR
Secreted 4 ACHE, GAA, IL6, MSTN
extracellular region 4 ACHE, ANXA5, GAA, IL6
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 3 HMOX1, MTOR, PGR
mitochondrial matrix 1 TFAM
Extracellular side 1 ACHE
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, EGFR
external side of plasma membrane 1 ANXA5
Melanosome membrane 1 TYR
Golgi-associated vesicle 1 TYR
Single-pass type II membrane protein 1 NRF1
Membrane raft 1 EGFR
focal adhesion 2 ANXA5, EGFR
mitochondrial nucleoid 1 TFAM
basement membrane 1 ACHE
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, PPARGC1A
PML body 2 MTOR, PPARGC1A
collagen-containing extracellular matrix 1 ANXA5
receptor complex 1 EGFR
Zymogen granule membrane 1 ANXA5
chromatin 3 NRF1, PGR, PPARGC1A
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
Melanosome 1 TYR
side of membrane 1 ACHE
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 1 IL6
transcription repressor complex 1 CCND1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule membrane 1 GAA
Single-pass type III membrane protein 1 NRF1
Single-pass type IV membrane protein 1 HMOX1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 PPARGC1A
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
interleukin-6 receptor complex 1 IL6
[Isoform 4]: Mitochondrion outer membrane 1 PGR
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
cyclin D1-CDK4 complex 1 CCND1
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
Mitochondrion matrix, mitochondrion nucleoid 1 TFAM
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane 1 NRF1
[Transcription factor NRF1]: Nucleus 1 NRF1
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Kuo-Hsiung Lee. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. Journal of natural products. 2010 Mar; 73(3):500-16. doi: 10.1021/np900821e. [PMID: 20187635]
  • Yuan-Bin Cheng, Meng-Ting Chang, Yi-Wen Lo, Ching-Jen Ho, Yuh-Chi Kuo, Ching-Te Chien, Shun-Ying Chen, Shorong-Shii Liou, Yao-Haur Kuo, Ya-Ching Shen. Oxygenated lignans from the fruits of Schisandra arisanensis. Journal of natural products. 2009 Sep; 72(9):1663-8. doi: 10.1021/np9003678. [PMID: 19673515]
  • Kuo-Hsiung Lee. Current developments in the discovery and design of new drug candidates from plant natural product leads. Journal of natural products. 2004 Feb; 67(2):273-83. doi: 10.1021/np030373o. [PMID: 14987069]
  • Dao-Feng Chen, Shun-Xiang Zhang, Mutsuo Kozuka, Quan-Zhong Sun, Ju Feng, Qiang Wang, Teruo Mukainaka, Yoshitaka Nobukuni, Harukuni Tokuda, Hoyoku Nishino, Hui-Kang Wang, Susan L Morris-Natschke, Kuo-Hsiung Lee. Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. Journal of natural products. 2002 Sep; 65(9):1242-5. doi: 10.1021/np0105127. [PMID: 12350139]