friedelanol (BioDeep_00000000544)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(3S,4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-3-ol

化学式: C30H52O (428.4018)
中文名称: 表木栓醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 93.18%

分子结构信息

SMILES: CC1C(CCC2C1(CCC3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C)C)C)C)C)C)O
InChI: InChI=1S/C30H52O/c1-20-21(31)9-10-22-27(20,5)12-11-23-28(22,6)16-18-30(8)24-19-25(2,3)13-14-26(24,4)15-17-29(23,30)7/h20-24,31H,9-19H2,1-8H3/t20-,21-,22+,23-,24+,26+,27+,28-,29+,30-/m0/s1



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

102 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ANG, BCL2, CASP3, CASP8, CASP9, ERBB2, GFAP, GRIN1, MAP3K1, MTOR, NR1I3, PDK1, PIK3CA
Peripheral membrane protein 1 MTOR
Endosome membrane 1 ERBB2
Endoplasmic reticulum membrane 3 BCL2, GRIN1, MTOR
Nucleus 11 ANG, BCL2, CASP3, CASP8, CASP9, ERBB2, MTOR, NR1I2, NR1I3, PARP1, PDK1
cytosol 13 ANG, BCL2, CASP3, CASP8, CASP9, ERBB2, GFAP, MAP3K1, MTOR, NR1I3, PARP1, PDK1, PIK3CA
dendrite 2 GRIN1, MTOR
nuclear body 2 NR1I2, PARP1
phagocytic vesicle 1 MTOR
nucleoplasm 7 CASP3, CASP8, ERBB2, MTOR, NR1I2, NR1I3, PARP1
Cell membrane 3 ERBB2, GRIN1, TNF
Cytoplasmic side 1 MTOR
lamellipodium 2 CASP8, PIK3CA
ruffle membrane 1 ERBB2
Multi-pass membrane protein 1 GRIN1
Golgi apparatus membrane 1 MTOR
Synapse 1 GRIN1
cell surface 2 GRIN1, TNF
glutamatergic synapse 1 CASP3
Golgi membrane 1 MTOR
growth cone 1 ANG
lysosomal membrane 2 GAA, MTOR
neuromuscular junction 1 ERBB2
neuronal cell body 3 ANG, CASP3, TNF
presynaptic membrane 1 ERBB2
synaptic vesicle 1 GRIN1
Cytoplasm, cytosol 1 PARP1
Lysosome 2 GAA, MTOR
plasma membrane 8 BCHE, ERBB2, GAA, GRIN1, IFNLR1, PDK1, PIK3CA, TNF
terminal bouton 1 GRIN1
Membrane 7 BCL2, ERBB2, GAA, GRIN1, IFNLR1, MTOR, PARP1
apical plasma membrane 1 ERBB2
basolateral plasma membrane 1 ERBB2
extracellular exosome 1 GAA
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 1 BCL2
extracellular space 4 ANG, BCHE, CXCL8, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ERBB2, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP8, CASP9, PARP1, PDK1
protein-containing complex 4 BCL2, CASP8, CASP9, PARP1
intracellular membrane-bounded organelle 1 GAA
Microsome membrane 1 MTOR
postsynaptic density 3 CASP3, GRIN1, PDK1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ERBB2, IFNLR1
Secreted 4 ANG, BCHE, CXCL8, GAA
extracellular region 6 ANG, BCHE, CXCL8, ERBB2, GAA, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, CASP8, MTOR
astrocyte end-foot 1 GFAP
excitatory synapse 1 GRIN1
Mitochondrion matrix 1 PDK1
mitochondrial matrix 1 PDK1
transcription regulator complex 2 NR1I2, PARP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
actin cytoskeleton 1 ANG
dendritic spine 1 GRIN1
cytoplasmic vesicle 2 ERBB2, PDK1
nucleolus 2 ANG, PARP1
Early endosome 1 ERBB2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 GRIN1
Cell projection, lamellipodium 1 CASP8
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 NR1I3
focal adhesion 1 PDK1
basement membrane 1 ANG
Nucleus, PML body 1 MTOR
PML body 1 MTOR
intermediate filament 1 GFAP
Postsynaptic cell membrane 1 GRIN1
receptor complex 1 ERBB2
neuron projection 1 GRIN1
chromatin 3 NR1I2, NR1I3, PARP1
cell projection 2 GFAP, PDK1
phagocytic cup 1 TNF
Chromosome 2 ANG, PARP1
cytoskeleton 2 CASP8, NR1I3
Nucleus, nucleolus 2 ANG, PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 BCHE
site of double-strand break 1 PARP1
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
tertiary granule membrane 1 GAA
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
cell body 2 CASP8, GFAP
myelin sheath 2 BCL2, ERBB2
intermediate filament cytoskeleton 2 GFAP, NR1I2
basal plasma membrane 1 ERBB2
Synaptic cell membrane 1 GRIN1
synaptic membrane 1 GRIN1
endoplasmic reticulum lumen 1 BCHE
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
pyruvate dehydrogenase complex 1 PDK1
endocytic vesicle 1 ANG
azurophil granule membrane 1 GAA
tight junction 1 MAP3K1
postsynaptic density membrane 1 GRIN1
nuclear envelope lumen 1 BCHE
apoptosome 1 CASP9
semaphorin receptor complex 1 ERBB2
synaptic cleft 1 GRIN1
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 GAA
NMDA selective glutamate receptor complex 1 GRIN1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
[Isoform 1]: Cell membrane 1 ERBB2
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
cytoplasmic side of lysosomal membrane 1 GFAP
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
ERBB3:ERBB2 complex 1 ERBB2
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jing Zhang, Yang He, Ying Zhou, Liping Hong, Zhansheng Jiang, Ying Zhao, Zhanyu Pan. Epifriedelinol Ameliorates DMBA-Induced Breast Cancer in Albino Rats by Regulating the PI3K/AKT Pathway. The Tohoku journal of experimental medicine. 2022 Jul; 257(4):283-289. doi: 10.1620/tjem.2022.j030. [PMID: 35598971]
  • D Credo, F P Mabiki, F Machumi, M Chacha, C Cornett, B Styrishave. Anti-Newcastle Disease Virus activity of 3β and 3α Friedelanol Triterpenoids from the leaves of Synadenium glaucescens Pax. Tropical biomedicine. 2022 Jun; 39(2):257-264. doi: 10.47665/tb.39.2.016. [PMID: 35838100]
  • Fabio Ferrini, Daniele Fraternale, Sabrina Donati Zeppa, Giancarlo Verardo, Andrea Gorassini, Vittoria Carrabs, Maria Cristina Albertini, Piero Sestili. Yield, Characterization, and Possible Exploitation of Cannabis Sativa L. Roots Grown under Aeroponics Cultivation. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26164889. [PMID: 34443479]
  • Patrícia Marques Rodrigues, João Victor Dutra Gomes, Claudia Masrouah Jamal, Álvaro Cunha Neto, Maria Lucilia Santos, Christopher William Fagg, Yris Maria Fonseca-Bazzo, Pérola de Oliveira Magalhães, Paloma Michelle de Sales, Dâmaris Silveira. Triterpenes from Pouteria ramiflora (Mart.) Radlk. Leaves (Sapotaceae). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Nov; 109(Pt 2):1063-1068. doi: 10.1016/j.fct.2017.05.026. [PMID: 28533130]
  • Jie Yang, Jing Fa, Bingxing Li. APOPTOSIS INDUCTION OF EPIFRIEDELINOL ON HUMAN CERVICAL CANCER CELL LINE. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2017; 14(4):80-86. doi: 10.21010/ajtcam.v14i4.10. [PMID: 28638870]
  • De-Feng Yin, Kai Zhou, Ji-Tao Liu, Li Hu, Ying Liu, Jun Deng, Song-Ping Wang, Ying Xiong, Wu Zhong. Development and validation of an LC/MS/MS method for simultaneous determination of shionone and epi-friedelinol in rat plasma for pharmacokinetic study after oral administration of Aster tataricus extract. Biomedical chromatography : BMC. 2016 Jul; 30(7):1112-1117. doi: 10.1002/bmc.3658. [PMID: 26581126]
  • Ling-Yun Jia, Jing Wang, Chong-Ning Lv, Tan-Ye Xu, Ben-Zhi Jia, Jin-Cai Lu. A new cycloartane nortriterpenoid from stem and leaf of Quercus variabilis. Journal of Asian natural products research. 2013 Sep; 15(9):1050-4. doi: 10.1080/10286020.2012.762911. [PMID: 23869388]
  • Jun Chen, Jian-Hua Wei, Shao-Fang Cai, Hong-Jian Zhang, Xiao-Hua Zhang, Wen-Jing Liang, Shan-Guang Wu. [Chemical constituents in whole herb of Bidens pilosa var. radiata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Mar; 36(3):410-3. doi: . [PMID: 24010324]
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  • Hyo Hyun Yang, Jong-Keun Son, Bochan Jung, Mingshan Zheng, Jae-Ryong Kim. Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells. Planta medica. 2011 Mar; 77(5):441-9. doi: 10.1055/s-0030-1250458. [PMID: 21049397]
  • David Torres-Romero, Beatriz King-Díaz, Reto J Strasser, Ignacio A Jiménez, Blas Lotina-Hennsen, Isabel L Bazzocchi. Friedelane triterpenes from Celastrus vulcanicola as photosynthetic inhibitors. Journal of agricultural and food chemistry. 2010 Oct; 58(20):10847-54. doi: 10.1021/jf1022115. [PMID: 20873773]
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