Nicotinamide riboside (BioDeep_00000005108)

 

Secondary id: BioDeep_00001868436, BioDeep_00001892813

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs natural product


代谢物信息卡片


3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium

化学式: C11H15N2O5+ (255.0981)
中文名称: 烟酰胺核糖
谱图信息: 最多检出来源 Homo sapiens(plant) 18.85%

分子结构信息

SMILES: C1=CC(=C[N+](=C1)C2C(C(C(O2)CO)O)O)C(=O)N
InChI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1

描述信息

Nicotinamide riboside is involved in nicotinate and nicotinamide metabolism. Nicotinamide riboside was originally identified as a nutrient in milk. It is a useful compound for the elevation of NAD+ levels in humans. Nicotinamide riboside has recently been discovered to be an NAD(+) precursor that is converted into nicotinamide mononucleotide by specific nicotinamide riboside kinases, Nrk1 and Nrk2. It has been shown that exogenous nicotinamide riboside promotes Sir2-dependent repression of recombination, improves gene silencing, and extends the lifespan of certain animal models without calorie restriction (PMID: 17482543). Supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities (PMID: 22682224). Recent data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis (PMID: 18429699). Nicotinamide riboside kinase has an essential role in the phosphorylation of nicotinamide riboside and the cancer drug tiazofurin (PMID: 15137942).
Nicotinamide riboside is involved in nicotinate and nicotinamide metabolism. Nicotinamide riboside has been identified as a nutrient in milk. It is a useful compound for elevation of NAD+ levels in humans. Recent data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis (PMID: 18429699). Nicotinamide riboside kinase has an essential role for phosphorylation of nicotinamide riboside and the cancer drug tiazofurin (PMID 15137942). [HMDB]
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同义名列表

23 个代谢物同义名

3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium; 3-(Aminocarbonyl)-1-beta-delta-ribofuranosyl-pyridinium; 3-(Aminocarbonyl)-1-beta-D-ribofuranosyl-pyridinium; 1-beta-delta-Ribosyl-3-pyridinecarboxamide; 1-beta-D-Ribosyl-3-pyridinecarboxamide; 1-(beta-D-Ribofuranosyl)nicotinamide; 1-b-D-Ribosyl-3-pyridinecarboxamide; 1-(b-D-Ribofuranosyl)nicotinamide; 1-(Β-D-ribofuranosyl)nicotinamide; beta-Nicotinamide D-riboside; Nicotinamide ribonucleoside; Nicotinamide-beta-riboside; b-Nicotinamide D-riboside; Β-nicotinamide D-riboside; Nicotinamide-β-riboside; Nicotinamide-b-riboside; N-Ribosylnicotinamide; Nicotinamide riboside; Ribosylnicotinamide; Nicotinamide ribose; SRT 647; SRT-647; Nicotinamide-beta-riboside



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(10)

BioCyc(1)

PlantCyc(0)

代谢反应

157 个相关的代谢反应过程信息。

Reactome(117)

BioCyc(16)

WikiPathways(3)

Plant Reactome(0)

INOH(2)

PlantCyc(8)

COVID-19 Disease Map(2)

PathBank(9)

  • Nicotinate and Nicotinamide Metabolism: NAD + Water ⟶ Adenosine monophosphate + Nicotinamide ribotide
  • Nicotinate and Nicotinamide Metabolism: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate
  • Nicotinate and Nicotinamide Metabolism: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate
  • Nicotinate and Nicotinamide Metabolism: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate
  • Nicotinate and Nicotinamide Metabolism: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate
  • NAD Metabolism: N'-Formylkynurenine + Water ⟶ Formic acid + Hydrogen Ion + L-Kynurenine
  • Nicotinate and Nicotinamide Metabolism: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate
  • NAD Salvage: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + Hydrogen Ion + L-Glutamic acid + NAD + Pyrophosphate
  • NAD Salvage: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + Hydrogen Ion + L-Glutamic acid + NAD + Pyrophosphate

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 CAT, NAMPT, NLRP3, NMRK1, NMRK2, PNP, PPARG, PRKAA2, SIRT1
Nucleus 8 NAMPT, NLRP3, PARP1, PPARG, PPARGC1A, PRKAA2, SIRT1, SIRT3
cytosol 14 CAT, GPT, NAMPT, NLRP3, NMRK1, NMRK2, NRK, NT5E, PARP1, PNP, PPARG, PPARGC1A, PRKAA2, SIRT1
dendrite 1 PRKAA2
nuclear body 1 PARP1
nucleoplasm 8 NMRK2, NT5E, PARP1, PPARG, PPARGC1A, PRKAA2, SIRT1, SIRT3
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 2 NT5E, TNF
Golgi apparatus membrane 1 NLRP3
cell junction 1 NAMPT
cell surface 3 CD38, NT5E, TNF
Golgi apparatus 1 PRKAA2
Golgi membrane 2 INS, NLRP3
neuronal cell body 2 PRKAA2, TNF
Cytoplasm, cytosol 2 NLRP3, PARP1
plasma membrane 4 CD38, NMRK2, NT5E, TNF
Membrane 7 CAT, CD38, NLRP3, NRK, NT5E, PARP1, PRKAA2
axon 1 PRKAA2
basolateral plasma membrane 1 CD38
extracellular exosome 7 CAT, CD38, GPT, NAMPT, NT5E, PNP, SOD2
endoplasmic reticulum 1 NLRP3
extracellular space 5 IL6, INS, NAMPT, PNP, TNF
perinuclear region of cytoplasm 1 PPARG
mitochondrion 6 CAT, NLRP3, PARP1, SIRT1, SIRT3, SOD2
protein-containing complex 3 CAT, PARP1, SIRT3
intracellular membrane-bounded organelle 3 CAT, NMRK2, PPARG
chromatin silencing complex 1 SIRT1
Secreted 5 IL6, INS, NAMPT, NLRP3, PNP
extracellular region 6 CAT, IL6, INS, NLRP3, PNP, TNF
Mitochondrion matrix 2 SIRT3, SOD2
mitochondrial matrix 3 CAT, SIRT3, SOD2
transcription regulator complex 1 PARP1
nuclear membrane 1 CD38
external side of plasma membrane 2 NT5E, TNF
nucleolus 2 PARP1, SIRT1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 CD38, TNF
heterochromatin 1 SIRT1
Membrane raft 1 TNF
focal adhesion 1 CAT
mitochondrial nucleoid 1 SOD2
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 PPARGC1A, SIRT1
PML body 2 PPARGC1A, SIRT1
nuclear speck 2 NAMPT, PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
nuclear inner membrane 1 SIRT1
receptor complex 1 PPARG
chromatin 4 PARP1, PPARG, PPARGC1A, SIRT1
phagocytic cup 1 TNF
Chromosome 1 PARP1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
Lipid-anchor, GPI-anchor 1 NT5E
site of double-strand break 1 PARP1
fibrillar center 1 SIRT1
nuclear envelope 2 PARP1, SIRT1
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
cytoplasmic stress granule 1 PRKAA2
euchromatin 1 SIRT1
side of membrane 1 NT5E
ficolin-1-rich granule lumen 2 CAT, PNP
secretory granule lumen 3 CAT, INS, PNP
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 1]: Nucleus 1 PPARGC1A
protein-DNA complex 1 PARP1
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Mohammad Hasan Maleki, Morvarid Siri, Amirhossein Jafarabadi, Mahsa Rajabi, Seyed Amirhossein Mazhari, Zahra Noori, Farhad Koohpeyma, Amirreza Dehghanian, Nafiseh Esmaeili, Zeinab Aryanian, Sanaz Dastghaib. Boosting wound healing in diabetic rats: The role of nicotinamide riboside and resveratrol in UPR modulation and pyroptosis inhibition. International immunopharmacology. 2024 May; 132(?):112013. doi: 10.1016/j.intimp.2024.112013. [PMID: 38583241]
  • Qiuyan Li, Xuye Jiang, Yujia Zhou, Yingying Gu, Yijie Ding, Jing Luo, Nengzhi Pang, Yan Sun, Lei Pei, Jie Pan, Mengqi Gao, Sixi Ma, Ying Xiao, De Hu, Feilong Wu, Lili Yang. Improving Mitochondrial Function in Skeletal Muscle Contributes to the Amelioration of Insulin Resistance by Nicotinamide Riboside. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210015. [PMID: 37373163]
  • Armin Ahmadi, Gwenaelle Begue, Ana P Valencia, Jennifer E Norman, Benjamin Lidgard, Brian J Bennett, Matthew P Van Doren, David J Marcinek, Sili Fan, David K Prince, Jorge L Gamboa, Jonathan Himmelfarb, Ian H de Boer, Bryan R Kestenbaum, Baback Roshanravan. Randomized crossover clinical trial of coenzyme Q10 and nicotinamide ribosome in chronic kidney disease. JCI insight. 2023 May; ?(?):. doi: 10.1172/jci.insight.167274. [PMID: 37159264]
  • Hui Zhao, Yingjie Tian, Yuwei Zuo, Xiaoqi Zhang, Yijun Gao, Peng Wang, Lirui Sun, Huaqi Zhang, Hui Liang. Nicotinamide riboside ameliorates high-fructose-induced lipid metabolism disorder in mice via improving FGF21 resistance in the liver and white adipose tissue. Food & function. 2022 Nov; 13(23):12400-12411. doi: 10.1039/d2fo01934e. [PMID: 36373585]
  • Ryan W Dellinger, Holly E Holmes, Tina Hu-Seliger, Rodney W Butt, Stephen A Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente. Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial. Hepatology (Baltimore, Md.). 2022 Sep; ?(?):. doi: 10.1002/hep.32778. [PMID: 36082508]
  • Jia Fang, Hongmin Wu, Jianning Zhang, Song Mao, Haosong Shi, Dongzhen Yu, Zhengnong Chen, Kaiming Su, Yazhi Xing, Hongjun Dong, Haibo Shi. A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113071. doi: 10.1016/j.biopha.2022.113071. [PMID: 35658237]
  • Alba Serrano, Andreu Palou, M Luisa Bonet, Joan Ribot. Nicotinamide Riboside Supplementation to Suckling Male Mice Improves Lipid and Energy Metabolism in Skeletal Muscle and Liver in Adulthood. Nutrients. 2022 May; 14(11):. doi: 10.3390/nu14112259. [PMID: 35684059]
  • Xiao Zhang, Bing Tian, Qin Deng, Jian Cao, Xionghui Ding, Qingshuang Liu, Yunfei Zhang, Cuilian Ye, Chun Deng, Lin Qiu, Chunbao Guo. Nicotinamide riboside relieves the severity of experimental necrotizing enterocolitis by regulating endothelial function via eNOS deacetylation. Free radical biology & medicine. 2022 05; 184(?):218-229. doi: 10.1016/j.freeradbiomed.2022.04.008. [PMID: 35430341]
  • Linfeng Zou, Bing Liang, YuanZhen Gao, Ting Ye, MengJiao Li, Yukun Zhang, Qi Lu, Xiaokun Hu, Huanting Li, Yang Yuan, Dongming Xing. Nicotinic Acid Riboside Regulates Nrf-2/P62-Related Oxidative Stress and Autophagy to Attenuate Doxorubicin-Induced Cardiomyocyte Injury. BioMed research international. 2022; 2022(?):6293329. doi: 10.1155/2022/6293329. [PMID: 35242876]
  • Stefanie J G Veenhuis, Nienke J H van Os, Anjo J W M Janssen, Marjo H J C van Gerven, Karlien L M Coene, Udo F H Engelke, Ron A Wevers, Gerjen H Tinnevelt, Rob Ter Heine, Bart P C van de Warrenburg, Corry M R Weemaes, Nel Roeleveld, Michèl A A P Willemsen. Nicotinamide Riboside Improves Ataxia Scores and Immunoglobulin Levels in Ataxia Telangiectasia. Movement disorders : official journal of the Movement Disorder Society. 2021 12; 36(12):2951-2957. doi: 10.1002/mds.28788. [PMID: 34515380]
  • David M Cartwright, Lucy A Oakey, Rachel S Fletcher, Craig L Doig, Silke Heising, Dean P Larner, Daniela Nasteska, Caitlin E Berry, Sam R Heaselgrave, Christian Ludwig, David J Hodson, Gareth G Lavery, Antje Garten. Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity. The Journal of endocrinology. 2021 09; 251(1):111-123. doi: 10.1530/joe-21-0123. [PMID: 34370682]
  • Anna Faivre, Elena Katsyuba, Thomas Verissimo, Maja Lindenmeyer, Renuga Devi Rajaram, Maarten Naesens, Carolyn Heckenmeyer, Adrienne Mottis, Eric Feraille, Pietro Cippà, Clemens Cohen, Alban Longchamp, Florent Allagnat, Joseph M Rutkowski, David Legouis, Johan Auwerx, Sophie de Seigneux. Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2021 01; 36(1):60-68. doi: 10.1093/ndt/gfaa124. [PMID: 33099633]
  • Marya Morevati, Søren Egstrand, Anders Nordholm, Maria L Mace, Claus B Andersen, Rouzbeh Salmani, Klaus Olgaard, Ewa Lewin. Effect of NAD+ boosting on kidney ischemia-reperfusion injury. PloS one. 2021; 16(6):e0252554. doi: 10.1371/journal.pone.0252554. [PMID: 34061900]
  • Collin D Heer, Daniel J Sanderson, Lynden S Voth, Yousef M O Alhammad, Mark S Schmidt, Samuel A J Trammell, Stanley Perlman, Michael S Cohen, Anthony R Fehr, Charles Brenner. Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. The Journal of biological chemistry. 2020 12; 295(52):17986-17996. doi: 10.1074/jbc.ra120.015138. [PMID: 33051211]
  • Ki-Hoon Park, Seok-Hyung Kim. Adult zebrafish as an in vivo drug testing model for ethanol induced acute hepatic injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Dec; 132(?):110836. doi: 10.1016/j.biopha.2020.110836. [PMID: 33035832]
  • Arkadiy A Bazhin, Riccardo Sinisi, Umberto De Marchi, Aurélie Hermant, Nicolas Sambiagio, Tamara Maric, Ghyslain Budin, Elena A Goun. A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential. Nature chemical biology. 2020 12; 16(12):1385-1393. doi: 10.1038/s41589-020-0602-1. [PMID: 32778841]
  • Petra Simic, Xavier Fernando Vela Parada, Samir M Parikh, Ryan Dellinger, Leonard P Guarente, Eugene P Rhee. Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI. BMC nephrology. 2020 08; 21(1):342. doi: 10.1186/s12882-020-02006-1. [PMID: 32791973]
  • Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. The American journal of clinical nutrition. 2020 08; 112(2):413-426. doi: 10.1093/ajcn/nqaa072. [PMID: 32320006]
  • Utsav Joshi, James E Evans, Andrew Pearson, Nicole Saltiel, Adam Cseresznye, Teresa Darcey, Joseph Ojo, Andrew P Keegan, Sarah Oberlin, Benoit Mouzon, Daniel Paris, Nancy Klimas, Kimberly Sullivan, Michael Mullan, Fiona Crawford, Laila Abdullah. Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model. Neurotoxicology. 2020 07; 79(?):84-94. doi: 10.1016/j.neuro.2020.04.006. [PMID: 32343995]
  • Mario Mehmel, Nina Jovanović, Urs Spitz. Nicotinamide Riboside-The Current State of Research and Therapeutic Uses. Nutrients. 2020 May; 12(6):. doi: 10.3390/nu12061616. [PMID: 32486488]
  • Cheng Zhang, Elias Bjornson, Muhammad Arif, Abdellah Tebani, Alen Lovric, Rui Benfeitas, Mehmet Ozcan, Kajetan Juszczak, Woonghee Kim, Jung Tae Kim, Gholamreza Bidkhori, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Hasan Turkez, Marja-Riitta Taskinen, Jim Bosley, Hanns-Ulrich Marschall, Jens Nielsen, Mathias Uhlén, Jan Borén, Adil Mardinoglu. The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease. Molecular systems biology. 2020 04; 16(4):e9495. doi: 10.15252/msb.209495. [PMID: 32337855]
  • C F Dolopikou, I A Kourtzidis, N V Margaritelis, I S Vrabas, I Koidou, A Kyparos, A A Theodorou, V Paschalis, Michalis G Nikolaidis. Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study. European journal of nutrition. 2020 Mar; 59(2):505-515. doi: 10.1007/s00394-019-01919-4. [PMID: 30725213]
  • Judith Giroud-Gerbetant, Magali Joffraud, Maria Pilar Giner, Angelique Cercillieux, Simona Bartova, Mikhail V Makarov, Rubén Zapata-Pérez, José L Sánchez-García, Riekelt H Houtkooper, Marie E Migaud, Sofia Moco, Carles Canto. A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor. Molecular metabolism. 2019 12; 30(?):192-202. doi: 10.1016/j.molmet.2019.09.013. [PMID: 31767171]
  • Ole L Dollerup, Samuel A J Trammell, Bolette Hartmann, Jens J Holst, Britt Christensen, Niels Møller, Matthew P Gillum, Jonas T Treebak, Niels Jessen. Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity. The Journal of clinical endocrinology and metabolism. 2019 11; 104(11):5703-5714. doi: 10.1210/jc.2019-01081. [PMID: 31390002]
  • Audrey Sambeat, Joanna Ratajczak, Magali Joffraud, José L Sanchez-Garcia, Maria P Giner, Armand Valsesia, Judith Giroud-Gerbetant, Miriam Valera-Alberni, Angelique Cercillieux, Marie Boutant, Sameer S Kulkarni, Sofia Moco, Carles Canto. Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage. Nature communications. 2019 09; 10(1):4291. doi: 10.1038/s41467-019-12262-x. [PMID: 31541116]
  • Kanita Salic, Eveline Gart, Florine Seidel, Lars Verschuren, Martien Caspers, Wim van Duyvenvoorde, Kari E Wong, Jaap Keijer, Ivana Bobeldijk-Pastorova, Peter Y Wielinga, Robert Kleemann. Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis. International journal of molecular sciences. 2019 Sep; 20(18):. doi: 10.3390/ijms20184359. [PMID: 31491949]
  • Dietrich Conze, Charles Brenner, Claire L Kruger. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Scientific reports. 2019 07; 9(1):9772. doi: 10.1038/s41598-019-46120-z. [PMID: 31278280]
  • Xian Xie, Yi Gao, Min Zeng, Yi Wang, Tao-Feng Wei, Yun-Bi Lu, Wei-Ping Zhang. Nicotinamide ribose ameliorates cognitive impairment of aged and Alzheimer's disease model mice. Metabolic brain disease. 2019 02; 34(1):353-366. doi: 10.1007/s11011-018-0346-8. [PMID: 30523581]
  • Qinghai Zhang, Xun Liu, Na Li, Jihong Zhang, Jianmin Yang, Peili Bu. Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury. Journal of translational medicine. 2018 11; 16(1):313. doi: 10.1186/s12967-018-1690-5. [PMID: 30445987]
  • Alba Serrano, Madhu Asnani-Kishnani, Ana María Rodríguez, Andreu Palou, Joan Ribot, María Luisa Bonet. Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life. Molecular nutrition & food research. 2018 11; 62(21):e1800463. doi: 10.1002/mnfr.201800463. [PMID: 30095217]
  • Barbara M Crisol, Camilla B Veiga, Luciene Lenhare, Renata R Braga, Vagner R R Silva, Adelino S R da Silva, Dennys E Cintra, Leandro P Moura, José R Pauli, Eduardo R Ropelle. Nicotinamide riboside induces a thermogenic response in lean mice. Life sciences. 2018 Oct; 211(?):1-7. doi: 10.1016/j.lfs.2018.09.015. [PMID: 30195617]
  • I A Kourtzidis, C F Dolopikou, A N Tsiftsis, N V Margaritelis, A A Theodorou, I A Zervos, M P Tsantarliotou, A S Veskoukis, I S Vrabas, V Paschalis, A Kyparos, M G Nikolaidis. Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance. Experimental physiology. 2018 10; 103(10):1357-1366. doi: 10.1113/ep086964. [PMID: 30007015]
  • Guangliang Hong, Dong Zheng, Lulu Zhang, Rui Ni, Grace Wang, Guo-Chang Fan, Zhongqiu Lu, Tianqing Peng. Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis. Free radical biology & medicine. 2018 08; 123(?):125-137. doi: 10.1016/j.freeradbiomed.2018.05.073. [PMID: 29803807]
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