Telobufotoxin (BioDeep_00000000421)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C24H34O5 (402.2406)
中文名称: 端粒细胞生成素, 远华蟾毒精
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 33.66%
分子结构信息
SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@]([H])(C5=COC(=O)C=C5)CC[C@]4(O)[C@]3([H])CC[C@]2(O)C[C@@H](O)C1
InChI: InChI=1S/C24H34O5/c1-21-9-5-16(25)13-23(21,27)11-7-19-18(21)6-10-22(2)17(8-12-24(19,22)28)15-3-4-20(26)29-14-15/h3-4,14,16-19,25,27-28H,5-13H2,1-2H3
描述信息
Telocinobufagin is a steroid lactone. It is functionally related to a bufanolide.
Telocinobufagin is a natural product found in Bufo gargarizans, Bufo bufo, and other organisms with data available.
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002018 - Bufanolides
Telocinobufagin is one of anti-hepatoma constituent in Venenum Bufonis.
Telocinobufagin is one of anti-hepatoma constituent in Venenum Bufonis.
同义名列表
20 个代谢物同义名
5-[(3S,5S,8R,9S,10R,13R,14S,17R)-3,5,14-trihydroxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one; Bufa-20,22-dienolide, 3,5,14-trihydroxy-, (3beta,5beta)-; 5-beta-BUFA-20,22-DIENOLIDE, 3-beta,5,14-TRIHYDROXY-; 5beta-Bufa-20,22-dienolide, 3beta,5,14-trihydroxy-; 3beta,5beta,14beta-trihydroxy-bufa-20,22-dienolide; 3-beta,5,14-Trihydroxy-5-beta-bufa-20,22-dienolide; 3beta,5,14-Trihydroxy-5beta-bufa-20,22-dienolide; Bufa-20, 3,5,14-trihydroxy-, (3.beta.,5.beta.)-; 3beta,5beta,14-trihydroxy-bufa-20,22-dienolide; 4-18-00-02553 (Beilstein Handbook Reference); 5.beta.-Bufa-20, 3.beta.,5,14-trihydroxy-; 3,5,14-Trihydroxybufa-20,22-dienolide; Telobufotoxin;Telocinobufogenin; Telocinobufogenin; Telecinobufagin; Telocinobufagin; Telobufotoxin; ST 24:4;O5; SCHEMBL866976; Telocinobufagin
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:80908
- KEGG: C17072
- PubChem: 259991
- PubChem: 633458
- Metlin: METLIN71540
- ChEMBL: CHEMBL463273
- LipidMAPS: LMST01130025
- MeSH: telocinobufagin
- ChemIDplus: 0000472264
- chemspider: 228185
- CAS: 472-26-4
- PMhub: MS000025589
- PubChem: 96023550
- NIKKAJI: J5.951J
- medchemexpress: HY-N0885
- KNApSAcK: 80908
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
- 40674 - Animals: -
- 86345 - Bufo bankorensis: 10.1248/CPB.35.2300
- 8384 - Bufo bufo:
- 8384 - Bufo bufo: 10.1002/HLCA.19550380405
- 30331 - Bufo gargarizans:
- 16906 - Cornus Officinalis Sieb. Et Zucc.: -
- 8386 - Rhinella marina:
- 8386 - Rhinella marina: 10.1002/HLCA.19590420720
- 33090 - 蟾酥: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jie Li, Ru Ma, Jun-Lin Lv, Yu-Shan Ren, Yu-Jun Tan, Hao-Mai Wang, Zhui-En Wang, Bin-Sheng Wang, Jia-Ning Yu, Yu-Liang Wang, Jun Tian, Qiu-Sheng Zheng. Telocinobufagin, a PLK1 suppressor that inhibits tumor growth and metastasis by modulating CDC25c and CTCF in HNSCC cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 May; 127(?):155440. doi:
10.1016/j.phymed.2024.155440. [PMID: 38452691] - Yili Shen, Haijian Cai, Shenjie Ma, Wenjing Zhu, Haiyang Zhao, Jifa Li, Hua Ye, Lehe Yang, Chengguang Zhao, Xiaoying Huang, Zhongxiao Xiao. Telocinobufagin Has Antitumor Effects in Non-Small-Cell Lung Cancer by Inhibiting STAT3 Signaling.
Journal of natural products.
2022 04; 85(4):765-775. doi:
10.1021/acs.jnatprod.1c00761. [PMID: 35200033] - Dongzhu Tu, Jing Ning, Liwei Zou, Ping Wang, Yani Zhang, Xiangge Tian, Feng Zhang, Jiang Zheng, Guangbo Ge. Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A.
Journal of medicinal chemistry.
2022 03; 65(5):4018-4029. doi:
10.1021/acs.jmedchem.1c01875. [PMID: 35094507] - Shi-Wen Zhou, Jing-Yu Quan, Zi-Wei Li, Ge Ye, Zhuo Shang, Ze-Ping Chen, Lei Wang, Xin-Yuan Li, Xiao-Qi Zhang, Jie Li, Jun-Shan Liu, Hai-Yan Tian. Bufadienolides from the Eggs of the Toad Bufo bufo gargarizans and Their Antimelanoma Activities.
Journal of natural products.
2021 05; 84(5):1425-1433. doi:
10.1021/acs.jnatprod.0c00840. [PMID: 33882233] - Fatimah K Khalaf, Iman Tassavvor, Amal Mohamed, Yiliang Chen, Deepak Malhotra, Zijian Xie, Jiang Tian, Steven T Haller, Kristen Westfall, W H Wilson Tang, David J Kennedy. Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na+/K+-ATPase-α-1.
Journal of the American Heart Association.
2020 02; 9(3):e013933. doi:
10.1161/jaha.119.013933. [PMID: 32013704] - Fatimah K Khalaf, Prabhatchandra Dube, Andrew L Kleinhenz, Deepak Malhotra, Amira Gohara, Christopher A Drummond, Jiang Tian, Steven T Haller, Zijian Xie, David J Kennedy. Proinflammatory Effects of Cardiotonic Steroids Mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src Complex in Renal Epithelial Cells and Immune Cells.
Hypertension (Dallas, Tex. : 1979).
2019 07; 74(1):73-82. doi:
10.1161/hypertensionaha.118.12605. [PMID: 31132948] - Luciana S Amaral, Jainne Martins Ferreira, Danilo Predes, José Garcia Abreu, François Noël, Luis Eduardo M Quintas. Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides.
International journal of molecular sciences.
2018 Sep; 19(9):. doi:
10.3390/ijms19092769. [PMID: 30223494] - David J Kennedy, Fatimah K Khalaf, Brendan Sheehy, Malory E Weber, Brendan Agatisa-Boyle, Julijana Conic, Kayla Hauser, Charles M Medert, Kristen Westfall, Philip Bucur, Olga V Fedorova, Alexei Y Bagrov, W H Wilson Tang. Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na⁺/K⁺-ATPase Profibrotic Signaling Pathways.
International journal of molecular sciences.
2018 Aug; 19(9):. doi:
10.3390/ijms19092566. [PMID: 30158457] - Yi-Wu Dang, Peng Lin, Li-Min Liu, Rong-Quan He, Li-Jie Zhang, Zhi-Gang Peng, Xiao-Jiao Li, Gang Chen. In silico analysis of the potential mechanism of telocinobufagin on breast cancer MCF-7 cells.
Pathology, research and practice.
2018 May; 214(5):631-643. doi:
10.1016/j.prp.2018.03.029. [PMID: 29656985] - Alana N Godinho, Graciana T Costa, Nádia O Oliveira, Bruno A Cardi, Daniel Esdras A Uchoa, Edilberto R Silveira, Luis Eduardo M Quintas, François G Noël, Manassés C Fonteles, Krishnamurti M Carvalho, Cláudia F Santos, Lucília M A Lessa, Nilberto R F do Nascimento. Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules.
Biochimica et biophysica acta. General subjects.
2017 Aug; 1861(8):1943-1950. doi:
10.1016/j.bbagen.2017.05.012. [PMID: 28506883] - Shun-Tian Liang, Yuan Li, Xiao-Wu Li, Jun-Jiang Wang, Fu-Xian Tan, Qin-Rui Han, Lu Li, Xue-Qing Yao, Xue-Gang Sun. [Mechanism of colon cancer cell apoptosis induced by telocinobufagin: role of oxidative stress and apoptosis pathway].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2016 Jun; 36(7):921-6. doi:
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International immunopharmacology.
2015 Apr; 25(2):353-62. doi:
10.1016/j.intimp.2015.02.005. [PMID: 25687199] - Hai-Yan Tian, Shi-Lin Luo, Jun-Shan Liu, Lei Wang, Ying Wang, Dong-Mei Zhang, Xiao-Qi Zhang, Ren-Wang Jiang, Wen-Cai Ye. C23 steroids from the venom of Bufo bufo gargarizans.
Journal of natural products.
2013 Oct; 76(10):1842-7. doi:
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European journal of pharmacology.
2012 Oct; 692(1-3):19-28. doi:
10.1016/j.ejphar.2012.06.045. [PMID: 22841670] - Fanghua Qi, Anyuan Li, Yoshinori Inagaki, Norihiro Kokudo, Sumihito Tamura, Munehiro Nakata, Wei Tang. Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor.
International immunopharmacology.
2011 Mar; 11(3):342-9. doi:
10.1016/j.intimp.2010.12.007. [PMID: 21185919] - Natália Araújo Touza, Elisa Suzana Carneiro Pôças, Luis Eduardo M Quintas, Geraldino Cunha-Filho, Maria Lucília Santos, François Noël. Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation.
Life sciences.
2011 Jan; 88(1-2):39-42. doi:
10.1016/j.lfs.2010.10.027. [PMID: 21047518] - Jingkui Li, Xiaochi Ma, Fengyun Li, Jingkui Wang, Huirong Chen, Gang Wang, Xia Lv, Changkai Sun, Jingming Jia. Preparative separation and purification of bufadienolides from Chinese traditional medicine of ChanSu using high-speed counter-current chromatography.
Journal of separation science.
2010 May; 33(9):1325-30. doi:
10.1002/jssc.200900782. [PMID: 20201046] - Yongguo Cao, Yu Song, Na An, Sheng Zeng, Dacheng Wang, Lu Yu, Tongfei Zhu, Tingdi Zhang, Jian Cui, Changfang Zhou, Xuming Deng. The effects of telocinobufagin isolated from Chan Su on the activation and cytokine secretion of immunocytes in vitro.
Fundamental & clinical pharmacology.
2009 Aug; 23(4):457-64. doi:
10.1111/j.1472-8206.2009.00696.x. [PMID: 19709323] - Xiao Chi Ma, Bao Jing Zhang, Xin Lan Xin, Shan Shan Huang, Sha Deng, Hou Li Zhang, Xiao Hong Shu, Yun Peng Diao, Jian Cui. Simultaneous quantification of seven major bufadienolides in three traditional Chinese medicinal preparations of chansu by HPLC-DAD.
Natural product communications.
2009 Feb; 4(2):179-84. doi:
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Toxicon : official journal of the International Society on Toxinology.
2008 Jul; 52(1):13-21. doi:
10.1016/j.toxicon.2008.05.008. [PMID: 18588907] - Yan Liang, Ai-hua Liu, Song Qin, Jiang-hao Sun, Min Yang, Ping Li, De-an Guo. Simultaneous determination and pharmacokinetics of five bufadienolides in rat plasma after oral administration of Chansu extract by SPE-HPLC method.
Journal of pharmaceutical and biomedical analysis.
2008 Feb; 46(3):442-8. doi:
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2007; 7(3):173-89. doi:
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Clinical biochemistry.
2005 Jan; 38(1):36-45. doi:
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