Lanosterol (BioDeep_00000004169)

 

Secondary id: BioDeep_00000636694, BioDeep_00000861027

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(2S,5S,7R,11R,14R,15R)-2,6,6,11,15-pentamethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-1(10)-en-5-ol

化学式: C30H50O (426.3861)
中文名称: 羊毛甾醇
谱图信息: 最多检出来源 Homo sapiens(blood) 38.92%

分子结构信息

SMILES: C1[C@@H](C([C@H]2[C@](C1)(C1=C(CC2)[C@]2([C@](CC1)([C@H](CC2)[C@@H](CCC=C(C)C)C)C)C)C)(C)C)O
InChI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3

描述信息

Lanosterol, also known as lanosterin, belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. Thus, lanosterol is considered to be a sterol lipid molecule. Lanosterol is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Lanosterol is biochemically synthesized starting from acetyl-CoA by the HMG-CoA reductase pathway. The critical step is the enzymatic conversion of the acyclic terpene squalene to the polycylic lanosterol via 2,3-squalene oxide.
Constituent of wool fat used e.g. as chewing-gum softenerand is) also from yeast
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

35 个代谢物同义名

(2S,5S,7R,11R,14R,15R)-2,6,6,11,15-pentamethyl-14-[(2R)-6-methylhept-5-en-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-1(10)-en-5-ol; 4,4,14 alpha-Trimethyl-5 alpha-cholesta-8,24-dien-3 beta-ol; 4,4,14alpha-Trimethyl-5alpha-cholesta-8,24-dien-3beta-ol; (3beta,5alpha)-4,4,14-Trimethyl-cholesta-8,24-dien-3-ol; (3beta,5alpha)-4,4,14-Trimethylcholesta-8,24-dien-3-ol; (3alpha)-4,4,14-Trimethyl-cholesta-8,24-dien-3-ol; 4,4,14alpha-Trimethylcholesta-8,24-dien-3beta-ol; (3b,5a)-4,4,14-Trimethylcholesta-8,24-dien-3-ol; (3β,5α)-4,4,14-Trimethylcholesta-8,24-dien-3-ol; 4,4,14α-Trimethyl-5α-cholesta-8,24-dien-3β-ol; 4,4,14a-Trimethyl-5a-cholesta-8,24-dien-3b-ol; 3beta-Hydroxy-lansota-8,24-dien-21-oic acid; 4,4,14α-Trimethylcholesta-8,24-dien-3β-ol; 3β-Hydroxy-lansota-8,24-dien-21-oic acid; 5alpha-Lanosta-8,24-dien-3beta-ol; (3 beta)-Lanosta-8,24-dien-3-ol; 3beta-Hydroxylanosta-8,24-diene; (3beta)-Lanosta-8,24-dien-3-ol; 3β-Hydroxylanosta-8,24-diene; (3b)-Lanosta-8,24-dien-3-ol; (3β)-Lanosta-8,24-dien-3-ol; 5α-Lanosta-8,24-dien-3β-ol; Lanosta-8,24-dien-3beta-ol; Lanosta-8,24-dien-3β-ol; Lanosta-8,24-dien-3-ol; Lanostadien-3beta-ol; Lanosta-8,24-dienol; Lanostadien-3β-ol; Botalan base 138; Kryptosterol; Euphadienol; Lanosterin; Lanosterol; Lanster; Lanosterol



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(8)

BioCyc(8)

PlantCyc(2)

代谢反应

226 个相关的代谢反应过程信息。

Reactome(120)

BioCyc(26)

WikiPathways(7)

Plant Reactome(5)

INOH(2)

PlantCyc(8)

COVID-19 Disease Map(1)

PathBank(57)

PharmGKB(0)

243 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 APOB, CAT, DHCR24, SREBF1
Peripheral membrane protein 5 CYP11A1, CYP1B1, CYP27A1, LSS, SQLE
Endosome membrane 2 APOB, LDLR
Endoplasmic reticulum membrane 13 ACAT1, APOB, CYP1B1, CYP51A1, CYP7A1, DHCR24, DHCR7, FDFT1, HMGCR, HSP90B1, LSS, SQLE, SREBF1
Mitochondrion membrane 2 CYP11A1, CYP27A1
Nucleus 3 DHCR24, HSP90B1, SREBF1
cytosol 4 APOB, CAT, HSP90B1, SREBF1
nucleoplasm 1 SREBF1
Cell membrane 1 LDLR
Multi-pass membrane protein 5 ACAT1, DHCR7, FDFT1, HMGCR, SREBF1
Golgi apparatus membrane 2 DHCR24, SREBF1
cell surface 1 LDLR
Golgi apparatus 1 LDLR
Golgi membrane 3 DHCR24, INS, SREBF1
mitochondrial inner membrane 2 CYP11A1, CYP27A1
neuronal cell body 1 APOB
smooth endoplasmic reticulum 2 APOB, HSP90B1
Lysosome 1 LDLR
plasma membrane 3 APOB, F2, LDLR
Membrane 13 ACAT1, CAT, CYP11A1, CYP1B1, CYP51A1, DHCR24, DHCR7, FDFT1, HMGCR, HSP90B1, LDLR, LSS, SQLE
basolateral plasma membrane 1 LDLR
extracellular exosome 5 ACAT1, APOB, CAT, F2, HSP90B1
endoplasmic reticulum 8 ACAT1, DHCR24, DHCR7, FDFT1, HMGCR, HSP90B1, SQLE, SREBF1
extracellular space 4 APOB, F2, IL6, INS
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 5 ACAT1, CAT, CYP11A1, CYP1B1, CYP27A1
protein-containing complex 3 CAT, HSP90B1, SREBF1
intracellular membrane-bounded organelle 6 APOB, CAT, CYP1B1, CYP51A1, CYP7A1, SQLE
Microsome membrane 4 CYP1B1, CYP51A1, CYP7A1, SQLE
Single-pass type I membrane protein 1 LDLR
Secreted 4 APOB, F2, IL6, INS
extracellular region 6 APOB, CAT, F2, HSP90B1, IL6, INS
Single-pass membrane protein 4 CYP51A1, CYP7A1, DHCR24, LDLR
mitochondrial matrix 4 ACAT1, CAT, CYP11A1, CYP27A1
external side of plasma membrane 1 LDLR
chylomicron 1 APOB
low-density lipoprotein particle 2 APOB, LDLR
very-low-density lipoprotein particle 1 APOB
midbody 1 HSP90B1
Early endosome 2 APOB, LDLR
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
Mitochondrion inner membrane 2 CYP11A1, CYP27A1
focal adhesion 2 CAT, HSP90B1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
collagen-containing extracellular matrix 2 F2, HSP90B1
nuclear outer membrane 1 DHCR7
Late endosome 1 LDLR
receptor complex 1 LDLR
chromatin 1 SREBF1
blood microparticle 1 F2
nuclear envelope 1 SREBF1
Endomembrane system 1 LDLR
endosome lumen 2 APOB, INS
sorting endosome 1 LDLR
Lipid droplet 2 APOB, LSS
Cytoplasmic vesicle membrane 1 SREBF1
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
Peroxisome membrane 1 HMGCR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 5 APOB, F2, HSP90B1, IL6, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
ER to Golgi transport vesicle membrane 1 SREBF1
clathrin-coated endocytic vesicle membrane 2 APOB, LDLR
Sarcoplasmic reticulum lumen 1 HSP90B1
endolysosome membrane 1 LDLR
somatodendritic compartment 1 LDLR
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
endocytic vesicle lumen 2 APOB, HSP90B1
PCSK9-LDLR complex 1 LDLR
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
catalase complex 1 CAT
mature chylomicron 1 APOB
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1


文献列表

  • Binbin Luo, Linyi Song, Limiao Chen, Yue Cai, Mingwei Zhang, Shenyi Wang. Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155675. doi: 10.1016/j.phymed.2024.155675. [PMID: 38678954]
  • Lingling Wei, Haiping Shi, Bin Chen, Xiujuan Li, Wenchan Chen, Chengdong Wu, Yunpeng Gai, Changjun Chen. Functional Plasticity, Redundancy, and Specificity of Lanosterol 14α-Demethylase in Regulating the Sensitivity to DMIs in Calonectria ilicicola. Journal of agricultural and food chemistry. 2024 Apr; 72(15):8444-8459. doi: 10.1021/acs.jafc.4c01948. [PMID: 38574108]
  • Yan Li, Guangyu Li, Chenwei Zuo, Xiaolin Wang, Fang Han, Yi Jia, Hai Shang, Yu Tian. Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer. European journal of medicinal chemistry. 2024 Apr; 270(?):116367. doi: 10.1016/j.ejmech.2024.116367. [PMID: 38581732]
  • Ayumi Okayama, Tatsuya Hoshino, Kohei Wada, Hiroshi Takahashi. Comparison of structural effects of cholesterol, lanosterol, and oxysterol on phospholipid (POPC) bilayers. Chemistry and physics of lipids. 2024 03; 259(?):105376. doi: 10.1016/j.chemphyslip.2024.105376. [PMID: 38325710]
  • Feifei Ma, Jing Wang, Wenming Jiang, Jiahao Luo, Rui Yang, Liying Zhang, Chunchao Han. Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review. International journal of medicinal mushrooms. 2024; 26(2):11-23. doi: 10.1615/intjmedmushrooms.2023051918. [PMID: 38421693]
  • Hanen Enneb, Khaled Athmouni, Rahma Thabet, Habib Ayadi. Phytochemical Compounds of Euphorbia bivonae Extract and Their Cytotoxicity Effects on the Lethality of Brine Shrimp Artemia salina and Embryonic Kidney (HEK293) Cells. Chemistry & biodiversity. 2023 Apr; ?(?):e202201135. doi: 10.1002/cbdv.202201135. [PMID: 37026603]
  • Ilijana Begcevic Brkovic, Madlen Reinicke, Soroth Chey, Ingo Bechmann, Uta Ceglarek. Characterization of Non-Cholesterol Sterols in Microglia Cell Membranes Using Targeted Mass Spectrometry. Cells. 2023 03; 12(7):. doi: 10.3390/cells12070974. [PMID: 37048046]
  • Yong-Nan Liu, Feng-Yuan Wu, Ren-Yuan Tian, Yi-Xin Shi, Zi-Qi Xu, Ji-Ye Liu, Jia Huang, Fei-Fei Xue, Bi-Yang Liu, Gao-Qiang Liu. The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi. Communications biology. 2023 01; 6(1):1. doi: 10.1038/s42003-022-04154-6. [PMID: 36596887]
  • Fook-Hwa Lim, Omar Abd Rasid, Abu Seman Idris, Abdul Wahab Mohd As'wad, Ganesan Vadamalai, Ghulam Kadir Ahmad Parveez, Mui-Yun Wong. Induced expression of Ganoderma boninense Lanosterol 14α-Demethylase (ERG11) during interaction with oil palm. Molecular biology reports. 2022 Dec; ?(?):. doi: 10.1007/s11033-022-08131-4. [PMID: 36580194]
  • Dominik Šťastný, Lívia Petrisková, Dana Tahotná, Jacob Bauer, Lucia Pokorná, Roman Holič, Martin Valachovič, Vladimír Pevala, Shamshad Cockcroft, Peter Griač. Yeast Sec14-like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol. FEBS letters. 2022 Dec; ?(?):. doi: 10.1002/1873-3468.14558. [PMID: 36482167]
  • Isaac Silvère Gade, Corinne Chadéneau, Richard Tagne Simo, Emmanuel Talla, Alex De Theodore Atchade, Paule Seité, Brigitte Vannier, Sophie Laurent, Céline Henoumont, Armel H Nwabo Kamdje, Jean-Marc Muller. Euphol from Tapinanthus sp. Induces Apoptosis and Affects Signaling Proteins in Glioblastoma and Prostate Cancer Cells. Asian Pacific journal of cancer prevention : APJCP. 2022 12; 23(12):4205-4212. doi: 10.31557/apjcp.2022.23.12.4205. [PMID: 36580003]
  • Thais Latansio de Oliveira, Ariádine Reder Custodio de Souza, Pâmela Dias Fontana, Milena Carvalho Carneiro, Flávio Luís Beltrame, Iara Jose de Messias Reason, Lorena Bavia. Bioactive Secondary Plant Metabolites from Euphorbia umbellata (PAX) BRUYNS (Euphorbiaceae). Chemistry & biodiversity. 2022 Dec; 19(12):e202200568. doi: 10.1002/cbdv.202200568. [PMID: 36259393]
  • Yong-Li Li, Zhuo-Ni Xu, Jie Li, Shuang Liang, Min-Jie Xue, Jian-Jun Wu, Xian-Wen Yang. Three New Lanostanoids with Anti-HCV Effects from Abies nukiangensis. Chemistry & biodiversity. 2022 Dec; 19(12):e202200941. doi: 10.1002/cbdv.202200941. [PMID: 36398785]
  • Ao Lu, Ping Duan, Jing Xie, Hui Gao, Mengmeng Chen, Yu Gong, Jiawen Li, Haiwei Xu. Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review. European journal of pharmacology. 2022 Nov; 934(?):175299. doi: 10.1016/j.ejphar.2022.175299. [PMID: 36181780]
  • Felix Rüttler, Tim Hammerschick, Sarah Schlag, Walter Vetter. Isolation of lanosterol and dihydrolanosterol from the unsaponifiable matter of lanolin by urea complexation and countercurrent chromatography in heart-cut recycling mode. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Nov; 1210(?):123470. doi: 10.1016/j.jchromb.2022.123470. [PMID: 36191441]
  • Hezhong Ouyang, Jinquan Hu, XingYing Qiu, Shaochang Wu, Fudong Guo, Youguo Tan. Improved biopharmaceutical performance of antipsychotic drug using lipid nanoparticles via intraperitoneal route. Pharmaceutical development and technology. 2022 Sep; 27(7):853-863. doi: 10.1080/10837450.2022.2124521. [PMID: 36124550]
  • Mohd Waseem, Jitendra K Thakur, Naidu Subbarao. Prediction of novel and potent inhibitors of lanosterol 14-α demethylase. Journal of biomolecular structure & dynamics. 2022 Jul; ?(?):1-13. doi: 10.1080/07391102.2022.2096116. [PMID: 35815531]
  • Shogo Harashima, Yuto Yamazaki, Naoki Motomura, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Go Eun Kwon, Man Ho Choi, Hironobu Sasano. Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism. The Journal of steroid biochemistry and molecular biology. 2022 07; 221(?):106116. doi: 10.1016/j.jsbmb.2022.106116. [PMID: 35533918]
  • Yi-Ni Cao, Shan-Shan Yue, An-Yi Wang, Lu Xu, Yi-Tong Hu, Xue Qiao, Tung-Ying Wu, Min Ye, Yang-Chang Wu, Rong Qi. Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity. Journal of ethnopharmacology. 2022 Jun; 292(?):115146. doi: 10.1016/j.jep.2022.115146. [PMID: 35304272]
  • Xu-Cong Lv, Qi Wu, Ying-Jia Cao, Yi-Chen Lin, Wei-Ling Guo, Ping-Fan Rao, Yan-Yan Zhang, You-Ting Chen, Lian-Zhong Ai, Li Ni. Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition. Food & function. 2022 May; 13(10):5820-5837. doi: 10.1039/d1fo03219d. [PMID: 35543349]
  • Xiao-Li Zhang, Er-Kun Chao, Meng-Chu Sun, Hong-Fei Zhao, Cai-Xia Wang, Bo-Lin Zhang. [Effects of tHMGR from three different plant sources on mevalonate (MVA) pathway flux in Saccharomyces cerevisiae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(10):2614-2622. doi: 10.19540/j.cnki.cjcmm.20220116.102. [PMID: 35718479]
  • Dan Wang, Xianhua Cai, Feng Xu, Hui Kang, Yanjin Li, Ruibing Feng. Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway. Bioengineered. 2022 05; 13(5):11684-11693. doi: 10.1080/21655979.2022.2070996. [PMID: 35506157]
  • Roubi Abuobeid, Javier Sánchez-Marco, María J Felices, Carmen Arnal, Juan Carlos Burillo, Roberto Lasheras, Rebeca Busto, Miguel A Lasunción, María Jesús Rodríguez-Yoldi, Roberto Martínez-Beamonte, Jesús Osada. Squalene through Its Post-Squalene Metabolites Is a Modulator of Hepatic Transcriptome in Rabbits. International journal of molecular sciences. 2022 Apr; 23(8):. doi: 10.3390/ijms23084172. [PMID: 35456988]
  • Yu-Ting Li, Zhen Zhang, Yunjiang Feng, Yuanyuan Cheng, Shuyuan Li, Can Li, Li-Wen Tian. Cardioprotective 22-hydroxylanostane triterpenoids from the fruiting bodies of Phellinus igniarius. Phytochemistry. 2021 Nov; 191(?):112907. doi: 10.1016/j.phytochem.2021.112907. [PMID: 34399303]
  • B Sangeetha, A S Krishnamoorthy, D Jeya Sundara Sharmila, P Renukadevi, V G Malathi, D Amirtham. Molecular modelling of coat protein of the Groundnut bud necrosis tospovirus and its binding with Squalene as an antiviral agent: In vitro and in silico docking investigations. International journal of biological macromolecules. 2021 Oct; 189(?):618-634. doi: 10.1016/j.ijbiomac.2021.08.143. [PMID: 34437921]
  • Tao Wang, Huihe Lu. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2021 Oct; 30(10):1031-1041. doi: 10.17219/acem/137914. [PMID: 34329545]
  • Weibo Qiao, Wei Feng, Lu Yang, Changfu Li, Xudong Qu, Yansheng Zhang. De Novo Biosynthesis of the Anticancer Compound Euphol in Saccharomyces cerevisiae. ACS synthetic biology. 2021 09; 10(9):2351-2358. doi: 10.1021/acssynbio.1c00257. [PMID: 34445867]
  • Zsófia Garádi, Miklós Dékány, Ágnes M Móricz, Anikó Gaál, Viktor Papp, Szabolcs Béni, Attila Ványolós. Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185453. [PMID: 34576923]
  • Yuyuan Li, He Liu, Huawen Qi, Wei Tang, Caihua Zhang, Zhaiyi Liu, Yinhui Liu, Xiaoqing Wei, Zhen Kong, Shangyi Jia, Borong Du, Jieli Yuan, Chaoran Wang, Ming Li. Probiotic fermentation of Ganoderma lucidum fruiting body extracts promoted its immunostimulatory activity in mice with dexamethasone-induced immunosuppression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111909. doi: 10.1016/j.biopha.2021.111909. [PMID: 34328088]
  • Jie-Qiong Ma, Yu-Jia Zhang, Zhi-Kai Tian. Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway. Chemico-biological interactions. 2021 Aug; 344(?):109529. doi: 10.1016/j.cbi.2021.109529. [PMID: 34029542]
  • Yue Jia, Dandan Zhang, Hua Yin, Haoran Li, Jing Du, Hongkun Bao. Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor. Neurochemical research. 2021 Jul; 46(7):1725-1736. doi: 10.1007/s11064-021-03303-3. [PMID: 33821438]
  • Nonhlakanipho F Sangweni, Rebamang A Mosa, Phiwayinkosi V Dludla, Abidemi P Kappo, Andy R Opoku, Christo J F Muller, Rabia Johnson. The triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA3), attenuates high glucose-induced oxidative damage and apoptosis by improving energy metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 May; 85(?):153546. doi: 10.1016/j.phymed.2021.153546. [PMID: 33799221]
  • Dieter Lütjohann, Frans Stellaard, Anja Kerksiek, Jörn Lötsch, Bruno G Oertel. Serum 4β-hydroxycholesterol increases during fluconazole treatment. European journal of clinical pharmacology. 2021 May; 77(5):659-669. doi: 10.1007/s00228-020-03041-5. [PMID: 33201347]
  • Mahfoozur Rahman, Waleed H Almalki, Imran Kazmi, Obaid Afzal, Hanadi A Katouah, Majed Alrobaian, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Mohammed S Alshammari, Rehan Abdur Rub, Sarwar Beg, Vikas Kumar. Development and validation of a new UPLC-MS/MS method for quantification of ganoderic acid-A loaded nanolipidic carrier in rat plasma and application to pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jan; 1163(?):122501. doi: 10.1016/j.jchromb.2020.122501. [PMID: 33388522]
  • Pooja M, Gangavaram Jyothi Reddy, Kanipakam Hema, Sujatha Dodoala, Bharathi Koganti. Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies. European journal of pharmacology. 2021 Jan; 890(?):173688. doi: 10.1016/j.ejphar.2020.173688. [PMID: 33130280]
  • Lu Xu, An-Kang Peng, Yi-Ni Cao, Xue Qiao, Shan-Shan Yue, Min Ye, Rong Qi. Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 Against Alcoholic Fatty Liver Disease. Current molecular pharmacology. 2021; 14(5):871-882. doi: 10.2174/1874467214666210120152140. [PMID: 33494689]
  • Nitish Boodhoo, Nitin Kamble, Shahriar Behboudi. De Novo Cholesterol Biosynthesis and Its Trafficking in LAMP-1-Positive Vesicles Are Involved in Replication and Spread of Marek's Disease Virus. Journal of virology. 2020 11; 94(24):. doi: 10.1128/jvi.01001-20. [PMID: 32999035]
  • Beibei Zhao, Yan Zhang, Hua Li, Jiawen Deng, Haodi Gong, Zhicheng Chen. Nutritional Component and Chemical Characterization of Chinese Highland Barley Bran Oil. Journal of oleo science. 2020 Nov; 69(11):1339-1347. doi: 10.5650/jos.ess19318. [PMID: 33055435]
  • Hai-Guo Su, Qian Wang, Lin Zhou, Xing-Rong Peng, Wen-Yong Xiong, Ming-Hua Qiu. Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes. Bioorganic chemistry. 2020 11; 104(?):104263. doi: 10.1016/j.bioorg.2020.104263. [PMID: 32920365]
  • Jianxin Han, Wei Liu, Miaomiao Li, Yanpei Gu, Ying Zhang, Tao Yuan. Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities. Molecules (Basel, Switzerland). 2020 Oct; 25(20):. doi: 10.3390/molecules25204807. [PMID: 33086725]
  • Nomadlozi Blessings Hlophe, Andrew Rowland Opoku, Foluso Oluwagbemiga Osunsanmi, Trayana Georgieva Djarova-Daniels, Oladipupo Adejumobi Lawal, Rebamang Anthony Mosa. A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats. Molecules (Basel, Switzerland). 2020 Sep; 25(17):. doi: 10.3390/molecules25174010. [PMID: 32887389]
  • Wei-Ling Guo, Jian-Bin Guo, Bin-Yu Liu, Jin-Qiang Lu, Min Chen, Bin Liu, Wei-Dong Bai, Ping-Fan Rao, Li Ni, Xu-Cong Lv. Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet. Food & function. 2020 Aug; 11(8):6818-6833. doi: 10.1039/d0fo00436g. [PMID: 32686808]
  • Songyot Anuchapreeda, Riki Anzawa, Natsima Viriyaadhammaa, Waranya Neimkhum, Wantida Chaiyana, Siriporn Okonogi, Toyonobu Usuki. Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves. Bioorganic & medicinal chemistry letters. 2020 07; 30(14):127256. doi: 10.1016/j.bmcl.2020.127256. [PMID: 32527555]
  • Fuli Liu, Kejian Shi, Jiaojiao Dong, Zhousheng Jin, Yiquan Wu, Yaoyao Cai, Tingting Lin, Qianqian Cai, Le Liu, Yujian Zhang. Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation. Archives of pharmacal research. 2020 Jul; 43(7):744-754. doi: 10.1007/s12272-020-01256-9. [PMID: 32715385]
  • Jia Meng, Sai-Zhen Wang, Jin-Zhao He, Shuai Zhu, Bo-Yue Huang, Shu-Yuan Wang, Min Li, Hong Zhou, Shu-Qian Lin, Bao-Xue Yang. Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease. Acta pharmacologica Sinica. 2020 Jun; 41(6):782-790. doi: 10.1038/s41401-019-0329-2. [PMID: 31911637]
  • Zhongpeng Hu, Ruiping Du, Lei Xiu, Ziyao Bian, Chaomei Ma, Naoto Sato, Masao Hattori, Haochi Zhang, Yanchen Liang, Shuixing Yu, Xiao Wang. Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury. Cytokine. 2020 03; 127(?):154917. doi: 10.1016/j.cyto.2019.154917. [PMID: 31775117]
  • Noriaki Nagai, Yuya Fukuoka, Kanta Sato, Hiroko Otake, Atsushi Taga, Mikako Oka, Noriko Hiramatsu, Naoki Yamamoto. The Intravitreal Injection of Lanosterol Nanoparticles Rescues Lens Structure Collapse at an Early Stage in Shumiya Cataract Rats. International journal of molecular sciences. 2020 Feb; 21(3):. doi: 10.3390/ijms21031048. [PMID: 32033321]
  • Gaoyan Wen, Tian Li, Hua He, Xianmei Zhou, Jia Zhu. Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice. Pharmacology. 2020; 105(9-10):568-575. doi: 10.1159/000505297. [PMID: 31940650]
  • Feiya Sheng, Lele Zhang, Songsong Wang, Lele Yang, Peng Li. Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo. Nutrients. 2019 Dec; 12(1):. doi: 10.3390/nu12010085. [PMID: 31892211]
  • Asuka Suzuki, Yuko Aikawa, Ryousuke Ito, Tsutomu Hoshino. Oryza sativa Parkeol Cyclase: Changes in the Substrate-Folding Conformation and the Deprotonation Sites on Mutation at Tyr257: Importance of the Hydroxy Group and Steric Bulk. Chembiochem : a European journal of chemical biology. 2019 11; 20(22):2862-2875. doi: 10.1002/cbic.201900314. [PMID: 31180162]
  • Qosimjon Khalilov, Liya Li, Yushuang Liu, Zeynep Tohtahon, Xiaoyu Chen, Haji Akber Aisa, Tao Yuan. Piptolinic acids F-J, five new lanostane-type triterpenoids from Piptoporus betulinus. Natural product research. 2019 Nov; 33(21):3044-3051. doi: 10.1080/14786419.2018.1516218. [PMID: 30362364]
  • Liang Chen, Mei-Yan Ma, Ming Sun, Lu-Yi Jiang, Xue-Tong Zhao, Xian-Xiu Fang, Sin Man Lam, Guang-Hou Shui, Jie Luo, Xiong-Jie Shi, Bao-Liang Song. Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing. Journal of lipid research. 2019 10; 60(10):1765-1775. doi: 10.1194/jlr.ra119000201. [PMID: 31455613]
  • Hudson W Coates, Andrew J Brown. A wolf in sheep's clothing: unmasking the lanosterol-induced degradation of HMG-CoA reductase. Journal of lipid research. 2019 10; 60(10):1643-1645. doi: 10.1194/jlr.c119000358. [PMID: 31462514]
  • Sun-Dong Zhang, Liang Yu, Peng Wang, Ping Kou, Ji Li, Li-Tao Wang, Wei Wang, Li-Ping Yao, Xiu-Hua Zhao, Yu-Jie Fu. Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jul; 60(?):152957. doi: 10.1016/j.phymed.2019.152957. [PMID: 31128995]
  • Xu Lixin, Yan Lijun, Huang Songping. Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in mice. Journal of biochemical and molecular toxicology. 2019 Apr; 33(4):e22271. doi: 10.1002/jbt.22271. [PMID: 30506662]
  • Viviane A O Silva, Marcela N Rosa, Vera Miranda-Gonçalves, Angela M Costa, Aline Tansini, Adriane F Evangelista, Olga Martinho, Adriana C Carloni, Chris Jones, João Paulo Lima, Luiz F Pianowski, Rui Manuel Reis. Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells. Investigational new drugs. 2019 04; 37(2):223-237. doi: 10.1007/s10637-018-0620-y. [PMID: 29931585]
  • Guohua Yao, Yuhan Ma, Muhammad Muhammad, Qing Huang. Understanding the infrared and Raman spectra of ganoderic acid A: An experimental and DFT study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Mar; 210(?):372-380. doi: 10.1016/j.saa.2018.11.019. [PMID: 30502725]
  • Fei-Fei Zhang, Ru-Ming Liu. [Pharmacokinetics of ganoderic acids]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Mar; 44(5):905-911. doi: 10.19540/j.cnki.cjcmm.20181213.002. [PMID: 30989848]
  • Nonhlakanipho F Sangweni, Phiwayinkosi V Dludla, Rebamang A Mosa, Abidemi P Kappo, Andy Opoku, Christo J F Muller, Rabia Johnson. Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review. Heart failure reviews. 2019 01; 24(1):155-166. doi: 10.1007/s10741-018-9733-9. [PMID: 30167929]
  • Elijah J Weber, Kevin A Lidberg, Lu Wang, Theo K Bammler, James W MacDonald, Mavis J Li, Michelle Redhair, William M Atkins, Cecilia Tran, Kelly M Hines, Josi Herron, Libin Xu, Maria Beatriz Monteiro, Susanne Ramm, Vishal Vaidya, Martti Vaara, Timo Vaara, Jonathan Himmelfarb, Edward J Kelly. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. JCI insight. 2018 12; 3(24):. doi: 10.1172/jci.insight.123673. [PMID: 30568031]
  • Gui-Fang Feng, Yan Zheng, Yufei Sun, Shu Liu, Zi-Feng Pi, Feng-Rui Song, Zhi-Qiang Liu. A targeted strategy for analyzing untargeted mass spectral data to identify lanostane-type triterpene acids in Poria cocos by integrating a scientific information system and liquid chromatography-tandem mass spectrometry combined with ion mobility spectrometry. Analytica chimica acta. 2018 Nov; 1033(?):87-99. doi: 10.1016/j.aca.2018.06.048. [PMID: 30172336]
  • Sihle Ephraim Mabhida, Rabia Johnson, Musawenkosi Ndlovu, Nonhlakanipho Felicia Sangweni, Johan Louw, Andrew Opoku, Rebamang Anthony Mosa. A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats. BMC complementary and alternative medicine. 2018 Oct; 18(1):265. doi: 10.1186/s12906-018-2337-z. [PMID: 30285704]
  • Yan Liu, Jiang Hu, Yan Lv, Xiao-Yun Huang, Guo-Xu Zhang. Cytotoxic lanostane triterpenoids from the stems of Schisandra glaucescens. Journal of Asian natural products research. 2018 Aug; 20(8):727-733. doi: 10.1080/10286020.2018.1492564. [PMID: 30010405]
  • Luiza S Cruz, Thais L de Oliveira, Carla C Kanunfre, Katia S Paludo, Bruno R Minozzo, Ana P Prestes, Mei Wang, Daniel Fernandes, Fábio A Dos Santos, Vamshi K Manda, Shabana I Khan, Zulfiqar Ali, Iara J de Messias-Reason, Bharathi Avula, Ikhlas A Khan, Flávio L Beltrame. Pharmacokinetics and cytotoxic study of euphol from Euphorbia umbellata (Bruyns) Pax latex. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Aug; 47(?):105-112. doi: 10.1016/j.phymed.2018.04.055. [PMID: 30166094]
  • Ming Fu, Li Wang, Xianyou Wang, Boxia Deng, Xing Hu, Juan Zou. Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos. Molecules (Basel, Switzerland). 2018 Jul; 23(8):. doi: 10.3390/molecules23081839. [PMID: 30042340]
  • Yang Teng, Hanqi Zhang, Junfei Zhou, Guanqun Zhan, Guangmin Yao. Hebecarposides A-K, antiproliferative lanostane-type triterpene glycosides from the leaves of Lyonia ovalifolia var. hebecarpa. Phytochemistry. 2018 Jul; 151(?):32-41. doi: 10.1016/j.phytochem.2018.03.012. [PMID: 29660562]
  • Jing Zhu, Jie Jin, Jiexia Ding, Siying Li, Panpan Cen, Keyi Wang, Hai Wang, Junbo Xia. Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway. Chemico-biological interactions. 2018 Jun; 290(?):77-87. doi: 10.1016/j.cbi.2018.05.014. [PMID: 29852127]
  • Zheyong Xue, Zhengwei Tan, Ancheng Huang, Yuan Zhou, Juncong Sun, Xiaoning Wang, Ramesha B Thimmappa, Michael J Stephenson, Anne Osbourn, Xiaoquan Qi. Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species. The New phytologist. 2018 05; 218(3):1076-1088. doi: 10.1111/nph.15080. [PMID: 29528490]
  • Xia Zhang, Cuiyu Bao, Jingping Zhang. Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of β-catenin signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Mar; 99(?):142-150. doi: 10.1016/j.biopha.2017.12.084. [PMID: 29331760]
  • Da-Lin Lu, Disorn Sookthai, Charlotte Le Cornet, Verena A Katzke, Theron S Johnson, Rudolf Kaaks, Renée T Fortner. Reproducibility of serum oxysterols and lanosterol among postmenopausal women: Results from EPIC-Heidelberg. Clinical biochemistry. 2018 Feb; 52(?):117-122. doi: 10.1016/j.clinbiochem.2017.11.001. [PMID: 29108727]
  • Medhanie E Kidane, Boden H Vanderloop, Wenxu Zhou, Crista D Thomas, Emilio Ramos, Ujjal Singha, Minu Chaudhuri, W David Nes. Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design. Journal of lipid research. 2017 12; 58(12):2310-2323. doi: 10.1194/jlr.m079418. [PMID: 29042405]
  • Subramanian Karunagaran, Rengarajan Kavitha, Muthu Vadivelu, Keun Woo Lee, Chandrasekaran Meganathan. Insight Mechanism of the Selective Lanosterol Synthase Inhibitor: Molecular Modeling, Docking and Density Functional Theory Approaches. Current computer-aided drug design. 2017 Nov; 13(4):275-293. doi: 10.2174/1573409913666170426153509. [PMID: 28462697]
  • Cheng-Hsiu Lin, Yueh-Hsiung Kuo, Chun-Ching Shih. Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice. International journal of molecular sciences. 2017 Nov; 18(11):. doi: 10.3390/ijms18112314. [PMID: 29099085]
  • Lazare S Sidjui, Kenneth O Eyong, Kenneth G Hull, Gabriel N Folefoc, Valérie M Leddet, Gaëtan Herbette, Evelyne Ollivier, Joseph Taube, Kevin Klausmeyer, Daniel Romo. Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis. Journal of natural products. 2017 10; 80(10):2644-2651. doi: 10.1021/acs.jnatprod.7b00210. [PMID: 28945373]
  • Keri A Tallman, Hye-Young H Kim, Zeljka Korade, Thiago C Genaro-Mattos, Phillip A Wages, Wei Liu, Ned A Porter. Probes for protein adduction in cholesterol biosynthesis disorders: Alkynyl lanosterol as a viable sterol precursor. Redox biology. 2017 08; 12(?):182-190. doi: 10.1016/j.redox.2017.02.013. [PMID: 28258022]
  • Sihle E Mabhida, Rebamang A Mosa, Dambudzo Penduka, Foluso O Osunsanmi, Phiwayinkosi V Dludla, Tryana G Djarova, Andy R Opoku. A Lanosteryl Triterpene from Protorhus longifolia Improves Glucose Tolerance and Pancreatic Beta Cell Ultrastructure in Type 2 Diabetic Rats. Molecules (Basel, Switzerland). 2017 Jul; 22(8):. doi: 10.3390/molecules22081252. [PMID: 28933769]
  • Fang-Rui Cao, Bing-Xin Xiao, Li-Sha Wang, Xue Tao, Ming-Zhu Yan, Rui-Le Pan, Yong-Hong Liao, Xin-Min Liu, Qi Chang. Plasma and brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC-MS/MS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 May; 1052(?):19-26. doi: 10.1016/j.jchromb.2017.03.009. [PMID: 28346885]
  • Jian Dai, Matthew A Miller, Nicholas J Everetts, Xia Wang, Peng Li, Ye Li, Jian-Hua Xu, Guang Yao. Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum. Oncotarget. 2017 Feb; 8(8):13770-13781. doi: 10.18632/oncotarget.14634. [PMID: 28099150]
  • Dewa Gede Katja, Kindi Farabi, Nurlelasari, Desi Harneti, Tri Mayanti, Unang Supratman, Khalijah Awang, Hideo Hayashi. Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae). Journal of Asian natural products research. 2017 Feb; 19(2):194-200. doi: 10.1080/10286020.2016.1196671. [PMID: 27329305]
  • Ye Gao, Pan Wang, Yaqin Wang, Lijie Wu, Xiaobing Wang, Kun Zhang, Quanhong Liu. In Vitro and In Vivo Activity of Fomitopsis Pinicola (Sw. Ex Fr.) Karst Chloroform (Fpkc) Extract Against S180 Tumor Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 44(5):2042-2056. doi: 10.1159/000485944. [PMID: 29241162]
  • Rebamang A Mosa, Nomadlozi B Hlophe, Namani T Ngema, Dambudzo Penduka, Oladipupo A Lawal, Andy R Opoku. Cardioprotective potential of a lanosteryl triterpene from Protorhus longifolia. Pharmaceutical biology. 2016 Dec; 54(12):3244-3248. doi: 10.1080/13880209.2016.1223144. [PMID: 27572517]
  • Sakchai Hongthong, Jatuporn Meesin, Phanruethai Pailee, Darunee Soorukram, Palangpon Kongsaeree, Samran Prabpai, Pawinee Piyachaturawat, Surawat Jariyawat, Kanoknetr Suksen, Thaworn Jaipetch, Narong Nuntasaen, Vichai Reutrakul, Chutima Kuhakarn. Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae). Bioorganic & medicinal chemistry letters. 2016 12; 26(23):5773-5779. doi: 10.1016/j.bmcl.2016.10.045. [PMID: 27793565]
  • S Schrack, C Hohl, W Schwack. Oxysterols in cosmetics-Determination by planar solid phase extraction and gas chromatography-mass spectrometry. Journal of chromatography. A. 2016 Nov; 1473(?):10-18. doi: 10.1016/j.chroma.2016.10.056. [PMID: 28314390]
  • Zheng-Xi Hu, Kun Hu, Yi-Ming Shi, Wei-Guang Wang, Xue Du, Yan Li, Yong-Hui Zhang, Jian-Xin Pu, Han-Dong Sun. Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea. Journal of natural products. 2016 10; 79(10):2590-2598. doi: 10.1021/acs.jnatprod.6b00508. [PMID: 27704807]
  • Jianxin Han, Liya Li, Jialiang Zhong, Zeynep Tohtaton, Qing Ren, Li Han, Xueshi Huang, Tao Yuan. Officimalonic acids A-H, lanostane triterpenes from the fruiting bodies of Fomes officinalis. Phytochemistry. 2016 Oct; 130(?):193-200. doi: 10.1016/j.phytochem.2016.05.004. [PMID: 27216472]
  • Qiuli OuYang, Nengguo Tao, Guoxing Jing. Transcriptional profiling analysis of Penicillium digitatum, the causal agent of citrus green mold, unravels an inhibited ergosterol biosynthesis pathway in response to citral. BMC genomics. 2016 08; 17(1):599. doi: 10.1186/s12864-016-2943-4. [PMID: 27514516]
  • Tatiana Y Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Suneethi Sivakumaran, Eugenia M Yazlovitskaya, Scott W Hiebert, F Peter Guengerich, Michael R Waterman, Galina I Lepesheva. Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design. Journal of lipid research. 2016 08; 57(8):1552-63. doi: 10.1194/jlr.m069229. [PMID: 27313059]
  • Yhiya M Amen, Qinchang Zhu, Hai-Bang Tran, Mohamed S Afifi, Ahmed F Halim, Ahmed Ashour, Amira Mira, Kuniyoshi Shimizu. Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells. Journal of natural medicines. 2016 Jul; 70(3):661-6. doi: 10.1007/s11418-016-0976-2. [PMID: 26899240]
  • Yueh-Hsiung Kuo, Cheng-Hsiu Lin, Chun-Ching Shih. Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor α Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice. International journal of molecular sciences. 2016 Jun; 17(6):. doi: 10.3390/ijms17060872. [PMID: 27271603]
  • Maria Bailen, Mourad Daoubi Khamlichi, Ahmed Benharref, Rafael A Martinez-Diaz, Azucena Gonzalez-Coloma. New Bioactive Semisynthetic Derivatives of 31-Norlanostenol and Obtusifoliol from Euphorbia officinarum. Natural product communications. 2016 Jun; 11(6):733-8. doi: . [PMID: 27534104]
  • Sanghoon Lee, Jun-Xue Jin, Candrani Khoirinaya, Geon A Kim, Byeong Chun Lee. Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. Theriogenology. 2016 Mar; 85(4):575-84. doi: 10.1016/j.theriogenology.2015.09.041. [PMID: 26494176]
  • Claudia Stäubert, Rosanna Krakowsky, Hasanuzzaman Bhuiyan, Barbara Witek, Anna Lindahl, Oliver Broom, Anders Nordström. Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells. Medical oncology (Northwood, London, England). 2016 Jan; 33(1):6. doi: 10.1007/s12032-015-0717-5. [PMID: 26698156]
  • Zheng-Xi Hu, Yi-Ming Shi, Wei-Guang Wang, Xiao-Nian Li, Xue Du, Miao Liu, Yan Li, Yong-Bo Xue, Yong-Hui Zhang, Jian-Xin Pu, Han-Dong Sun. Kadcoccinones A-F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea. Organic letters. 2015 Sep; 17(18):4616-9. doi: 10.1021/acs.orglett.5b02360. [PMID: 26348535]
  • Arabinda Das, Rickey Miller, Philip Lee, Chrysanthe Alyssa Holden, Scott M Lindhorst, Jerry Jaboin, William A Vandergrift, Naren L Banik, Pierre Giglio, Abhay K Varma, Jeffery J Raizer, Sunil J Patel. A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015 Sep; 36(9):7027-34. doi: 10.1007/s13277-015-3388-0. [PMID: 25864108]
  • Gang Li, Souvik Kusari, Parijat Kusari, Oliver Kayser, Michael Spiteller. Endophytic Diaporthe sp. LG23 Produces a Potent Antibacterial Tetracyclic Triterpenoid. Journal of natural products. 2015 Aug; 78(8):2128-32. doi: 10.1021/acs.jnatprod.5b00170. [PMID: 26186257]
  • Valerio Leoni, Claudio Caccia. The impairment of cholesterol metabolism in Huntington disease. Biochimica et biophysica acta. 2015 Aug; 1851(8):1095-105. doi: 10.1016/j.bbalip.2014.12.018. [PMID: 25596342]
  • Guo-Wei Wang, Chao Lv, Xing Yuan, Ji Ye, Hui-Zi Jin, Lei Shan, Xi-Ke Xu, Yun-Heng Shen, Wei-Dong Zhang. Lanostane-type triterpenoids from Abies faxoniana and their DNA topoisomerase inhibitory activities. Phytochemistry. 2015 Aug; 116(?):221-229. doi: 10.1016/j.phytochem.2015.04.012. [PMID: 25986863]
  • Rebamang A Mosa, Nkosinathi D Cele, Sihle E Mabhida, Samkelisiwe C Shabalala, Dambudzo Penduka, Andy R Opoku. In vivo antihyperglycemic activity of a lanosteryl triterpene from Protorhus longifolia. Molecules (Basel, Switzerland). 2015 Jul; 20(7):13374-83. doi: 10.3390/molecules200713374. [PMID: 26205060]
  • Roisin O'Keeffe, Olivia Kenny, Nigel P Brunton, Mohammad B Hossain, Dilip K Rai, Peter W Jones, Nora O'Brien, Anita R Maguire, Stuart G Collins. Synthesis of novel 24-amino-25,26,27-trinorlanost-8-enes: cytotoxic and apoptotic potential in U937 cells. Bioorganic & medicinal chemistry. 2015 May; 23(9):2270-80. doi: 10.1016/j.bmc.2015.02.034. [PMID: 25800433]