Palmatin (BioDeep_00000410458)

PANOMIX_OTCML-2023

代谢物信息卡片

Palmatine

化学式: [C21H22NO4]+ (352.1549)
中文名称: 黄藤素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC
InChI: InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1

描述信息

Origin: Plant; Formula(Parent): C21H22NO4; Bottle Name:Palmatine chloride; PRIME Parent Name:Palmatine; PRIME in-house No.:V0288; SubCategory_DNP: Isoquinoline alkaloids, Benzylisoquinoline alkaloids

同义名列表

3 个代谢物同义名

Palmatine; Palmatin; Palmatine

数据库引用编号

12 个数据库交叉引用编号

ChEBI: CHEBI:16096
KEGG: C05315
PubChem: 19009
ChEMBL: CHEMBL206106
ChEMBL: CHEMBL274189
CAS: 3486-67-7
MoNA: CB000101
PubChem: 7697
KNApSAcK: C00001898
3DMET: B00765
NIKKAJI: J12.970D
KNApSAcK: 16096

分类词条

生物碱

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

124 个相关的物种来源信息

432627 - Anamirta cocculus: 10.1021/NP50014A013
2109290 - Annickia affinis: 10.1016/S0031-9422(98)00382-3
306909 - Annickia chlorantha:
301703 - Annona glabra:
7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
461553 - Arcangelisia flava:
2602203 - Berberis aemulans: 10.1007/BF00630564
2306210 - Berberis aggregata:
258140 - Berberis amurensis: 10.1007/BF00630564
203270 - Berberis aquifolium:
659592 - Berberis aristata:
659593 - Berberis asiatica: 10.2307/4117899
1431200 - Berberis barandana: 10.2307/4117899
13601 - Berberis bealei:
258145 - Berberis bodinieri:
258147 - Berberis canadensis:
411565 - Berberis chitria:
2602221 - Berberis crataegina:
1433307 - Berberis cretica: 10.1021/NP50043A025
1616471 - Berberis diaphana: 10.1007/BF00630564
2306211 - Berberis dubia: 10.1007/BF00630564
186724 - Berberis empetrifolia: 10.1016/S0031-9422(00)82337-7
258158 - Berberis eurybracteata:
258160 - Berberis fendleri: 10.1016/S0305-1978(01)00025-4
258162 - Berberis fortunei:
258164 - Berberis gagnepainii: 10.1007/BF00398618
2602231 - Berberis glauca: 10.1016/0031-9422(73)85042-3
258165 - Berberis gracilipes: 10.1016/S0031-6865(99)00061-8
2602233 - Berberis grandiflora: 10.1016/0031-9422(73)85042-3
2602235 - Berberis henryana: 10.1007/BF00398618
1433312 - Berberis heteropoda: 10.2307/4117899
186727 - Berberis ilicifolia: 10.3987/COM-94-6909
1112794 - Berberis integerrima:
116719 - Berberis japonica:
258178 - Berberis julianae: 10.1016/S0031-9422(00)82337-7
2364036 - Berberis laurina: 10.1021/NP50061A010
659594 - Berberis lycium: 10.1007/978-1-4614-0560-3_5
258186 - Berberis morrisonensis: 10.2307/4117899
1439896 - Berberis nummularia: 10.1007/BF00630533
2602253 - Berberis oblonga:
1026947 - Berberis poiretii: 10.1007/BF00630564
258195 - Berberis polyodonta:
258196 - Berberis pruinosa: 10.1007/BF00630564
559508 - Berberis repens: 10.1021/NP50018A011
2602266 - Berberis salicaria: 10.1016/S0031-9422(00)82337-7
1433329 - Berberis sibirica: 10.1007/BF00630540
153725 - Berberis silva-taroucana: 10.2307/4117899
33814 - Berberis stolonifera:
2602268 - Berberis taliensis: 10.1016/S0031-9422(00)82337-7
121720 - Berberis thunbergii:
258207 - Berberis vernae: 10.1016/S0031-9422(00)82337-7
2602278 - Berberis virescens: 10.1016/S0031-9422(00)82337-7
258209 - Berberis vulgaris:
258211 - Berberis wilsoniae:
461559 - Burasaia madagascariensis: 10.2307/4117899
211976 - Cocculus carolinus: 10.1002/JPS.2600650131
261450 - Coptis chinensis:
1054456 - Coptis chinensis var. brevisepala: 10.1021/NP100645D
261449 - Coptis deltoidea:
3442 - Coptis japonica:
261451 - Coptis omeiensis: 10.1021/NP100645D
261444 - Coptis quinquefolia: 10.1016/S0031-9422(97)00775-9
261448 - Coptis teeta: 10.1021/NP100645D
1852778 - Corydalis balansae: 10.1055/S-1999-14090
581246 - Corydalis cava: 10.1055/S-2003-38869
38904 - Corydalis decumbens:
54425 - Corydalis intermedia: 10.1135/CCCC19892009
38909 - Corydalis nobilis: 10.1135/CCCC19892009
38903 - Corydalis pallida: 10.1055/S-2006-959483
38914 - Corydalis solida: 10.1135/CCCC19852299
1852784 - Corydalis speciosa: 10.1007/BF02975117
1577077 - Corydalis turtschaninovii: 10.1002/JCCS.199700053
38913 - Corydalis uniflora: 10.3109/13880208809053911
458692 - Corydalis yanhusuo: 10.1248/CPB.33.5369
3457 - Dioscoreophyllum cumminsii:
461588 - Fibraurea tinctoria: 10.1021/NP0704248
1464625 - Fumaria parviflora: 10.1002/(SICI)1099-1565(199901/02)10:1<6::AID-PCA431>3.0.CO;2-0
2072396 - Glaucium arabicum: 10.1016/0031-9422(88)84134-7
1602035 - Goniothalamus amuyon: 10.1016/S0031-9422(00)82561-3
13569 - Hydrastis canadensis:
432643 - Isopyrum thalictroides: 10.1016/S0031-9422(00)00068-6
2750601 - Mahonia fargesii: 10.1016/S0031-6865(99)00061-8
248829 - Meconopsis cambrica: 10.1135/CCCC19961815
41776 - Nandina domestica:
357466 - Papaver atlanticum: 10.1135/CCCC19862232
215227 - Papaver bracteatum: 10.1135/CCCC19851216
74823 - Papaver nudicaule: 10.1135/CCCC19871634
22694 - Papaver orientale: 10.1135/CCCC19911534
152836 - Papaver tatricum: 10.1135/CCCC19851745
152351 - Parabaena sagittata: 10.1055/S-2007-969933
2708930 - Penianthus zenkeri: 10.1016/0031-9422(91)85047-4
68554 - Phellodendron amurense:
354508 - Phellodendron chinense:
354509 - Phellodendron chinense var. glabriusculum:
286994 - Ranunculus serbicus: 10.1016/0031-9422(90)83089-J
461624 - Rhigiocarya racemifera: 10.1021/NP50007A010
461632 - Sphenocentrum jollyanum: 10.3987/COM-89-5168
152367 - Stephania cephalantha: 10.1248/BPB.22.268
1501467 - Stephania lincangensis: 10.1016/S0031-9422(00)80650-0
461634 - Stephania rotunda: 10.1021/NP50022A007
152371 - Stephania yunnanensis: 10.1016/S0031-9422(00)80650-0
46968 - Thalictrum: 10.1007/BF02492316
395328 - Thalictrum alpinum: 10.1021/NP50009A009
1277765 - Thalictrum atriplex: 10.1021/NP50045A018
341022 - Thalictrum cultratum: 10.1016/S0031-9422(00)84580-X
1277777 - Thalictrum foliolosum:
327930 - Thalictrum javanicum: 10.1021/NP50028A002
1277780 - Thalictrum lankesteri: 10.1016/0031-9422(88)80063-3
476039 - Thalictrum minus:
1084684 - Thalictrum petaloideum: 10.1021/NP50045A018
1084686 - Thalictrum podocarpum: 10.1021/NP50009A009
495765 - Thalictrum simplex: 10.1021/NP50045A018
1960964 - Tinospora baenzigeri: 10.1055/S-2007-969933
150903 - Tinospora capillipes:
285590 - Tinospora cordifolia:
285591 - Tinospora crispa: 10.1055/S-2007-969933
527512 - Tinospora glabra: 10.1055/S-2007-969933
280791 - Tinospora malabarica: 10.1016/0031-9422(92)83465-B
152349 - Tinospora sinensis:
461643 - Tinospora smilacina: 10.1055/S-2007-969933
992813 - Xylopia parviflora: 10.1016/J.PHYTOCHEM.2003.12.010
1671342 - Zanthoxylum chalybeum: 10.1021/NP960183W
2099532 - Zanthoxylum coco: 10.2307/4117899
569774 - 金线莲: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	10	ABCB1, AKT1, BCL2, CASP3, CAT, MTOR, NLRP3, NOS2, PIK3CA, PTGS2
Peripheral membrane protein	4	ACHE, CYP1B1, MTOR, PTGS2
Endoplasmic reticulum membrane	6	BCL2, CYP1A2, CYP1B1, HMOX1, MTOR, PTGS2
Nucleus	9	ACHE, AKT1, BCL2, CASP3, GABPA, HMOX1, MTOR, NLRP3, NOS2
cytosol	9	AKT1, BCL2, CASP3, CAT, HMOX1, MTOR, NLRP3, NOS2, PIK3CA
dendrite	1	MTOR
phagocytic vesicle	1	MTOR
nucleoplasm	6	AKT1, CASP3, GABPA, HMOX1, MTOR, NOS2
Cell membrane	4	ABCB1, ACHE, AKT1, TNF
Cytoplasmic side	2	HMOX1, MTOR
lamellipodium	2	AKT1, PIK3CA
Multi-pass membrane protein	1	ABCB1
Golgi apparatus membrane	2	MTOR, NLRP3
Synapse	1	ACHE
cell cortex	1	AKT1
cell surface	3	ABCB1, ACHE, TNF
glutamatergic synapse	2	AKT1, CASP3
Golgi apparatus	1	ACHE
Golgi membrane	3	INS, MTOR, NLRP3
lysosomal membrane	1	MTOR
neuromuscular junction	1	ACHE
neuronal cell body	2	CASP3, TNF
postsynapse	1	AKT1
Cytoplasm, cytosol	2	NLRP3, NOS2
Lysosome	1	MTOR
plasma membrane	7	ABCB1, ACHE, AKT1, BCHE, NOS2, PIK3CA, TNF
Membrane	9	ABCB1, ACHE, AKT1, BCL2, CAT, CYP1B1, HMOX1, MTOR, NLRP3
apical plasma membrane	1	ABCB1
caveola	1	PTGS2
extracellular exosome	2	ABCB1, CAT
Lysosome membrane	1	MTOR
endoplasmic reticulum	4	BCL2, HMOX1, NLRP3, PTGS2
extracellular space	7	ACHE, BCHE, HMOX1, IL10, IL6, INS, TNF
perinuclear region of cytoplasm	4	ACHE, HMOX1, NOS2, PIK3CA
intercalated disc	1	PIK3CA
mitochondrion	4	BCL2, CAT, CYP1B1, NLRP3
protein-containing complex	4	AKT1, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle	3	CAT, CYP1A2, CYP1B1
Microsome membrane	4	CYP1A2, CYP1B1, MTOR, PTGS2
postsynaptic density	1	CASP3
TORC1 complex	1	MTOR
TORC2 complex	1	MTOR
Secreted	6	ACHE, BCHE, IL10, IL6, INS, NLRP3
extracellular region	8	ACHE, BCHE, CAT, IL10, IL6, INS, NLRP3, TNF
Mitochondrion outer membrane	2	BCL2, MTOR
Single-pass membrane protein	1	BCL2
mitochondrial outer membrane	3	BCL2, HMOX1, MTOR
mitochondrial matrix	1	CAT
Extracellular side	1	ACHE
Nucleus membrane	1	BCL2
Bcl-2 family protein complex	1	BCL2
nuclear membrane	1	BCL2
external side of plasma membrane	1	TNF
microtubule cytoskeleton	1	AKT1
Cytoplasm, P-body	1	NOS2
P-body	1	NOS2
cell-cell junction	1	AKT1
recycling endosome	1	TNF
Single-pass type II membrane protein	1	TNF
vesicle	1	AKT1
Apical cell membrane	1	ABCB1
Cytoplasm, perinuclear region	1	NOS2
Membrane raft	1	TNF
pore complex	1	BCL2
focal adhesion	1	CAT
spindle	1	AKT1
Peroxisome	2	CAT, NOS2
basement membrane	1	ACHE
Peroxisome matrix	1	CAT
peroxisomal matrix	2	CAT, NOS2
peroxisomal membrane	1	CAT
Nucleus, PML body	1	MTOR
PML body	1	MTOR
Mitochondrion intermembrane space	1	AKT1
mitochondrial intermembrane space	1	AKT1
Cytoplasm, cytoskeleton, microtubule organizing center	1	NLRP3
Inflammasome	1	NLRP3
interphase microtubule organizing center	1	NLRP3
NLRP3 inflammasome complex	1	NLRP3
Nucleus inner membrane	1	PTGS2
Nucleus outer membrane	1	PTGS2
nuclear inner membrane	1	PTGS2
nuclear outer membrane	1	PTGS2
neuron projection	1	PTGS2
ciliary basal body	1	AKT1
chromatin	1	GABPA
phagocytic cup	1	TNF
blood microparticle	1	BCHE
Lipid-anchor, GPI-anchor	1	ACHE
nuclear envelope	1	MTOR
Endomembrane system	2	MTOR, NLRP3
endosome lumen	1	INS
microtubule organizing center	1	NLRP3
side of membrane	1	ACHE
myelin sheath	1	BCL2
ficolin-1-rich granule lumen	1	CAT
secretory granule lumen	2	CAT, INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	4	BCHE, IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex	1	PIK3CA
phosphatidylinositol 3-kinase complex, class IA	1	PIK3CA
transport vesicle	1	INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
Single-pass type IV membrane protein	1	HMOX1
nuclear envelope lumen	1	BCHE
synaptic cleft	1	ACHE
external side of apical plasma membrane	1	ABCB1
death-inducing signaling complex	1	CASP3
Cytoplasmic vesicle, phagosome	1	MTOR
[Tumor necrosis factor, soluble form]: Secreted	1	TNF
cortical cytoskeleton	1	NOS2
catalase complex	1	CAT
interleukin-6 receptor complex	1	IL6
BAD-BCL-2 complex	1	BCL2
[Isoform H]: Cell membrane	1	ACHE
phosphatidylinositol 3-kinase complex, class IB	1	PIK3CA
[C-domain 2]: Secreted	1	TNF
[Tumor necrosis factor, membrane form]: Membrane	1	TNF
[C-domain 1]: Secreted	1	TNF

文献列表

Wanli Ji, Yan Huo, Yifan Zhang, Xiaojing Qian, Yi Ren, Cheng Hu, Jiaqi Zhang. Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis. International immunopharmacology. 2024 May; 132(?):111968. doi: 10.1016/j.intimp.2024.111968. [PMID: 38579565]
Shaoling Lin, Shengxi Zhang, Angyu Zhan, Jiaojiao Feng, Qianqian Yang, Tongjun Li, Zijian Liu, Quqian Mo, Hui Fan, Keke Wang, Lexun Wang. Palmatine alleviates cardiac fibrosis by inhibiting fibroblast activation through the STAT3 pathway. European journal of pharmacology. 2024 Mar; 967(?):176395. doi: 10.1016/j.ejphar.2024.176395. [PMID: 38350592]
Yubin Xu, Bixin Shen, Xusheng Pan, Chang Liu, Yingyue Wang, Xiaowei Chen, Ting Wang, Guirong Chen, Jing Chen. Palmatine ameliorated lipopolysaccharide-induced sepsis-associated encephalopathy mice by regulating the microbiota-gut-brain axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155307. doi: 10.1016/j.phymed.2023.155307. [PMID: 38181529]
Chih-Hsin Lin, Yih-Ru Wu, Chih-Ying Chao, Kuo-Hsuan Chang, Chiung-Mei Chen, Wan-Ling Chen, Pei-Ning Yang, Guey-Jen Lee-Chen. Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells. Biological & pharmaceutical bulletin. 2024; 47(4):827-839. doi: 10.1248/bpb.b23-00758. [PMID: 38599826]
Jianning Zeng, Hongyan Pei, Hong Wu, Weijia Chen, Rui Du, Zhongmei He. Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway. Journal of biochemical and molecular toxicology. 2023 Oct; ?(?):e23544. doi: 10.1002/jbt.23544. [PMID: 37815058]
Jinghua Qin, Zhuo Luo, Qianyi Wang, Chaoling Tang, Mingwei Meng, Zheng Huang, Bingjian Guo, Ying He, Linlin Feng, Yunyuan Nong, Lijun Deng, Dan Zhu, Hongwei Guo, Yonghong Liang, Zhiheng Su. Integrating metabonomics and metagenomics sequencing to study the anti-liver fibrosis effects of palmatine in Corydalis saxicola Bunting. Journal of ethnopharmacology. 2023 May; 315(?):116666. doi: 10.1016/j.jep.2023.116666. [PMID: 37211189]
Gaoxiang Ai, Ronglei Huang, Jianhui Xie, Linjiang Zhong, Xiaoyan Wu, Zehui Qin, Ziren Su, Jiannan Chen, Xiaobo Yang, Yaoxing Dou. Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis. Journal of ethnopharmacology. 2023 Jan; 301(?):115775. doi: 10.1016/j.jep.2022.115775. [PMID: 36198377]
Xin Zhao, Pingyuan Ge, Shaohua Lei, Siqi Guo, Peng Zhou, Li Zhao, Yiyu Qi, Xiaotong Wei, Weizhen Wu, Ningjing Wang, Rui Guo, Nianyun Yang, Qingqing Xiao, Qichun Zhang, Huaxu Zhu. An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer's Disease with Berberine and Palmatine. Drug design, development and therapy. 2023; 17(?):2401-2420. doi: 10.2147/dddt.s417465. [PMID: 37609432]
Guo-Shuai Lin, Mao-Mao Zhao, Qi-Chao Fu, Shu-Yi Zhao, Tao-Tao Ba, Hong-Xia Yu. Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease. Drug development research. 2022 11; 83(7):1613-1622. doi: 10.1002/ddr.21981. [PMID: 35976121]
Lei Wang, Min Li, Cuiping Zhu, Aiping Qin, Jinchun Wang, Xianni Wei. The protective effect of Palmatine on depressive like behavior by modulating microglia polarization in LPS-induced mice. Neurochemical research. 2022 Oct; 47(10):3178-3191. doi: 10.1007/s11064-022-03672-3. [PMID: 35917005]
Juanjuan Cheng, Xingdong Ma, Haitao Zhang, Xiaoyan Wu, Minhua Li, Gaoxiang Ai, Ruoting Zhan, Jianhui Xie, Ziren Su, Xiaoqi Huang. 8-Oxypalmatine, a novel oxidative metabolite of palmatine, exhibits superior anti-colitis effect via regulating Nrf2 and NLRP3 inflammasome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113335. doi: 10.1016/j.biopha.2022.113335. [PMID: 35779424]
Tianyun Fan, Yangyang Cheng, Wei Wei, Qingxuan Zeng, Xixi Guo, Zhihao Guo, Yinghong Li, Liping Zhao, Yulong Shi, Xintong Zhang, Jiandong Jiang, Yanxiang Wang, Weijia Kong, Danqing Song. Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3-Kinase/Akt Phosphorylation. Journal of medicinal chemistry. 2022 05; 65(10):7399-7413. doi: 10.1021/acs.jmedchem.2c00592. [PMID: 35549263]
Juan-Juan Cheng, Xing-Dong Ma, Gao-Xiang Ai, Qiu-Xia Yu, Xiao-Ying Chen, Fang Yan, Yu-Cui Li, Jian-Hui Xie, Zi-Ren Su, Qing-Feng Xie. Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways. Drug design, development and therapy. 2022; 16(?):2119-2132. doi: 10.2147/dddt.s356307. [PMID: 35812134]
Lan Xie, Shanshan Feng, Xiaoling Zhang, Wenlong Zhao, Juan Feng, Chengmei Ma, Ruijun Wang, Weifang Song, Jing Cheng. Biological Response Profiling Reveals the Functional Differences of Main Alkaloids in Rhizoma Coptidis. Molecules (Basel, Switzerland). 2021 Dec; 26(23):. doi: 10.3390/molecules26237389. [PMID: 34885971]
Ting Liu, Ruiyun Li, Nan Zhang, Yue Cui, Yunli Zhao, Zhiguo Yu. Screening of differential components of Gegenqinlian decoction and their comparative pharmacokinetics in normal and pyrexia rats using UHPLC-FT-ICR-MS and UHPLC-MS/MS. Biomedical chromatography : BMC. 2021 Nov; 35(11):e5186. doi: 10.1002/bmc.5186. [PMID: 34075601]
Aneta Grabarska, Paula Wróblewska-Łuczka, Wirginia Kukula-Koch, Jarogniew J Łuszczki, Eleftherios Kalpoutzakis, Grzegorz Adamczuk, Alexios Leandros Skaltsounis, Andrzej Stepulak. Palmatine, a Bioactive Protoberberine Alkaloid Isolated from Berberis cretica, Inhibits the Growth of Human Estrogen Receptor-Positive Breast Cancer Cells and Acts Synergistically and Additively with Doxorubicin. Molecules (Basel, Switzerland). 2021 Oct; 26(20):. doi: 10.3390/molecules26206253. [PMID: 34684834]
Yang Song, Kefei Wang, Xiaoyi Wei, Tongyuan Wei, Tianhao Xiao, Minjie Wei. Pharmacokinetics, tissue distribution and plasma protein binding rate of palmatine following intragastric and intravenous administration in rats using liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2021 Sep; 203(?):114226. doi: 10.1016/j.jpba.2021.114226. [PMID: 34182412]
Mehdi Khaksari, Samira Esmaili, Reyhane Abedloo, Hossein Khastar. Palmatine ameliorates nephrotoxicity and hepatotoxicity induced by gentamicin in rats. Archives of physiology and biochemistry. 2021 Jun; 127(3):273-278. doi: 10.1080/13813455.2019.1633354. [PMID: 31241354]
Dong-Jun Fu, Jun Li, Bin Yu. Annual review of LSD1/KDM1A inhibitors in 2020. European journal of medicinal chemistry. 2021 Mar; 214(?):113254. doi: 10.1016/j.ejmech.2021.113254. [PMID: 33581557]
Patrick N Okechukwu, Sophia O Ekeuku, Hor K Chan, Kalpana Eluri, Gabriele R A Froemming. Palmatine Inhibits Up-Regulation of GRP78 and CALR Protein in an STZ-Induced Diabetic Rat Model. Current pharmaceutical biotechnology. 2021; 22(2):288-298. doi: 10.2174/1389201021666200730124208. [PMID: 32744968]
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