Berbamine (BioDeep_00000000041)

 

Secondary id: BioDeep_00000015683, BioDeep_00000171860

natural product PANOMIX_OTCML-2023


代谢物信息卡片


16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido(2,3:17,18)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, hydrochloride, hydrate (1:1:4), (4aS,16aR)-

化学式: C37H40N2O6 (608.2886)
中文名称: 小檗胺
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 16.86%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Berbamine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/berbamine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000041). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
InChI: InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3

描述信息

Berbamine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.
Berbamine is a natural product found in Berberis poiretii, Berberis integerrima

Berbamine inhibits the proliferation of KM3 cells in a dose- and time-dependent manner. Combination of berbamine with dexamethasone (Dex), doxorubicin (Dox) or arsenic trioxide (ATO) resulted in enhanced inhibition of cell growth. Flow cytometric analysis revealed that KM3 cells were arrested at G1 phase and apoptotic cells increased from 0.54\\\% to 51.83\\\% for 36 h. Morphological changes of cells undergoing apoptosis were observed under light microscope. Berbamine treatment led to increased expression of A20, down-regulation of IKKα, p-IκBα, and followed by inhibition of p65 nuclear localization. As a result, NF-κB downstream targets such as cyclinD1, Bcl-xL, Bid and survivin were down-regulated.

Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2.

(+)-Berbamine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=478-61-5 (retrieved 2024-06-29) (CAS RN: 478-61-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Berbamine is a natural compound extracted from traditional Chinese medicine?Phellodendron amurense Rupr. with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine?is a calcium channel blocker.
Berbamine is a natural compound extracted from traditional Chinese medicine?Phellodendron amurense Rupr. with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine?is a calcium channel blocker.

同义名列表

31 个代谢物同义名

16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido(2,3:17,18)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, hydrochloride, hydrate (1:1:4), (4aS,16aR)-; 16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido(2,3:17,18)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, hydrochloride (1:2), (4aS,16aR)-; 16h-1,24:6,9-dietheno-11,15-metheno-2H-pyrido(2,3:17,18)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, (4aS-(4aR*,16aS*))-; 16h-1,24:6,9-dietheno-11,15-metheno-2H-pyrido(2,3:17,18)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, (4aS,16aR)-; WLN: T-T66 CNT&J C1 HO1 IO- JT66 CNT&J C1 HO1 IO1 B1R DQ COR D1- B-18-J; berbaman-12-ol, 6,6,7-trimethoxy-2,2-dimethyl-, dihydrochloride; berbaman-12-ol, 6,6,7-trimethoxy-2,2-dimethyl-; 2-27-00-00891 (Beilstein Handbook Reference); 6,6,7-trimethoxy-2,2-dimethylberbaman-12-ol; Berbaman-12-ol,6,7-trimethoxy-2,2-dimethyl-; berbamine, monohydrochloride, tetrahydrate; TERT-BUTYL1,3-BENZODIOXOL-4-YLCARBAMATE; berbamine hydrochloride tetrahydrate; berbamine monohydrochloride; berbamine, (1beta)-isomer; berbamine dihydrochloride; berbamine hydrochloride; BERBAMINE [WHO-DD]; UNII-V5KM4XJ0WM; BERBAMINE, (+)-; berbamine, (+); BERBAMINE [MI]; (+)-berbamine; NCI60_003398; d-Berbamine; V5KM4XJ0WM; pycnamine; Berbamine; Berbenine; penduline; Berbamine



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

58 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ABCB1, ANXA5, BCL2, BIRC5, CASP3, CHUK, CTNNB1, DCTN4, MAPK8, MTOR, MYC, NFKB1, PIK3CA, PTGS2, STAT3
Peripheral membrane protein 4 ANXA5, GORASP1, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 13 BCL2, BIRC5, CASP3, CHUK, CTNNB1, DCTN4, HMOX1, JUN, MAPK8, MTOR, MYC, NFKB1, STAT3
cytosol 13 ANXA5, BCL2, BIRC5, CASP3, CHUK, CTNNB1, DCTN4, HMOX1, MAPK8, MTOR, NFKB1, PIK3CA, STAT3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 2 CTNNB1, DCTN4
nucleoplasm 11 BIRC5, CASP3, CHUK, CTNNB1, HMOX1, JUN, MAPK8, MTOR, MYC, NFKB1, STAT3
RNA polymerase II transcription regulator complex 2 JUN, STAT3
Cell membrane 3 ABCB1, CTNNB1, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
lamellipodium 2 CTNNB1, PIK3CA
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 2 CTNNB1, MAPK8
cell cortex 2 CTNNB1, DCTN4
cell junction 1 CTNNB1
cell surface 2 ABCB1, TNF
glutamatergic synapse 2 CASP3, CTNNB1
Golgi apparatus 1 GORASP1
Golgi membrane 2 GORASP1, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 CTNNB1
sarcolemma 1 ANXA5
Lysosome 1 MTOR
plasma membrane 5 ABCB1, CTNNB1, PIK3CA, STAT3, TNF
Membrane 7 ABCB1, ANXA5, BCL2, CTNNB1, HMOX1, MTOR, MYC
apical plasma membrane 1 ABCB1
axon 1 MAPK8
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 3 ABCB1, ANXA5, CTNNB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, HMOX1, PTGS2
extracellular space 2 HMOX1, TNF
perinuclear region of cytoplasm 3 CTNNB1, HMOX1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, NFKB1
protein-containing complex 5 BCL2, BIRC5, CTNNB1, MYC, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
extracellular region 3 ANXA5, NFKB1, TNF
cytoplasmic side of plasma membrane 1 CHUK
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
transcription regulator complex 4 CTNNB1, JUN, NFKB1, STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 DCTN4
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
CD40 receptor complex 1 CHUK
external side of plasma membrane 2 ANXA5, TNF
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 BIRC5
nucleolus 1 MYC
Wnt signalosome 1 CTNNB1
midbody 1 BIRC5
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 CTNNB1, DCTN4
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 3 ANXA5, CTNNB1, DCTN4
microtubule 1 BIRC5
spindle 1 BIRC5
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA5
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cytoplasm, myofibril, sarcomere 1 DCTN4
sarcomere 1 DCTN4
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 4 JUN, MYC, NFKB1, STAT3
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Chromosome 1 BIRC5
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
centriole 1 BIRC5
Nucleus, nucleolus 1 MYC
spindle pole 2 CTNNB1, DCTN4
nuclear chromosome 2 BIRC5, JUN
Cytoplasm, cell cortex 1 DCTN4
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 2 MTOR, MYC
Endomembrane system 2 CTNNB1, MTOR
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Nucleus, nucleoplasm 1 MYC
euchromatin 2 CTNNB1, JUN
myelin sheath 1 BCL2
stress fiber 1 DCTN4
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 1 PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
dynactin complex 1 DCTN4
kinetochore 2 BIRC5, DCTN4
RNA polymerase II transcription repressor complex 1 MYC
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
cytoplasmic dynein complex 1 DCTN4
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
chromosome, centromeric region 1 BIRC5
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
IkappaB kinase complex 1 CHUK
chromosome passenger complex 1 BIRC5
Cytoplasm, cytoskeleton, stress fiber 1 DCTN4
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 CTNNB1
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Rough endoplasmic reticulum 1 MYC
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
transcription factor AP-1 complex 1 JUN
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Lu Liu, Dan Liang, Qiao Zheng, Maoyuan Zhao, RuiTing Lv, Jianyuan Tang, Nianzhi Chen. Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis. Journal of ethnopharmacology. 2023 Mar; 303(?):116025. doi: 10.1016/j.jep.2022.116025. [PMID: 36496042]
  • Junhai Zhu, Lihong Huang, Fei Gao, Weijun Jian, Huahan Chen, Ming Liao, Wenbao Qi. Berbamine Hydrochloride Inhibits African Swine Fever Virus Infection In Vitro. Molecules (Basel, Switzerland). 2022 Dec; 28(1):. doi: 10.3390/molecules28010170. [PMID: 36615369]
  • Zhe-Rui Zhang, Ya-Nan Zhang, Hong-Qing Zhang, Qiu-Yan Zhang, Na Li, Qi Li, Cheng-Lin Deng, Bo Zhang, Xiao-Dan Li, Han-Qing Ye. Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion. PLoS neglected tropical diseases. 2022 04; 16(4):e0010363. doi: 10.1371/journal.pntd.0010363. [PMID: 35468133]
  • Liufang Yin, Lijun Zhang, Lingling Luo, Yalei Liu, Fei Wang, Yaru Feng, Hongqing Wang, Yongli Han, Yingxuan Yan, Cheng Huang, Shengjie Fan. Berbamine reduces body weight via suppression of small GTPase Rab8a activity and activation of paraventricular hypothalamic neurons in obese mice. European journal of pharmacology. 2022 Feb; 916(?):174679. doi: 10.1016/j.ejphar.2021.174679. [PMID: 34982965]
  • Chongjing Zhang, Zeyuan Zhong, Weicong Sang, Farnaz Ghorbani, Behafarid Ghalandari, Marjan Mohamadali, Shiva Irani, Zhi Qian, Chengqing Yi, Baoqing Yu. The Dibenzyl Isoquinoline Alkaloid Berbamine Ameliorates Osteoporosis by Inhibiting Bone Resorption. Frontiers in endocrinology. 2022; 13(?):885507. doi: 10.3389/fendo.2022.885507. [PMID: 35663327]
  • Hongchun Li, Kexue Luo, Zhuying Yang, Miao Chen, Xiuyun Yang, Jiesheng Wang, Yin Ying, Dengxuan Wu, Qinxian Wang. Berbamine Suppresses the Growth of Gastric Cancer Cells by Inactivating the BRD4/c-MYC Signaling Pathway. Drug design, development and therapy. 2022; 16(?):129-141. doi: 10.2147/dddt.s338881. [PMID: 35046638]
  • Zhiyi Tang, Yichun Niu, Zhiyuan Xu, Yanmei Shi, Yaqiong Liu, Wen Fu, Mengyao Zheng, Haiyu He, Tao Wu. Anti-Tumor and Anti-Metastasis Effects of Berbamine-Loaded Lipid Nanoparticles on Pancreatic Cancer. Anti-cancer agents in medicinal chemistry. 2022; 22(18):3097-3106. doi: 10.2174/1871520622666220501161636. [PMID: 35490430]
  • Tanuja Joshi, Sunaullah Bhat, Hemlata Pundir, Subhash Chandra. Identification of Berbamine, Oxyacanthine and Rutin from Berberis asiatica as anti-SARS-CoV-2 compounds: An in silico study. Journal of molecular graphics & modelling. 2021 12; 109(?):108028. doi: 10.1016/j.jmgm.2021.108028. [PMID: 34649146]
  • Lihong Huang, Huanan Li, Zuodong Ye, Qiang Xu, Qiang Fu, Wei Sun, Wenbao Qi, Jianbo Yue. Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR). Emerging microbes & infections. 2021 Dec; 10(1):1257-1271. doi: 10.1080/22221751.2021.1941276. [PMID: 34102949]
  • Songpeng Yang, Shu Yang, Hongying Zhang, Hui Hua, Qingbin Kong, Jiao Wang, Yangfu Jiang. Targeting Na+ /K+ -ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma. British journal of pharmacology. 2021 11; 178(21):4389-4407. doi: 10.1111/bph.15616. [PMID: 34233013]
  • Yu Jin Kim, Jang Mi Han, Hye Jin Jung. Antiangiogenic and antitumor potential of berbamine, a natural CaMKIIγ inhibitor, against glioblastoma. Biochemical and biophysical research communications. 2021 08; 566(?):129-134. doi: 10.1016/j.bbrc.2021.06.025. [PMID: 34119825]
  • Lihong Huang, Terrence Tsz-Tai Yuen, Zuodong Ye, Shuyan Liu, Guoliang Zhang, Hin Chu, Jianbo Yue. Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2. Signal transduction and targeted therapy. 2021 04; 6(1):168. doi: 10.1038/s41392-021-00584-6. [PMID: 33895782]
  • Ankita Sharma, Sumit Kr Anand, Neha Singh, Akshay Dwarkanath, Upendra Nath Dwivedi, Poonam Kakkar. Berbamine induced activation of the SIRT1/LKB1/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats. Food & function. 2021 Jan; 12(2):892-909. doi: 10.1039/d0fo02501a. [PMID: 33411880]
  • Ankita Sharma, Sumit Kr Anand, Neha Singh, Upendra Nath Dwivedi, Poonam Kakkar. Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. European journal of pharmacology. 2020 Sep; 882(?):173244. doi: 10.1016/j.ejphar.2020.173244. [PMID: 32526241]
  • Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Hongguang Wu, Haruki Yamada, Toshihiko Hirano. Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study. Bioorganic & medicinal chemistry. 2020 06; 28(12):115553. doi: 10.1016/j.bmc.2020.115553. [PMID: 32503690]
  • Xiufang Liang, Yunan Xiang, Yanling Li, Ping Feng, Yongping Qin, Xianrong Lai. A rapid method for simultaneous quantification of berberine, berbamine, magnoflorine and berberrubine in mouse serum using UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1142(?):122040. doi: 10.1016/j.jchromb.2020.122040. [PMID: 32145638]
  • Xin-Yu Liu, Guan-Nan Chen, Guo-Ming DU, Yue Pan, Wu-Qi Song, Ting-Wang Jiang, Hai-Liang Liu. Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice. Chinese journal of natural medicines. 2020 Mar; 18(3):186-195. doi: 10.1016/s1875-5364(20)30020-0. [PMID: 32245588]
  • Hui Xu, Yanan Kong, Ying Chen, Na Li, Shuqiang Zhang, Hong Lu. Natural Plant Extract Berbamine Is a Potent Inhibitor of Cell Growth and Survival of Human Tenon's Fibroblasts. Ophthalmic research. 2020; 63(6):555-563. doi: 10.1159/000506644. [PMID: 32079013]
  • Lianjun Mou, Bingyu Liang, Guanjun Liu, Junjun Jiang, Jie Liu, Bo Zhou, Jiegang Huang, Ning Zang, Yanyan Liao, Li Ye, Hao Liang. Berbamine exerts anticancer effects on human colon cancer cells via induction of autophagy and apoptosis, inhibition of cell migration and MEK/ERK signalling pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2019 Sep; 24(5):1870-1875. doi: . [PMID: 31786849]
  • Sithuraj Saranya, Rathinasamy Baskaran, Paramasivan Poornima, Viswanadha Vijaya Padma. Berbamine ameliorates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and apoptosis in rats. Journal of cellular biochemistry. 2019 03; 120(3):3101-3113. doi: 10.1002/jcb.27522. [PMID: 30485494]
  • Anna Hostalkova, Jana Marikova, Lubomir Opletal, Jan Korabecny, Daniela Hulcova, Jiri Kunes, Lucie Novakova, Daniel I Perez, Daniel Jun, Tomas Kucera, Vincenza Andrisano, Tomas Siatka, Lucie Cahlikova. Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease. Journal of natural products. 2019 02; 82(2):239-248. doi: 10.1021/acs.jnatprod.8b00592. [PMID: 30701972]
  • Chandrasekaran Sankaranarayanan, Ramajayam Nishanthi, Pachaiappan Pugalendi. Ameliorating effect of berbamine on hepatic key enzymes of carbohydrate metabolism in high-fat diet and streptozotocin induced type 2 diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jul; 103(?):539-545. doi: 10.1016/j.biopha.2018.04.066. [PMID: 29677540]
  • Heng Zhang, Yunping Jiao, Chunyang Shi, Xiao Song, Ying Chang, Yong Ren, Xiaolin Shi. Berbamine suppresses cell proliferation and promotes apoptosis in ovarian cancer partially via the inhibition of Wnt/β-catenin signaling. Acta biochimica et biophysica Sinica. 2018 Jun; 50(6):532-539. doi: 10.1093/abbs/gmy036. [PMID: 29701777]
  • Ruoqiu Fu, Qin Deng, Hongwei Zhang, Xiaoye Hu, Yunong Li, Yanxia Liu, Jinjiao Hu, Qingsong Luo, Yanhao Zhang, Xiuxing Jiang, Lirong Li, Chong Yang, Ning Gao. A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3. Cell death & disease. 2018 02; 9(2):243. doi: 10.1038/s41419-018-0276-8. [PMID: 29445175]
  • Guangyi Yang, Chenning Zhang, Pei Hu, Meiling Zhu, Ming Hu, Song Gao. An UPLC-MS/MS method for quantifying tetrandrine and its metabolite berbamine in human blood: Application to a human pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Dec; 1070(?):92-96. doi: 10.1016/j.jchromb.2017.10.048. [PMID: 29100757]
  • Priyambada Parhi, Sujit Suklabaidya, Sanjeeb Kumar Sahoo. Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo. Scientific reports. 2017 07; 7(1):5806. doi: 10.1038/s41598-017-05296-y. [PMID: 28724926]
  • Yao Sun, Tong Yao, Hui Li, Ying Peng, Jiang Zheng. In vitro and in vivo metabolic activation of berbamine to quinone methide intermediate. Journal of biochemical and molecular toxicology. 2017 Apr; 31(4):. doi: 10.1002/jbt.21876. [PMID: 27902864]
  • Muobarak J Tuorkey. Cancer Therapy with Phytochemicals: Present and Future Perspectives. Biomedical and environmental sciences : BES. 2015 Nov; 28(11):808-19. doi: 10.3967/bes2015.112. [PMID: 26695359]
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