Benzamide (BioDeep_00000405587)

Main id: BioDeep_00000002325

 

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


InChI=1\C7H7NO\c8-7(9)6-4-2-1-3-5-6\h1-5H,(H2,8,9

化学式: C7H7NO (121.0527612)
中文名称: 苯酰胺-Alpha-13C, 苯甲酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)C(=O)N
InChI: InChI=1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)

描述信息

Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].

同义名列表

43 个代谢物同义名

Benzamide; InChI=1\C7H7NO\c8-7(9)6-4-2-1-3-5-6\h1-5H,(H2,8,9; 4-09-00-00725 (Beilstein Handbook Reference); Amid kyseliny benzoove [Czech]; Amid kyseliny benzoove; Phenyl carboxyamide; Benzoic acid amide; BENZOIC ACID,AMIDE; Benzenecarboxamide; Phenylcarboxyamide; Phenylcarboxamide; EINECS 200-227-7; NCGC00091355-01; NCGC00015142-01; 135828_ALDRICH; 399337_ALDRICH; 150762_ALDRICH; Lopac0_000160; Benzoylamide; MLS000069472; Lopac-B-2009; SMR000059089; ARONIS003511; ZINC00152996; CHEBI:28179; BRN 0385876; AIDS-018394; 27208-38-4; AIDS018394; CCRIS 4594; EU-0100160; AI3-01031; HSDB 6360; STK069333; WLN: ZVR; NSC 3114; NSC3114; 55-21-0; C09815; c0368; Benzamide; Phenylamide; Benzamide



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yi-Dan Ma, Huan Zhou, Guo-Tai Lin, Ke-Huan Wu, Gong Xu, Xili Liu, Dan Xu. Design, Synthesis, and Fungicidal Activities of Novel N-(Pyrazol-5-yl)benzamide Derivatives Containing a Diphenylamine Moiety. Journal of agricultural and food chemistry. 2024 Mar; 72(12):6691-6701. doi: 10.1021/acs.jafc.3c07567. [PMID: 38498985]
  • Tan Dai, Jikun Yang, Chuang Zhao, Jinzhu Chen, Can Zhang, Zhiwen Wang, Qin Peng, Pengfei Liu, Jianqiang Miao, Xili Liu. Unveiling Vacuolar H+-ATPase Subunit a as the Primary Target of the Pyridinylmethyl-Benzamide Fungicide, Fluopicolide. Journal of agricultural and food chemistry. 2024 Jan; 72(3):1527-1538. doi: 10.1021/acs.jafc.3c08485. [PMID: 38193425]
  • Tingting Wang, Pengfei Xu, Jianyang Fang, Cijuan Li, Xinying Zeng, Jia Liu, Lingxin Meng, Rongqiang Zhuang, Xianzhong Zhang, Xinhui Su, Zhide Guo. Synthesis and Preclinical Evaluation of a 68Ga-Labeled Pyridine-Based Benzamide Dimer for Malignant Melanoma Imaging. Molecular pharmaceutics. 2023 Feb; 20(2):1015-1024. doi: 10.1021/acs.molpharmaceut.2c00745. [PMID: 36562303]
  • Bashir Lawal, Yu-Cheng Kuo, Sung-Ling Tang, Feng-Cheng Liu, Alexander T H Wu, Hung-Yun Lin, Hsu-Shan Huang. Transcriptomic-Based Identification of the Immuno-Oncogenic Signature of Cholangiocarcinoma for HLC-018 Multi-Target Therapy Exploration. Cells. 2021 10; 10(11):. doi: 10.3390/cells10112873. [PMID: 34831096]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Huajian Zhu, Wenlong Li, Wen Shuai, Yang Liu, Limei Yang, Yuchen Tan, Tiandong Zheng, Hong Yao, Jinyi Xu, Zheying Zhu, Dong-Hua Yang, Zhe-Sheng Chen, Shengtao Xu. Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. European journal of medicinal chemistry. 2021 Apr; 216(?):113316. doi: 10.1016/j.ejmech.2021.113316. [PMID: 33676300]
  • Jelena Lazarević, Andrija Šmelcerović, Jelena Zvezdanović, Denitsa Yancheva, Silvana Casati, Roberta Ottria, Pierangela Ciuffreda. Lipid peroxidation inhibition study: A promising case of 1,3-di([1,1'-biphenyl]-3-yl)urea. Chemico-biological interactions. 2020 Aug; 326(?):109137. doi: 10.1016/j.cbi.2020.109137. [PMID: 32442417]
  • Agnieszka Niemczynowicz, Iwona Budziak, Sławomir Kulesza, Andrzej Górecki, Marcin Makowski, Dariusz Karcz, Karolina Starzak, Bożena Gładyszewska, Janusz Podleśny, Agnieszka I Piotrowicz-Cieślak, Arkadiusz Matwijczuk. Spectroscopic and theoretical studies of fluorescence effects induced by the ESIPT process in a new derivative 2-Hydroxy-N-(2-phenylethyl)benzamide - Study on the effects of pH and medium polarity changes. PloS one. 2020; 15(2):e0229149. doi: 10.1371/journal.pone.0229149. [PMID: 32097423]
  • Shane D Hellyer, Sabine Albold, Kathy Sengmany, Junaid Singh, Katie Leach, Karen J Gregory. Metabotropic glutamate receptor 5 (mGlu5 )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons. Journal of neurochemistry. 2019 11; 151(3):301-315. doi: 10.1111/jnc.14844. [PMID: 31376155]
  • Amjad Ali, Tapan Kumar Mohanta, Sajjad Asaf, Najeebur Rehman, Saif Al-Housni, Ahmed Al-Harrasi, Abdul Latif Khan, Ahmed Al-Rawahi. Biotransformation of benzoin by Sphingomonas sp. LK11 and ameliorative effects on growth of Cucumis sativus. Archives of microbiology. 2019 Jul; 201(5):591-601. doi: 10.1007/s00203-019-01623-1. [PMID: 30714085]
  • M Adnan, M S Hamada, G Q Li, C X Luo. Detection and Molecular Characterization of Resistance to the Dicarboximide and Benzamide Fungicides in Botrytis cinerea From Tomato in Hubei Province, China. Plant disease. 2018 Jul; 102(7):1299-1306. doi: 10.1094/pdis-10-17-1531-re. [PMID: 30673571]
  • Nehaben A Gujarati, Leli Zeng, Pranav Gupta, Zhe-Sheng Chen, Vijaya L Korlipara. Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors. Bioorganic & medicinal chemistry letters. 2017 10; 27(20):4698-4704. doi: 10.1016/j.bmcl.2017.09.009. [PMID: 28916341]
  • Chen Hu, Shi-Wen Zhou, Fang Chen, Xin-Heng Zheng, Hui-Fang Shen, Bi-Run Lin, Guang-Xiong Zhou. Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15. Molecules (Basel, Switzerland). 2017 Mar; 22(4):. doi: 10.3390/molecules22040557. [PMID: 28358337]
  • Sabrin Ragab Mohamed Ibrahim, Ehab Saad Elkhayat, Gamal Abd Allah Mohamed, Shaukat Mohammed Fat'hi, Samir Anis Ross. Fusarithioamide A, a new antimicrobial and cytotoxic benzamide derivative from the endophytic fungus Fusarium chlamydosporium. Biochemical and biophysical research communications. 2016 10; 479(2):211-216. doi: 10.1016/j.bbrc.2016.09.041. [PMID: 27634222]
  • Wen Zhang, Guoqing Sui, Yulin Li, Mei Fang, Xinjuan Yang, Xihan Ma, Wenming Zhou. Synthesis and in Vitro Antifungal Activities of Novel Benzamide Derivatives Containing a Triazole Moiety. Chemical & pharmaceutical bulletin. 2016; 64(6):616-24. doi: 10.1248/cpb.c16-00056. [PMID: 27250796]
  • Kebiao Song, Xing Xu, Peng Liu, Lili Chen, Xu Shen, Junhua Liu, Lihong Hu. Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists. Bioorganic & medicinal chemistry. 2015 Oct; 23(19):6427-36. doi: 10.1016/j.bmc.2015.08.021. [PMID: 26337021]
  • Jessica A Burket, Andrew D Benson, Torrian L Green, Jerri M Rook, Craig W Lindsley, P Jeffrey Conn, Stephen I Deutsch. Effects of VU0410120, a novel GlyT1 inhibitor, on measures of sociability, cognition and stereotypic behaviors in a mouse model of autism. Progress in neuro-psychopharmacology & biological psychiatry. 2015 Aug; 61(?):10-7. doi: 10.1016/j.pnpbp.2015.03.003. [PMID: 25784602]
  • Emma Boström, Yi-Fang Cheng, Niclas Brynne, Märta Segerdahl. Prediction of H3 receptor occupancy diurnal fluctuations using population modeling and simulation with focus on guiding dose selection in a Phase IIa study. Pharmaceutical research. 2014 Feb; 31(2):489-99. doi: 10.1007/s11095-013-1177-2. [PMID: 24078286]
  • Dong Jae Baek, Neil MacRitchie, Nahoum G Anthony, Simon P Mackay, Susan Pyne, Nigel J Pyne, Robert Bittman. Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. Journal of medicinal chemistry. 2013 Nov; 56(22):9310-27. doi: 10.1021/jm401399c. [PMID: 24164513]
  • R W Kirby, A Martelli, V Calderone, N G McKay, K Lawson. Large conductance Ca(2+)-activated K(+) channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects. Bioorganic & medicinal chemistry. 2013 Jul; 21(14):4186-91. doi: 10.1016/j.bmc.2013.05.003. [PMID: 23707646]
  • Zhongli Gao, William J Hurst, Etienne Guillot, Raisa Nagorny, Marie-Pierre Pruniaux, James A Hendrix, Pascal G George. Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide. Bioorganic & medicinal chemistry letters. 2013 Jul; 23(14):4044-7. doi: 10.1016/j.bmcl.2013.05.068. [PMID: 23769643]
  • Jonathan E Harms, Morris Benveniste, John K F Maclean, Kathryn M Partin, Craig Jamieson. Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology. 2013 Jan; 64(?):45-52. doi: 10.1016/j.neuropharm.2012.06.008. [PMID: 22735771]
  • Rosalind Pei Theng Kim, Vicky Bihud, Khalit Bin Mohamad, Kok Hoong Leong, Jamaludin Bin Mohamad, Fasihuddin Bin Ahmad, Hazrina Hazni, Noraini Kasim, Siti Nadiah Abdul Halim, Khalijah Awang. Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides Mat Salleh. Molecules (Basel, Switzerland). 2012 Dec; 18(1):128-39. doi: 10.3390/molecules18010128. [PMID: 23344192]
  • Liping Wang, Huajun Fan, Kunhong Wu, Xiaosheng Peng, Zitao Jiang, Linquan Zang. [Chiral separation of benzamide antipsychotics and determination of their enantiomers by high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2012 Dec; 30(12):1265-70. doi: 10.3724/sp.j.1123.2012.07035. [PMID: 23593884]
  • Shin-Hee Kim, Yoo-Sin Park, Jung Mogg Kim, Hae-Jeong Park, Min-Ho Lee, Hoon-Ki Park, Young-Jae Kim, Sam Hyun Cho, Leslie M Shaw, Juâ Seop Kang. Pharmacokinetic and bioavailability studies of 5 mg mosapride tablets in healthy Korean volunteers. International journal of clinical pharmacology and therapeutics. 2012 Jul; 50(7):524-31. doi: 10.5414/cp201506. [PMID: 22541755]
  • Alejandro Orlowski, Verónica C De Giusti, Patricio E Morgan, Ernesto A Aiello, Bernardo V Alvarez. Binding of carbonic anhydrase IX to extracellular loop 4 of the NBCe1 Na+/HCO3- cotransporter enhances NBCe1-mediated HCO3- influx in the rat heart. American journal of physiology. Cell physiology. 2012 Jul; 303(1):C69-80. doi: 10.1152/ajpcell.00431.2011. [PMID: 22538240]
  • Zhenyu Li, Peng Zhan, Lieve Naesens, Evelien Vanderlinden, Ailin Liu, Guanhua Du, Erik De Clercq, Xinyong Liu. synthesis and preliminary biologic evaluation of 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles as a novel class of influenza virus A inhibitors. Chemical biology & drug design. 2012 Jun; 79(6):1018-24. doi: 10.1111/j.1747-0285.2012.01344.x. [PMID: 22284752]
  • Thomas Veloukas, George S Karaoglanidis. Biological activity of the succinate dehydrogenase inhibitor fluopyram against Botrytis cinerea and fungal baseline sensitivity. Pest management science. 2012 Jun; 68(6):858-64. doi: 10.1002/ps.3241. [PMID: 22262495]
  • Janka Reimer, Sandra Bien, Sabine Ameling, Elke Hammer, Uwe Völker, Georg Hempel, Joachim Boos, Heyo K Kroemer, Christoph A Ritter. Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis. European journal of clinical pharmacology. 2012 Jun; 68(6):923-35. doi: 10.1007/s00228-011-1209-y. [PMID: 22286157]
  • Alexandra Wormit, Salman M Butt, Issariya Chairam, Joseph F McKenna, Adriano Nunes-Nesi, Lars Kjaer, Kerry O'Donnelly, Alisdair R Fernie, Rüdiger Woscholski, M C Laura Barter, Thorsten Hamann. Osmosensitive changes of carbohydrate metabolism in response to cellulose biosynthesis inhibition. Plant physiology. 2012 May; 159(1):105-17. doi: 10.1104/pp.112.195198. [PMID: 22422940]
  • Asish K Ghosh, Varun Nagpal, Joseph W Covington, Marissa A Michaels, Douglas E Vaughan. Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT. Cellular signalling. 2012 May; 24(5):1031-6. doi: 10.1016/j.cellsig.2011.12.024. [PMID: 22245495]
  • Rolf W Sparidans, Selvi Durmus, Ning Xu, Alfred H Schinkel, Jan H M Schellens, Jos H Beijnen. Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 May; 895-896(?):169-73. doi: 10.1016/j.jchromb.2012.03.020. [PMID: 22476055]
  • Rolf W Sparidans, Selvi Durmus, Ning Xu, Alfred H Schinkel, Jan H M Schellens, Jos H Beijnen. Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 May; 895-896(?):174-7. doi: 10.1016/j.jchromb.2012.03.021. [PMID: 22476054]
  • Patricio E Ray. Can we cure HIV-1-associated nephropathy in transgenic mice?. Kidney international. 2012 May; 81(9):811-3. doi: 10.1038/ki.2012.13. [PMID: 22499139]
  • Yong Yang, Ke Liu, Dafang Zhong, Xiaoyan Chen. Simultaneous determination of flumatinib and its two major metabolites in plasma of chronic myelogenous leukemia patients by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 May; 895-896(?):25-30. doi: 10.1016/j.jchromb.2012.03.008. [PMID: 22472641]
  • Yifei Zhong, Yingwei Wu, Ruijie Liu, Yueyi Deng, Sandeep K Mallipattu, Paul E Klotman, Peter Y Chuang, John C He. Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure. Kidney international. 2012 May; 81(9):856-64. doi: 10.1038/ki.2011.467. [PMID: 22258322]
  • Maria Kwiatkowska, Katarzyna Popłońska, Agnieszka Wojtczak, Dariusz Stępiński, Justyna Teresa Polit. Lipid body biogenesis and the role of microtubules in lipid synthesis in Ornithogalum umbellatum lipotubuloids. Cell biology international. 2012 May; 36(5):455-62. doi: 10.1042/cbi20100638. [PMID: 22295975]
  • Weiwei Mao, Mengmeng Ning, Zhiqing Liu, Qingzhang Zhu, Ying Leng, Ao Zhang. Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators. Bioorganic & medicinal chemistry. 2012 May; 20(9):2982-91. doi: 10.1016/j.bmc.2012.03.008. [PMID: 22459213]
  • Oscar Sasso, Rosalia Bertorelli, Tiziano Bandiera, Rita Scarpelli, Giampiero Colombano, Andrea Armirotti, Guillermo Moreno-Sanz, Angelo Reggiani, Daniele Piomelli. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacological research. 2012 May; 65(5):553-63. doi: 10.1016/j.phrs.2012.02.012. [PMID: 22420940]
  • Jean Charles Isner, Thomas Nühse, Frans J M Maathuis. The cyclic nucleotide cGMP is involved in plant hormone signalling and alters phosphorylation of Arabidopsis thaliana root proteins. Journal of experimental botany. 2012 May; 63(8):3199-205. doi: 10.1093/jxb/ers045. [PMID: 22345640]
  • Paul R Gavine, Lorraine Mooney, Elaine Kilgour, Andrew P Thomas, Katherine Al-Kadhimi, Sarah Beck, Claire Rooney, Tanya Coleman, Dawn Baker, Martine J Mellor, A Nigel Brooks, Teresa Klinowska. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer research. 2012 Apr; 72(8):2045-56. doi: 10.1158/0008-5472.can-11-3034. [PMID: 22369928]
  • Norbert G Knebel, Rolf Herzog, Felix Reutter, Karl Zech. Sensitive quantification of roflumilast and roflumilast N-oxide in human plasma by LC-MS/MS employing parallel chromatography and electrospray ionisation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 893-894(?):82-91. doi: 10.1016/j.jchromb.2012.02.038. [PMID: 22425388]
  • G J E Schmitt, S Dresel, T Frodl, C la Fougère, R Boerner, K Hahn, H-J Möller, E M Meisenzahl. Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients. European archives of psychiatry and clinical neuroscience. 2012 Apr; 262(3):183-91. doi: 10.1007/s00406-011-0269-4. [PMID: 22081145]
  • Martin Y H Zhang, Daniel Ranch, Renata C Pereira, Harvey J Armbrecht, Anthony A Portale, Farzana Perwad. Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice. Endocrinology. 2012 Apr; 153(4):1806-16. doi: 10.1210/en.2011-1831. [PMID: 22334725]
  • Scott Parker, Nanhai G Chen, Scott Foster, Hollyce Hartzler, Ed Hembrador, Dennis Hruby, Robert Jordan, Randall Lanier, George Painter, Wesley Painter, John E Sagartz, Jill Schriewer, R Mark Buller. Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox. Antiviral research. 2012 Apr; 94(1):44-53. doi: 10.1016/j.antiviral.2012.02.005. [PMID: 22381921]
  • Hervé F Avenot, Anna Thomas, Ronald D Gitaitis, David B Langston, Katherine L Stevenson. Molecular characterization of boscalid- and penthiopyrad-resistant isolates of Didymella bryoniae and assessment of their sensitivity to fluopyram. Pest management science. 2012 Apr; 68(4):645-51. doi: 10.1002/ps.2311. [PMID: 22076736]
  • Bixi Jian, Shaolong Yang, Irshad H Chaudry, Raghavan Raju. Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1. Molecular medicine (Cambridge, Mass.). 2012 Mar; 18(?):209-14. doi: 10.2119/molmed.2011.00365. [PMID: 22113495]
  • Huirong Fan, Ruixing Li, Yuan Gu, Duanyun Si, Changxiao Liu. Quantitation of bentysrepinine (Y101) in rat plasma by liquid chromatography tandem mass spectrometry: application to pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Mar; 889-890(?):103-9. doi: 10.1016/j.jchromb.2012.02.002. [PMID: 22366283]
  • Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. Journal of medicinal chemistry. 2012 Mar; 55(5):2287-300. doi: 10.1021/jm201528b. [PMID: 22263894]
  • Wei Zhang, Xue-Jun Li, Xin Zeng, Dong-Yan Shen, Chang-Qin Liu, Hui-Jie Zhang, Cang-Bao Xu, Xiao-Ying Li. Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro. Toxicology letters. 2012 Mar; 209(2):107-12. doi: 10.1016/j.toxlet.2011.12.005. [PMID: 22207076]
  • D M Kerr, N N Burke, G K Ford, T J Connor, B Harhen, L J Egan, D P Finn, M Roche. Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor. Neuroscience. 2012 Mar; 204(?):53-63. doi: 10.1016/j.neuroscience.2011.09.032. [PMID: 21952131]
  • Fatma Acheuk, Michel Cusson, Bahia Doumandji-Mitiche. Effects of a methanolic extract of the plant Haplophyllum tuberculatum and of teflubenzuron on female reproduction in the migratory locust, Locusta migratoria (Orthoptera: Oedipodinae). Journal of insect physiology. 2012 Mar; 58(3):335-41. doi: 10.1016/j.jinsphys.2011.12.004. [PMID: 22206884]
  • Nicholas P Gray, Stuart A McDougall, John R Dean. Analytical bias between species caused by matrix effects in quantitative analysis of a small-molecule pharmaceutical candidate in plasma. Bioanalysis. 2012 Mar; 4(6):675-84. doi: 10.4155/bio.12.11. [PMID: 22452258]
  • Quan Hu, Jiake Chai, Sen Hu, Guoyong Zhou, Zhiyong Sheng. Oral hypertonic electrolyte-glucose/mosapride complex solution for resuscitation of burn shock in dogs. Journal of burn care & research : official publication of the American Burn Association. 2012 Mar; 33(2):e63-9. doi: 10.1097/bcr.0b013e31823dc6f4. [PMID: 22138812]
  • Emilie Le Roux-Goglin, Christine Varon, Pirjo Spuul, Corinne Asencio, Francis Mégraud, Elisabeth Génot. Helicobacter infection induces podosome assembly in primary hepatocytes in vitro. European journal of cell biology. 2012 Mar; 91(3):161-70. doi: 10.1016/j.ejcb.2011.11.003. [PMID: 22306377]
  • Verónica Rachel Olate, Mariano Walter Pertino, Cristina Theoduloz, Erdem Yesilada, Francisco Monsalve, Paulo González, Daniel Droguett, Pascal Richomme, A Hamid Hadi, Guillermo Schmeda-Hirschmann. New gastroprotective labdeneamides from (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-diene-15-oate. Planta medica. 2012 Mar; 78(4):362-7. doi: 10.1055/s-0031-1280453. [PMID: 22250049]
  • Zhigang Wang, Xiaobing Dou, Dongfang Gu, Chen Shen, Tong Yao, Van Nguyen, Carol Braunschweig, Zhenyuan Song. 4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin-proteasome degradation. Molecular and cellular endocrinology. 2012 Feb; 349(2):222-31. doi: 10.1016/j.mce.2011.10.027. [PMID: 22085560]
  • Sylvie Mavel, Zoya Mincheva, Nathalie Méheux, Yvan Carcenac, Denis Guilloteau, Mohamed Abarbri, Patrick Emond. QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT). Bioorganic & medicinal chemistry. 2012 Feb; 20(4):1388-95. doi: 10.1016/j.bmc.2012.01.014. [PMID: 22300887]
  • D P K Ng, A Salim, Y Liu, L Zou, F G Xu, S Huang, H Leong, C N Ong. A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus. Diabetologia. 2012 Feb; 55(2):499-508. doi: 10.1007/s00125-011-2339-6. [PMID: 22038517]
  • Toshifumi Shiraga, Kanako Yajima, Kenta Suzuki, Katsuhiro Suzuki, Tadashi Hashimoto, Takafumi Iwatsubo, Aiji Miyashita, Takashi Usui. Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine. Drug metabolism and disposition: the biological fate of chemicals. 2012 Feb; 40(2):276-82. doi: 10.1124/dmd.111.042614. [PMID: 22031623]
  • Dorothy B Colagiovanni, Daniel W Drolet, Emilie Langlois-Forget, Marie-Pier Piché, Doug Looker, Gary J Rosenthal. A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma. Regulatory toxicology and pharmacology : RTP. 2012 Feb; 62(1):115-24. doi: 10.1016/j.yrtph.2011.12.012. [PMID: 22210450]
  • R Pili, B Salumbides, M Zhao, S Altiok, D Qian, J Zwiebel, M A Carducci, M A Rudek. Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours. British journal of cancer. 2012 Jan; 106(1):77-84. doi: 10.1038/bjc.2011.527. [PMID: 22134508]
  • H Matsushita, M Matsuzaki, X-J Han, T-I Nishiki, I Ohmori, H Michiue, H Matsui, K Tomizawa. Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation. Neuroscience. 2012 Jan; 200(?):13-8. doi: 10.1016/j.neuroscience.2011.11.001. [PMID: 22088430]
  • Sugunadevi Sakkiah, Chandrasekaran Meganathan, Young-Sik Sohn, Sundaraganesan Namadevan, Keun Woo Lee. Identification of important chemical features of 11β-hydroxysteroid dehydrogenase type1 inhibitors: application of ligand based virtual screening and density functional theory. International journal of molecular sciences. 2012; 13(4):5138-5162. doi: 10.3390/ijms13045138. [PMID: 22606035]
  • Bruce C Campbell, Kathleen L Chan, Jong H Kim. Chemosensitization as a means to augment commercial antifungal agents. Frontiers in microbiology. 2012; 3(?):79. doi: 10.3389/fmicb.2012.00079. [PMID: 22393330]
  • Li Shen, Michael Ciesielski, Swathi Ramakrishnan, Kiersten M Miles, Leigh Ellis, Paula Sotomayor, Protul Shrikant, Robert Fenstermaker, Roberto Pili. Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models. PloS one. 2012; 7(1):e30815. doi: 10.1371/journal.pone.0030815. [PMID: 22303460]
  • Jueun Oh, Tao Yu, Soo Jeong Choi, Yanyan Yang, Heung Soo Baek, Soon Ae An, Lee Kyoung Kwon, Jinsol Kim, Ho Sik Rho, Song Seok Shin, Wahn Soo Choi, Sungyoul Hong, Jae Youl Cho. Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid. Mediators of inflammation. 2012; 2012(?):781375. doi: 10.1155/2012/781375. [PMID: 22577255]
  • Victor Fang, Lori D Wazny, Colette B Raymond. Hypoglycemics for the treatment of type 2 diabetes in patients with chronic kidney disease: a focus on new agents. CANNT journal = Journal ACITN. 2012 Jan; 22(1):30-6; quiz 37. doi: NULL. [PMID: 22558681]
  • Toshifumi Shiraga, Kanako Yajima, Takuya Teragaki, Katsuhiro Suzuki, Tadashi Hashimoto, Takafumi Iwatsubo, Aiji Miyashita, Takashi Usui. Identification of enzymes responsible for the N-oxidation of darexaban glucuronide, the pharmacologically active metabolite of darexaban, and the glucuronidation of darexaban N-oxides in human liver microsomes. Biological & pharmaceutical bulletin. 2012; 35(3):413-21. doi: 10.1248/bpb.35.413. [PMID: 22382330]
  • Jesper T Andreasen, John P Redrobe, Elsebet Ø Nielsen. Combined α7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: a comparison of SSR180711 and PNU-282987. Pharmacology, biochemistry, and behavior. 2012 Jan; 100(3):624-9. doi: 10.1016/j.pbb.2011.11.004. [PMID: 22108649]
  • Yoshiyuki Iwatsuki, Takayuki Sato, Yumiko Moritani, Takeshi Shigenaga, Mami Suzuki, Tomihisa Kawasaki, Toshiyuki Funatsu, Seiji Kaku. Biochemical and pharmacological profile of darexaban, an oral direct factor Xa inhibitor. European journal of pharmacology. 2011 Dec; 673(1-3):49-55. doi: 10.1016/j.ejphar.2011.10.009. [PMID: 22040919]
  • Mat Ropi Muktar, Norfaizah Osman, Khalijah Awang, Hazrina Hazni, Ahmad Kaleem Qureshi, A Hamid A Hadi, Kazuma Zaima, Hiroshi Morita, Marc Litaudon. Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae). Molecules (Basel, Switzerland). 2011 Dec; 17(1):267-74. doi: 10.3390/molecules17010267. [PMID: 22205092]
  • Juan L Vivero-Escoto, Kathryn M L Taylor-Pashow, Rachel C Huxford, Joseph Della Rocca, Christie Okoruwa, Hongyu An, Weili Lin, Wenbin Lin. Multifunctional mesoporous silica nanospheres with cleavable Gd(III) chelates as MRI contrast agents: synthesis, characterization, target-specificity, and renal clearance. Small (Weinheim an der Bergstrasse, Germany). 2011 Dec; 7(24):3519-28. doi: 10.1002/smll.201100521. [PMID: 22069305]
  • Fukushi Hirayama, Hiroyuki Koshio, Tsukasa Ishihara, Shunichiro Hachiya, Keizo Sugasawa, Yuji Koga, Norio Seki, Ryouta Shiraki, Takeshi Shigenaga, Yoshiyuki Iwatsuki, Yumiko Moritani, Kenichi Mori, Takeshi Kadokura, Tomihisa Kawasaki, Yuzo Matsumoto, Shuichi Sakamoto, Shin-ichi Tsukamoto. Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor. Journal of medicinal chemistry. 2011 Dec; 54(23):8051-65. doi: 10.1021/jm200868m. [PMID: 21995444]
  • Gary E Meininger, Russell Scott, Maria Alba, Yue Shentu, Edmund Luo, Himal Amin, Michael J Davies, Keith D Kaufman, Barry J Goldstein. Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes. Diabetes care. 2011 Dec; 34(12):2560-6. doi: 10.2337/dc11-1200. [PMID: 21994424]
  • M D Cantley, P M Bartold, V Marino, D P Fairlie, G T Le, A J Lucke, D R Haynes. Histone deacetylase inhibitors and periodontal bone loss. Journal of periodontal research. 2011 Dec; 46(6):697-703. doi: 10.1111/j.1600-0765.2011.01392.x. [PMID: 21745207]
  • Masakazu Ishii, Ryouta Iizuka, Yuji Kiuchi, Yasuo Mori, Shunichi Shimizu. Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity. Molecular and cellular biochemistry. 2011 Dec; 358(1-2):1-11. doi: 10.1007/s11010-011-0913-3. [PMID: 21656126]
  • Roger N Gunn, Venkatesha Murthy, Ana M Catafau, Graham Searle, Santiago Bullich, Mark Slifstein, Daniele Ouellet, Stefano Zamuner, Raul Herance, Cristian Salinas, Ricardo Pardo-Lozano, Eugenii A Rabiner, Magi Farre, Marc Laruelle. Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1. Synapse (New York, N.Y.). 2011 Dec; 65(12):1319-32. doi: 10.1002/syn.20966. [PMID: 21688322]
  • Seung Hee Kang, Hee-Jeong Cho, Gayong Shim, Sangbin Lee, Su-Hyeon Kim, Han-Gon Choi, Chan-Wha Kim, Yu-Kyoung Oh. Cationic liposomal co-delivery of small interfering RNA and a MEK inhibitor for enhanced anticancer efficacy. Pharmaceutical research. 2011 Dec; 28(12):3069-78. doi: 10.1007/s11095-011-0569-4. [PMID: 21879387]
  • C Ferreira, D C Soares, C B Barreto-Junior, M T Nascimento, L Freire-de-Lima, J C Delorenzi, M E F Lima, G C Atella, E Folly, T M U Carvalho, E M Saraiva, L H Pinto-da-Silva. Leishmanicidal effects of piperine, its derivatives, and analogues on Leishmania amazonensis. Phytochemistry. 2011 Dec; 72(17):2155-64. doi: 10.1016/j.phytochem.2011.08.006. [PMID: 21885074]
  • Jun-ichi Eiki, Yasufumi Nagata, Mayumi Futamura, Kaori Sasaki-Yamamoto, Tomoharu Iino, Teruyuki Nishimura, Masato Chiba, Sumika Ohyama, Riki Yoshida-Yoshimioto, Kenji Fujii, Hideka Hosaka, Hiroko Goto-Shimazaki, Akito Kadotani, Tomoyuki Ohe, Songnian Lin, Ronald B Langdon, Joel P Berger. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs. Molecular pharmacology. 2011 Dec; 80(6):1156-65. doi: 10.1124/mol.111.074401. [PMID: 21937665]
  • Xin Li, Lina Du, Chenyun Wang. Validation of a LC/MS/MS method for the quantitation of a new gastroprokinetic agent SHR116958 and its metabolite in rat plasma. Die Pharmazie. 2011 Nov; 66(11):826-30. doi: NULL. [PMID: 22204126]
  • Mohammed N Tantawy, Todd E Peterson, Carrie K Jones, Kari Johnson, Jerri M Rook, P Jeffrey Conn, Ronald M Baldwin, M Sib Ansari, Robert M Kessler. Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot. Synapse (New York, N.Y.). 2011 Nov; 65(11):1173-80. doi: 10.1002/syn.20955. [PMID: 21584868]
  • Gregor Jost, Philipp Lengsfeld, Diana C Lenhard, Hubertus Pietsch, Joachim Hütter, Martin A Sieber. Viscosity of iodinated contrast agents during renal excretion. European journal of radiology. 2011 Nov; 80(2):373-7. doi: 10.1016/j.ejrad.2011.02.003. [PMID: 21376497]
  • Sunipa Majumdar, Eric Buckles, John Estrada, Shahriar Koochekpour. Aberrant DNA methylation and prostate cancer. Current genomics. 2011 Nov; 12(7):486-505. doi: 10.2174/138920211797904061. [PMID: 22547956]
  • Takeshi Fuchigami, Mamoru Haratake, Yasuhiro Magata, Terushi Haradahira, Morio Nakayama. Synthesis and characterization of [¹²⁵I]2-iodo N-[(S)-{(S)-1-methylpiperidin-2-yl}(phenyl)methyl]3-trifluoromethyl-benzamide as novel imaging probe for glycine transporter 1. Bioorganic & medicinal chemistry. 2011 Nov; 19(21):6245-53. doi: 10.1016/j.bmc.2011.09.010. [PMID: 21975065]
  • Kazuyoshi Yoshii, Masamichi Hirayama, Toshifumi Nakamura, Ryoko Toda, Junko Hasegawa, Mineo Takei, Yukinori Mera, Yoshihiro Kawabata. Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach. Journal of pharmaceutical sciences. 2011 Nov; 100(11):4965-73. doi: 10.1002/jps.22649. [PMID: 21630282]
  • Sócrates Golzio dos Santos, Karine Formiga Queiroga, Adriana Maria Fernandes de Oliveira, Josean Fechine Tavares, Stanley Juan Chavez Gutierrez, Margareth de Fátima Formiga Melo Diniz, José Maria Barbosa-Filho, Marcelo Sobral da Silva. Blood matrix effects for male and female Wistar rats, in simultaneous HPLC-UV determination of riparin I and III from Aniba riparia (Nees) Mez. (Lauraceae). Talanta. 2011 Oct; 86(?):233-40. doi: 10.1016/j.talanta.2011.09.008. [PMID: 22063536]
  • Victoria J Burton, Alan M Holmes, Loredana I Ciuclan, Alexander Robinson, Jan S Roger, Gabor Jarai, Andrew C Pearce, David C Budd. Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II. Blood. 2011 Oct; 118(17):4750-8. doi: 10.1182/blood-2011-05-347393. [PMID: 21900197]
  • A A Ensafi, H Karimi-Maleh, S Mallakpour, B Rezaei. Highly sensitive voltammetric sensor based on catechol-derivative-multiwall carbon nanotubes for the catalytic determination of captopril in patient human urine samples. Colloids and surfaces. B, Biointerfaces. 2011 Oct; 87(2):480-8. doi: 10.1016/j.colsurfb.2011.06.013. [PMID: 21726986]
  • Masataka Kusunoki, Kazuhiko Tsutsumi, Daisuke Sato, Aki Nakamura, Satoshi Habu, Yuichi Mori, Munehiko Morishita, Takayuki Yonemoto, Tetsuro Miyata, Yutaka Nakaya, Takao Nakamura. Pioglitazone-induced body weight gain is prevented by combined administration with the lipoprotein lipase activator NO-1886. European journal of pharmacology. 2011 Oct; 668(3):486-91. doi: 10.1016/j.ejphar.2011.07.030. [PMID: 21835171]
  • D Ouellet, S Sutherland, T Wang, P Griffini, V Murthy. First-time-in-human study with GSK1018921, a selective GlyT1 inhibitor: relationship between exposure and dizziness. Clinical pharmacology and therapeutics. 2011 Oct; 90(4):597-604. doi: 10.1038/clpt.2011.154. [PMID: 21866096]
  • J Vasantha, P Soundararajan, N Vanitharani, G Kannan, P Thennarasu, G Neenu, C Umamaheswara Reddy. Safety and efficacy of nicotinamide in the management of hyperphosphatemia in patients on hemodialysis. Indian journal of nephrology. 2011 Oct; 21(4):245-9. doi: 10.4103/0971-4065.83735. [PMID: 22022084]
  • Masataka Kusunoki, Kazuhiko Tsutsumi, Daisuke Sato, Aki Nakamura, Satoshi Habu, Yuichi Mori, Munehiko Morishita, Takayuki Yonemoto, Tetsuro Miyata, Yutaka Nakaya, Takao Nakamura. Activation of lipoprotein lipase increases serum high density lipoprotein 2 cholesterol and enlarges high density lipoprotein 2 particles in rats. European journal of pharmacology. 2011 Oct; 668(1-2):337-9. doi: 10.1016/j.ejphar.2011.06.040. [PMID: 21756896]
  • San-Cher Chen, Jinn-Yuh Guh, Tai-Du Lin, Shean-Jaw Chiou, Chi-Ching Hwang, Yu-Min Ko, Lea-Yea Chuang. Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells. Translational research : the journal of laboratory and clinical medicine. 2011 Oct; 158(4):214-24. doi: 10.1016/j.trsl.2011.06.002. [PMID: 21925118]
  • Cristina Romei, Silvia Di Prisco, Maurizio Raiteri, Luca Raiteri. Glycine release provoked by disturbed Na⁺, Na⁺ and Ca²⁺ homeostasis in cerebellar nerve endings: roles of Ca²⁺ channels, Na⁺/Ca²⁺ exchangers and GlyT2 transporter reversal. Journal of neurochemistry. 2011 Oct; 119(1):50-63. doi: 10.1111/j.1471-4159.2011.07401.x. [PMID: 21790607]
  • Ljuba Iovkova-Berends, Carmen Wängler, Thomas Zöller, Georg Höfner, Klaus Theodor Wanner, Christian Rensch, Peter Bartenstein, Alexey Kostikov, Ralf Schirrmacher, Klaus Jurkschat, Björn Wängler. t-Bu2SiF-derivatized D2-receptor ligands: the first SiFA-containing small molecule radiotracers for target-specific PET-imaging. Molecules (Basel, Switzerland). 2011 Sep; 16(9):7458-79. doi: 10.3390/molecules16097458. [PMID: 21892125]
  • Paul Hamberg, Margaret M Woo, Lin-Chi Chen, Jaap Verweij, Maria Grazia Porro, Lily Zhao, Wenkui Li, Diane van der Biessen, Sunil Sharma, Thomas Hengelage, Maja de Jonge. Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor. Cancer chemotherapy and pharmacology. 2011 Sep; 68(3):805-13. doi: 10.1007/s00280-011-1693-x. [PMID: 21706316]
  • Gregory Valania, Manmeet Singh, Mara T Slawsky. Targeting hyponatremia and hemodynamics in acute decompensated heart failure: is there a role for vasopressin antagonists?. Current heart failure reports. 2011 Sep; 8(3):198-205. doi: 10.1007/s11897-010-0035-3. [PMID: 21046492]