dethiobiotin (BioDeep_00000400006)

 

Secondary id: BioDeep_00000001323

natural product PANOMIX_OTCML-2023


代谢物信息卡片


dl-Dithiobiotin

化学式: C10H18N2O3 (214.1317358)
中文名称: 5-甲基-2-氧-4-咪唑啉己酸, D-脱硫生物素
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.06%

分子结构信息

SMILES: CC1C(NC(=O)N1)CCCCCC(=O)O
InChI: InChI=1S/C10H18N2O3/c1-7-8(12-10(15)11-7)5-3-2-4-6-9(13)14/h7-8H,2-6H2,1H3,(H,13,14)(H2,11,12,15)

描述信息

A hexanoic acid having a 5-methyl-2-oxoimidazolidin-4-yl group at the 6-position.
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D050258 - Mitosis Modulators > D008934 - Mitogens
D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography. D-Desthiobiotin also can be used for protein and cell labeling, detection and isolation[1].

同义名列表

3 个代谢物同义名

dethiobiotin; dl-Dithiobiotin; D-Desthiobiotin



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M Bean, Inna V Krieger, James C Sacchettini, Sabine Ehrt, Courtney C Aldrich, Dirk Schnappinger. Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin. Nature communications. 2024 May; 15(1):4161. doi: 10.1038/s41467-024-48448-1. [PMID: 38755122]
  • Chaoxiang Chen, Mengdi Sun, Jialin Wang, Liyun Su, Junjie Lin, Xiaomei Yan. Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour. Journal of extracellular vesicles. 2021 11; 10(13):e12163. doi: 10.1002/jev2.12163. [PMID: 34719860]
  • Benjamin Lake, Nickolas Serniuck, Eden Kapcan, Alex Wang, Anthony F Rullo. Covalent Immune Recruiters: Tools to Gain Chemical Control Over Immune Recognition. ACS chemical biology. 2020 04; 15(4):1089-1095. doi: 10.1021/acschembio.0c00112. [PMID: 32100991]
  • Yudi Ding, Nicholas H Williams, Christopher A Hunter. A Synthetic Vesicle-to-Vesicle Communication System. Journal of the American Chemical Society. 2019 11; 141(44):17847-17853. doi: 10.1021/jacs.9b09102. [PMID: 31642667]
  • Kathrin E Witzke, Kristin Rosowski, Christian Müller, Maike Ahrens, Martin Eisenacher, Dominik A Megger, Jürgen Knobloch, Andrea Koch, Thilo Bracht, Barbara Sitek. Quantitative Secretome Analysis of Activated Jurkat Cells Using Click Chemistry-Based Enrichment of Secreted Glycoproteins. Journal of proteome research. 2017 01; 16(1):137-146. doi: 10.1021/acs.jproteome.6b00575. [PMID: 27696881]
  • Anne-Marie Haughey, Benoit Guilhabert, Alexander L Kanibolotsky, Peter J Skabara, Martin D Dawson, Glenn A Burley, Nicolas Laurand. An oligofluorene truxene based distributed feedback laser for biosensing applications. Biosensors & bioelectronics. 2014 Apr; 54(?):679-86. doi: 10.1016/j.bios.2013.11.054. [PMID: 24355421]
  • Joji Grace Villamor, Farnusch Kaschani, Tom Colby, Julian Oeljeklaus, David Zhao, Markus Kaiser, Matthew P Patricelli, Renier A L van der Hoorn. Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes. Molecular & cellular proteomics : MCP. 2013 Sep; 12(9):2481-96. doi: 10.1074/mcp.m112.026278. [PMID: 23722185]
  • David Cobessi, Renaud Dumas, Virginie Pautre, Céline Meinguet, Jean-Luc Ferrer, Claude Alban. Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis. The Plant cell. 2012 Apr; 24(4):1608-25. doi: 10.1105/tpc.112.097675. [PMID: 22547782]
  • Guy Patchornik. Purification of His-tagged proteins with [desthiobiotin-BSA-EDTA] conjugates exhibiting resistance to EDTA. Bioconjugate chemistry. 2008 Mar; 19(3):673-9. doi: 10.1021/bc700368y. [PMID: 18311907]
  • S Chiruvolu, S Walker, J Israelachvili, F J Schmitt, D Leckband, J A Zasadzinski. Higher order self-assembly of vesicles by site-specific binding. Science (New York, N.Y.). 1994 Jun; 264(5166):1753-6. doi: 10.1126/science.8209255. [PMID: 8209255]
  • S M Krassner, B Granger, P Phermsangngnam, T Le, V Linden. Further studies on substrates inducing metacyclogenesis in Trypanosoma cruzi. The Journal of protozoology. 1990 Mar; 37(2):128-32. doi: 10.1111/j.1550-7408.1990.tb05882.x. [PMID: 2181116]
  • T Schneider, R Dinkins, K Robinson, J Shellhammer, D W Meinke. An embryo-lethal mutant of Arabidopsis thaliana is a biotin auxotroph. Developmental biology. 1989 Jan; 131(1):161-7. doi: 10.1016/s0012-1606(89)80047-8. [PMID: 2909401]