deferoxamine (BioDeep_00000399828)

Main id: BioDeep_00000006382

 

natural product


代谢物信息卡片


N-(5-aminopentyl)-N-hydroxy-N-[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl]butanediamide

化学式: C25H48N6O8 (560.3533448)
中文名称: 去铁胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(=O)N(O)CCCCCNC(CCC(=O)N(O)CCCCCN)=O)CC(=O)NCCCCCN(C(C)=O)O
InChI: InChI=1/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)

描述信息

V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AC - Iron chelating agents
D064449 - Sequestering Agents > D002614 - Chelating Agents > D007502 - Iron Chelating Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19[1][2][3][4][5].

同义名列表

6 个代谢物同义名

deferoxamine; N-(5-aminopentyl)-N-hydroxy-N-[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl]butanediamide; Desferrioxamine b; Deferoxamine B; Deferriferrioxamine B; Deferrioxamine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jinfu Zhou, Jianping Tang, Chenran Zhang, Guilin Li, Xinpei Lin, Sining Liao, Jinying Luo, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Wenya Shao, Hong Hu, Liangpu Xu, Siying Wu, Huangyuan Li. ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage. Free radical biology & medicine. 2024 Aug; 220(?):271-287. doi: 10.1016/j.freeradbiomed.2024.05.014. [PMID: 38734267]
  • Mahdi Babamir Satehi, Mahdi Karimi, Zohreh Farrokhian, Fateme Pakbaz. The effect of aqueous extract of Iranian oak (Quercus brantii) on antioxidant capacity and oxidative stress in beta-thalassemia patients: Randomized controlled trial. Clinical nutrition ESPEN. 2024 Jun; 61(?):230-236. doi: 10.1016/j.clnesp.2024.03.037. [PMID: 38777439]
  • Jing Li, Xiang Lu, Mengjia Weng, Yiru Wang, Jun Tang, Qian Xu, Lei Zhang, Jiaojiao Bai. Promoting tissue repair using deferoxamine nanoparticles loaded biomimetic gelatin/HA composite hydrogel. Biomedical materials (Bristol, England). 2024 May; 19(4):. doi: 10.1088/1748-605x/ad46ba. [PMID: 38697149]
  • S Nithyapriya, Lalitha Sundaram, Sakthi Uma Devi Eswaran, Kahkashan Perveen, Najla A Alshaikh, R Z Sayyed, Andrea Mastinu. Purification and Characterization of Desferrioxamine B of Pseudomonas fluorescens and Its Application to Improve Oil Content, Nutrient Uptake, and Plant Growth in Peanuts. Microbial ecology. 2024 Apr; 87(1):60. doi: 10.1007/s00248-024-02377-0. [PMID: 38630182]
  • Pei-Heng Lu, Peng-Wei Ma, Wei-Long Wang, Wei Gao, Jia-Wei Chen, Hao Yuan, Xue-Rui Ding, Yu-Qiang Lun, Rui Liang, Si-Yu Li, Zi Wang, Jia-Ning Guo, Hong-Kai Mei, Lian-Jun Lu. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity. Biochimica et biophysica acta. Molecular basis of disease. 2024 Jan; 1870(3):167024. doi: 10.1016/j.bbadis.2024.167024. [PMID: 38242180]
  • Yidan Liang, Yanglingxi Wang, Chao Sun, Yi Xiang, Yongbing Deng. Deferoxamine reduces endothelial ferroptosis and protects cerebrovascular function after experimental traumatic brain injury. Brain research bulletin. 2024 Jan; 207(?):110878. doi: 10.1016/j.brainresbull.2024.110878. [PMID: 38218407]
  • Mahdi Aalikhani, Ensie Taheri, Masoumeh Khalili. Vanillin serves as a potential substitute for chemical chelator desferal in iron-overloaded mice. European journal of pharmacology. 2023 Dec; 960(?):176153. doi: 10.1016/j.ejphar.2023.176153. [PMID: 38059446]
  • Caihong Wu, Wenxin Zhang, Feifei Yan, Wenwen Dai, Fang Fang, Yanli Gao, Weiwei Cui. Amelioration effects of the soybean lecithin-gallic acid complex on iron-overload-induced oxidative stress and liver damage in C57BL/6J mice. Pharmaceutical biology. 2023 Dec; 61(1):37-49. doi: 10.1080/13880209.2022.2151632. [PMID: 36573499]
  • Vasko Gerzilov, Madlena Andreeva, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova. Improvement of diluted semen from Muscovy (Cairina moschata) drakes by the addition of water-soluble antioxidants. Reproduction in domestic animals = Zuchthygiene. 2023 Oct; ?(?):. doi: 10.1111/rda.14487. [PMID: 37818658]
  • X Zhang, Z Wu, H Lan, S Chen, J Wu, L Zhu, Y Xiao. [Deferoxamine promotes recovery of bone marrow hematopoietic function in mice exposed to a sublethal dose of X-ray irradiation]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 Sep; 43(9):1577-1584. doi: 10.12122/j.issn.1673-4254.2023.09.15. [PMID: 37814872]
  • Haoran Jia, Xilei Liu, Yiyao Cao, Hanhong Niu, LanZhang, RuiJun Li, Fanjian Li, Dongdong Sun, Mingming Shi, Liang Wa, Xiao Liu, Guili Yang, Fanglian Chen, Shu Zhang, Jianning Zhang. Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury. Brain research. 2023 May; ?(?):148383. doi: 10.1016/j.brainres.2023.148383. [PMID: 37149247]
  • Silvia Ghislanzoni, Gaia Martina Sarcinelli, Arianna Bresci, Francesco Manetti, Dario Polli, Antonella Tomassetti, Maria Teresa Radice, Italia Bongarzone. Reduced sulfatide content in deferoxamine-induced senescent HepG2 cells. The international journal of biochemistry & cell biology. 2023 Apr; 159(?):106419. doi: 10.1016/j.biocel.2023.106419. [PMID: 37086817]
  • Yong-Il Cheon, Ji Min Kim, Sung-Chan Shin, Hyung-Sik Kim, Jin-Choon Lee, Gi Cheol Park, Eui-Suk Sung, Minhyung Lee, Byung-Joo Lee. Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats. Aging. 2023 04; 15(7):2418-2432. doi: 10.18632/aging.204641. [PMID: 37036468]
  • Sandra Díez-Villares, Lara García-Varela, Soraya Groba-de Antas, José Ramón Caeiro, Paula Carpintero-Fernandez, María D Mayán, Pablo Aguiar, María de la Fuente. Quantitative PET tracking of intra-articularly administered 89Zr-peptide-decorated nanoemulsions. Journal of controlled release : official journal of the Controlled Release Society. 2023 04; 356(?):702-713. doi: 10.1016/j.jconrel.2023.03.025. [PMID: 36931471]
  • Shiyu Chen, Fangfang Fan, Yingrui Zhang, Jiuseng Zeng, Yuxuan Li, Ning Xu, Yi Zhang, Xian-Li Meng, Jin-Ming Lin. Metabolites from scutellarin alleviating deferoxamine-induced hypoxia injury in BV2 cells cultured on microfluidic chip combined with a mass spectrometer. Talanta. 2023 Mar; 259(?):124478. doi: 10.1016/j.talanta.2023.124478. [PMID: 36989966]
  • Xiuli Liu, Guilan Li, Shaoxiong Chen, Huiyun Jin, Xiaodong Liu, Linfang Zhang, Zhaohui Zhang. Hydrogen sulfide alleviates beryllium sulfate-induced ferroptosis and ferritinophagy in 16HBE cells. Journal of applied toxicology : JAT. 2023 Feb; ?(?):. doi: 10.1002/jat.4453. [PMID: 36843388]
  • Yufei Chen, Xueting Li, Siyuan Wang, Ran Miao, Jiuchang Zhong. Targeting Iron Metabolism and Ferroptosis as Novel Therapeutic Approaches in Cardiovascular Diseases. Nutrients. 2023 Jan; 15(3):. doi: 10.3390/nu15030591. [PMID: 36771298]
  • Zengxin Jiang, Hao Wang, Guobin Qi, Chang Jiang, Kangning Chen, Zuoqin Yan. Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study. IUBMB life. 2022 11; 74(11):1052-1069. doi: 10.1002/iub.2656. [PMID: 35638167]
  • Borong Zhou, Zhongchao Mai, Ying Ye, Yanan Song, Miao Zhang, Xinlin Yang, Wei Xia, Xiaofeng Qiu. The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer. Human cell. 2022 Nov; 35(6):1900-1911. doi: 10.1007/s13577-022-00775-5. [PMID: 36104652]
  • Yuehong Shen, Xinyu Shen, Shulin Wang, Yunyun Zhang, Yue Wang, Ye Ding, Jiayun Shen, Jianqiao Zhao, Huahan Qin, Yijiao Xu, Qian Zhou, Xindong Wang, Jianping Shen. Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway. International immunopharmacology. 2022 Nov; 112(?):109257. doi: 10.1016/j.intimp.2022.109257. [PMID: 36174419]
  • Zhaoqi He, Peng Shen, Lianjun Feng, Haoyang Hao, Yuhong He, Guyue Fan, Zhuoyu Liu, Kun Zhu, Yiqi Wang, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Jiacheng Wu. Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis. Ecotoxicology and environmental safety. 2022 Oct; 245(?):114123. doi: 10.1016/j.ecoenv.2022.114123. [PMID: 36183427]
  • Wenya Feng, Yuanjing Xiao, Chuanfang Zhao, Zhanming Zhang, Wei Liu, Juan Ma, Tomas Ganz, Junliang Zhang, Sijin Liu. New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 10; 9(29):e2202679. doi: 10.1002/advs.202202679. [PMID: 36031399]
  • Wei-Liang Kong, Tong-Yue Wen, Ya-Hui Wang, Xiao-Qin Wu. Physiological and Transcriptome Analyses Revealed the Mechanism by Which Deferoxamine Promotes Iron Absorption in Cinnamomum camphora. International journal of molecular sciences. 2022 Aug; 23(17):. doi: 10.3390/ijms23179854. [PMID: 36077250]
  • Rongli Sun, Manman Liu, Kai Xu, Yunqiu Pu, Jiawei Huang, Jinyan Liu, Juan Zhang, Lihong Yin, Yuepu Pu. Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway. Chemico-biological interactions. 2022 Aug; 362(?):110004. doi: 10.1016/j.cbi.2022.110004. [PMID: 35661779]
  • Elisa Borella, Sean Oosterholt, Paolo Magni, Oscar Della Pasqua. Characterisation of individual ferritin response in patients receiving chelation therapy. British journal of clinical pharmacology. 2022 Aug; 88(8):3683-3694. doi: 10.1111/bcp.15290. [PMID: 35199367]
  • V A Aneesha, Asif Qayoom, S Anagha, Shah Ayub Almas, V K Naresh, Sanjay Kumawat, W Ramdas Singh, Abdul Sadam, M Dinesh, T S Shyamkumar, Monalisa Sahoo, Madhu C Lingaraju, Thakur Uttam Singh, Dinesh Kumar. Topical bilirubin-deferoxamine hastens excisional wound healing by modulating inflammation, oxidative stress, angiogenesis, and collagen deposition in diabetic rats. Journal of tissue viability. 2022 Aug; 31(3):474-484. doi: 10.1016/j.jtv.2022.04.009. [PMID: 35595596]
  • Xing Peng, Qingyun Tan, Leiming Wu, Deyin Wu, Jun Xu, Huihao Zhou, Qiong Gu. Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes. Journal of natural products. 2022 07; 85(7):1808-1815. doi: 10.1021/acs.jnatprod.2c00352. [PMID: 35796002]
  • Zhexin Ni, Yangshuo Li, Di Song, Jie Ding, Shanshan Mei, Shuai Sun, Wen Cheng, Jin Yu, Ling Zhou, Yanping Kuang, Mingqing Li, Zailong Cai, Chaoqin Yu. Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity. Cell death & disease. 2022 07; 13(7):579. doi: 10.1038/s41419-022-05037-8. [PMID: 35787614]
  • Sen Lin, Wa Gao, Chenchen Zhu, Qi Lou, Cong Ye, Yueping Ren, Rashid Mehmood, Baoshan Huang, Kaihui Nan. Efficiently suppress of ferroptosis using deferoxamine nanoparticles as a new method for retinal ganglion cell protection after traumatic optic neuropathy. Biomaterials advances. 2022 Jul; 138(?):212936. doi: 10.1016/j.bioadv.2022.212936. [PMID: 35913229]
  • Olamide B Adelusi, Anup Ramachandran, John J Lemasters, Hartmut Jaeschke. The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice. Toxicology and applied pharmacology. 2022 06; 445(?):116043. doi: 10.1016/j.taap.2022.116043. [PMID: 35513057]
  • Pavlína Hašková, Lenka Applová, Hana Jansová, Pavel Homola, Katherine J Franz, Kateřina Vávrová, Jaroslav Roh, Tomáš Šimůnek. Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine. Scientific reports. 2022 06; 12(1):9765. doi: 10.1038/s41598-022-13554-x. [PMID: 35697900]
  • Ahmad Zargari, Simon Wu, Anthea Greenway, Ken Cheng, Zane Kaplan. Effects of dual chelation therapy with deferasirox and deferoxamine in patients with beta thalassaemia major. Vox sanguinis. 2022 May; 117(5):733-737. doi: 10.1111/vox.13248. [PMID: 35014065]
  • Laurin Müller, Denise C Müller, Sandrine Kammerecker, Marco Fluri, Lukas Neutsch, Mitja Remus Emsermann, Cosima Pelludat. Priority Effects in the Apple Flower Determine If the Siderophore Desferrioxamine Is a Virulence Factor for Erwinia amylovora CFBP1430. Applied and environmental microbiology. 2022 04; 88(7):e0243321. doi: 10.1128/aem.02433-21. [PMID: 35285239]
  • Janet L Kwiatkowski, Mona Hamdy, Amal El-Beshlawy, Fatma S E Ebeid, Mohammed Badr, Abdulrahman Alshehri, Julie Kanter, Baba Inusa, Amira A M Adly, Suzan Williams, Yurdanur Kilinc, David Lee, Fernando Tricta, Mohsen S Elalfy. Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study. Blood advances. 2022 02; 6(4):1243-1254. doi: 10.1182/bloodadvances.2021004938. [PMID: 34847228]
  • Rachel P L van Swelm, Sanne Beurskens, Henry Dijkman, Erwin T G Wiegerinck, Rian Roelofs, Frank Thévenod, Johan van der Vlag, Jack F M Wetzels, Dorine W Swinkels, Bart Smeets. Kidney tubule iron loading in experimental focal segmental glomerulosclerosis. Scientific reports. 2022 01; 12(1):1199. doi: 10.1038/s41598-022-05261-4. [PMID: 35075227]
  • Yu Cao, Hong Zhang, Jianming Tang, Rui Wang. Ferulic Acid Mitigates Growth and Invasion of Esophageal Squamous Cell Carcinoma through Inducing Ferroptotic Cell Death. Disease markers. 2022; 2022(?):4607966. doi: 10.1155/2022/4607966. [PMID: 36267458]
  • Ola E Nafea, Marwa Zakaria, Tamer Hassan, Sherif M El Gebaly, Hosam E Salah. Subclinical nephrotoxicity in patients with beta-thalassemia: role of urinary kidney injury molecule. Drug and chemical toxicology. 2022 Jan; 45(1):93-102. doi: 10.1080/01480545.2019.1660362. [PMID: 31905029]
  • Yi Lyu, Xue-Ke Ren, Can-Can Guo, Zhao-Fei Li, Jin-Ping Zheng. Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance. The Journal of toxicological sciences. 2022; 47(12):519-529. doi: 10.2131/jts.47.519. [PMID: 36450496]
  • Osama Tanous, Yossi Azulay, Raphael Halevy, Tal Dujovny, Neta Swartz, Raul Colodner, Ariel Koren, Carina Levin. Renal function in β-thalassemia major patients treated with two different iron-chelation regimes. BMC nephrology. 2021 12; 22(1):418. doi: 10.1186/s12882-021-02630-5. [PMID: 34930156]
  • Shohra Qaderi, Sayed Hamid Mousavi, Attaullah Ahmadi, Shamim Arif, Shekiba Madadi, Sohrab Ayoubi, Don Eliseo Lucero-Prisno. Transfusion-dependent beta thalassemia in Afghanistan: current evidence amid COVID-19 and future recommendations. Hematology (Amsterdam, Netherlands). 2021 Dec; 26(1):432-434. doi: 10.1080/16078454.2021.1938814. [PMID: 34130618]
  • Dingxi Li, Mengli Zhang, Hongtu Chao. Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells-'utilization' of ferroptosis mechanism. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2021 Dec; 70(10-12):1177-1189. doi: 10.1007/s00011-021-01495-6. [PMID: 34537856]
  • Haipeng Cheng, Dandan Feng, Xiaohong Li, Lihua Gao, Siyuan Tang, Wei Liu, Xiaoying Wu, Shaojie Yue, Chen Li, Ziqiang Luo. Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis. Biochimica et biophysica acta. Molecular basis of disease. 2021 12; 1867(12):166204. doi: 10.1016/j.bbadis.2021.166204. [PMID: 34175430]
  • Ali Cm Johnson, Richard A Zager. Catalytic iron mediated renal stress responses during experimental cardiorenal syndrome 1 ("CRS-1"). Translational research : the journal of laboratory and clinical medicine. 2021 11; 237(?):53-62. doi: 10.1016/j.trsl.2021.06.005. [PMID: 34217897]
  • Bingquan Jian, Jiaqi Pang, Hao Xiong, Weijian Zhang, Ting Zhan, Zhongwu Su, Hanqing Lin, Huasong Zhang, Wuhui He, Yiqing Zheng. Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss. Toxicology letters. 2021 Oct; 350(?):249-260. doi: 10.1016/j.toxlet.2021.07.010. [PMID: 34302894]
  • Jinghan Li, Simeng Wang, Jiaqi Duan, Peixin Le, Chao Li, Yongpei Ding, Rui Wang, Yonggang Gao. The protective mechanism of resveratrol against hepatic injury induced by iron overload in mice. Toxicology and applied pharmacology. 2021 08; 424(?):115596. doi: 10.1016/j.taap.2021.115596. [PMID: 34044072]
  • Stephanie Probst, Johannes Fels, Bettina Scharner, Natascha A Wolff, Eleni Roussa, Rachel P L van Swelm, Wing-Kee Lee, Frank Thévenod. Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium. Archives of toxicology. 2021 08; 95(8):2719-2735. doi: 10.1007/s00204-021-03106-z. [PMID: 34181029]
  • Olga P Ajsuvakova, Margarita G Skalnaya, Bernhard Michalke, Alexey A Tinkov, Eugeny P Serebryansky, Mikhail Yu Karganov, Yulia S Medvedeva, Anatoly V Skalny. Alteration of iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) tissue levels and speciation in rats with desferioxamine-induced iron deficiency. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2021 08; 34(4):923-936. doi: 10.1007/s10534-021-00318-9. [PMID: 34003408]
  • Yasir Abdul, Weiguo Li, Rebecca Ward, Mohammed Abdelsaid, Sherif Hafez, Guangkuo Dong, Sarah Jamil, Victoria Wolf, Maribeth H Johnson, Susan C Fagan, Adviye Ergul. Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis. Translational stroke research. 2021 08; 12(4):615-630. doi: 10.1007/s12975-020-00844-7. [PMID: 32875455]
  • Amaury Guillou, Daniel F Earley, Simon Klingler, Eda Nisli, Laura J Nüesch, Rachael Fay, Jason P Holland. The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody. Bioconjugate chemistry. 2021 07; 32(7):1263-1275. doi: 10.1021/acs.bioconjchem.1c00172. [PMID: 34056896]
  • Mohamed Belmouhand, Christina Eckmann-Hansen, Tomas Ilginis, Eva Birgitte Leinøe, Bo Kok Mortensen, Michael Larsen. Iron overload and iron chelating agent exposure in anemia-associated outer retinal degeneration: a case report and review of the literature. BMC ophthalmology. 2021 Jul; 21(1):277. doi: 10.1186/s12886-021-02030-1. [PMID: 34256738]
  • Dhiman Maitra, Benjamin M Pinsky, Amenah Soherawardy, Haiyan Zheng, Ruma Banerjee, M Bishr Omary. Protein-aggregating ability of different protoporphyrin-IX nanostructures is dependent on their oxidation and protein-binding capacity. The Journal of biological chemistry. 2021 07; 297(1):100778. doi: 10.1016/j.jbc.2021.100778. [PMID: 34023387]
  • Denise Bellotti, Maurizio Remelli. Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113255. [PMID: 34071479]
  • Valeria M Nurchi, Rosita Cappai, Nadia Spano, Gavino Sanna. A Friendly Complexing Agent for Spectrophotometric Determination of Total Iron. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113071. [PMID: 34063849]
  • Hua Tu, Yuan-Jing Zhou, Li-Jing Tang, Xiao-Ming Xiong, Xiao-Jie Zhang, Md Sayed Ali Sheikh, Jie-Jie Zhang, Xiu-Ju Luo, Chuang Yuan, Jun Peng. Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis. European journal of pharmacology. 2021 May; 898(?):173999. doi: 10.1016/j.ejphar.2021.173999. [PMID: 33675785]
  • Run-Ze Yang, Wen-Ning Xu, Huo-Liang Zheng, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang, Sheng-Dan Jiang. Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis. Journal of cellular physiology. 2021 04; 236(4):2725-2739. doi: 10.1002/jcp.30039. [PMID: 32892384]
  • Marion Chomet, Maxime Schreurs, Maria J Bolijn, Mariska Verlaan, Wissam Beaino, Kari Brown, Alex J Poot, Albert D Windhorst, Herman Gill, Jan Marik, Simon Williams, Joseph Cowell, Gilles Gasser, Thomas L Mindt, Guus A M S van Dongen, Danielle J Vugts. Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical 89Zr-immuno-PET. European journal of nuclear medicine and molecular imaging. 2021 03; 48(3):694-707. doi: 10.1007/s00259-020-05002-7. [PMID: 32889615]
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