Mevastatin (BioDeep_00000399728)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

化学式: C23H34O5 (390.2406)
中文名称: 美伐他汀
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 85.96%

Reviewed

Last reviewed on 2024-10-09.

Cite this Page

Mevastatin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/mevastatin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000399728). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
InChI: InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1

描述信息

Mevastatin is a carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals. It has a role as a fungal metabolite, an EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor, an antifungal agent, a Penicillium metabolite and an apoptosis inducer. It is a carboxylic ester, a statin (naturally occurring), a member of hexahydronaphthalenes, a member of 2-pyranones and a polyketide.

Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G0/G1 phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment.

Mevastatin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=73573-88-3 (retrieved 2024-10-09) (CAS RN: 73573-88-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

6 个代谢物同义名

Mevastatin; Compactin_120180; Compactin; ML236B; Mevastatin; Mevastatin



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

53 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 BCL2, CDH1, CTNNB1, GLI3, MYH7, MYLK, PCNT, PRC1, PRKX, TTN
Peripheral membrane protein 2 MBP, TAFAZZIN
Endoplasmic reticulum membrane 2 BCL2, HMGCR
Nucleus 11 BCL2, CBX5, CDH1, CTNNB1, GLI3, H2BC21, MBP, PARP1, PRC1, PRKX, TTN
cytosol 12 BCL2, CDH1, CTNNB1, GLI3, H2BC21, MBP, MYLK, PARP1, PCNT, PRC1, TPM1, TTN
mitochondrial membrane 1 TAFAZZIN
nuclear body 1 PARP1
trans-Golgi network 1 CDH1
centrosome 2 CTNNB1, PCNT
nucleoplasm 8 CBX5, CDH1, CTNNB1, GLI3, H2BC21, PARP1, PRC1, PRKX
Cell membrane 3 CDH1, CTNNB1, ITGAM
Cytoplasmic side 1 MBP
Cleavage furrow 1 MYLK
lamellipodium 3 CDH1, CTNNB1, MYLK
ruffle membrane 1 TPM1
Multi-pass membrane protein 1 HMGCR
Synapse 3 CTNNB1, MBP, MYLK
cell cortex 1 CTNNB1
cell junction 2 CDH1, CTNNB1
cell surface 2 ITGAM, MBP
glutamatergic synapse 2 CDH1, CTNNB1
Golgi apparatus 2 ATRN, CDH1
Golgi membrane 1 INS
mitochondrial inner membrane 1 TAFAZZIN
neuronal cell body 1 MBP
postsynapse 1 CDH1
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 PARP1
endosome 1 CDH1
plasma membrane 7 ATRN, CDH1, CTNNB1, ITGAM, MBP, MYLK, PRC1
Membrane 9 BCL2, CDH1, CTNNB1, HMGCR, ITGAM, PARP1, PCNT, TAFAZZIN, TPM1
basolateral plasma membrane 1 CTNNB1
extracellular exosome 7 ATRN, CDH1, CTNNB1, H2BC21, ITGAM, MBP, TTN
endoplasmic reticulum 2 BCL2, HMGCR
extracellular space 4 ATRN, H2BC21, INS, ITGAM
perinuclear region of cytoplasm 2 CDH1, CTNNB1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CDH1, CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 3 BCL2, PARP1, TAFAZZIN
protein-containing complex 5 BCL2, CBX5, CTNNB1, MBP, PARP1
intracellular membrane-bounded organelle 1 GLI3
pericentric heterochromatin 1 CBX5
Single-pass type I membrane protein 3 ATRN, CDH1, ITGAM
Secreted 1 INS
extracellular region 4 CDH1, INS, MBP, TTN
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 2 BCL2, TAFAZZIN
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, TAFAZZIN
[Isoform 2]: Secreted 1 ATRN
transcription regulator complex 2 CTNNB1, PARP1
centriolar satellite 1 PCNT
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PCNT
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CDH1
external side of plasma membrane 1 ITGAM
actin cytoskeleton 3 CDH1, MYLK, TPM1
Z disc 3 CTNNB1, MYH7, TTN
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 PRC1
nucleolus 3 CBX5, GLI3, PARP1
Wnt signalosome 1 CTNNB1
midbody 1 PRC1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Cell projection, lamellipodium 1 MYLK
Mitochondrion inner membrane 1 TAFAZZIN
heterochromatin 1 CBX5
Membrane raft 1 ITGAM
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 CTNNB1, TPM1
focal adhesion 1 CTNNB1
microtubule 1 PCNT
spindle 1 PRC1
Cell junction, adherens junction 2 CDH1, CTNNB1
flotillin complex 2 CDH1, CTNNB1
myofibril 1 MYH7
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 1 MBP
fascia adherens 1 CTNNB1
lateral plasma membrane 2 CDH1, CTNNB1
axoneme 1 GLI3
ciliary tip 1 GLI3
nuclear speck 1 GLI3
Cytoplasm, myofibril, sarcomere 1 MYH7
sarcomere 2 MYH7, TPM1
ciliary base 1 GLI3
cilium 1 GLI3
chromatin 1 PARP1
cell periphery 2 CTNNB1, MBP
Chromosome 3 CBX5, PARP1, PRC1
cytoskeleton 1 TPM1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
[Isoform 3]: Nucleus 1 MBP
centriole 1 PCNT
Golgi apparatus, trans-Golgi network 1 CDH1
Nucleus, nucleolus 1 PARP1
spindle pole 2 CTNNB1, PRC1
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 CBX5, PARP1
actin filament 1 TPM1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 PARP1
[Isoform 3]: Secreted 1 ATRN
Cytoplasm, cytoskeleton, spindle pole 1 PRC1
intercellular bridge 1 PRC1
myosin filament 1 MYH7
myosin II complex 1 MYH7
nuclear envelope 2 CBX5, PARP1
Endomembrane system 1 CTNNB1
endosome lumen 1 INS
Chromosome, centromere 1 CBX5
Cytoplasm, myofibril 1 MYH7
I band 1 TTN
M band 1 TTN
myosin complex 1 MYH7
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
euchromatin 1 CTNNB1
myelin sheath 2 BCL2, MBP
Peroxisome membrane 1 HMGCR
stress fiber 3 MYH7, MYLK, TPM1
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 1 MBP
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
histone methyltransferase complex 1 CBX5
transcription repressor complex 2 CBX5, GLI3
kinetochore 1 CBX5
histone deacetylase complex 1 CBX5
mitotic spindle midzone 1 PRC1
transport vesicle 2 INS, MBP
beta-catenin-TCF complex 1 CTNNB1
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
condensed nuclear chromosome 1 TTN
[Isoform 2]: Cytoplasm 1 TAFAZZIN
presynaptic active zone cytoplasmic component 1 CTNNB1
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
ribonucleoprotein complex 1 CBX5
[Isoform 2]: Nucleus 1 CDH1
protein-DNA complex 2 CTNNB1, PARP1
spindle microtubule 1 PRC1
apical junction complex 1 CDH1
[Isoform 1]: Cell membrane 1 ATRN
nucleosome 1 H2BC21
chromocenter 1 CBX5
contractile ring 1 PRC1
Intermembrane side 1 TAFAZZIN
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 2 CDH1, CTNNB1
site of DNA damage 2 CBX5, PARP1
integrin complex 1 ITGAM
bleb 1 TPM1
compact myelin 1 MBP
internode region of axon 1 MBP
integrin alphaM-beta2 complex 1 ITGAM
muscle myosin complex 1 MYH7
muscle thin filament tropomyosin 1 TPM1
GLI-SUFU complex 1 GLI3
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[Isoform 6]: Cytoplasm 1 TAFAZZIN
[Bone marrow proteoglycan]: Secreted 1 MBP
beta-catenin-TCF7L2 complex 1 CTNNB1
striated muscle thin filament 1 TTN
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
Myelin membrane 1 MBP
[Isoform 8]: Cytoplasm 1 TAFAZZIN
[Isoform 9]: Cytoplasm 1 TAFAZZIN
[Isoform 1]: Mitochondrion membrane 1 TAFAZZIN
[Isoform 3]: Mitochondrion membrane 1 TAFAZZIN
[Isoform 5]: Mitochondrion membrane 1 TAFAZZIN
[Isoform 7]: Mitochondrion membrane 1 TAFAZZIN
organelle 1 TTN


文献列表

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