Chrysophanic acid (BioDeep_00000398597)

PANOMIX_OTCML-2023

代谢物信息卡片

Chrysophanic acid

化学式: C15H10O4 (254.0579)
中文名称: 大黄酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=C2C(=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O
InChI: InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3

描述信息

relative retention time with respect to 9-anthracene Carboxylic Acid is 1.321
D009676 - Noxae > D009153 - Mutagens
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.322
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.318
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.324
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.

同义名列表

3 个代谢物同义名

Chrysophanic acid; Chrysophanol; Chrysophanol

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:3687
PubChem: 10208
ChEMBL: CHEMBL41092
CAS: 481-74-3
MoNA: BML80948
MoNA: BML80947
MoNA: BML80946
MoNA: BML80945
MoNA: BML01181
MoNA: BML01172
MoNA: BML01163
MoNA: BML01132
MoNA: BML01120
medchemexpress: HY-13595
KEGG: C10315
PubChem: 12501
KNApSAcK: 3687

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

205 个相关的物种来源信息

2182550 - Abrus melanospermus: 10.1055/S-2007-971214
102750 - Ageratina altissima: 10.1515/ZNB-2005-0916
25641 - Aloe: 10.1002/JPS.2600580211
1389490 - Aloe aculeata: 10.1016/S0031-9422(00)94771-X
45385 - Aloe arborescens:
48875 - Aloe bakeri:
1331516 - Aloe broomii: 10.1016/S0176-1617(11)81144-2
1813110 - Aloe calidophila: 10.1016/S0031-9422(00)94771-X
1593063 - Aloe camperi: 10.1016/S0031-9422(00)94771-X
1389495 - Aloe castellorum: 10.1080/14786410802242851
1188283 - Aloe chabaudii: 10.1016/S0031-9422(00)94771-X
1593069 - Aloe debrana:
1813113 - Aloe elgonica: 10.1016/S0176-1617(11)81144-2
1389501 - Aloe ellenbeckii: 10.1016/S0031-9422(00)94771-X
117798 - Aloe ferox: 10.1016/S0176-1617(11)81144-2
1128790 - Aloe globuligemma:
1128792 - Aloe greatheadii: 10.1016/S0031-9422(00)94771-X
1389509 - Aloe harlana: 10.1016/S0031-9422(00)94771-X
247124 - Aloe humilis: 10.1016/S0176-1617(11)81144-2
1593082 - Aloe khamiesensis: 10.1016/0305-1978(94)90102-3
1389513 - Aloe kilifiensis: 10.1016/S0031-9422(00)94771-X
1593086 - Aloe lateritia: 10.1016/S0031-9422(00)94771-X
212387 - Aloe macra: 10.1016/0305-1978(95)00063-1
1593091 - Aloe macrocarpa: 10.1016/S0031-9422(00)94771-X
1155789 - Aloe maculata:
1389516 - Aloe megalacantha: 10.1016/S0031-9422(00)94771-X
117806 - Aloe nyeriensis: 10.1016/S0176-1617(11)81144-2
210981 - Aloe occidentalis: 10.1016/0305-1978(95)00063-1
49726 - Aloe purpurea: 10.1016/0305-1978(95)00063-1
1811902 - Aloe rivae:
1593106 - Aloe schelpei: 10.1016/S0031-9422(00)94771-X
1593107 - Aloe secundiflora: 10.1016/S0031-9422(00)94771-X
1593109 - Aloe sinana: 10.1016/S0031-9422(00)94771-X
1128810 - Aloe succotrina:
1389527 - Aloe trichosantha: 10.1016/S0031-9422(00)94771-X
1331519 - Aloe vaombe: 10.1016/0305-1978(94)90102-3
34199 - Aloe vera:
1593115 - Aloe volkensii: 10.1016/S0176-1617(11)81144-2
888276 - Aloidendron dichotomum: 10.1016/S0176-1617(11)81144-2
2686335 - Alvaradoa haitiensis:
2686329 - Alvaradoa jamaicensis:
714442 - Ampelopsis Japonica: -
184783 - Areca Catechu L.: -
35608 - Artemisia annua: 10.1016/S0278-6915(99)00027-7
180472 - Asahinea chrysantha: 10.1007/BF00638766
1133552 - Asphodeline damascena: 10.1016/0031-9422(85)80028-5
49696 - Asphodeline lutea: 10.1007/S10600-010-9604-7
2269067 - Asphodeline taurica: 10.1016/0031-9422(89)80076-7
49698 - Asphodelus aestivus: 10.1016/S0031-9422(00)90193-6
207931 - Asphodelus albus: 10.1055/S-0028-1097723
1497607 - Asphodelus fistulosus:
1423376 - Asphodelus tenuifolius: 10.1016/S0031-9422(00)90193-6
314325 - Aster sedifolius: 10.1016/S0031-9422(98)00354-9
588669 - Aster tataricus: 10.1016/S0031-9422(98)00354-9
1226760 - Berchemia floribunda: 10.1248/CPB.56.1248
749552 - Boeremia foveata: 10.1042/BJ0980112
2511937 - Bulbine abyssinica: 10.1016/J.TET.2005.01.040
53852 - Cassia fistula:
162709 - Cassia grandis:
508996 - Cassia javanica:
1231245 - Cassia renigera:
948717 - Cassia roxburghii:
38033 - Chaetomium globosum: 10.1055/S-2002-34415
948715 - Chamaecrista mimosoides: 10.1055/S-2007-969598
1526916 - Chamaecrista pumila: 10.1016/S0367-326X(99)00041-6
103745 - Chromolaena odorata: 10.1515/ZNB-2005-0916
13427 - Cichorium intybus: 10.1016/S0278-6915(99)00027-7
392618 - Cunila: 10.1007/S00299-018-2303-8
117953 - Dendrobium fimbriatum: 10.5530/PJ.2014.3.6
117978 - Dendrobium thyrsiflorum: 10.1016/J.PHYTOCHEM.2005.04.001
52152 - Elymus repens: 10.1016/S0278-6915(99)00027-7
142771 - Entodon luridus: 10.4268/CJCMM20161809
928054 - Eremurus chinensis: 10.1021/NP9904915
526195 - Euphorbia hylonoma: 10.1016/J.FITOTE.2006.09.019
3617 - Fagopyrum esculentum: 10.1016/S0278-6915(99)00027-7
76025 - Fallopia multiflora: 10.1002/PTR.2358
198768 - Harungana madagascariensis:
34190 - Hemerocallis fulva: 10.3109/13880209009082803
106683 - Karwinskia humboldtiana: 10.1016/S0031-9422(00)88492-7
555898 - Kniphofia caulescens: 10.1016/0305-1978(88)90089-0
555937 - Kniphofia ensifolia: 10.1016/J.BMC.2013.11.032
214838 - Kniphofia foliosa:
214840 - Kniphofia insignis: 10.1016/0031-9422(86)80014-0
214841 - Kniphofia isoetifolia: 10.1016/0031-9422(86)80014-0
555912 - Kniphofia linearifolia: 10.1016/0305-1978(88)90089-0
214842 - Kniphofia pumila: 10.1016/0031-9422(86)80014-0
214843 - Kniphofia schimperi: 10.1016/0031-9422(86)80014-0
4236 - Lactuca sativa: 10.1016/S0278-6915(99)00027-7
2689076 - Ligusticum chuanxiong: 10.4268/CJCMM20111013
2689076 - Ligusticum chuanxiong Hort.: -
1508160 - Ligusticum striatum: 10.4268/CJCMM20111013
106689 - Maesopsis eminii: 10.1055/S-2007-969586
38448 - Monilinia fructicola:
71662 - Monodictys: 10.1248/CPB.55.1097
424903 - Osmanthus armatus: 10.1080/14786410802689713
217990 - Phormium cookianum: 10.1021/NP50052A039
51475 - Phormium tenax: 10.1021/NP50052A039
1129486 - Picramnia antidesma:
2686326 - Picramnia hirsuta:
681474 - Picramnia latifolia:
2686319 - Picramnia sellowii: 10.1021/NP070560C
3888 - Pisum sativum: 10.1016/S0278-6915(99)00027-7
101996 - Plantago coronopus: 10.1016/S0278-6915(99)00027-7
39414 - Plantago lanceolata: 10.1016/S0278-6915(99)00027-7
33090 - Plants: -
158314 - Polyporus umbellatus: 10.1007/S10600-009-9229-X
999591 - Psorospermum febrifugum: 10.1016/0031-9422(83)83041-6
139234 - Pyrenophora catenaria: 10.1016/S0031-9422(00)91370-0
438378 - Ramularia uredinicola: 10.1021/NP800138Y
3610 - Rhamnus cathartica:
105902 - Rhamnus davurica: 10.1021/NP010030V
1813053 - Rhamnus formosana: 10.1016/0031-9422(90)85356-K
1813059 - Rhamnus kurdica: 10.3109/13880209209053982
1813207 - Rhamnus nakaharae: 10.1021/NP50085A021
1813065 - Rhamnus pallasii: 10.1007/BF00574350
280022 - Rhamnus prinoides: 10.1002/(SICI)1099-1565(199903/04)10:2<69::AID-PCA447>3.0.CO;2-4
1778787 - Rhamnus punctata: 10.3109/13880209209053982
1819798 - Rhamnus wightii: 10.1016/0031-9422(91)83502-C
3620 - Rheum: 10.1002/(SICI)1099-0801(199807/08)12:4<193::AID-BMC729>3.0.CO;2-7
694412 - Rheum acuminatum: 10.1016/0378-8741(84)90016-3
284362 - Rheum alexandrae: 10.1016/0378-8741(84)90016-3
574896 - Rheum altaicum: 10.1016/0378-8741(84)90016-3
284363 - Rheum australe:
137216 - Rheum compactum: 10.1016/0378-8741(84)90016-3
694413 - Rheum delavayi:
240182 - Rheum franzenbachii:
137217 - Rheum hotaoense: 10.1016/0378-8741(84)90016-3
240183 - Rheum kialense: 10.1016/0378-8741(84)90016-3
137218 - Rheum likiangense: 10.1016/0378-8741(84)90016-3
137219 - Rheum nanum: 10.1055/S-2008-1074562
137697 - Rheum nobile: 10.1016/0378-8741(84)90016-3
137220 - Rheum officinale:
694414 - Rheum palaestinum: 10.1016/S0031-9422(00)00341-1
137221 - Rheum palmatum:
137223 - Rheum pumilum: 10.1016/0378-8741(84)90016-3
2743666 - Rheum racemiferum:
137224 - Rheum reticulatum: 10.1016/0378-8741(84)90016-3
3621 - Rheum rhabarbarum:
46087 - Rheum rhaponticum:
240184 - Rheum spiciforme: 10.1016/0378-8741(84)90016-3
137225 - Rheum sublanceolatum: 10.1055/S-2008-1074562
137226 - Rheum tanguticum:
205071 - Rheum tataricum: 10.1016/0378-8741(84)90016-3
137227 - Rheum undulatum:
137228 - Rheum wittrockii: 10.1016/0378-8741(84)90016-3
267261 - Rosa villosa:
3618 - Rumex: 10.1016/J.BMCL.2013.04.059
273505 - Rumex abyssinicus:
41241 - Rumex acetosa:
1351827 - Rumex alpinus:
1786032 - Rumex chalepensis:
174649 - Rumex crispus:
278676 - Rumex cristatus: 10.1042/BJ0980112
1006352 - Rumex dentatus: 10.1039/P19750000689
174651 - Rumex japonicus:
174652 - Rumex nepalensis:
137229 - Rumex patientia:
1786036 - Rumex pictus: 10.1016/0305-1978(93)90049-W
242528 - Rumex scutatus: 10.1515/ZNC-1997-9-1014
59067 - Ruscus aculeatus: 10.1007/S40278-014-1868-4
268908 - Salvia greggii:
281910 - Sanguisorba alpina: 10.1016/0031-9422(92)80123-V
1353961 - Selaginella delicatula: 10.1007/S10600-011-0013-3
53923 - Senna alata:
72402 - Senna alexandrina:
948713 - Senna auriculata: 10.1111/J.2042-7158.1974.TB09356.X
346959 - Senna corymbosa: 10.1016/0031-9422(92)80483-U
72401 - Senna didymobotrya:
756587 - Senna garrettiana: 10.1111/J.2042-7158.1974.TB09356.X
1842781 - Senna gaudichaudii: 10.1055/S-0028-1097458
346974 - Senna italica:
162908 - Senna lindheimeriana: 10.1016/0031-9422(92)80483-U
2601745 - Senna longiracemosa: 10.1016/S0031-9422(00)95104-5
346975 - Senna macranthera: 10.1111/J.2042-7158.1974.TB09356.X
1288009 - Senna macranthera var. micans:
346985 - Senna obtusifolia:
126820 - Senna occidentalis:
992784 - Senna petersiana: 10.1016/S0367-326X(00)00155-6
346407 - Senna quinquangulata:
346998 - Senna septemtrionalis:
346999 - Senna siamea:
1977557 - Senna singueana:
948718 - Senna sophera:
347003 - Senna spectabilis: 10.1111/J.2042-7158.1974.TB09356.X
948714 - Senna sulfurea: 10.1055/S-0028-1097458
362788 - Senna tora:
347010 - Senna villosa: 10.1016/S0031-9422(00)94783-6
365555 - Shorea worthingtonii: 10.1016/S0031-9422(00)91468-7
66098 - Simethis mattiazzii: 10.3109/13880208509070680
1883 - Streptomyces: 10.1038/JA.2008.63
2382096 - Strossmayeria bakeriana: 10.1016/S0031-9422(00)88708-7
28573 - Talaromyces islandicus: 10.3390/BIOM9020068
5544 - Trichoderma harzianum:
40695 - Trichoderma polysporum: 10.1016/S0031-9422(00)81684-2
5547 - Trichoderma viride: 10.1139/V67-020
263405 - Trirhabda geminata: 10.1515/ZNC-1996-3-417
5691 - Trypanosoma brucei:
1390085 - Ventilago denticulata:
108868 - Ventilago leiocarpa: 10.1021/NP000569D
106720 - Ventilago viminalis: 10.1071/CH9630695
1137045 - Vismia cayennensis: 10.1016/S0031-9422(00)83481-0
999598 - Vismia guianensis:
1348480 - Vismia latifolia: 10.1002/1097-458X(200012)38:12<1027::AID-MRC777>3.0.CO;2-3
29760 - Vitis vinifera: 10.1016/S0278-6915(99)00027-7
72655 - Xanthorrhoea australis: 10.1071/CH9740331

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	14	AKT1, ANXA5, BCL2, CASP1, CASP3, CCND1, MAPK8, MTOR, NLRP3, NOS2, PIK3CA, PPARG, PTGS2, STAT3
Peripheral membrane protein	4	ANXA5, GORASP1, MTOR, PTGS2
Endoplasmic reticulum membrane	3	BCL2, MTOR, PTGS2
Nucleus	10	AKT1, BCL2, CASP3, CCND1, MAPK8, MTOR, NLRP3, NOS2, PPARG, STAT3
cytosol	13	AKT1, ANXA5, BCL2, CASP1, CASP3, CCND1, MAPK8, MTOR, NLRP3, NOS2, PIK3CA, PPARG, STAT3
dendrite	1	MTOR
phagocytic vesicle	1	MTOR
centrosome	1	CCND1
nucleoplasm	8	AKT1, CASP3, CCND1, MAPK8, MTOR, NOS2, PPARG, STAT3
RNA polymerase II transcription regulator complex	2	PPARG, STAT3
Cell membrane	3	AKT1, CASP1, TNF
Cytoplasmic side	2	GORASP1, MTOR
lamellipodium	2	AKT1, PIK3CA
Golgi apparatus membrane	3	GORASP1, MTOR, NLRP3
Synapse	1	MAPK8
cell cortex	1	AKT1
cell surface	1	TNF
glutamatergic synapse	2	AKT1, CASP3
Golgi apparatus	1	GORASP1
Golgi membrane	4	GORASP1, INS, MTOR, NLRP3
lysosomal membrane	1	MTOR
neuronal cell body	2	CASP3, TNF
postsynapse	1	AKT1
sarcolemma	1	ANXA5
Cytoplasm, cytosol	2	NLRP3, NOS2
Lysosome	1	MTOR
plasma membrane	6	AKT1, CASP1, NOS2, PIK3CA, STAT3, TNF
Membrane	5	AKT1, ANXA5, BCL2, MTOR, NLRP3
axon	2	CCK, MAPK8
caveola	1	PTGS2
extracellular exosome	1	ANXA5
Lysosome membrane	1	MTOR
endoplasmic reticulum	3	BCL2, NLRP3, PTGS2
extracellular space	5	CCK, IL10, IL6, INS, TNF
perinuclear region of cytoplasm	3	NOS2, PIK3CA, PPARG
bicellular tight junction	1	CCND1
intercalated disc	1	PIK3CA
mitochondrion	2	BCL2, NLRP3
protein-containing complex	4	AKT1, BCL2, CASP1, PTGS2
intracellular membrane-bounded organelle	1	PPARG
Microsome membrane	2	MTOR, PTGS2
postsynaptic density	1	CASP3
TORC1 complex	1	MTOR
TORC2 complex	1	MTOR
Secreted	5	CCK, IL10, IL6, INS, NLRP3
extracellular region	7	ANXA5, CCK, IL10, IL6, INS, NLRP3, TNF
Mitochondrion outer membrane	2	BCL2, MTOR
Single-pass membrane protein	1	BCL2
mitochondrial outer membrane	2	BCL2, MTOR
transcription regulator complex	1	STAT3
Nucleus membrane	2	BCL2, CCND1
Bcl-2 family protein complex	1	BCL2
nuclear membrane	2	BCL2, CCND1
external side of plasma membrane	2	ANXA5, TNF
microtubule cytoskeleton	1	AKT1
nucleolus	1	CASP1
Cytoplasm, P-body	1	NOS2
P-body	1	NOS2
cell-cell junction	1	AKT1
recycling endosome	1	TNF
Single-pass type II membrane protein	1	TNF
vesicle	1	AKT1
Cytoplasm, perinuclear region	1	NOS2
Membrane raft	1	TNF
pore complex	1	BCL2
focal adhesion	1	ANXA5
microtubule	1	CASP1
spindle	1	AKT1
cis-Golgi network	1	GORASP1
Peroxisome	1	NOS2
peroxisomal matrix	1	NOS2
Nucleus, PML body	1	MTOR
PML body	1	MTOR
Mitochondrion intermembrane space	1	AKT1
mitochondrial intermembrane space	1	AKT1
collagen-containing extracellular matrix	1	ANXA5
Cytoplasm, cytoskeleton, microtubule organizing center	1	NLRP3
Inflammasome	1	NLRP3
interphase microtubule organizing center	1	NLRP3
NLRP3 inflammasome complex	2	CASP1, NLRP3
Nucleus inner membrane	1	PTGS2
Nucleus outer membrane	1	PTGS2
nuclear inner membrane	1	PTGS2
nuclear outer membrane	1	PTGS2
receptor complex	1	PPARG
Zymogen granule membrane	1	ANXA5
neuron projection	1	PTGS2
ciliary basal body	1	AKT1
chromatin	2	PPARG, STAT3
phagocytic cup	1	TNF
nuclear envelope	1	MTOR
Endomembrane system	2	MTOR, NLRP3
endosome lumen	1	INS
microtubule organizing center	1	NLRP3
myelin sheath	1	BCL2
secretory granule lumen	1	INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	3	IL6, INS, PTGS2
transcription repressor complex	1	CCND1
phosphatidylinositol 3-kinase complex	1	PIK3CA
phosphatidylinositol 3-kinase complex, class IA	1	PIK3CA
transport vesicle	1	INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	2	GORASP1, INS
Golgi apparatus, cis-Golgi network membrane	1	GORASP1
AIM2 inflammasome complex	1	CASP1
vesicle membrane	1	ANXA5
basal dendrite	1	MAPK8
death-inducing signaling complex	1	CASP3
canonical inflammasome complex	1	CASP1
Cytoplasmic vesicle, phagosome	1	MTOR
cyclin-dependent protein kinase holoenzyme complex	1	CCND1
[Tumor necrosis factor, soluble form]: Secreted	1	TNF
cortical cytoskeleton	1	NOS2
interleukin-6 receptor complex	1	IL6
endothelial microparticle	1	ANXA5
BAD-BCL-2 complex	1	BCL2
cyclin D1-CDK4 complex	1	CCND1
cyclin D1-CDK6 complex	1	CCND1
IPAF inflammasome complex	1	CASP1
NLRP1 inflammasome complex	1	CASP1
protease inhibitor complex	1	CASP1
phosphatidylinositol 3-kinase complex, class IB	1	PIK3CA
[C-domain 2]: Secreted	1	TNF
[Tumor necrosis factor, membrane form]: Membrane	1	TNF
[C-domain 1]: Secreted	1	TNF

文献列表

Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
吉 Deji, Jun Lan, Basangyangzong, Dawazhuoma. [Establishment and Optimization of Quality Standards for the Traditional Tibetan Medicine Preparation of Liuwei Nengxiao Pills]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2024 Mar; 55(2):425-432. doi: 10.12182/20240360102. [PMID: 38645843]
Razieh Amini, Shadi Moradi, Rezvan Najafi, Mehrdokht Mazdeh, Amir Taherkhani. BACE1 Inhibition Utilizing Organic Compounds Holds Promise as a Potential Treatment for Alzheimer's and Parkinson's Diseases. Oxidative medicine and cellular longevity. 2024; 2024(?):6654606. doi: 10.1155/2024/6654606. [PMID: 38425997]
Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
Huijuan Lv, Jingjing Niu, Wenhao Pan, Yudong Wang, Lifang Wang, Meng Wang, Yali Shi, Guifang Zhang, Bandar Al Hamyari, Shaohua Wang, Xuefeng Li, Yanbin Shi. Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117336. doi: 10.1016/j.jep.2023.117336. [PMID: 37907143]
H Wang, M Li, S Li, J Shi, L Huang, S Cheng, C Zou, H Yan. [Spectrum-effect relationship of total anthraquinone extract of Cassia seeds against fluorouracil-induced liver injury in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 May; 43(5):825-831. doi: 10.12122/j.issn.1673-4254.2023.05.19. [PMID: 37313825]
Hanaa M Sayed, Mahmoud A Ramadan, Heba H Salem, Iqrar Ahmad, Harun Patel, Marwa A A Fayed. Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L. Steroids. 2023 May; 196(?):109245. doi: 10.1016/j.steroids.2023.109245. [PMID: 37141980]
Su-Kang Kim, Ju-Yeon Ban, Hyungoo Kang, Sang-Il Park. Anti-Apoptotic Effect of Chrysophanol Isolated from Cassia tora Seed Extract on Blue-Light-Induced A2E-Loaded Human Retinal Pigment Epithelial Cells. International journal of molecular sciences. 2023 Apr; 24(7):. doi: 10.3390/ijms24076676. [PMID: 37047648]
Meng Zhang, Zhi-Xian Ding, Wei Huang, Jing Luo, Shu Ye, Sheng-Lin Hu, Peng Zhou, Biao Cai. Chrysophanol exerts a protective effect against Aβ25-35-induced Alzheimer's disease model through regulating the ROS/TXNIP/NLRP3 pathway. Inflammopharmacology. 2023 Mar; ?(?):. doi: 10.1007/s10787-023-01201-4. [PMID: 36976486]
Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
Lingling Wang, Guoying Zhou, Shuo Zhao, Yang Yang. Soluble protein content, bioactive compounds and the antioxidant activity in seeds of ten Rheum tanguticum lines from Qinghai-Tibet Plateau. Chemistry & biodiversity. 2023 Feb; ?(?):e202200901. doi: 10.1002/cbdv.202200901. [PMID: 36788177]
Jiajie Lu, Zhimin Miao, Yuhan Jiang, Weiyi Xia, Xian Wang, Yifeng Shi, Libin Ni, Sunlong Li, Jian Xiao, Sunren Sheng, Haiming Jin. Chrysophanol prevents IL-1β-Induced inflammation and ECM degradation in osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis. Biochemical pharmacology. 2023 02; 208(?):115402. doi: 10.1016/j.bcp.2022.115402. [PMID: 36592706]
Maria Goretti de Vasconcelos Silva, Daniele Rodrigues de Lima, Jackelyne Alves Monteiro, Francisco Ernani Alves Magalhães. Anxiolytic-like effect of chrysophanol from Senna cana stem in adult zebrafish (Danio rerio). Natural product research. 2022 Sep; 36(17):4426-4430. doi: 10.1080/14786419.2021.1980788. [PMID: 34547943]
Aarti Sharma, Sonalika Bhalla, Sidharth Mehan. PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats. Metabolic brain disease. 2022 08; 37(6):1909-1929. doi: 10.1007/s11011-022-01026-0. [PMID: 35687217]
Pengchegn Li, Xiaohan Zhu, Mi Xiao, Yanqi Su, Shanshan Yu, Jintian Tang, Hongkun Xue, Xu Cai. Rapid Isolation and Hypoglycemic Activity of Secondary Metabolites of Eurotium cristatum by High-Speed Countercurrent Chromatography. Journal of chromatographic science. 2022 Mar; ?(?):. doi: 10.1093/chromsci/bmac020. [PMID: 35325046]
Xinquan Li, Yaxun Cheng, Yunpeng Qin, Huawu Gao, Guangyun Wang, Hang Song, Yan Wang, Biao Cai. Chrysophanol exerts neuroprotective effects via interfering with endoplasmic reticulum stress apoptotic pathways in cell and animal models of Alzheimer's disease. The Journal of pharmacy and pharmacology. 2022 Jan; 74(1):32-40. doi: 10.1093/jpp/rgab148. [PMID: 34791341]
Xu Zhao, Dongge Qiao, Dongsheng Guan, Kun Wang, Yinglin Cui. Chrysophanol Ameliorates Hemin-Induced Oxidative Stress and Endoplasmic Reticulum Stress by Regulating MicroRNA-320-5p/Wnt3a Pathway in HT22 Cells. Oxidative medicine and cellular longevity. 2022; 2022(?):9399658. doi: 10.1155/2022/9399658. [PMID: 35936221]
Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang. A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112482. doi: 10.1016/j.biopha.2021.112482. [PMID: 34915669]
Wanlapa Nuankaew, Armad Heemman, Chatchai Wattanapiromsakul, Ji Heon Shim, Na Woo Kim, Tamanna Yasmin, Seo Yule Jeong, Youn Hee Nam, Bin Na Hong, Sukanya Dej-Adisai, Tong Ho Kang. Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure-activity relationships. Journal of natural medicines. 2021 Jun; 75(3):520-531. doi: 10.1007/s11418-021-01490-5. [PMID: 33620670]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Cheemalamarri Chandrasekhar, Hemshikha Rajpurohit, Kalpana Javaji, Madhusudana Kuncha, Aravind Setti, A Zehra Ali, Ashok K Tiwari, Sunil Misra, C Ganesh Kumar. Anti-hyperglycemic and genotoxic studies of 1-O-methyl chrysophanol, a new anthraquinone isolated from Amycolatopsis thermoflava strain SFMA-103. Drug and chemical toxicology. 2021 Mar; 44(2):148-160. doi: 10.1080/01480545.2018.1551406. [PMID: 30614298]
Ramasamy Harikrishnan, Gunapathy Devi, Chellam Balasundaram, Hien Van Doan, Sanchai Jaturasitha, Einar Ringø, Caterina Faggio. Effect of chrysophanic acid on immune response and immune genes transcriptomic profile in Catla catla against Aeromonas hydrophila. Scientific reports. 2021 01; 11(1):612. doi: 10.1038/s41598-020-79629-9. [PMID: 33436677]
Mingjia Gu, Lidan Lu, Qingxue Wei, Zhiwei Miao, Hang Zhang, Leiping Gao, Lejun Li. Improved oral bioavailability and anti-chronic renal failure activity of chrysophanol via mixed polymeric micelles. Journal of microencapsulation. 2021 Jan; 38(1):47-60. doi: 10.1080/02652048.2020.1849440. [PMID: 33175576]
Chan-Yen Kuo, Valeria Chiu, Po-Chun Hsieh, Chun-Yen Huang, S Joseph Huang, I-Shiang Tzeng, Fu-Ming Tsai, Mao-Liang Chen, Chien-Ting Liu, Yi-Ru Chen. Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis. Journal of pharmacological sciences. 2020 Nov; 144(3):172-182. doi: 10.1016/j.jphs.2020.07.014. [PMID: 32811746]
Fang Dou, Yi Ding, Cheng Wang, Jialin Duan, Wenjun Wang, Hang Xu, Xian Zhao, Jingwen Wang, Aidong Wen. Chrysophanol ameliorates renal interstitial fibrosis by inhibiting the TGF-β/Smad signaling pathway. Biochemical pharmacology. 2020 10; 180(?):114079. doi: 10.1016/j.bcp.2020.114079. [PMID: 32511988]
Danting Li, Bo Lv, Di Wang, Doudou Xu, Siyuan Qin, Ying Zhang, Jie Chen, Wei Zhang, Zunjian Zhang, Fengguo Xu. Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Jul; 72(?):153236. doi: 10.1016/j.phymed.2020.153236. [PMID: 32464544]
Yuanyuan Liu, Chuanqian Liu, Xueting Zhang, Zhenzhen Liu, Xipeng Yan. Chrysophanol protects PC12 cells against oxygen glucose deprivation-evoked injury by up-regulating miR-216a. Cell cycle (Georgetown, Tex.). 2020 06; 19(12):1433-1442. doi: 10.1080/15384101.2020.1731655. [PMID: 32401588]
Xueying Liu, Zehong Yang, Huixuan Li, Wen Luo, Wentao Duan, Junmei Zhang, Zhangzhi Zhu, Min Liu, Saimei Li, Xiaoyi Xin, Haoxiang Wu, Shaoxiang Xian, Meijing Liu, Changhui Liu, Chuangpeng Shen. Chrysophanol Alleviates Metabolic Syndrome by Activating the SIRT6/AMPK Signaling Pathway in Brown Adipocytes. Oxidative medicine and cellular longevity. 2020; 2020(?):7374086. doi: 10.1155/2020/7374086. [PMID: 33274005]
Chuan Guo, Yarong Wang, Yuanlin Piao, Xiangrong Rao, Dehai Yin. Chrysophanol Inhibits the Progression of Diabetic Nephropathy via Inactivation of TGF-β Pathway. Drug design, development and therapy. 2020; 14(?):4951-4962. doi: 10.2147/dddt.s274191. [PMID: 33235436]
Ya-Jun Bai, Yan-Bin Du, Xin-Zhu Yuan, Ning Yuan, Jiang Pu, Quan-Jun Zhang. [Regulation of Chrysophanol-mediated TLR4/NF-κB Pathway on Renal Injury and Immune Response in IgA Nephropathy Rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2019 Dec; 50(6):840-846. doi: . [PMID: 31880115]
Mohammad K Parvez, Mohammed S Al-Dosari, Perwez Alam, MdTabish Rehman, Mohammed F Alajmi, Ali S Alqahtani. The anti-hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera. Phytotherapy research : PTR. 2019 Nov; 33(11):2960-2970. doi: 10.1002/ptr.6471. [PMID: 31410907]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Noha Fathalla, Mokhtar Bishr, Abdel Nasser Singab, Osama Salama. GC-MS and LC-MS Identification of the Phenolic Compounds Present in the ethyl Acetate Fraction Obtained from Senna tora, L. Roxb. seeds. Natural product research. 2019 Oct; 33(19):2878-2881. doi: 10.1080/14786419.2018.1508138. [PMID: 30445876]
Long Xie, Hailong Tang, Jiawen Song, Jiaying Long, Linlin Zhang, Xiaofang Li. Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics. The Journal of pharmacy and pharmacology. 2019 Oct; 71(10):1475-1487. doi: 10.1111/jphp.13143. [PMID: 31373015]
Bing Yang, Li Xie, Siying Peng, Kanping Sun, Junjie Jin, Yanping Zhen, Kunming Qin, Baochang Cai. Nine components pharmacokinetic study of rat plasma after oral administration raw and prepared Semen Cassiae in normal and acute liver injury rats. Journal of separation science. 2019 Jul; 42(14):2341-2350. doi: 10.1002/jssc.201900007. [PMID: 31037812]
Hyuk Chul Kwon, Tae Yang Kim, Chun Mong Lee, Kwang Sik Lee, Kun Kook Lee. Active compound chrysophanol of Cassia tora seeds suppresses heat-induced lipogenesis via inactivation of JNK/p38 MAPK signaling in human sebocytes. Lipids in health and disease. 2019 Jun; 18(1):135. doi: 10.1186/s12944-019-1072-x. [PMID: 31174532]
Rong-Rong Li, Xue-Fang Liu, Su-Xiang Feng, Sheng-Nan Shu, Pei-Yang Wang, Na Zhang, Jian-Sheng Li, Ling-Bo Qu. Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101898. [PMID: 31108858]
Hee-Yun Kim, Hyunwoo Jee, Jun-Ho Yeom, Hyun-Ja Jeong, Hyung-Min Kim. The ameliorative effect of AST2017-01 in an ovalbumin-induced allergic rhinitis animal model. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2019 May; 68(5):387-395. doi: 10.1007/s00011-019-01226-y. [PMID: 30874868]
Hui-Jun Gou, Ying Yang, Jie Ren, Jun Lu, Yuan Zheng, Ting Li. [Research on period of validity of emodin standard solution and chrysophanol standard solution]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Dec; 43(24):4892-4899. doi: 10.19540/j.cnki.cjcmm.2018.0129. [PMID: 30717536]
Whasun Lim, Yikyung An, Changwon Yang, Fuller W Bazer, Gwonhwa Song. Chrysophanol induces cell death and inhibits invasiveness via mitochondrial calcium overload in ovarian cancer cells. Journal of cellular biochemistry. 2018 12; 119(12):10216-10227. doi: 10.1002/jcb.27363. [PMID: 30129050]
Anzhen Chen, Lei Sun, Hang Yuan, Aiying Wu, Jingguang Lu, Shuangcheng Ma. Simultaneous qualitative and quantitative analysis of 11 active compounds in rhubarb using two reference substances by UHPLC. Journal of separation science. 2018 Oct; 41(19):3686-3696. doi: 10.1002/jssc.201800479. [PMID: 30059192]
Ki Sun Kwon, Ju Hee Lee, Kyung Su So, Byung Kyu Park, Hyun Lim, Jae Sue Choi, Hyun Pyo Kim. Aurantio-obtusin, an anthraquinone from cassiae semen, ameliorates lung inflammatory responses. Phytotherapy research : PTR. 2018 Aug; 32(8):1537-1545. doi: 10.1002/ptr.6082. [PMID: 29675883]
Ying Sun, Xin Xin, Kehan Zhang, Tiantian Cui, Ying Peng, Jiang Zheng. Cytochrome P450 mediated metabolic activation of chrysophanol. Chemico-biological interactions. 2018 Jun; 289(?):57-67. doi: 10.1016/j.cbi.2018.04.015. [PMID: 29698620]
Ulrich Hildebrandt, Alexander Marsell, Markus Riederer. Direct Effects of Physcion, Chrysophanol, Emodin, and Pachybasin on Germination and Appressorium Formation of the Barley ( Hordeum vulgare L.) Powdery Mildew Fungus Blumeria graminis f. sp. hordei (DC.) Speer. Journal of agricultural and food chemistry. 2018 Apr; 66(13):3393-3401. doi: 10.1021/acs.jafc.7b05977. [PMID: 29554805]
Jie Zhang, Hua Kang, Lifang Wang, Xiaoyan Zhao. Chrysophanol ameliorates high-fat diet-induced obesity and inflammation in neonatal rats. Die Pharmazie. 2018 04; 73(4):228-233. doi: 10.1691/ph.2018.7980. [PMID: 29609691]
Xu Chu, Shuhu Zhou, Ran Sun, Lin Wang, Chunye Xing, Ruqing Liang, Qingxia Kong. Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice. Neurochemical research. 2018 Apr; 43(4):972-983. doi: 10.1007/s11064-018-2503-1. [PMID: 29497904]
Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu. Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines. Molecular medicine reports. 2018 03; 17(3):4376-4382. doi: 10.3892/mmr.2018.8443. [PMID: 29344652]
Renato Sonchini Gonçalves, Expedito Leite Silva, Noboru Hioka, Celso Vataru Nakamura, Marcos Luciano Bruschi, Wilker Caetano. An optimized protocol for anthraquinones isolation from Rhamnus frangula L. Natural product research. 2018 Feb; 32(3):366-369. doi: 10.1080/14786419.2017.1356836. [PMID: 28745519]
Xue Wang, Lifeng Han, Gentao Li, Wei Peng, Xiumei Gao, Curtis D Klaassen, Guanwei Fan, Youcai Zhang. From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2018 02; 161(2):321-334. doi: 10.1093/toxsci/kfx216. [PMID: 29045746]
Li Kang, Luqin Si, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Apr; 40(?):313-323. doi: 10.1016/j.tiv.2017.01.022. [PMID: 28161596]
Yu-Mei Zhang, Hong-Yu Ren, Xian-Lin Zhao, Juan Li, Jun-Yi Li, Fu-Sheng Wu, Hang Su, Wen-Fu Tang. Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis. World journal of gastroenterology. 2017 Feb; 23(8):1367-1374. doi: 10.3748/wjg.v23.i8.1367. [PMID: 28293083]
Kan Chen, Chang-Qian Wang, Yu-Qi Fan, Zhi-Hua Han, Yue Wang, Lin Gao, Hua-Su Zeng. [Lipid-lowering effect of seven traditional Chinese medicine monomers in zebrafish system]. Sheng li xue bao : [Acta physiologica Sinica]. 2017 Feb; 69(1):55-60. doi: . [PMID: 28217808]
Jianhui Cheng, Lingyu Wang, Weifen Liu, David D Y Chen. Quantitative Nonaqueous Capillary Electrophoresis-Mass Spectrometry Method for Determining Active Ingredients in Plant Extracts. Analytical chemistry. 2017 02; 89(3):1411-1415. doi: 10.1021/acs.analchem.6b04944. [PMID: 28208307]
Alistair T B Richardson, Janice M Lord, Nigel B Perry. Phenylanthraquinones and flavone-C-glucosides from the disjunct Bulbinella in New Zealand. Phytochemistry. 2017 Feb; 134(?):64-70. doi: 10.1016/j.phytochem.2016.11.014. [PMID: 27939308]
Weiru Jiang, Xiangge Tian, Yan Wang, Zheng Sun, Peipei Dong, Chao Wang, Xiaokui Huo, Baojing Zhang, Shanshan Huang, Sa Deng, Xiaobo Wang, Xiaochi Ma. The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes. Toxicology letters. 2016 Nov; 262(?):27-38. doi: 10.1016/j.toxlet.2016.09.004. [PMID: 27633141]
Ang Li, Yuguang Liu, Lu Zhai, Liying Wang, Zhe Lin, Shumin Wang. Activating Peroxisome Proliferator-Activated Receptors (PPARs): a New Sight for Chrysophanol to Treat Paraquat-Induced Lung Injury. Inflammation. 2016 Apr; 39(2):928-37. doi: 10.1007/s10753-016-0326-2. [PMID: 26920845]
Lei-Chi Dong, Ya-Xi Fan, Qiong Yu, Jiang Ma, Xin Dong, Ping Li, Hui-Jun Li. Synergistic effects of rhubarb-gardenia herb pair in cholestatic rats at pharmacodynamic and pharmacokinetic levels. Journal of ethnopharmacology. 2015 Dec; 175(?):67-74. doi: 10.1016/j.jep.2015.09.012. [PMID: 26376237]
Yun-xia Li, Xiao-hong Gong, Yan Li, Ruo-qi Zhang, An Yuan, Meng-jie Zhao, Dai-wen Zeng, Cheng Peng. The Influence of Aconitum carmichaelii Debx. on the Pharmacokinetic Characteristics of Main Components in Rheum palmatum L. Phytotherapy research : PTR. 2015 Aug; 29(8):1259-64. doi: 10.1002/ptr.5369. [PMID: 25963314]
Rabigul Islam, Yultuz Mamat, Ilyar Ismayil, Ming Yan, Mahsutjan Kadir, Abdujilil Abdugheny, Haximjan Rapkat, Mardan Niyaz, Yusupjan Ali, Sirapil Abay. Toxicity of anthraquinones: differential effects of rumex seed extracts on rat organ weights and biochemical and haematological parameters. Phytotherapy research : PTR. 2015 May; 29(5):777-84. doi: 10.1002/ptr.5317. [PMID: 25753342]
Jin-Mei Li, Li-Li Ding, Bao-Liang Song, Li Yang, Zheng-Tao Wang. [Effects of chrysophanol on expression of SREBPs and lipid metabolism in Huh-7 cells]. Yao xue xue bao = Acta pharmaceutica Sinica. 2015 Feb; 50(2):174-9. doi: ". [PMID: 25975024]
Xiao Liu, Huan Li, Li Wu, Jiangwa Xing, Yanhong Poh, Hao Cai, Bao Chang Cai. Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Feb; 980(?):88-93. doi: 10.1016/j.jchromb.2014.11.025. [PMID: 25597888]
Yan-bin Shi, Hui-li Li, Hai-qin Wang, Yan-biao Yang, Xiao-yun Zhang, Hui Wang, Zong-jie Zhu, Zhi-Ye Zhang, Cheng-an Zhang. Simultaneous determination of five anthraquinones in a Chinese traditional preparation by RP-HPLC using an improved extraction procedure. Journal of integrative medicine. 2014 Sep; 12(5):455-62. doi: 10.1016/s2095-4964(14)60037-6. [PMID: 25292345]
Wenjin Wu, Nan Hu, Qingwen Zhang, Yaping Li, Peng Li, Ru Yan, Yitao Wang. In vitro glucuronidation of five rhubarb anthraquinones by intestinal and liver microsomes from humans and rats. Chemico-biological interactions. 2014 Aug; 219(?):18-27. doi: 10.1016/j.cbi.2014.05.006. [PMID: 24854283]
Ji-wen Wang, Zhi-jian Fang, Jin-le Cheng, Han-jing Yan. [Determination of anthraquinones from different medicinal parts of Berchemia lineata by HPLC]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Jun; 37(6):957-60. doi: ". [PMID: 25470957]
Xiao-yan Dai, Yun-liang Yan, Qiao-feng Wu, Chen-huan Yu, Xin Liu, Ya-qi Jiang. Comparative pharmacokinetics of rhein and chrysophanol after oral administration of Quyu Qingre granules in normal and acute blood stasis rabbits. Journal of ethnopharmacology. 2014 Apr; 153(2):338-43. doi: 10.1016/j.jep.2014.02.005. [PMID: 24642020]
Yun-Liang Yan, Xiao-Yan Dai. [Total quantity statistical moment analysis on pharmacokinetics of rhein and chrysophanol after oral administration of Quyu Qingre granules in normal and acute blood stasis rabbits]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Feb; 39(3):520-5. doi: NULL. [PMID: 24946560]
Nan Zhang, Xiangjian Zhang, Xiaoxia Liu, Hong Wang, Jing Xue, Jingying Yu, Ning Kang, Xiaolu Wang. Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice. Mediators of inflammation. 2014; 2014(?):370530. doi: 10.1155/2014/370530. [PMID: 24876671]
Yumin Dai, Liva Harinantenaina, Jessica D Bowman, Isabel Osorio Da Fonseca, Peggy J Brodie, Michael Goetz, Maria B Cassera, David G I Kingston. Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds. Bioorganic & medicinal chemistry. 2014 Jan; 22(1):269-76. doi: 10.1016/j.bmc.2013.11.032. [PMID: 24326280]
Su-xiang Feng, Jian-sheng Li, Ling-bo Qu, Yan-mei Shi, Di Zhao. Comparative pharmacokinetics of five rhubarb anthraquinones in normal and thrombotic focal cerebral ischemia-induced rats. Phytotherapy research : PTR. 2013 Oct; 27(10):1489-94. doi: 10.1002/ptr.4890. [PMID: 23180574]
Haiming Chen, Yucui Li, Xiaoli Wu, Chuwen Li, Qingguo Li, Zhen Qin, Yuyang Yi, Jiannan Chen, Xiaoping Lai, Ziren Su. LC-MS/MS determination of pogostone in rat plasma and its application in pharmacokinetic studies. Biomedical chromatography : BMC. 2013 Sep; 27(9):1092-9. doi: 10.1002/bmc.2897. [PMID: 23505096]
Yang Yang, Yong-Ming Yan, Wei Wei, Jie Luo, Lan-Sheng Zhang, Xiao-Jiang Zhou, Peng-Cheng Wang, Yong-Xun Yang, Yong-Xian Cheng. Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy. Bioorganic & medicinal chemistry letters. 2013 Jul; 23(13):3905-9. doi: 10.1016/j.bmcl.2013.04.059. [PMID: 23683594]
Zhi-Wei Wang, Jun-Song Wang, Ming-Hua Yang, Jian-Guang Luo, Ling-Yi Kong. Developmental changes in the composition of five anthraquinones from Rheum palmatum as quantified by (1) H-NMR. Phytochemical analysis : PCA. 2013 Jul; 24(4):329-35. doi: 10.1002/pca.2414. [PMID: 23364921]
I Kosalec, D Kremer, M Locatelli, F Epifano, S Genovese, G Carlucci, M Randić, M Zovko Končić. Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus alaternus, R. fallax, R. intermedia and R. pumila. Food chemistry. 2013 Jan; 136(2):335-41. doi: 10.1016/j.foodchem.2012.08.026. [PMID: 23122067]
Yong Zeng, Jian-Jun Luo, Chong Li. [Chemical constituents from aerial part of Rumex patientia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Jan; 36(1):57-60. doi: . [PMID: 23750410]
Thilo Christopher Fischer, Christian Gosch, Beate Mirbeth, Markus Gselmann, Veronika Thallmair, Karl Stich. Potent and specific bactericidal effect of juglone (5-hydroxy-1,4-naphthoquinone) on the fire blight pathogen Erwinia amylovora. Journal of agricultural and food chemistry. 2012 Dec; 60(49):12074-81. doi: 10.1021/jf303584r. [PMID: 23163769]
Yan-Min Liu, Di Tian, He Bao, Gui-Lan Zhao, Jun-Xian Wang. [Study on chemical constituents of root bark of Discocleidion rufescens]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Nov; 35(11):1795-8. doi: . [PMID: 23627092]
Hiroshi Nakano, Kevin K Schrader, Leonid K Mamonov, Tatyana S Kustova, Valentina K Mursaliyeva, Charles L Cantrell. Isolation and identification of Flavobacterium columnare and Streptococcus iniae antibacterial compounds from the terrestrial plant Atraphaxis laetevirens. Journal of agricultural and food chemistry. 2012 Oct; 60(42):10415-9. doi: 10.1021/jf304155n. [PMID: 23030835]
Han-Lin Gong, Wen-Fu Tang, Jia Wang, Guang-Yuan Chen, Xi Huang. Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats. Chinese journal of integrative medicine. 2012 Sep; 18(9):708-13. doi: 10.1007/s11655-012-1205-9. [PMID: 22936325]
Yang Wang, Xi Huang, Qing-Hua Liang, Rong Fan, Feng Qin, Yong Guo, Kui-Po Yan, Wei Liu, Jie-Kun Luo, Yun-Hui Li, Xi-Lian Mao, Zhao-Qian Liu, Hong-Hao Zhou. A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector. Chinese journal of integrative medicine. 2012 Sep; 18(9):690-8. doi: 10.1007/s11655-012-1053-7. [PMID: 22936323]
Howaida I Abd-Alla, Nagat S Abu-Gabal, Amal Z Hassan, Mounir M El-Safty, Nagwa M M Shalaby. Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents. Archives of pharmacal research. 2012 Aug; 35(8):1347-54. doi: 10.1007/s12272-012-0804-5. [PMID: 22941477]
Chu VanMen, Yu Seon Jang, Hong Mei Zhu, Jae Hyun Lee, Trinh Nam Trung, Tran Minh Ngoc, Young Ho Kim, Jong Seong Kang. Chemical-based species classification of rhubarb using simultaneous determination of five bioactive substances by HPLC and LDA analysis. Phytochemical analysis : PCA. 2012 Jul; 23(4):359-64. doi: 10.1002/pca.1365. [PMID: 22009582]
Tiffany Chien-Ting Lo, Hung-Chi Nian, Kong-Hwa Chiu, Ai-Yih Wang, Ben-Zen Wu. Rapid and efficient purification of chrysophanol in Rheum Palmatum LINN by supercritical fluid extraction coupled with preparative liquid chromatography in tandem. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 893-894(?):101-6. doi: 10.1016/j.jchromb.2012.02.040. [PMID: 22436825]
. Toxicology study of senna (CAS No. 8013-11-4) in C57BL/6NTAC Mice and toxicology and carcinogenesis study of senna in genetically modified C3B6.129F1/Tac-Trp53tm1Brd haploinsufficient mice (Feed Studies). National Toxicology Program genetically modified model report. 2012 Apr; ?(15):1-114. doi: . [PMID: 23001288]
Yong-Mao Yang, Ping Wang, Yan Zhang. [A comparative study on the absorption kinetics parameters of rhubarb free anthraquinones between normal dogs and dogs with severe acute pancreatitis]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2012 Apr; 32(4):494-8. doi: . [PMID: 22803431]
Woojung Lee, Goo Yoon, Ye Ran Hwang, Yong Kee Kim, Su-Nam Kim. Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition. BMB reports. 2012 Mar; 45(3):141-6. doi: 10.5483/bmbrep.2012.45.3.141. [PMID: 22449699]
Lijia Xu, Chi-On Chan, Ching-Ching Lau, Zhiling Yu, Daniel K W Mok, Sibao Chen. Simultaneous determination of eight anthraquinones in Semen Cassiae by HPLC-DAD. Phytochemical analysis : PCA. 2012 Mar; 23(2):110-6. doi: 10.1002/pca.1331. [PMID: 21618311]
Chuan-Li Lu, Liang Zhu, Jin-Hua Piao, Jian-Guo Jiang. Chemical compositions extracted from Wikstroemia indica and their multiple activities. Pharmaceutical biology. 2012 Feb; 50(2):225-31. doi: 10.3109/13880209.2011.596207. [PMID: 22235889]
Xiao-jun Zeng, Ying Hu, Xiao-qiong Wen, Ai-hua Hong, Ying-zhou Cen. [Chemical constituents of Berchemia lineate]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Feb; 35(2):223-5. doi: . [PMID: 22822666]
Hui Zhang, Zengjun Guo, Nan Wu, Wenming Xu, Ling Han, Nan Li, Yanxia Han. Two novel naphthalene glucosides and an anthraquinone isolated from Rumex dentatus and their antiproliferation activities in four cell lines. Molecules (Basel, Switzerland). 2012 Jan; 17(1):843-50. doi: 10.3390/molecules17010843. [PMID: 22252500]
George Binh Lenon, Kang Xiao Li, Yung-Hsien Chang, Angela Weihong Yang, Clifford Da Costa, Chun Guang Li, Marc Cohen, Neil Mann, Charlie C L Xue. Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):435702. doi: 10.1155/2012/435702. [PMID: 22550541]
Heng Wei, Chunxiu Hu, Mei Wang, Anita M van den Hoek, Theo H Reijmers, Suzan Wopereis, Jildau Bouwman, Raymond Ramaker, Henrie A A J Korthout, Marco Vennik, Thomas Hankemeier, Louis M Havekes, Renger F Witkamp, Elwin R Verheij, Guowang Xu, Jan van der Greef. Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice. PloS one. 2012; 7(1):e30332. doi: 10.1371/journal.pone.0030332. [PMID: 22291936]
Jie Tian, Xuan Chen, Xiaohong Bai. Comparison of dispersive liquid-liquid microextraction based on organic solvent and ionic liquid combined with high-performance liquid chromatography for the analysis of emodin and its metabolites in urine samples. Journal of separation science. 2012 Jan; 35(1):145-52. doi: 10.1002/jssc.201100729. [PMID: 22144110]
Yuying Wang, Weihong Feng, Fei Yang, Qiwei Zhang, Lina Ji, Dongying Li, Zhimin Wang. [Determination of four anthraquinones in Sanhuang tablets by QAMS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jan; 37(2):212-7. doi: 10.4268/cjcmm20120218. [PMID: 22737853]
Jianxin Chen, Huihui Zhao, Xueling Ma, Xiao Han, Liangtao Luo, Luya Wang, Jing Han, Bing Liu, Wei Wang. The effects of jiang-zhi-ning and its main components on cholesterol metabolism. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):928234. doi: 10.1155/2012/928234. [PMID: 22649479]
Zenghui Teng, Chengjun Yuan, Feng Zhang, Menglei Huan, Weidong Cao, Kangchu Li, Jingyue Yang, Dayong Cao, Siyuan Zhou, Qibing Mei. Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells. PloS one. 2012; 7(1):e29647. doi: 10.1371/journal.pone.0029647. [PMID: 22253753]
Samuel Saito, Givaldo Silva, Regineide Xavier Santos, Grace Gosmann, Cristina Pungartnik, Martin Brendel. Astragalin from Cassia alata induces DNA adducts in vitro and repairable DNA damage in the yeast Saccharomyces cerevisiae. International journal of molecular sciences. 2012; 13(3):2846-2862. doi: 10.3390/ijms13032846. [PMID: 22489129]
Jackson Roberto Guedes da Silva Almeida, Edigênia Cavalcante da Cruz Araújo, Luciano Augusto de Araújo Ribeiro, Julianeli Tolentino de Lima, Xirley Pereira Nunes, Ana Sílvia Suassuna Carneiro Lúcio, Maria de Fátima Agra, José Maria Barbosa Filho. Antinociceptive activity of ethanol extract from Duguetia chrysocarpa Maas (Annonaceae). TheScientificWorldJournal. 2012; 2012(?):859210. doi: 10.1100/2012/859210. [PMID: 22645460]
Zhi-Wei Wang, Jun-Song Wang, Jun Luo, Dan-Dan Wei, Ling-Yi Kong. Three new phenolic glucosides from the roots of Rheum palmatum. Chemical & pharmaceutical bulletin. 2012; 60(2):241-5. doi: 10.1248/cpb.60.241. [PMID: 22293484]
Alexsandro Branco, Angelo C Pinto, Jan Schripsema, Raimundo Braz-Filho. Anthraquinones from the bark of Senna macranthera. Anais da Academia Brasileira de Ciencias. 2011 Dec; 83(4):1159-64. doi: 10.1590/s0001-37652011000400003. [PMID: 22146951]