Dihydrocapsaicin (BioDeep_00000398299)
Main id: BioDeep_00000000325
Secondary id: BioDeep_00000866905
natural product PANOMIX_OTCML-2023
代谢物信息卡片
Dihydrocapsaicin
化学式: C18H29NO3 (307.2147)
中文名称: 二氢辣椒素
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 62.86%
分子结构信息
SMILES: CC(C)CCCCCCC(=O)NCc(c1)cc(OC)c(O)c1
InChI: InChI=1S/C18H29NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h10-12,14,20H,4-9,13H2,1-3H3,(H,19,21)
描述信息
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.274
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.271
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.269
Acquisition and generation of the data is financially supported in part by CREST/JST.
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[1][2][3].
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[1][2][3].
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[1][2][3].
同义名列表
2 个代谢物同义名
数据库引用编号
56 个数据库交叉引用编号
- ChEBI: CHEBI:46932
- KEGG: C16952
- PubChem: 107982
- ChEMBL: CHEMBL311158
- CAS: 19408-84-5
- MoNA: PS044201
- MoNA: PS044202
- MoNA: PS044203
- MoNA: PS044204
- MoNA: PS044205
- MoNA: PS044206
- MoNA: VF-NPL-QTOF007475
- MoNA: VF-NPL-QTOF007474
- MoNA: VF-NPL-QTOF007473
- MoNA: VF-NPL-QTOF007472
- MoNA: VF-NPL-QTOF007471
- MoNA: VF-NPL-QTOF007470
- MoNA: VF-NPL-QTOF007469
- MoNA: VF-NPL-QTOF007468
- MoNA: VF-NPL-QTOF007467
- MoNA: VF-NPL-LTQ000216
- MoNA: VF-NPL-LTQ000215
- MoNA: VF-NPL-LTQ000214
- MoNA: VF-NPL-LTQ000213
- MoNA: VF-NPL-QEHF000462
- MoNA: VF-NPL-QEHF000461
- MoNA: VF-NPL-QEHF000460
- MoNA: VF-NPL-QEHF000459
- MoNA: VF-NPL-QEHF000458
- MoNA: VF-NPL-QEHF000457
- MoNA: FiehnHILIC002665
- MoNA: FiehnHILIC001884
- MoNA: FiehnHILIC001152
- MoNA: FiehnHILIC000307
- MoNA: CCMSLIB00003142411
- MoNA: PT204420
- MoNA: PT104420
- MoNA: BML81108
- MoNA: BML81107
- MoNA: BML81106
- MoNA: BML81105
- MoNA: BML00778
- MoNA: BML00773
- MoNA: BML00768
- MoNA: BML00762
- MoNA: BML00755
- MoNA: BML00748
- MoNA: TY000094
- MoNA: PR100684
- MoNA: PR100260
- PubChem: 96023439
- LipidMAPS: LMFA08020318
- NIKKAJI: J126.282C
- RefMet: Dihydrocapsaicin
- medchemexpress: HY-N0361
- KNApSAcK: 46932
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 4072 - Capsicum annuum:
- 4072 - Capsicum annuum L.: -
- 40321 - Capsicum annuum var. annuum:
- 113210 - Capsicum pubescens: 10.1055/S-0028-1097200
- 33090 - Plants: -
- 94328 - Zingiber Officinale Roscoe: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mostafakamal Shams, Esra Arslan Yuksel, Guleray Agar, Melek Ekinci, Raziye Kul, Metin Turan, Ertan Yildirim. Biosynthesis of capsaicinoids in pungent peppers under salinity stress.
Physiologia plantarum.
2023 Mar; ?(?):e13889. doi:
10.1111/ppl.13889. [PMID: 36905231] - Xueqin Chen, Jingyue Yu, Huan Lei, Lei Li, Xupin Liu, Bo Liu, Yanfei Xie, Haihong Fang. Exploring the Mechanism of Buyang Huanwu Decoction Alleviating Restenosis by Regulating VSMC Phenotype Switching and Proliferation by Network Pharmacology and Molecular Docking.
Current computer-aided drug design.
2023 Feb; ?(?):. doi:
10.2174/1573409919666230203144207. [PMID: 36740793] - Uthai Wichai, Ploychanok Keawsomnuk, Saowarose Thongin, Chaiyot Mukthung, Chatchai Boonthip, Pattama Pittayakhajonwut, Pimonrat Ketsawatsomkron, Nuntavan Bunyapraphatsara, Kenjiro Muta. Cellular responses to 8-methyl nonanoic acid, a degradation by-product of dihydrocapsaicin, in 3T3-L1 adipocytes.
BMC complementary medicine and therapies.
2023 Jan; 23(1):18. doi:
10.1186/s12906-023-03844-w. [PMID: 36681810] - Leeseul Jang, Jungwon Choi, Sullim Lee, Sanghyun Lee. Protective effects of Capsicum fruits and their constituents on damage in TNF-α-stimulated human dermal fibroblasts.
Journal of the science of food and agriculture.
2022 Nov; ?(?):. doi:
10.1002/jsfa.12313. [PMID: 36325913] - Sangeeta Bhandari, Roktim Gogoi, Twahira Begum, Joyashree Baruah, Mohan Lal. Evaluation of ultra high-performance liquid chromatography (uHPLC) assisted capsaicinoids content in four different extracts of (Capsicum chinense Jacq.): their pharmacological potentials and genotoxicity study.
Natural product research.
2022 Nov; 36(21):5638-5642. doi:
10.1080/14786419.2021.2019735. [PMID: 34937448] - Alaadin E El-Haddad, Ahmed S Saad, Soad Z El-Emam, Asmaa A Amer. Correlation of Chillies Capsaicinoids Contents with their Cytotoxic Effects against Hepatocarcinoma Cells.
Pakistan journal of biological sciences : PJBS.
2021 Jan; 24(2):219-226. doi:
10.3923/pjbs.2021.219.226. [PMID: 33683051] - Catharine A Adams, Kolea Zimmerman, Kristi Fenstermacher, Mitchell G Thompson, Will Skyrud, Scott Behie, Anne Pringle. Fungal Seed Pathogens of Wild Chili Peppers Possess Multiple Mechanisms To Tolerate Capsaicinoids.
Applied and environmental microbiology.
2020 01; 86(3):. doi:
10.1128/aem.01697-19. [PMID: 31732572] - Kesinee Nanok, Sompong Sansenya. α-Glucosidase, α-amylase, and tyrosinase inhibitory potential of capsaicin and dihydrocapsaicin.
Journal of food biochemistry.
2020 01; 44(1):e13099. doi:
10.1111/jfbc.13099. [PMID: 31724206] - Milagros Liseth Castillo Rivera, Neuza Mariko Aymoto Hassimotto, Vanessa Bueris, Marcelo Palma Sircili, Felipe Alves de Almeida, Uelinton Manoel Pinto. Effect of Capsicum Frutescens Extract, Capsaicin, and Luteolin on Quorum Sensing Regulated Phenotypes.
Journal of food science.
2019 Jun; 84(6):1477-1486. doi:
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2019 Mar; 99(4):1577-1585. doi:
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2019 Jan; 99(1):269-280. doi:
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PloS one.
2019; 14(4):e0215901. doi:
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BMC veterinary research.
2018 Jun; 14(1):193. doi:
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2018 May; 98(7):2498-2506. doi:
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Journal of the science of food and agriculture.
2018 Jan; 98(1):217-224. doi:
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PloS one.
2018; 13(10):e0206183. doi:
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Plant physiology.
2017 Jul; 174(3):1359-1370. doi:
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Scientific reports.
2016 11; 6(?):38081. doi:
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Molecular medicine reports.
2016 Nov; 14(5):4198-4208. doi:
10.3892/mmr.2016.5784. [PMID: 27748914] - Qingqing Yang, Jianguo Zhu, Fei Ma, Peiwu Li, Liangxiao Zhang, Wen Zhang, Xiaoxia Ding, Qi Zhang. Quantitative determination of major capsaicinoids in serum by ELISA and time-resolved fluorescent immunoassay based on monoclonal antibodies.
Biosensors & bioelectronics.
2016 Jul; 81(?):229-235. doi:
10.1016/j.bios.2016.02.074. [PMID: 26954788] - Chiara Bignardi, Antonella Cavazza, Massimiliano Rinaldi, Claudio Corradini. Correlation between different markers for the assessment of red chilli pepper powders stability during shelf-life.
International journal of food sciences and nutrition.
2016 Jun; 67(4):391-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 May; 1021(?):137-144. doi:
10.1016/j.jchromb.2015.12.017. [PMID: 26739369] - Dimin Wang, Fanhua Meng, Lin Yu, Lu Sun, Lili Sun, Jifen Guo. A sensitive LC-MS/MS method for quantifying capsaicin and dihydrocapsaicin in rabbit plasma and tissue: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2015 Apr; 29(4):496-503. doi:
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Journal of chromatographic science.
2015 Jan; 53(1):16-23. doi:
10.1093/chromsci/bmu004. [PMID: 24557717] - George F Antonious. Elevating concentrations of capsaicin and dihydrocapsaicin in hot peppers using recycled waste.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2015; 50(7):523-32. doi:
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Journal of separation science.
2015 Jan; 38(1):100-7. doi:
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Thrombosis research.
2014 Aug; 134(2):412-7. doi:
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2014 Jul; 43(4):614-9. doi:
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Lipids in health and disease.
2014 Mar; 13(?):50. doi:
10.1186/1476-511x-13-50. [PMID: 24642298] - Qumer Iqbal, Muhammad Amjad, Muhammad Rafique Asi, Agustin Ariño. Characterization of capsaicinoids and antioxidants in hot peppers as influenced by hybrid and harvesting stage.
Plant foods for human nutrition (Dordrecht, Netherlands).
2013 Dec; 68(4):358-63. doi:
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Molecules (Basel, Switzerland).
2013 Oct; 18(11):13471-86. doi:
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Talanta.
2013 Aug; 112(?):11-9. doi:
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Molecular nutrition & food research.
2013 Jun; 57(6):1080-8. doi:
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Journal of analytical toxicology.
2013 Mar; 37(2):122-32. doi:
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PloS one.
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Journal of separation science.
2012 Nov; 35(21):2892-6. doi:
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Bioorganic & medicinal chemistry.
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Plant foods for human nutrition (Dordrecht, Netherlands).
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Phytochemistry.
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The Journal of toxicological sciences.
2011 Jan; 36(1):109-16. doi:
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2010 Aug; 878(24):2292-7. doi:
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Journal of agricultural and food chemistry.
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Hypertension (Dallas, Tex. : 1979).
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Natural product communications.
2010 Jan; 5(1):91-4. doi:
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Inflammopharmacology.
2009 Jun; 17(3):113-50. doi:
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Journal of nutritional science and vitaminology.
2009 Jun; 55(3):282-7. doi:
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Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2009 Feb; 44(2):179-84. doi:
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