Phenylalanine (BioDeep_00000398010)

Main id: BioDeep_00000000351

Secondary id: BioDeep_00000229695

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


(2S)-2-amino-3-phenylpropanoic acid

化学式: C9H11NO2 (165.0789746)
中文名称: DL-苯丙氨酸, L-苯丙氨酸, L-苯基丙氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.08%

分子结构信息

SMILES: C1=CC=C(C=C1)CC(C(=O)O)N
InChI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)

描述信息

An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.
Annotation level-2
Acquisition and generation of the data is financially supported by the Max-Planck-Society
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
IPB_RECORD: 2701; CONFIDENCE confident structure
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

同义名列表

6 个代谢物同义名

Phenylalanine; DL-Phenylalanine; L-Phenylalanine; (2S)-2-amino-3-phenylpropanoic acid; L-Phenylalanine; Phenylalanine



数据库引用编号

101 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

192 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • María A Brandan, Hugo A Pérez, Aníbal Disalvo, María de Los A Frías. Interaction of L-phenylalanine with carbonyl groups in mixed lipid membranes. Biochimica et biophysica acta. Biomembranes. 2024 Jun; 1866(5):184328. doi: 10.1016/j.bbamem.2024.184328. [PMID: 38688404]
  • Ruixiang Kang, Dong Guo, Jiawei Wang, Zhencong Xie. Association of dietary nutrient intake with type 2 diabetes: A Mendelian randomization study. Medicine. 2024 May; 103(19):e38090. doi: 10.1097/md.0000000000038090. [PMID: 38728475]
  • Xiao-Yu Zhang, Kai-Rou Xia, Ya-Ni Wang, Pei Liu, Er-Xin Shang, Cong-Yan Liu, Yu-Ping Liu, Ding Qu, Wei-Wen Li, Jin-Ao Duan, Yan Chen, Huang-Qin Zhang. Unraveling the pharmacodynamic substances and possible mechanism of Trichosanthis Pericarpium in the treatment of coronary heart disease based on plasma pharmacochemistry, network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 May; 325(?):117869. doi: 10.1016/j.jep.2024.117869. [PMID: 38342153]
  • Zhengda Zhang, Jiao Dang, Luqiao Yuan, Yuhui Zhang, Fan Zhou, Tianlai Li, Xiaohui Hu. Exogenous 5-Aminolevulinic acid improved low-temperature tolerance tomato seedling by regulating starch content and phenylalanine metabolism. Plant physiology and biochemistry : PPB. 2024 May; 210(?):108083. doi: 10.1016/j.plaphy.2023.108083. [PMID: 38615441]
  • Alex H Crum, Lisa Philander, Lucas Busta, Ya Yang. Traditional medicinal use is linked with apparency, not specialized metabolite profiles in the order Caryophyllales. American journal of botany. 2024 Apr; 111(4):e16308. doi: 10.1002/ajb2.16308. [PMID: 38581167]
  • Chun Chu, Shengquan Liu, Liangui Nie, Hongming Hu, Yi Liu, Jun Yang. The interactions and biological pathways among metabolomics products of patients with coronary heart disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116305. doi: 10.1016/j.biopha.2024.116305. [PMID: 38422653]
  • Mette G B Pedersen, Nikolaj Rittig, Maj Bangshaab, Kristoffer Berg-Hansen, Nigopan Gopalasingam, Lars C Gormsen, Esben Søndergaard, Niels Møller. Effects of exogenous lactate on lipid, protein, and glucose metabolism-a randomized crossover trial in healthy males. American journal of physiology. Endocrinology and metabolism. 2024 Apr; 326(4):E443-E453. doi: 10.1152/ajpendo.00301.2023. [PMID: 38324259]
  • Yingjie Qin, Jiayi Chen, Dali Qian, Zhongyu Li, Licong Zhang, Qingquan Ma. Excessive Tryptophan and Phenylalanine Induced Pancreatic Injury and Glycometabolism Disorder in Grower-finisher Pigs. The Journal of nutrition. 2024 Apr; 154(4):1333-1346. doi: 10.1016/j.tjnut.2024.01.019. [PMID: 38582698]
  • Krystle Angelique A Santiago, Wei Chee Wong, You Keng Goh, Seng Heng Tey, Adeline Su Yien Ting. Pathogenicity of monokaryotic and dikaryotic mycelia of Ganoderma boninense revealed via LC-MS-based metabolomics. Scientific reports. 2024 03; 14(1):5330. doi: 10.1038/s41598-024-56129-8. [PMID: 38438519]
  • Huma Tabassum, Avijit Maity, Krishna Singh, Debanjan Bagchi, Abhinav Prasad, Anjan Chakraborty. Effect of Lipid Corona on Phenylalanine-Functionalized Gold Nanoparticles to Develop Stable and Corona-Free Systems. Langmuir : the ACS journal of surfaces and colloids. 2024 02; 40(8):4531-4543. doi: 10.1021/acs.langmuir.4c00019. [PMID: 38357868]
  • Xiaocui Chen, Xue Niu, Longju Li, Kuai Chen, Dandan Song, Biao Chen, Song Yang, Zhibing Wu. Design, Synthesis, and Target Identification of Novel Phenylalanine Derivatives by Drug Affinity Responsive Target Stability (DARTS) in Xanthomonas oryzae pv Oryzae. Journal of agricultural and food chemistry. 2024 Feb; 72(7):3436-3444. doi: 10.1021/acs.jafc.3c09267. [PMID: 38320759]
  • Kateryna Kukil, Pia Lindberg. Metabolic engineering of Synechocystis sp. PCC 6803 for the improved production of phenylpropanoids. Microbial cell factories. 2024 Feb; 23(1):57. doi: 10.1186/s12934-024-02330-3. [PMID: 38369470]
  • Thais Regina Mezzomo, Marcia Regina Messaggi Gomes Dias, Tatiane Santos, Rosana Marques Pereira. Dietary intake in individuals with phenylketonuria: an integrative review. Nutricion hospitalaria. 2024 Feb; 41(1):212-223. doi: 10.20960/nh.04579. [PMID: 37705455]
  • Sarathadevi Rajendran, Patrick Silcock, Phil Bremer. Volatile Organic Compounds (VOCs) Produced by Levilactobacillus brevis WLP672 Fermentation in Defined Media Supplemented with Different Amino Acids. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040753. [PMID: 38398505]
  • Maria A Aksenova, Tatiana L Nechaeva, Evgenia A Goncharuk, Maria Y Zubova, Varvara V Kazantseva, Petr V Lapshin, Andrej Frolov, Natalia V Zagoskina. Changes in the Antioxidant Potential of Camellia sinensis Cultures under the Influence of Phenolic Precursors. Molecules (Basel, Switzerland). 2024 Jan; 29(2):. doi: 10.3390/molecules29020474. [PMID: 38257387]
  • Marlou L Dirks, Tom S O Jameson, Rob C Andrews, Mandy V Dunlop, Doaa R Abdelrahman, Andrew J Murton, Benjamin T Wall, Francis B Stephens. The impact of forearm immobilization and acipimox administration on muscle amino acid metabolism and insulin sensitivity in healthy, young volunteers. American journal of physiology. Endocrinology and metabolism. 2024 Jan; ?(?):. doi: 10.1152/ajpendo.00345.2023. [PMID: 38231001]
  • Zeyuan Zou, Qian Fan, Xiaochen Zhou, Xiumin Fu, Yongxia Jia, Hanxiang Li, Yinyin Liao. Biochemical Pathways of Salicylic Acid Derived from l-Phenylalanine in Plants with Different Basal SA Levels. Journal of agricultural and food chemistry. 2024 Jan; ?(?):. doi: 10.1021/acs.jafc.3c06939. [PMID: 38197566]
  • Jia Liu, Zhi-Dan Zhang, Chun-Xiao Lyu, Xi DU, Yu-Hong Huang. [Clinical metabolomics of Zicuiyin in treatment of diabetic kidney disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Jan; 49(2):550-558. doi: 10.19540/j.cnki.cjcmm.20231010.501. [PMID: 38403329]
  • Gwangsu Shin, Soonsil Hyun, Dongwoo Kim, Yoonhwa Choi, Kyu Hong Kim, Dongmin Kim, Soie Kwon, Yon Su Kim, Seung Hee Yang, Jaehoon Yu. Cyclohexylalanine-Containing α-Helical Amphipathic Peptide Targets Cardiolipin, Rescuing Mitochondrial Dysfunction in Kidney Injury. Journal of medicinal chemistry. 2023 Dec; ?(?):. doi: 10.1021/acs.jmedchem.3c01578. [PMID: 38112308]
  • Jinxia Wu, Zhenchang Li, Hongwei Zhu, Yajie Chang, Quanquan Li, Jing Chen, Guiping Shen, Jianghua Feng. Childhood overweight and obesity: age stratification contributes to the differences in metabolic characteristics. Obesity (Silver Spring, Md.). 2023 Dec; ?(?):. doi: 10.1002/oby.23964. [PMID: 38112246]
  • Xuemin Chen, Tuo Zhang, Hanxiong Liu, Jiachen Zang, Chenyan Lv, Ming Du, Guanghua Zhao. Shape-Anisotropic Assembly of Protein Nanocages with Identical Building Blocks by Designed Intermolecular π-π Interactions. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Dec; 10(35):e2305398. doi: 10.1002/advs.202305398. [PMID: 37870198]
  • Jorge El-Azaz, Bethany Moore, Yuri Takeda-Kimura, Ryo Yokoyama, Micha Wijesingha Ahchige, Xuan Chen, Matthew Schneider, Hiroshi A Maeda. Coordinated regulation of the entry and exit steps of aromatic amino acid biosynthesis supports the dual lignin pathway in grasses. Nature communications. 2023 11; 14(1):7242. doi: 10.1038/s41467-023-42587-7. [PMID: 37945591]
  • Zhongnan Chen, Zhigang Wang, Weihui Xu. Bacillus velezensis WB induces systemic resistance in watermelon against Fusarium wilt. Pest management science. 2023 Nov; ?(?):. doi: 10.1002/ps.7873. [PMID: 37939121]
  • Xia Zhu, Xueshan Yang, Liu Yang, Yan Fang, Yaping Jiang, Yongcai Li. Preharvest salicylic acid application improves the amino acid content and volatile profile in Vitis vinifera L. cv. Chardonnay during development. Plant physiology and biochemistry : PPB. 2023 Nov; 204(?):108103. doi: 10.1016/j.plaphy.2023.108103. [PMID: 37862932]
  • Abigail Loren Tung Uy, Atsushi Yamamoto, Mami Matsuda, Toshihiro Arae, Tomohisa Hasunuma, Taku Demura, Misato Ohtani. The Carbon Flow Shifts from Primary to Secondary Metabolism during Xylem Vessel Cell Differentiation in Arabidopsis thaliana. Plant & cell physiology. 2023 Oct; ?(?):. doi: 10.1093/pcp/pcad130. [PMID: 37875012]
  • Mario Mutz, Dominic Kösters, Benedikt Wynands, Nick Wierckx, Jan Marienhagen. Microbial synthesis of the plant natural product precursor p-coumaric acid with Corynebacterium glutamicum. Microbial cell factories. 2023 Oct; 22(1):209. doi: 10.1186/s12934-023-02222-y. [PMID: 37833813]
  • Yanan Li, Pingping Dong, Long Dai, Shaoping Wang. Untargeted and Targeted Metabolomics Reveal the Active Peptide of Eupolyphaga sinensis Walker against Hyperlipidemia by Modulating Imbalance in Amino Acid Metabolism. Molecules (Basel, Switzerland). 2023 Oct; 28(20):. doi: 10.3390/molecules28207049. [PMID: 37894528]
  • Zengwei Feng, Xiaolin Xie, Peidong Wu, Meng Chen, Yongqiang Qin, Yang Zhou, Honghui Zhu, Qing Yao. Phenylalanine-mediated changes in the soil bacterial community promote nitrogen cycling and plant growth. Microbiological research. 2023 Oct; 275(?):127447. doi: 10.1016/j.micres.2023.127447. [PMID: 37441843]
  • Meihong Zhang, Jinjia Zhang, Maoqi Hou, Shujuan Zhao. Comparative metabolomic and transcriptomic analysis of Saccharomyces cerevisiae W303a and CEN.PK2-1C. World journal of microbiology & biotechnology. 2023 Sep; 39(11):298. doi: 10.1007/s11274-023-03736-8. [PMID: 37661201]
  • Alyssa Paoletti, Paul B Pencharz, Ronald O Ball, Dehan Kong, Libai Xu, Rajavel Elango, Glenda Courtney-Martin. The dietary requirement for total sulfur amino acids in adults aged ≥60 years appears to be higher in males than in females. The American journal of clinical nutrition. 2023 09; 118(3):538-548. doi: 10.1016/j.ajcnut.2023.06.015. [PMID: 37356549]
  • Alicia B Merriam, Jenna M Malone, James P Hereward, Gurjeet Gill, Christopher Preston. Point mutations including a novel Pro-197-Phe mutation confer cross resistance to acetolactate synthase (ALS) inhibiting herbicides in Lactuca serriola in Australia. Pest management science. 2023 Aug; ?(?):. doi: 10.1002/ps.7743. [PMID: 37615238]
  • Cristini Milech, Priscila Ariane Auler, Marcelo Nogueira do Amaral, Simone Ribeiro Lucho, Jaqueline da Silva Dos Santos, Valcenir Júnior Mendes Furlan, Valmor João Bianchi, Eugenia Jacira Bolacel Braga. Biosynthesis of Betalains Elicited by Methyl Jasmonate in Two Species of Alternanthera Genus: Antagonistic Regulations Result in Increase of Pigments. Applied biochemistry and biotechnology. 2023 Aug; 195(8):4965-4982. doi: 10.1007/s12010-023-04535-5. [PMID: 37119502]
  • Tahrim Ramzan, Muhammad Shahbaz, Muhammad Faisal Maqsood, Usman Zulfiqar, Rafia Urooj Saman, Nian Lili, Muhammad Irshad, Sana Maqsood, Arslan Haider, Babar Shahzad, Abdel-Rhman Z Gaafar, Fasih Ullah Haider. Phenylalanine supply alleviates the drought stress in mustard (Brassica campestris) by modulating plant growth, photosynthesis, and antioxidant defense system. Plant physiology and biochemistry : PPB. 2023 Aug; 201(?):107828. doi: 10.1016/j.plaphy.2023.107828. [PMID: 37329687]
  • Kateryna Kukil, Elias Englund, Nick Crang, Elton P Hudson, Pia Lindberg. Laboratory evolution of Synechocystis PCC6803 for phenylpropanoid production. Metabolic engineering. 2023 Jun; ?(?):. doi: 10.1016/j.ymben.2023.06.014. [PMID: 37392984]
  • Katelyn M Duncan, Rhys C Trousdale, Cristina N Gonzales, William H Steel, Robert A Walker. l-Phenylalanine Partitioning Mechanisms in Model Biological Membranes. The journal of physical chemistry. B. 2023 06; 127(25):5633-5644. doi: 10.1021/acs.jpcb.2c08582. [PMID: 37315336]
  • Fan Zhang, Yunpeng Wang, Jingyang Yue, Rongrong Zhang, Yong-Er Hu, Ruoshi Huang, Ai-Jia Ji, B Andes Hess, Zhongqiu Liu, Lixin Duan, Ruibo Wu. Discovering a uniform functional trade-off of the CBC-type 2,3-oxidosqualene cyclases and deciphering its chemical logic. Science advances. 2023 06; 9(23):eadh1418. doi: 10.1126/sciadv.adh1418. [PMID: 37285431]
  • Nestor Vazquez-Agra, Silvia Fernandez-Crespo, Ana-Teresa Marques-Afonso, Anton Cruces-Sande, Sofia Barbosa-Gouveia, Miguel-Angel Martinez-Olmos, Alvaro Hermida-Ameijeiras. The correlation of lipid profile and waist circumference with phenylalanine levels in adult patients with classical phenylketonuria. Medicina clinica. 2023 05; 160(9):385-391. doi: 10.1016/j.medcli.2022.09.025. [PMID: 36628809]
  • Farah Al-Marzooq, Akela Ghazawi, Lana Daoud, Saeed Tariq. Boosting the Antibacterial Activity of Azithromycin on Multidrug-Resistant Escherichia coli by Efflux Pump Inhibition Coupled with Outer Membrane Permeabilization Induced by Phenylalanine-Arginine β-Naphthylamide. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108662. [PMID: 37240007]
  • Yansi Xian, Yunyuan Nong, Yijie Gao, Yuangang Su, Zhiqiang Lei, Haoyu Lian, Jianwen Cheng, Jiamin Liang, Xiaoliang Feng, Zhijuan Liu, Jinmin Zhao, Tongling Zhao, Zhiheng Su, Qian Liu, Fangming Song. UPLC/Q-TOF-MS-based metabolomics evaluate the efficacy of oroxylin A against postmenopausal osteoporosis. Biomedical chromatography : BMC. 2023 May; 37(5):e5609. doi: 10.1002/bmc.5609. [PMID: 36811170]
  • Pedro Martínez-Rodríguez, M Alejandra Guerrero-Rubio, Samanta Hernández-García, Paula Henarejos-Escudero, Francisco García-Carmona, Fernando Gandía-Herrero. Characterization of betalain-loaded liposomes and its bioactive potential in vivo after ingestion. Food chemistry. 2023 May; 407(?):135180. doi: 10.1016/j.foodchem.2022.135180. [PMID: 36521390]
  • Julia T Tanzo, Veronica L Li, Amanda L Wiggenhorn, Maria Dolores Moya-Garzon, Wei Wei, Xuchao Lyu, Wentao Dong, Usman A Tahir, Zsu-Zsu Chen, Daniel E Cruz, Shuliang Deng, Xu Shi, Shuning Zheng, Yan Guo, Mario Sims, Monther Abu-Remaileh, James G Wilson, Robert E Gerszten, Jonathan Z Long, Mark D Benson. CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels. The Journal of biological chemistry. 2023 Apr; ?(?):104764. doi: 10.1016/j.jbc.2023.104764. [PMID: 37121548]
  • Tobias Schwanemann, Maike Otto, Benedikt Wynands, Jan Marienhagen, Nick Wierckx. A Pseudomonas taiwanensis malonyl-CoA platform strain for polyketide synthesis. Metabolic engineering. 2023 Apr; 77(?):219-230. doi: 10.1016/j.ymben.2023.04.001. [PMID: 37031949]
  • Yan Huang, Yezi Kong, Bingyu Shen, Bowen Li, Juan J Loor, Panpan Tan, Bo Wei, Linshan Mei, Zixin Zhang, Chenxu Zhao, Xiaoyan Zhu, Simeng Qi, Jianguo Wang. Untargeted metabolomics and lipidomics to assess plasma metabolite changes in dairy goats with subclinical hyperketonemia. Journal of dairy science. 2023 Apr; ?(?):. doi: 10.3168/jds.2022-22812. [PMID: 37028962]
  • Jingjing Tan, Ping He, De-Yu Xie. Unrelated to phenylalanine: Feeding studies provide new insight into salicylic acid biosynthesis. Journal of integrative plant biology. 2023 04; 65(4):879-880. doi: 10.1111/jipb.13479. [PMID: 36897024]
  • Manish Kumar Patel, Michal Fanyuk, Oleg Feyngenberg, Dalia Maurer, Noa Sela, Rinat Ovadia, Michal Oren-Shamir, Noam Alkan. Phenylalanine induces mango fruit resistance against chilling injuries during storage at suboptimal temperature. Food chemistry. 2023 Mar; 405(Pt B):134909. doi: 10.1016/j.foodchem.2022.134909. [PMID: 36442247]
  • Karolina Urban, Tomasz Hura. The use of L-phenylalanine ammonia lyase inhibitors in plant ecophysiological studies. Postepy biochemii. 2023 03; 69(1):11-17. doi: 10.18388/pb.2021_471. [PMID: 37493563]
  • Avijit Maity, Debanjan Bagchi, Soumya Kanti De, Anjan Chakraborty. Insight into the Lysozyme-Induced Aggregation of Aromatic Amino Acid-Functionalized Gold Nanoparticles: Impact of the Protein Conjugation and Lipid Corona on the Aggregation Phenomena. Langmuir : the ACS journal of surfaces and colloids. 2023 Mar; ?(?):. doi: 10.1021/acs.langmuir.2c03077. [PMID: 36988163]
  • Xuan Fu, Shovra Sarker, Weijia Ma, Weijie Zhao, Yan Rong, Qi Liu. Novel phenylalanine-modified magnetic ferroferric oxide nanoparticles for ciprofloxacin removal from aqueous solution. Journal of colloid and interface science. 2023 Feb; 632(Pt B):345-356. doi: 10.1016/j.jcis.2022.11.067. [PMID: 36436393]
  • Shan Yang, Na Chu, Naijie Feng, Bolin Zhou, Hongkai Zhou, Zuhu Deng, Xuefeng Shen, Dianfeng Zheng. Global Responses of Autopolyploid Sugarcane Badila (Saccharum officinarum L.) to Drought Stress Based on Comparative Transcriptome and Metabolome Profiling. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043856. [PMID: 36835268]
  • Yanxing Yang, Cristiano L Dias. Peptide-Membrane Binding: Effects of the Amino Acid Sequence. The journal of physical chemistry. B. 2023 02; 127(4):912-920. doi: 10.1021/acs.jpcb.2c06404. [PMID: 36652390]
  • Haiwen Chen, Jintao Cheng, Yuan Huang, Qiusheng Kong, Zhilong Bie. Comparative analysis of sugar, acid, and volatile compounds in CPPU-treated and honeybee-pollinated melon fruits during different developmental stages. Food chemistry. 2023 Feb; 401(?):134072. doi: 10.1016/j.foodchem.2022.134072. [PMID: 36108381]
  • Yan Guo, Xue Li, Canying Li, Ruxin Jinyue, Hengping Xu, Yonghong Ge. Acibenzolar-S-methyl activates phenylpropanoid pathway to enhance resistance against Alternaria alternata in pear fruit. Journal of the science of food and agriculture. 2023 Jan; 103(2):829-836. doi: 10.1002/jsfa.12194. [PMID: 36045074]
  • Pan Liao, Itay Maoz, Meng-Ling Shih, Ji Hee Lee, Xing-Qi Huang, John A Morgan, Natalia Dudareva. Emission of floral volatiles is facilitated by cell-wall non-specific lipid transfer proteins. Nature communications. 2023 01; 14(1):330. doi: 10.1038/s41467-023-36027-9. [PMID: 36658137]
  • Agnieszka Szewczyk, Wojciech Paździora, Halina Ekiert. The Influence of Exogenous Phenylalanine on the Accumulation of Secondary Metabolites in Agitated Shoot Cultures of Ruta graveolens L. Molecules (Basel, Switzerland). 2023 Jan; 28(2):. doi: 10.3390/molecules28020727. [PMID: 36677781]
  • Veronica C Perez, Ru Dai, Breanna Tomiczek, Jorrel Mendoza, Emily S A Wolf, Alexander Grenning, Wilfred Vermerris, Anna K Block, Jeongim Kim. Metabolic link between auxin production and specialized metabolites in Sorghum bicolor. Journal of experimental botany. 2023 01; 74(1):364-376. doi: 10.1093/jxb/erac421. [PMID: 36300527]
  • Jolanta Bugajska, Joanna Berska, Małgorzata Wójcik, Krystyna Sztefko. Amino acid profile in overweight and obese prepubertal children - can simple biochemical tests help in the early prevention of associated comorbidities?. Frontiers in endocrinology. 2023; 14(?):1274011. doi: 10.3389/fendo.2023.1274011. [PMID: 37964971]
  • Yu Jiang, Bingbing Sun, Fenghui Qian, Feng Dong, Chongmao Xu, Wuling Zhong, Rui Huang, Qiwei Zhai, Yu Jiang, Sheng Yang. Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria. Science China. Life sciences. 2023 01; 66(1):127-136. doi: 10.1007/s11427-021-2137-3. [PMID: 35907113]
  • Ewa Rodziewicz-Flis, Ulana Juhas, Jakub Antoni Kortas, Joanna Jaworska, Ilona Bidzan-Bluma, Anna Babińska, Katarzyna Micielska, Małgorzata Żychowska, Giovanni Lombardi, Jędrzej Antosiewicz, Ewa Ziemann. Nordic Walking training in BungyPump form improves cognitive functions and physical performance and induces changes in amino acids and kynurenine profiles in older adults. Frontiers in endocrinology. 2023; 14(?):1151184. doi: 10.3389/fendo.2023.1151184. [PMID: 37766686]
  • Arata Banno, Mako Yamamoto, Maihemuti Mijiti, Asahi Takeuchi, Yuyang Ye, Natsuki Oda, Nanami Nishino, Akio Ebihara, Satoshi Nagaoka. The physiological blood concentration of phenylalanine-proline can ameliorate cholesterol metabolism in HepG2 cells. Bioscience, biotechnology, and biochemistry. 2022 Dec; 87(1):90-98. doi: 10.1093/bbb/zbac167. [PMID: 36352466]
  • Junwei Yuan, Shiwei Zhong, Yu Long, Jingling Guo, Yixun Yu, Juanxu Liu. Shikimate Kinase Plays Important Roles in Anthocyanin Synthesis in Petunia. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232415964. [PMID: 36555606]
  • Hussain Ahmad, Xinrui Zhao, Nisar Ahmad, Abbas Khan, Yuexin Jin, Jie Du, Xuewei Zheng, Li Zeng, Yanan Ouyang, Pengfei Yang, Meng Chen, Xiaoxue Li, Zhe Yang, Zhongmin Tian. Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns. Journal of food biochemistry. 2022 12; 46(12):e14497. doi: 10.1111/jfbc.14497. [PMID: 36314446]
  • Chaoyang Liu, Zehua Liu, Yanyan Fang, Zhen Du, Zhi Yan, Xin Yuan, Lijun Dai, Ting Yu, Min Xiong, Ye Tian, Honghu Li, Fei Li, Jingdong Zhang, Lanxia Meng, Zhihao Wang, Haiqiang Jiang, Zhentao Zhang. Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis. Chemosphere. 2022 Dec; 308(Pt 2):136344. doi: 10.1016/j.chemosphere.2022.136344. [PMID: 36087732]
  • Lijing Deng, Xingyi Zhou, Gabriel Tao, Wenzhi Hao, Lu Wang, Zhifang Lan, Yuan Song, Mansi Wu, Jun-Qing Huang. Ferulic acid and feruloylated oligosaccharides alleviate anxiety and depression symptom via regulating gut microbiome and microbial metabolism. Food research international (Ottawa, Ont.). 2022 12; 162(Pt A):111887. doi: 10.1016/j.foodres.2022.111887. [PMID: 36461269]
  • Mahaboubeh Hosseinzadeh, Alejandra Gilabert, Cinta Porte. Precision cut tissue slices to investigate the effects of triclosan exposure in Mytilus galloprovincialis. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Dec; 85(?):105477. doi: 10.1016/j.tiv.2022.105477. [PMID: 36122805]
  • Valeria Rondelli, Alexandros Koutsioubas, Emanuela Di Cola, Giovanna Fragneto, I Grillo, Elena Del Favero, Laura Colombo, Laura Cantù, Paola Brocca, Mario Salmona. Dysmyelination and glycolipid interference caused by phenylalanine in phenylketonuria. International journal of biological macromolecules. 2022 Nov; 221(?):784-795. doi: 10.1016/j.ijbiomac.2022.09.062. [PMID: 36099998]
  • Song Cang, Ran Liu, Kunqian Mu, Qi Tang, Haiyue Cui, Kaishun Bi, Yiwen Zhang, Qing Li. Assessment of plasma amino acids, purines, tricarboxylic acid cycle metabolites, and lipids levels in NSCLC patients based on LC-MS/MS quantification. Journal of pharmaceutical and biomedical analysis. 2022 Nov; 221(?):114990. doi: 10.1016/j.jpba.2022.114990. [PMID: 36208488]
  • Cuiwei Wang, Michal Poborsky, Christoph Crocoll, Christina Spuur Nødvig, Uffe Hasbro Mortensen, Barbara Ann Halkier. Comparison of Genome and Plasmid-Based Engineering of Multigene Benzylglucosinolate Pathway in Saccharomyces cerevisiae. Applied and environmental microbiology. 2022 11; 88(22):e0097822. doi: 10.1128/aem.00978-22. [PMID: 36326240]
  • Amit Kumar, Hukum Singh, Garima Kumari, Sarita Bisht, Apurva Malik, Narendra Kumar, Manish Singh, Asha Raturi, Santan Barthwal, Ajay Thakur, Rajesh Kaushal. Adaptive resilience of roadside trees to vehicular emissions via leaf enzymatic, physiological, and anatomical trait modulations. Environmental pollution (Barking, Essex : 1987). 2022 Nov; 313(?):120191. doi: 10.1016/j.envpol.2022.120191. [PMID: 36116570]
  • Jie Wu, Wentao Zhu, Qiao Zhao. Salicylic acid biosynthesis is not from phenylalanine in Arabidopsis. Journal of integrative plant biology. 2022 Nov; ?(?):. doi: 10.1111/jipb.13410. [PMID: 36377737]
  • Hongzhao Yuan, Zhen He, Xiangbi Chen, Tida Ge, Liping Zhang, Jiurong Wang. Rapid, sensitive analysis method for determining the nitrogen stable isotope ratio of total free amino acids in soil. Rapid communications in mass spectrometry : RCM. 2022 Nov; 36(21):e9390. doi: 10.1002/rcm.9390. [PMID: 36056455]
  • Changguo Yi, Hualiang Liang, Gangchun Xu, Jian Zhu, Yongli Wang, Songlin Li, Mingchun Ren, Xiaoru Chen. Appropriate dietary phenylalanine improved growth, protein metabolism and lipid metabolism, and glycolysis in largemouth bass (Micropterus salmoides). Fish physiology and biochemistry. 2022 Nov; ?(?):. doi: 10.1007/s10695-022-01138-5. [PMID: 36367675]
  • Pan Liang, Yining Ma, Luyin Yang, Linshen Mao, Qin Sun, Changzhen Sun, Zengjin Liu, Maryam Mazhar, Sijin Yang, Wei Ren. Uncovering the Mechanisms of Active Components from Toad Venom against Hepatocellular Carcinoma Using Untargeted Metabolomics. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27227758. [PMID: 36431859]
  • Meshal M Almutairi, Hany M Almotairy. Analysis of Heat Shock Proteins Based on Amino Acids for the Tomato Genome. Genes. 2022 11; 13(11):. doi: 10.3390/genes13112014. [PMID: 36360251]
  • Zhang-Xuan Guo, Xiao-Ke Li, Jin-Long Cui, Shuang-Man Miao, Meng-Liang Wang, Jun-Hong Wang, Muhammad Danial. Transcriptional Regulatory Mechanism of Differential Metabolite Formation in Root and Stem of Ephedra sinica. Applied biochemistry and biotechnology. 2022 Nov; 194(11):5506-5521. doi: 10.1007/s12010-022-04039-8. [PMID: 35789982]
  • Homa Kabiri, Zahra Tayarani-Najaran, Pouria Rahmanian-Devin, Mohadeseh Sadat Vaziri, Samira Nasirizadeh, Shiva Golmohammadzadeh, Hossein Kamali. Preparation, characterization, and evaluation of anti-tyrosinase activity of solid lipid nanoparticles containing Undecylenoyl phenylalanine (Sepiwhite®). Journal of cosmetic dermatology. 2022 Nov; 21(11):6061-6071. doi: 10.1111/jocd.15102. [PMID: 35593521]
  • Na Yi, Haoqiang Yang, Xintong Zhang, Ruiqi Pian, Huiling Li, Wei Zeng, Ai-Min Wu. The physiological and transcriptomic study of secondary growth in Neolamarckia cadamba stimulated by the ethylene precursor ACC. Plant physiology and biochemistry : PPB. 2022 Nov; 190(?):35-46. doi: 10.1016/j.plaphy.2022.08.030. [PMID: 36096025]
  • Danny Farhat, Fatemeh Rezaei, Milica Ristovski, Yidai Yang, Albert Stancescu, Lucia Dzimkova, Sabrina Samnani, Jean-François Couture, Jyh-Yeuan Lee. Structural Analysis of Cholesterol Binding and Sterol Selectivity by ABCG5/G8. Journal of molecular biology. 2022 10; 434(20):167795. doi: 10.1016/j.jmb.2022.167795. [PMID: 35988751]
  • Jun-Fan Chen, Ying Liu, Tian-Yu Zhang, Zheng-Fu Zhou, Jin-Yong Huang, Ting Zhou, Ying-Peng Hua. Integrated physiological and transcriptional dissection reveals the core genes involving nutrient transport and osmoregulatory substance biosynthesis in allohexaploid wheat seedlings under salt stress. BMC plant biology. 2022 Oct; 22(1):502. doi: 10.1186/s12870-022-03887-0. [PMID: 36289462]
  • Rachel L Shrode, Nicole Cady, Samantha N Jensen, Nicholas Borcherding, Ashutosh K Mangalam. Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism. Metabolomics : Official journal of the Metabolomic Society. 2022 10; 18(11):84. doi: 10.1007/s11306-022-01944-1. [PMID: 36289122]
  • Chenyi Li, Min Tang, Xingan Li, Xin Zhou. Community Dynamics in Structure and Function of Honey Bee Gut Bacteria in Response to Winter Dietary Shift. mBio. 2022 10; 13(5):e0113122. doi: 10.1128/mbio.01131-22. [PMID: 36036626]
  • Husheem Michael, Vishal Srivastava, Loic Deblais, Joshua O Amimo, Juliet Chepngeno, Linda J Saif, Gireesh Rajashekara, Anastasia N Vlasova. The Combined Escherichia coli Nissle 1917 and Tryptophan Treatment Modulates Immune and Metabolome Responses to Human Rotavirus Infection in a Human Infant Fecal Microbiota-Transplanted Malnourished Gnotobiotic Pig Model. mSphere. 2022 Oct; 7(5):e0027022. doi: 10.1128/msphere.00270-22. [PMID: 36073800]
  • Xueting Wang, Qiming Hu, Jiaxi Wang, Lina Lou, Xuewen Xu, Xuehao Chen. Comparative Biochemical and Transcriptomic Analyses Provide New Insights into Phytoplasma Infection Responses in Cucumber. Genes. 2022 10; 13(10):. doi: 10.3390/genes13101903. [PMID: 36292788]
  • Xuewen Zhu, Yaolei Mi, Xiangxiao Meng, Yiming Zhang, Weiqiang Chen, Xue Cao, Huihua Wan, Wei Yang, Jun Li, Sifan Wang, Zhichao Xu, Atia Tul Wahab, Shilin Chen, Wei Sun. Genome-wide identification of key enzyme-encoding genes and the catalytic roles of two 2-oxoglutarate-dependent dioxygenase involved in flavonoid biosynthesis in Cannabis sativa L. Microbial cell factories. 2022 Oct; 21(1):215. doi: 10.1186/s12934-022-01933-y. [PMID: 36243861]
  • Alex Pinto, Anne Daly, Júlio César Rocha, Catherine Ashmore, Sharon Evans, Richard Jackson, Anne Payne, Mary Hickson, Anita MacDonald. Impact of Fruit and Vegetable Protein vs. Milk Protein on Metabolic Control of Children with Phenylketonuria: A Randomized Crossover Controlled Trial. Nutrients. 2022 Oct; 14(20):. doi: 10.3390/nu14204268. [PMID: 36296952]
  • Chong Xie, Pei Wang, Jianwei Chang, Qiaoe Wang, Yongbin Han, Runqiang Yang. Effect of Amino Acids on Folates Accumulation in Wheat Seedlings during Germination under Red Light Radiation. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206868. [PMID: 36296459]
  • Zhiqiang Xiong, Liang Wang, Jingyi Sun, Xuefei Jiang, Hanqing Cong, Huapeng Sun, Fei Qiao. Functional characterization of a Colchicum autumnale L. double-bond reductase (CaDBR1) in colchicine biosynthesis. Planta. 2022 Oct; 256(5):95. doi: 10.1007/s00425-022-04003-0. [PMID: 36214872]
  • Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang, Xingjun Wang. De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa. BMC genomics. 2022 Oct; 23(1):698. doi: 10.1186/s12864-022-08921-x. [PMID: 36209069]
  • Peng Chen, He-Qin Li, Xing-Yue Li, Xian-Hong Zhou, Xiu-Xia Zhang, An-Sheng Zhang, Qi-Zhi Liu. Transcriptomic analysis provides insight into defensive strategies in response to continuous cropping in strawberry (Fragaria × ananassa Duch.) plants. BMC plant biology. 2022 Oct; 22(1):476. doi: 10.1186/s12870-022-03857-6. [PMID: 36203126]
  • Lu Li, Jiaqi Wang, Jiajun Chen, Zhihua Wang, Mirza Faisal Qaseem, Huiling Li, Aimin Wu. Physiological and Transcriptomic Responses of Growth in Neolamarckia cadamba Stimulated by Exogenous Gibberellins. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911842. [PMID: 36233144]
  • Jie Wu, Wentao Zhu, Xiaotong Shan, Jinyue Liu, Lingling Zhao, Qiao Zhao. Glycoside-specific metabolomics combined with precursor isotopic labeling for characterizing plant glycosyltransferases. Molecular plant. 2022 10; 15(10):1517-1532. doi: 10.1016/j.molp.2022.08.003. [PMID: 35996753]
  • Chang Liu, Wenhao Jiang, Fangwei Yang, Yuliang Cheng, Yahui Guo, Weirong Yao, Yong Zhao, He Qian. The combination of microbiome and metabolome to analyze the cross-cooperation mechanism of Echinacea purpurea polysaccharide with the gut microbiota in vitro and in vivo. Food & function. 2022 Oct; 13(19):10069-10082. doi: 10.1039/d2fo02336a. [PMID: 36093868]
  • Yuan Kong, Chenyang Ji, Dong Guo, Rujian He, Meirong Zhao, Jun Fan. Triticonazole enantiomers induced enantioselective metabolic phenotypes in Fusarium graminearum and HepG2 cells. Environmental science and pollution research international. 2022 Oct; 29(50):75978-75988. doi: 10.1007/s11356-022-21137-6. [PMID: 35665887]
  • Maria Doppler, Christoph Bueschl, Florian Ertl, Jakob Woischitzschlaeger, Alexandra Parich, Rainer Schuhmacher. Towards a broader view of the metabolome: untargeted profiling of soluble and bound polyphenols in plants. Analytical and bioanalytical chemistry. 2022 Oct; 414(25):7421-7433. doi: 10.1007/s00216-022-04134-z. [PMID: 35678834]
  • Xia Zhou, Ya Yang, Renyue Ming, Hong Chen, Deyu Hu, Ping Lu. Insight into the differences in the toxicity mechanisms of dinotefuran enantiomers in zebrafish by UPLC-Q/TOF-MS. Environmental science and pollution research international. 2022 Oct; 29(47):70833-70841. doi: 10.1007/s11356-022-20424-6. [PMID: 35589890]
  • Thayse Evellyn Silva do Nascimento, Jorge A López, Eder Alves Barbosa, Marcela Abbott Galvão Ururahy, Adriana da Silva Brito, Gabriel Araujo-Silva, Jefferson Romáryo Duarte da Luz, Maria das Graças Almeida. Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196291. [PMID: 36234829]
  • Yu-Heng Tseng, Sandra S Scholz, Judith Fliegmann, Thomas Krüger, Akanksha Gandhi, Alexandra C U Furch, Olaf Kniemeyer, Axel A Brakhage, Ralf Oelmüller. CORK1, A LRR-Malectin Receptor Kinase, Is Required for Cellooligomer-Induced Responses in Arabidopsis thaliana. Cells. 2022 09; 11(19):. doi: 10.3390/cells11192960. [PMID: 36230919]
  • Amna Devi, Romit Seth, Mamta Masand, Gopal Singh, Ashlesha Holkar, Shikha Sharma, Ashok Singh, Ram Kumar Sharma. Spatial Genomic Resource Reveals Molecular Insights into Key Bioactive-Metabolite Biosynthesis in Endangered Angelica glauca Edgew. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911064. [PMID: 36232367]
  • Venelina Popova, Zhana Petkova, Nadezhda Mazova, Tanya Ivanova, Nadezhda Petkova, Magdalena Stoyanova, Albena Stoyanova, Sezai Ercisli, Zuhal Okcu, Sona Skrovankova, Jiri Mlcek. Chemical Composition Assessment of Structural Parts (Seeds, Peel, Pulp) of Physalis alkekengi L. Fruits. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185787. [PMID: 36144521]
  • Siquan Ling, Hualong Qiu, Jinzhu Xu, Yanping Gu, Jinxin Yu, Wei Wang, Jiali Liu, Xinnian Zeng. Volatile Dimethyl Disulfide from Guava Plants Regulate Developmental Performance of Asian Citrus Psyllid through Activation of Defense Responses in Neighboring Orange Plants. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810271. [PMID: 36142192]