Salidroside (BioDeep_00000000374)

Secondary id: BioDeep_00000183132, BioDeep_00000862209

natural product PANOMIX_OTCML-2023

代谢物信息卡片

(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]tetrahydropyran-3,4,5-triol

化学式: C14H20O7 (300.120897)
中文名称: 红景天苷, 红景天甙, 毛柳甙, 红景天苷
谱图信息: 最多检出来源 Viridiplantae(plant) 0.06%

分子结构信息

SMILES: C1=CC(=CC=C1CCOC2C(C(C(C(O2)CO)O)O)O)O
InChI: InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1

描述信息

Salidroside is a glycoside.
Salidroside is a natural product found in Plantago australis, Plantago coronopus, and other organisms with data available.
See also: Sedum roseum root (part of); Rhodiola crenulata root (part of).
Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

同义名列表

42 个代谢物同义名

(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]tetrahydropyran-3,4,5-triol; (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenethoxy)tetrahydro-2H-pyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[2-(4-hydroxyphenyl)ethoxy]-6-methylol-tetrahydropyran-3,4,5-triol; (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol; 2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]tetrahydropyran-3,4,5-triol; Salidroside, United States Pharmacopeia (USP) Reference Standard; Salidroside, primary pharmaceutical reference standard; .BETA.-D-GLUCOPYRANOSIDE, 2-(4-HYDROXYPHENYL)ETHYL-; 2-(4-HYDROXYPHENYL)ETHYL-.BETA.-D-GLUCOPYRANOSIDE; SALIDROSIDE (CONSTITUENT OF RHODIOLA ROSEA) [DSC]; beta-D-glucopyranoside, 2-(4-hydroxyphenyl)ethyl-; beta-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl; 2-(4-Hydroxyphenyl)ethyl beta-D-glucopyranoside; 2-(4-hydroxyphenyl)ethyl-beta-d-glucopyranoside; p-Hydroxyphenethyl alcohol 1-O-beta-D-glucoside; 2-(4-Hydroxyphenyl)ethyl ?-D-glucopyranoside; SALIDROSIDE (CONSTITUENT OF RHODIOLA ROSEA); TYROSOL .ALPHA.-(.BETA.-D-GLUCOPYRANOSIDE); 4-hydroxyphenyl-2-ethylglucopyranoside; TYROSOL alpha-(beta-D-GLUCOPYRANOSIDE); (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-; Glucopyranoside, p-hydroxyphenethyl; (4-hydroxyphenethoxy)tetrahydro-2H-; Salidroside, analytical standard; Salidroside, >=95\\% (LC/MS-ELSD); 8-O-b-D-glucoside of tyrosol; salidroside (rhodioloside); SALIDROSIDE [USP-RS]; SALIDROSIDE (USP-RS); Tyrosol glucoside; pyran-3,4,5-triol; salidroside, (-)-; Salidroside,(S); Tox21_113565_1; MEGxp0_000478; sallidroside; Tox21_113565; ACon1_000366; rhodioloside; Salidroside; rhodosin; Hydroxyphenylethanol + Pen

数据库引用编号

42 个数据库交叉引用编号

ChEBI: CHEBI:9009
KEGG: C06046
PubChem: 159278
PubChem: 4961358
Metlin: METLIN44847
ChEMBL: CHEMBL465208
Wikipedia: Salidroside
MeSH: rhodioloside
ChemIDplus: 0010338519
MetaCyc: CPD-13354
chemspider: 140088
CAS: 10338-51-9
MoNA: Bruker_HCD_library000713
MoNA: Bruker_HCD_library000714
MoNA: Bruker_HCD_library001659
MoNA: CCMSLIB00005436086
MoNA: VF-NPL-LTQ006526
MoNA: VF-NPL-LTQ006525
MoNA: VF-NPL-LTQ006524
MoNA: VF-NPL-LTQ006523
MoNA: VF-NPL-QEHF011091
MoNA: VF-NPL-QEHF011090
MoNA: VF-NPL-QEHF011089
MoNA: VF-NPL-QEHF011088
MoNA: VF-NPL-QEHF011087
MoNA: VF-NPL-QEHF011086
MoNA: VF-NPL-QEHF011085
MoNA: VF-NPL-QEHF011084
MoNA: VF-NPL-QEHF011083
MoNA: VF-NPL-QEHF011082
MoNA: VF-NPL-QEHF011081
MoNA: VF-NPL-QEHF011080
MoNA: VF-NPL-QEHF011079
MoNA: VF-NPL-QEHF011078
MoNA: VF-NPL-QEHF011077
medchemexpress: HY-N0109
PMhub: MS000011469
PubChem: 8317
KNApSAcK: C00031274
3DMET: B01958
NIKKAJI: J15.618C
RefMet: 4-Hydroxyphenyl-2-ethylglucopyranoside

分类词条

酚类

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

salidroside biosynthesis: 4-tyrosol + UDP-α-D-glucose ⟶ H⁺ + UDP + salidroside
salidroside biosynthesis: 4-tyrosol + UDP-α-D-glucose ⟶ H⁺ + UDP + salidroside

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(3)

salidroside biosynthesis: H₂O + O₂ + tyramine ⟶ (4-hydroxyphenyl)acetaldehyde + ammonium + hydrogen peroxide
salidroside biosynthesis: H₂O + O₂ + tyramine ⟶ (4-hydroxyphenyl)acetaldehyde + ammonium + hydrogen peroxide
salidroside biosynthesis: H₂O + O₂ + tyramine ⟶ (4-hydroxyphenyl)acetaldehyde + ammonium + hydrogen peroxide

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

198 个相关的物种来源信息

33090 红景天: -
242839 Rhodiola crenulata:
203000 Rhodiola sacra:
487764 Rhodiola quadrifida:
1442767 Rhodiola coccinea:
203008 Rhodiola kirilowii:
202995 Rhodiola algida:
1674046 Rhodiola subopposita:
203015 Rhodiola rosea: 10.1248/CPB.56.536
265354 Rhodiola sachalinensis:
141291 Asystasia: 10.1007/S11418-007-0158-3
56154 Campanula medium: 10.1248/CPB.35.1109
13432 Clerodendrum: 10.1016/S0031-9422(01)00208-4
486058 Inga feuillei: 10.1016/J.BMCL.2011.08.089
260310 Fernandoa: 10.1016/S0031-9422(01)00212-6
458695 Ligustrum lucidum: 10.1007/S10600-010-9719-X
99300 Rehmannia glutinosa: 10.1016/0031-9422(90)80204-T
49563 Peucedanum japonicum: 10.1021/JF0349127
203015 Rhodiola rosea:
265354 Rhodiola sachalinensis:
282539 Hypericum erectum: 10.1007/S11418-008-0256-X
242839 Rhodiola crenulata:
498914 Hydrangea chinensis: 10.1021/NP0302394
880141 Fraxinus malacophylla: 10.1016/S0031-9422(00)90529-6
880137 Fraxinus griffithii:
880136 Fraxinus formosana:
203008 Rhodiola kirilowii: 10.5246/JCPS.2011.02.019
50506 Sargentodoxa cuneata: 10.3987/COM-03-9777
158539 Aristolochia cucurbitifolia: 10.1248/CPB.48.1006
145513 Centaurea raphanina: 10.1016/J.CARRES.2010.09.002
203004 Rhodiola heterodonta:
323038 Croton chilensis: 10.1016/0031-9422(92)80479-X
34270 Syringa vulgaris:
1442767 Rhodiola coccinea: 10.1055/S-2006-960220
35883 Ipomoea nil: 10.1248/CPB.59.1425
487764 Rhodiola quadrifida:
3649 Carica papaya: 10.1016/0031-9422(88)80450-3
203003 Rhodiola fastigiata: 10.4268/CJCMM20111611
65409 Scutellaria baicalensis: 10.1016/S0031-9422(96)00443-8
161396 Cistanche salsa: 10.1248/CPB.32.3009
1719525 Peperomia humilis: 10.1016/S0031-9422(03)00183-3
511531 Peperomia leptostachya: 10.1016/S0031-9422(03)00183-3
1197397 Pedicularis plicata: 10.1016/0031-9422(91)83660-D
101996 Plantago coronopus: 10.1016/S0031-9422(00)00306-X
101995 Plantago australis: 10.1016/S0031-9422(00)00306-X
99300 Rehmannia glutinosa: 10.1016/0031-9422(91)84224-G
75715 Salix pentandra:
172267 Salix caprea:
77065 Salix purpurea:
75706 Salix babylonica:
75704 Salix alba:
77069 Salix triandra:
470278 Salix cinerea:
75707 Salix bebbiana:
470269 Salix phylicifolia:
40686 Salix viminalis:
1004002 Salix atrocinerea:
1087216 Salix candida: 10.1016/S0031-9422(00)88609-4
75712 Salix interior:
395313 Salix arctica: 10.1016/S0031-9422(00)88609-4
77063 Salix fragilis:
339964 Salix myrsinifolia:
470274 Salix daphnoides: 10.1016/S0031-9422(00)88609-4
470272 Salix lapponum:
77064 Salix herbacea: 10.1016/S0031-9422(00)85563-6
113636 Populus tremula: 10.1016/0031-9422(86)88020-7
141292 Asystasia gangetica: 10.1007/S11418-007-0158-3
244027 Epimedium grandiflorum: 10.1248/CPB.35.1109
388204 Penstemon secundiflorus: 10.1016/0031-9422(92)80441-G
87754 Cistanche phelypaea:
161397 Cistanche tubulosa:
388112 Penstemon acuminatus: 10.1016/S0031-9422(00)89534-5
23110 Hydrangea macrophylla: 10.3987/COM-09-11886
49563 Peucedanum japonicum: 10.1021/JF0349127
1315792 Linaria japonica: 10.1016/0031-9422(93)85459-5
180010 Stachys byzantina: 10.1021/NP8001805
714454 Buddleja officinalis:
253601 Epimedium diphyllum: 10.1016/0031-9422(89)80369-3
680227 Millingtonia hortensis: 10.1016/0031-9422(94)00939-Q
53035 Ricciocarpos natans: 10.1016/S0031-9422(00)97567-8
53161 Lamium galeobdolon: 10.1016/J.PHYTOCHEM.2003.08.001
49994 Volkameria inermis: 10.1016/S0031-9422(01)00208-4
3711 Brassica rapa: 10.1016/S0031-9422(97)00362-2
126367 Syringa reticulata: 10.1016/J.BMCL.2011.08.089
942083 Scrophularia umbrosa: 10.1016/0031-9422(93)85028-P
1357594 Scrophularia alpestris: 10.1016/0031-9422(93)85028-P
3505 Betula pendula: 10.1016/0031-9422(95)00057-E
203000 Rhodiola sacra: 10.1248/CPB.45.1498
126558 Phillyrea latifolia:
28545 Strychnos nux-vomica: 10.1016/S0031-9422(00)97792-6
554952 Campylanthus glaber: 10.1016/S0305-1978(02)00061-3
1818589 Fernandoa adenophylla: 10.1016/S0031-9422(01)00212-6
237933 Viburnum dilatatum: 10.1016/0031-9422(91)85058-8
83689 Polypremum procumbens: 10.1016/S0305-1978(99)00040-X
2822952 Tecoma stans var. sambucifolia: 10.1016/S0031-9422(00)90799-4
78630 Betula platyphylla: 10.1007/BF00833499
2769829 Digitalis chalcantha: 10.1055/S-2007-969379
126418 Forsythia suspensa: 10.1016/S0031-9422(00)97772-0
242839 Rhodiola crenulata:
203000 Rhodiola sacra:
487764 Rhodiola quadrifida:
1442767 Rhodiola coccinea:
203008 Rhodiola kirilowii:
202995 Rhodiola algida:
1674046 Rhodiola subopposita:
203015 Rhodiola rosea: 10.1248/CPB.56.536
265354 Rhodiola sachalinensis:
141291 Asystasia: 10.1007/S11418-007-0158-3
56154 Campanula medium: 10.1248/CPB.35.1109
13432 Clerodendrum: 10.1016/S0031-9422(01)00208-4
486058 Inga feuillei: 10.1016/J.BMCL.2011.08.089
260310 Fernandoa: 10.1016/S0031-9422(01)00212-6
458695 Ligustrum lucidum: 10.1007/S10600-010-9719-X
99300 Rehmannia glutinosa: 10.1016/0031-9422(90)80204-T
49563 Peucedanum japonicum: 10.1021/JF0349127
203015 Rhodiola rosea:
265354 Rhodiola sachalinensis:
282539 Hypericum erectum: 10.1007/S11418-008-0256-X
242839 Rhodiola crenulata:
498914 Hydrangea chinensis: 10.1021/NP0302394
880141 Fraxinus malacophylla: 10.1016/S0031-9422(00)90529-6
880137 Fraxinus griffithii:
880136 Fraxinus formosana:
203008 Rhodiola kirilowii: 10.5246/JCPS.2011.02.019
50506 Sargentodoxa cuneata: 10.3987/COM-03-9777
158539 Aristolochia cucurbitifolia: 10.1248/CPB.48.1006
145513 Centaurea raphanina: 10.1016/J.CARRES.2010.09.002
203004 Rhodiola heterodonta:
323038 Croton chilensis: 10.1016/0031-9422(92)80479-X
34270 Syringa vulgaris:
1442767 Rhodiola coccinea: 10.1055/S-2006-960220
35883 Ipomoea nil: 10.1248/CPB.59.1425
487764 Rhodiola quadrifida:
3649 Carica papaya: 10.1016/0031-9422(88)80450-3
203003 Rhodiola fastigiata: 10.4268/CJCMM20111611
65409 Scutellaria baicalensis: 10.1016/S0031-9422(96)00443-8
161396 Cistanche salsa: 10.1248/CPB.32.3009
1719525 Peperomia humilis: 10.1016/S0031-9422(03)00183-3
511531 Peperomia leptostachya: 10.1016/S0031-9422(03)00183-3
1197397 Pedicularis plicata: 10.1016/0031-9422(91)83660-D
101996 Plantago coronopus: 10.1016/S0031-9422(00)00306-X
101995 Plantago australis: 10.1016/S0031-9422(00)00306-X
99300 Rehmannia glutinosa: 10.1016/0031-9422(91)84224-G
75715 Salix pentandra:
172267 Salix caprea:
77065 Salix purpurea:
75706 Salix babylonica:
75704 Salix alba:
77069 Salix triandra:
470278 Salix cinerea:
75707 Salix bebbiana:
470269 Salix phylicifolia:
40686 Salix viminalis:
1004002 Salix atrocinerea:
1087216 Salix candida: 10.1016/S0031-9422(00)88609-4
75712 Salix interior:
395313 Salix arctica: 10.1016/S0031-9422(00)88609-4
77063 Salix fragilis:
339964 Salix myrsinifolia:
470274 Salix daphnoides: 10.1016/S0031-9422(00)88609-4
470272 Salix lapponum:
77064 Salix herbacea: 10.1016/S0031-9422(00)85563-6
113636 Populus tremula: 10.1016/0031-9422(86)88020-7
141292 Asystasia gangetica: 10.1007/S11418-007-0158-3
244027 Epimedium grandiflorum: 10.1248/CPB.35.1109
388204 Penstemon secundiflorus: 10.1016/0031-9422(92)80441-G
87754 Cistanche phelypaea:
161397 Cistanche tubulosa:
388112 Penstemon acuminatus: 10.1016/S0031-9422(00)89534-5
23110 Hydrangea macrophylla: 10.3987/COM-09-11886
49563 Peucedanum japonicum: 10.1021/JF0349127
1315792 Linaria japonica: 10.1016/0031-9422(93)85459-5
180010 Stachys byzantina: 10.1021/NP8001805
714454 Buddleja officinalis:
253601 Epimedium diphyllum: 10.1016/0031-9422(89)80369-3
680227 Millingtonia hortensis: 10.1016/0031-9422(94)00939-Q
53035 Ricciocarpos natans: 10.1016/S0031-9422(00)97567-8
53161 Lamium galeobdolon: 10.1016/J.PHYTOCHEM.2003.08.001
49994 Volkameria inermis: 10.1016/S0031-9422(01)00208-4
3711 Brassica rapa: 10.1016/S0031-9422(97)00362-2
126367 Syringa reticulata: 10.1016/J.BMCL.2011.08.089
942083 Scrophularia umbrosa: 10.1016/0031-9422(93)85028-P
1357594 Scrophularia alpestris: 10.1016/0031-9422(93)85028-P
3505 Betula pendula: 10.1016/0031-9422(95)00057-E
203000 Rhodiola sacra: 10.1248/CPB.45.1498
126558 Phillyrea latifolia:
28545 Strychnos nux-vomica: 10.1016/S0031-9422(00)97792-6
554952 Campylanthus glaber: 10.1016/S0305-1978(02)00061-3
1818589 Fernandoa adenophylla: 10.1016/S0031-9422(01)00212-6
237933 Viburnum dilatatum: 10.1016/0031-9422(91)85058-8
83689 Polypremum procumbens: 10.1016/S0305-1978(99)00040-X
2822952 Tecoma stans var. sambucifolia: 10.1016/S0031-9422(00)90799-4
78630 Betula platyphylla: 10.1007/BF00833499
2769829 Digitalis chalcantha: 10.1055/S-2007-969379
126418 Forsythia suspensa: 10.1016/S0031-9422(00)97772-0
28545 Strychnos nux-vomica L.: -
458695 Ligustrum lucidum Ait.: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Zehui Li, Jiashan Li, Yuan Li, Li Guo, Panyu Xu, Hanqian Du, Na Lin, Ying Xu. The role of Cistanches Herba and its ingredients in improving reproductive outcomes: A comprehensive review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155681. doi: 10.1016/j.phymed.2024.155681. [PMID: 38718638]
Bin Yang, Ying Xu, Jingzhi Yu, Qihao Wang, Qigui Fan, Xiaoyu Zhao, Yang Qiao, Zeyu Zhang, Qing Zhou, Dong Yin, Ming He, Huan He. Salidroside pretreatment alleviates ferroptosis induced by myocardial ischemia/reperfusion through mitochondrial superoxide-dependent AMPKα2 activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155365. doi: 10.1016/j.phymed.2024.155365. [PMID: 38552436]
Ya Hou, Fuhan Fan, Na Xie, Yi Zhang, Xiaobo Wang, Xianli Meng. Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155529. doi: 10.1016/j.phymed.2024.155529. [PMID: 38503156]
Lirong Huang, Jiaxin Xu, Kun Jia, Yulin Wu, Wei Yuan, Zhipeng Liao, Bo Cheng, Qiang Luo, Guiyou Tian, Huiqiang Lu. Butylparaben induced zebrafish (Danio rerio) kidney injury by down-regulating the PI3K-AKT pathway. Journal of hazardous materials. 2024 May; 470(?):134129. doi: 10.1016/j.jhazmat.2024.134129. [PMID: 38565019]
Suxin You, Zhouyun Ma, Pei Zhang, Wenwen Xu, Changsen Zhan, Nina Sang, Jiazhen Xu, Feiyun Wang, Jiange Zhang. Neuroprotective effects of the salidroside derivative SHPL-49 via the BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116460. doi: 10.1016/j.biopha.2024.116460. [PMID: 38520864]
Xianqi Zhang, Mengdi Zhang, Ziyan Zhang, Shengbo Zhou. Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production. Experimental cell research. 2024 May; 438(1):114034. doi: 10.1016/j.yexcr.2024.114034. [PMID: 38588875]
Guosi Li, Wei Wang, Heng Guo, Shanyong Yi, Fang Wang, Shiping Huang, Nan Hu, Qilin Xu, Yongjun Zang, Bangxing Han, Xinjian Yin. Mutability landscape guided engineering of a promiscuous microbial glycosyltransferase for regioselective synthesis of salidroside and icariside D2. International journal of biological macromolecules. 2024 Apr; 263(Pt 1):130229. doi: 10.1016/j.ijbiomac.2024.130229. [PMID: 38378110]
Guosi Li, Qilin Xu, Nan Hu, Xinyang Liu, Yiqi Jiang, Hailong Xue, Yongjun Zang, Fucheng Zhu. Highly efficient biosynthesis of salidroside by a UDP-glucosyltransferase-catalyzed cascade reaction. Biotechnology letters. 2024 Jan; ?(?):. doi: 10.1007/s10529-023-03453-0. [PMID: 38184486]
Qiao Liu, Qingman Luo, Bin Zhong, Kecheng Tang, Xueling Chen, Shengqian Yang, Xiaohui Li. Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways. European journal of pharmacology. 2024 Jan; 962(?):176236. doi: 10.1016/j.ejphar.2023.176236. [PMID: 38048979]
Dan-Qing Zhang, Xiao-Ying Liu, Lin-Feng Qiu, Zhao-Rui Liu, Ya-Peng Yang, Long Huang, Shi-Yu Wang, Jian-Qiang Zhang. Two chromosome-level genome assemblies of Rhodiola shed new light on genome evolution in rapid radiation and evolution of the biosynthetic pathway of salidroside. The Plant journal : for cell and molecular biology. 2024 Jan; 117(2):464-482. doi: 10.1111/tpj.16501. [PMID: 37872890]
Ting Zhu, Hui Liu, Shiman Gao, Ning Jiang, Shuai Chen, Weijie Xie. Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):115999. doi: 10.1016/j.biopha.2023.115999. [PMID: 38091637]
Liu Shuyuan, Chen Haoyu. Mechanism of Nardostachyos Radix et Rhizoma-Salidroside in the treatment of premature ventricular beats based on network pharmacology and molecular docking. Scientific reports. 2023 11; 13(1):20741. doi: 10.1038/s41598-023-48277-0. [PMID: 38007574]
Bing Jiang, Yangyang Cui, Xinxin Ma, Yanmei Zhang, Xin Feng, Tao Yang, Longfei Feng, Wenjing Guo, Yangyang Li, Tao Wang, Huan Guo, Haining Li, Ying Duan, Haixiang Su. Crosstalk between autophagy inhibitor and salidroside-induced apoptosis: A novel strategy for autophagy-based treatment of hepatocellular cancer. International immunopharmacology. 2023 Nov; 124(Pt B):111040. doi: 10.1016/j.intimp.2023.111040. [PMID: 37839277]
Mu-Han Chen, Xin-Ze Liu, Xiu-Wu Qu, Rui-Bo Guo, Lu Zhang, Liang Kong, Yang Yu, Yang Liu, Juan Zang, Xiu-Ying Li, Xue-Tao Li. ApoE-modified liposomes encapsulating resveratrol and salidroside alleviate manifestations of Alzheimer's disease in APP/PS-1 mice. Drug development and industrial pharmacy. 2023 Sep; ?(?):1-13. doi: 10.1080/03639045.2023.2252062. [PMID: 37649422]
Feng Chen, Yi Hong Chai, Fa Zhang, Yong Qiang Liu, Yan Zhang, Ya Jing Shi, Jian Ming Zhang, Yu-Fang Leng. Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion. Bioscience reports. 2023 Aug; ?(?):. doi: 10.1042/bsr20230539. [PMID: 37530723]
Edward J Calabrese, Gaurav Dhawan, Rachna Kapoor, Evgenios Agathokleous, Vittorio Calabrese. Rhodiola rosea and salidroside commonly induce hormesis, with particular focus on longevity and neuroprotection. Chemico-biological interactions. 2023 Aug; 380(?):110540. doi: 10.1016/j.cbi.2023.110540. [PMID: 37169278]
Zexin Wen, Tong Liu, Yanli Zhang, Qiujuan Yue, Hang Meng, Yijie He, Yi Yang, Minghao Li, Jianwen Zheng, Wei Lin. Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs. BMC cancer. 2023 Aug; 23(1):717. doi: 10.1186/s12885-023-11036-5. [PMID: 37528345]
Jie Ma, Yujie Li, Xiaodi Ji, Anqi Wang, Yue Lan, Lihong Ma. Integrating network pharmacology and experimental verification to explore the mechanisms of salidroside against myocardial fibrosis. Biochemical and biophysical research communications. 2023 Aug; 677(?):38-44. doi: 10.1016/j.bbrc.2023.07.059. [PMID: 37544102]
Xue-Hua Wang, Zhong-Fu Zuo, Lu Meng, Qi Yang, Pan Lv, Li-Pan Zhao, Xiao-Bai Wang, Yu-Fei Wang, Ying Huang, Cong Fu, Wen-Qiang Liu, Xue-Zheng Liu, De-Yu Zheng. Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway. Psychopharmacology. 2023 Jul; ?(?):. doi: 10.1007/s00213-023-06373-z. [PMID: 37490132]
Ru-Han Liu, Teng-Fei Ma, Qin Yang, Wen-Chang Xiao, Lu Yin, Miao Yin, Jin-Song Zhang, Chi-Hua Wang. Salidroside suppresses proliferation and migration in prostate cancer via the PI3K/AKT pathway. Cancer biomarkers : section A of Disease markers. 2023 Jul; ?(?):. doi: 10.3233/cbm-220454. [PMID: 37545219]
Pei Zhang, Jiazhen Xu, Qianfei Cui, Guoqiang Lin, Feiyun Wang, Xinyue Ding, Suxin You, Nina Sang, Junchao Tan, Wenwen Xu, Changsen Zhan, Yuying Zhu, Jiange Zhang. Multi-pathway neuroprotective effects of a novel salidroside derivative SHPL-49 against acute cerebral ischemic injury. European journal of pharmacology. 2023 Jun; 949(?):175716. doi: 10.1016/j.ejphar.2023.175716. [PMID: 37059375]
Lin Tao, Zhi-Fang Liang, Liu Miao, Yu-Jie Guo, Ye Li, Yan-Li Liu, Dong-Ming Fang, Zhi-Jie Yang. Mechanism of salidroside against coronary artery disease by network pharmacology analysis. BMC complementary medicine and therapies. 2023 Jun; 23(1):194. doi: 10.1186/s12906-023-04027-3. [PMID: 37308900]
Yushiro Fuji, Kai Uchida, Tomoyoshi Akashi, Takashi Ohtsuki, Hiroshi Matsufuji, Masami Yokota Hirai. Molecular Identification of UDP-Sugar Dependent Glycosyltransferase and Acyltransferase Involved in the Phenylethanoid Glycoside Biosynthesis Induced by Methyl Jasmonate in Sesamum indicum L. Plant & cell physiology. 2023 May; ?(?):. doi: 10.1093/pcp/pcad053. [PMID: 37233612]
Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao. Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6'/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability. Journal of agricultural and food chemistry. 2023 May; 71(20):7689-7702. doi: 10.1021/acs.jafc.3c00527. [PMID: 37167604]
Shihua Shi, Demei Huang, Yongcan Wu, Caixia Pei, Yilan Wang, Zherui Shen, Sijing Zhao, Nan Jia, Xiaomin Wang, Bonan Chen, Jie Pan, Fei Wang, Zhenxing Wang. Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 Inflammasome. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 May; 177(?):113858. doi: 10.1016/j.fct.2023.113858. [PMID: 37236293]
Jiuxi Liu, Jiapei Cai, Peng Fan, Xue Dong, Naisheng Zhang, Jiandong Tai, Yongguo Cao. Salidroside protects mice from high-fat diet-induced obesity by modulating the gut microbiota. International immunopharmacology. 2023 May; 120(?):110278. doi: 10.1016/j.intimp.2023.110278. [PMID: 37192552]
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, Yuliang Cheng, Yahui Guo, He Qian, Yu Liu. Reshaped Gut Microbial Composition and Functions Associated with the Antifatigue Effect of Salidroside in Exercise Mice. Molecular nutrition & food research. 2023 Apr; ?(?):e2300015. doi: 10.1002/mnfr.202300015. [PMID: 37082899]
Lingling Xiao, Liang Li, Jingcong Huang, Yuting Luan, Jiaying Pan, Yun Gai, Zhenyu Xu. Salidroside attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in septic encephalopathy mice. International immunopharmacology. 2023 Apr; 117(?):109975. doi: 10.1016/j.intimp.2023.109975. [PMID: 36948107]
Hanna Nikolaichuk, Irena M Choma, Gertrud E Morlock. Effect-Directed Profiling of Akebia quinata and Clitoria ternatea via High-Performance Thin-Layer Chromatography, Planar Assays and High-Resolution Mass Spectrometry. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28072893. [PMID: 37049655]
Yihan Yang, Daoyi Xi, Yanan Wu, Tao Liu. Complete Biosynthesis of Phenylethanoid Glycoside Verbascoside. Plant communications. 2023 Mar; ?(?):100592. doi: 10.1016/j.xplc.2023.100592. [PMID: 36935606]
Sixia Yang, Linshuang Wang, Yi Zeng, Yong Wang, Tingting Pei, Zeping Xie, Qiaowu Xiong, Hui Wei, Wenxu Li, Jiaqi Li, Qian Su, Dongfeng Wei, Weidong Cheng. Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154762. doi: 10.1016/j.phymed.2023.154762. [PMID: 36965372]
Bing Jiang, Longfei Feng, Tao Yang, Wenjing Guo, Yangyang Li, Tao Wang, Chengguang Liu, Haixiang Su. Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy. Molecular medicine reports. 2023 Feb; 27(2):. doi: 10.3892/mmr.2022.12924. [PMID: 36579660]
Yun Wang, Zhe Chen, Jing Luo, Jing Zhang, A-Ming Sang, Zhen-Shun Cheng, Xin-Yi Li. Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis. International immunopharmacology. 2023 Feb; 115(?):109731. doi: 10.1016/j.intimp.2023.109731. [PMID: 36907990]
Yihong Chai, Feng Chen, Zijian Li, Panpan Yang, Qi Zhou, Wenling Liu, Yaming Xi. Mechanism of salidroside in the treatment of chronic myeloid leukemia based on the network pharmacology and molecular docking. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2023 Feb; 25(2):384-395. doi: 10.1007/s12094-022-02990-w. [PMID: 36369630]
Kun Wang, Li Wang, Guojing Zhao, Yong Liu, Fengchan Wang, Huan Song, Yin Sun, Zhaoshan Zhou, Xuechao Lu, Haibo Hu, Huantian Cui. Mechanistic study of salidroside on ovalbumin-induced asthmatic model mice based on untargeted metabolomics analysis. Food & function. 2023 Jan; 14(1):413-426. doi: 10.1039/d2fo02225g. [PMID: 36515134]
Jun Zhou, Shan Yan, Xu Guo, Yanguo Gao, Shiqi Chen, Xiaohan Li, Yonghong Zhang, Qibin Wang, Tao Zheng, Li Chen. Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions. International immunopharmacology. 2023 Jan; 114(?):109543. doi: 10.1016/j.intimp.2022.109543. [PMID: 36508922]
Jiaying Pan, Jie Zhu, Liang Li, Tao Zhang, Zhenyu Xu. Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway. Human & experimental toxicology. 2023 Jan; 42(?):9603271231169520. doi: 10.1177/09603271231169520. [PMID: 37078094]
Ya Hou, Yating Zhang, Shengnan Jiang, Na Xie, Yi Zhang, Xianli Meng, Xiaobo Wang. Salidroside intensifies mitochondrial function of CoCl2-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154568. doi: 10.1016/j.phymed.2022.154568. [PMID: 36610162]
Baocheng Xie, Huan Zhou, Hongyu Liu, Shiyi Liao, Chenhui Zhou, Daohua Xu. Salidroside alleviates dexamethasone-induced inhibition of bone formation via transforming growth factor-beta/Smad2/3 signaling pathway. Phytotherapy research : PTR. 2022 Dec; ?(?):. doi: 10.1002/ptr.7711. [PMID: 36567454]
Baozhen Qu, Xuemao Liu, Yanjiao Liang, Keke Zheng, Chunling Zhang, Linlin Lu. Salidroside in the Treatment of NAFLD/NASH. Chemistry & biodiversity. 2022 Dec; 19(12):e202200401. doi: 10.1002/cbdv.202200401. [PMID: 36210339]
Hanna Nikolaichuk, Marek Studziński, Marek Stankevič, Irena M Choma. Qualitative and Quantitative Evaluation of Rosavin, Salidroside, and p-Tyrosol in Artic Root Products via TLC-Screening, HPLC-DAD, and NMR Spectroscopy. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238299. [PMID: 36500392]
Sixia Yang, Tingting Pei, Linshuang Wang, Yi Zeng, Wenxu Li, Shihua Yan, Wei Xiao, Weidong Cheng. Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27228039. [PMID: 36432138]
Qinyun Du, Qingxiu He, Fengming Zhang, Jiao Mi, Yuying Li, Shaohui Wang, Yi Zhang. An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules. Journal of visualized experiments : JoVE. 2022 11; ?(189):. doi: 10.3791/64670. [PMID: 36408988]
Nazym K Korbozova, Nataliya O Kudrina, Nataliya A Zhukova, Alexander E Grazhdannikov, Irina V Blavachinskaya, Gulnaz A Seitimova, Timur E Kulmanov, Tatyana G Tolstikova, Nina V Terletskaya. Antihypothyroid Effect of Salidroside. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217487. [PMID: 36364314]
Jie Liu, Dezhao Li, Yaoshan Dun, Hui Li, Jeffrey W Ripley-Gonzalez, Jie Zhang, Ling Qiu, Baiyang You, Suixin Liu. Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease. Life sciences. 2022 Nov; 308(?):120949. doi: 10.1016/j.lfs.2022.120949. [PMID: 36096243]
Jiannan Li, Ruibin Wang, Qiang Chen, Yiqi Tian, Leilei Gao, Anmin Lei. Salidroside improves porcine oocyte maturation and subsequent embryonic development by promoting lipid metabolism. Theriogenology. 2022 Oct; 192(?):89-96. doi: 10.1016/j.theriogenology.2022.08.028. [PMID: 36084388]
Lu Jiang, Liying Xu, Lanzhi Zheng, Yuan Wang, Mingyang Zhuang, Dongdong Yang. Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. Bioorganic & medicinal chemistry. 2022 10; 71(?):116865. doi: 10.1016/j.bmc.2022.116865. [PMID: 35985062]
Zhifu Cui, Ningning Jin, Felix Kwame Amevor, Gang Shu, Xiaxia Du, Xincheng Kang, Zifan Ning, Xun Deng, Yaofu Tian, Qing Zhu, Yan Wang, Diyan Li, Yao Zhang, Xiaoqi Wang, Xue Han, Jing Feng, Xiaoling Zhao. Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3-β pathway. Poultry science. 2022 Sep; 101(9):102034. doi: 10.1016/j.psj.2022.102034. [PMID: 35926351]
Tingxu Yan, Xu Li, Tingting Nian, Xiaozhuo Zhang, Bosai He, Kaishun Bi, Zhenzhong Wang. Salidroside Inhibits Ischemia/Reperfusion-Induced Myocardial Apoptosis by Targeting Mir-378a-3p Via the Igf1r/Pi3k/Akt Signaling Pathway. Transplantation proceedings. 2022 Sep; 54(7):1970-1983. doi: 10.1016/j.transproceed.2022.05.017. [PMID: 35927086]
Cai-Long Pan, Guo-Liang Dai, Hui-Wen Zhang, Chen-Yang Zhang, Qing-Hai Meng, Lu Xu, Ning Xu, Yong Zhang, Qi-Lian Tan, Xiao-Liang Wang, Zhi-Yuan Zhang. Salidroside ameliorates orthopedic surgery-induced cognitive dysfunction by activating adenosine 5'-monophosphate-activated protein kinase signaling in mice. European journal of pharmacology. 2022 Aug; 929(?):175148. doi: 10.1016/j.ejphar.2022.175148. [PMID: 35834964]
Xin Tian, Ye Huang, Xiaofeng Zhang, Rong Fang, Yi Feng, Wanfang Zhang, Ling Li, Tian Li. Salidroside attenuates myocardial ischemia/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission. Toxicology and applied pharmacology. 2022 08; 448(?):116093. doi: 10.1016/j.taap.2022.116093. [PMID: 35659894]
Xiaobo Wang, Yan Tang, Na Xie, Jinrong Bai, Shengnan Jiang, Yi Zhang, Ya Hou, Xianli Meng. Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1/p53/Drp1 signaling. Journal of ethnopharmacology. 2022 Jul; 293(?):115278. doi: 10.1016/j.jep.2022.115278. [PMID: 35439546]
Shengnan Jiang, Fangfang Fan, Lu Yang, Ke Chen, Zhihao Sun, Yi Zhang, Nanjia Cairang, Xiaobo Wang, Xianli Meng. Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-κB/NLRP3 pathway. European journal of pharmacology. 2022 Jun; 925(?):175015. doi: 10.1016/j.ejphar.2022.175015. [PMID: 35561751]
Philip G Kasprzyk, Christopher Vickery, Mingli Ye, Magdalena Sewastianik, Wei Gong, Sheng Ding, Margitta Dziwenka, Amy Mozingo, Kaiti Valm, Holly Schachner, Jing-Ke Weng. Safety of a Sustainably Produced, Bioengineered, Nature-Identical Salidroside Compound. Nutrients. 2022 Jun; 14(11):. doi: 10.3390/nu14112330. [PMID: 35684130]
Xing-Mei Shu, Yang Hu, Xin Fang, Jing Wang, Xiao-Yan Qin, Rongfeng Lan. Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2022 Jun; 71(5-6):615-626. doi: 10.1007/s00011-022-01580-4. [PMID: 35583558]
Fangfang Fan, Ning Xu, Yucheng Sun, Xuanhao Li, Xinchang Gao, Xizhen Yi, Yi Zhang, Xianli Meng, Jin-Ming Lin. Uncovering the Metabolic Mechanism of Salidroside Alleviating Microglial Hypoxia Inflammation Based on Microfluidic Chip-Mass Spectrometry. Journal of proteome research. 2022 04; 21(4):921-929. doi: 10.1021/acs.jproteome.1c00647. [PMID: 34851127]
Jia-Qi Mao, Chuan-Chuan Liu, Yu-Wei Zhang, Qing-Qing Zhang, Hong Liu, Lan Ma. [Salidroside inhibits phenotypic transformation of rat pulmonary artery smooth muscle cells induced by hypoxia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Feb; 47(4):1024-1030. doi: 10.19540/j.cnki.cjcmm.20211103.706. [PMID: 35285203]
Jing Qian, Xiao-Hong Wang, Ben-Zhong Wei, Guo-Xiong Zhou, Shun-Xing Zhu, Chun Liu. Therapeutic effects of salidroside vs pyrrolidine dithiocarbamate against severe acute pancreatitis in rat. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 02; 42(1):49-57. doi: 10.19852/j.cnki.jtcm.20210707.002. [PMID: 35322632]
Yanjia Che, Yuanyang Chen, Zhiwei Wang, Sihao Zheng, Kai Xing, Shun Yuan, Xiaohan Zhong. The Combination of Rhodosin and MMF Prolongs Cardiac Allograft Survival by Inhibiting DC Maturation by Promoting Mitochondrial Fusion. Oxidative medicine and cellular longevity. 2022; 2022(?):7260305. doi: 10.1155/2022/7260305. [PMID: 35855862]
Yanjiao Hao, Zhiyu Li, Mingzhi Chang, Xiaoli Zhang. Effects of Salidroside Combined with Paclitaxel on Proliferation, Migration, and Epithelial Mesenchyme of Colorectal Cancer Cells. Drug design, development and therapy. 2022; 16(?):4079-4089. doi: 10.2147/dddt.s384151. [PMID: 36465266]
Jing Shi, Qin Zhao, Dou Dou Hao, Hong Xia Miao, Sha Wan, Chao Hua Zhou, Si Yu Wang, Si Yuan Chen, Jin Shang, Tian Hang Feng. Gut microbiota profiling revealed the regulating effects of salidroside on iron metabolism in diabetic mice. Frontiers in endocrinology. 2022; 13(?):1014577. doi: 10.3389/fendo.2022.1014577. [PMID: 36213297]
Heng Fan, Bin-Jie Su, Jian-Wei Le, Jian-Hua Zhu. Salidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting Inflammation and Apoptosis. Drug design, development and therapy. 2022; 16(?):899-907. doi: 10.2147/dddt.s361972. [PMID: 35386851]
Fei Yao, Xinyi Jiang, Ling Qiu, Zixuan Peng, Wei Zheng, Lexi Ding, Xiaobo Xia. Long-Term Oral Administration of Salidroside Alleviates Diabetic Retinopathy in db/db Mice. Frontiers in endocrinology. 2022; 13(?):861452. doi: 10.3389/fendo.2022.861452. [PMID: 35370972]
Xi Ming, Xingzhu Yu, Jijun Li, Junyu Wang, Jialin Zheng, Lei Xiong. Salidroside Attenuates Airway Inflammation and Remodeling via the miR-323-3p/SOCS5 Axis in Asthmatic Mice. International archives of allergy and immunology. 2022; 183(4):424-434. doi: 10.1159/000520444. [PMID: 34856542]
Yan Tang, Ya Hou, Yong Zeng, Yao Hu, Yi Zhang, Xiaobo Wang, Xianli Meng. Salidroside attenuates CoCl2-simulated hypoxia injury in PC12 cells partly by mitochondrial protection. European journal of pharmacology. 2021 Dec; 912(?):174617. doi: 10.1016/j.ejphar.2021.174617. [PMID: 34748770]
Manli Hu, Dingran Zhang, Hongyang Xu, Yan Zhang, Hongjie Shi, Xiaoli Huang, Xinhui Wang, Yan Wu, Zhili Qi. Salidroside Activates the AMP-Activated Protein Kinase Pathway to Suppress Nonalcoholic Steatohepatitis in Mice. Hepatology (Baltimore, Md.). 2021 12; 74(6):3056-3073. doi: 10.1002/hep.32066. [PMID: 34292604]
Ziying Dai, Xuan Zhang, Wuyan Li, Junxia Tang, Tingting Pan, Chenru Ma, Quanlin Guan. Salidroside Induces Apoptosis in Human Gastric Cancer Cells via the Downregulation of ENO1/PKM2/GLUT1 Expression. Biological & pharmaceutical bulletin. 2021 Nov; 44(11):1724-1731. doi: 10.1248/bpb.b21-00443. [PMID: 34471002]
Ya-Wen Hsiao, Yung-Nan Tsai, Yu-Ting Huang, Shuen-Hsin Liu, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Shien-Fong Lin, Shih-Lin Chang, Satoshi Higa, Shih-Ann Chen. Rhodiola crenulata reduces ventricular arrhythmia through mitigating the activation of IL-17 and inhibiting the MAPK signaling pathway. Cardiovascular drugs and therapy. 2021 10; 35(5):889-900. doi: 10.1007/s10557-020-07072-z. [PMID: 32946036]
Miaoyong Ye, Fan Zhao, Ke Ma, Kang Zhou, Jianxiong Ma, Huiying Fu, Zengbao Xu, Wenjie Huang, Wenzhi Wang, Jianfeng Zhao, Bodong Lv. Enhanced effects of salidroside on erectile function and corpora cavernosa autophagy in a cavernous nerve injury rat model. Andrologia. 2021 Jul; 53(6):e14044. doi: 10.1111/and.14044. [PMID: 33709426]
Cheng-Cheng Zhao, Xin-Yue Wu, Huan Yi, Rong Chen, Gang Fan. The Therapeutic Effects and Mechanisms of Salidroside on Cardiovascular and Metabolic Diseases: An Updated Review. Chemistry & biodiversity. 2021 Jul; 18(7):e2100033. doi: 10.1002/cbdv.202100033. [PMID: 33991395]
Qian-Nan Ye, Chang-Qing Zhao, Jian Ping, Lie-Ming Xu. [Study on mechanism of salidroside against liver fibrosis by regulating CXCL16]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Jun; 46(11):2865-2870. doi: 10.19540/j.cnki.cjcmm.20201224.401. [PMID: 34296587]
Marc-Sebastian F Straka, Noha Abdullah Al-Otaibi, Philip D Whitfield, Mary K Doherty, Bruno F E Matarèse, Nigel K H Slater, Hassan Rahmoune. Disaccahrides-Based Cryo-Formulant Effect on Modulating Phospho/Mitochondrial Lipids and Biological Profiles of Human Leukaemia Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2021 Apr; 55(2):206-221. doi: 10.33594/000000360. [PMID: 33914444]
Xumin Zhang, Long Xie, Jiaying Long, Qingxuan Xie, Yu Zheng, Kai Liu, Xiaofang Li. Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties. Chemico-biological interactions. 2021 Apr; 339(?):109268. doi: 10.1016/j.cbi.2020.109268. [PMID: 33617801]
Tao Zheng, Qibin Wang, Fang Bian, Yan Zhao, Weidong Ma, Yonghong Zhang, Wei Lu, Pan Lei, Lulu Zhang, Xincai Hao, Li Chen. Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis. Toxicology and applied pharmacology. 2021 04; 416(?):115468. doi: 10.1016/j.taap.2021.115468. [PMID: 33639149]
Chun-Xia Liang, Dong-Li Qi, Li-Na Zhang, Peng Lu, Zhi-Dong Liu. Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside. Chinese journal of natural medicines. 2021 Mar; 19(3):231-240. doi: 10.1016/s1875-5364(21)60025-0. [PMID: 33781457]
Tongxin Song, Pengli Wang, Chenyang Li, Li Jia, Qianqian Liang, Yuanlin Cao, Pengzhi Dong, Hong Shi, Miaomiao Jiang. Salidroside simultaneously reduces de novo lipogenesis and cholesterol biosynthesis to attenuate atherosclerosis in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Feb; 134(?):111137. doi: 10.1016/j.biopha.2020.111137. [PMID: 33341055]
Ping Jin, Liang-Hai Li, Yan Shi, Nan-Bin Hu. Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury. Gene. 2021 Jan; 767(?):145075. doi: 10.1016/j.gene.2020.145075. [PMID: 32858179]
Zelin Yang, Xin Huang, Wenfang Lai, Yuheng Tang, Junjie Liu, Yingzheng Wang, Kedan Chu, John Brown, Guizhu Hong. Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. European journal of medicinal chemistry. 2021 Jan; 209(?):112935. doi: 10.1016/j.ejmech.2020.112935. [PMID: 33097301]
Attalla F El-Kott, Eman R ElBealy, Ali S Alshehri, Ayman E El-Kenawy, Heba S Khalifa, Amira M AlRamlawy. Salidroside induces cell apoptosis and inhibits the invasiveness of HT29 colorectal cells by regulating protein kinase R, NF-κB and STAT3. Cancer biomarkers : section A of Disease markers. 2021; 31(1):13-25. doi: 10.3233/cbm-203257. [PMID: 33749640]
Weidong Ma, Ziyuan Wang, Yan Zhao, Qibin Wang, Yonghong Zhang, Pan Lei, Wei Lu, Shan Yan, Jun Zhou, Xiaojiao Li, Wenjun Yu, Yaoxin Zhong, Li Chen, Tao Zheng. Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation. Oxidative medicine and cellular longevity. 2021; 2021(?):6614574. doi: 10.1155/2021/6614574. [PMID: 34457117]
Xia Zhang, Jinglin Zhu, Jiangna Yan, Yue Xiao, Ruijie Yang, Ruifei Huang, Jun Zhou, Zhenzhong Wang, Wei Xiao, Chunli Zheng, Yonghua Wang. Systems pharmacology unravels the synergic target space and therapeutic potential of Rhodiola rosea L. for non-small cell lung cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153326. doi: 10.1016/j.phymed.2020.153326. [PMID: 32992083]
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