rhodosin (BioDeep_00000862209)

PANOMIX_OTCML-2023

代谢物信息卡片

(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]tetrahydropyran-3,4,5-triol

化学式: C14H20O7 (300.1209)
中文名称: 红景天苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1CCOC2C(C(C(C(O2)CO)O)O)O)O
InChI: InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1

描述信息

Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

同义名列表

13 个代谢物同义名

(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]tetrahydropyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[2-(4-hydroxyphenyl)ethoxy]-6-methylol-tetrahydropyran-3,4,5-triol; (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol; beta-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl; 2-(4-Hydroxyphenyl)ethyl beta-D-glucopyranoside; Glucopyranoside, p-hydroxyphenethyl; MEGxp0_000478; ACon1_000366; rhodioloside; Salidroside; 10338-51-9; rhodosin; Salidroside

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:9009
KEGG: C06046
PubChem: 159278
ChEMBL: CHEMBL465208
CAS: 10338-51-9
PubChem: 8317
KNApSAcK: C00031274
3DMET: B01958
NIKKAJI: J15.618C
medchemexpress: HY-N0109
KNApSAcK: 9009

分类词条

酚类

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

90 个相关的物种来源信息

158539 - Aristolochia cucurbitifolia: 10.1248/CPB.48.1006
141292 - Asystasia gangetica: 10.1007/S11418-007-0158-3
3505 - Betula pendula: 10.1016/0031-9422(95)00057-E
78630 - Betula platyphylla: 10.1007/BF00833499
3711 - Brassica rapa: 10.1016/S0031-9422(97)00362-2
714454 - Buddleja officinalis:
554952 - Campylanthus glaber: 10.1016/S0305-1978(02)00061-3
3649 - Carica papaya: 10.1016/0031-9422(88)80450-3
145513 - Centaurea raphanina: 10.1016/J.CARRES.2010.09.002
87754 - Cistanche phelypaea:
161396 - Cistanche salsa: 10.1248/CPB.32.3009
161397 - Cistanche tubulosa:
323038 - Croton chilensis: 10.1016/0031-9422(92)80479-X
2769829 - Digitalis chalcantha: 10.1055/S-2007-969379
253601 - Epimedium diphyllum: 10.1016/0031-9422(89)80369-3
244027 - Epimedium grandiflorum: 10.1248/CPB.35.1109
1818589 - Fernandoa adenophylla: 10.1016/S0031-9422(01)00212-6
126418 - Forsythia suspensa: 10.1016/S0031-9422(00)97772-0
880136 - Fraxinus formosana:
880137 - Fraxinus griffithii:
880141 - Fraxinus malacophylla: 10.1016/S0031-9422(00)90529-6
498914 - Hydrangea chinensis: 10.1021/NP0302394
23110 - Hydrangea macrophylla: 10.3987/COM-09-11886
282539 - Hypericum erectum: 10.1007/S11418-008-0256-X
35883 - Ipomoea nil: 10.1248/CPB.59.1425
53161 - Lamium galeobdolon: 10.1016/J.PHYTOCHEM.2003.08.001
458695 - Ligustrum lucidum Ait.: -
1315792 - Linaria japonica: 10.1016/0031-9422(93)85459-5
680227 - Millingtonia hortensis: 10.1016/0031-9422(94)00939-Q
1197397 - Pedicularis plicata: 10.1016/0031-9422(91)83660-D
388112 - Penstemon acuminatus: 10.1016/S0031-9422(00)89534-5
388204 - Penstemon secundiflorus: 10.1016/0031-9422(92)80441-G
1719525 - Peperomia humilis: 10.1016/S0031-9422(03)00183-3
511531 - Peperomia leptostachya: 10.1016/S0031-9422(03)00183-3
49563 - Peucedanum japonicum: 10.1021/JF0349127
126558 - Phillyrea latifolia:
101995 - Plantago australis: 10.1016/S0031-9422(00)00306-X
101996 - Plantago coronopus: 10.1016/S0031-9422(00)00306-X
33090 - Plants: -
83689 - Polypremum procumbens: 10.1016/S0305-1978(99)00040-X
113636 - Populus tremula: 10.1016/0031-9422(86)88020-7
99300 - Rehmannia glutinosa: 10.1016/0031-9422(91)84224-G
1442767 - Rhodiola coccinea: 10.1055/S-2006-960220
242839 - Rhodiola crenulata:
203003 - Rhodiola fastigiata: 10.4268/CJCMM20111611
203004 - Rhodiola heterodonta:
203008 - Rhodiola kirilowii: 10.5246/JCPS.2011.02.019
487764 - Rhodiola quadrifida:
203015 - Rhodiola rosea:
265354 - Rhodiola sachalinensis:
203000 - Rhodiola sacra: 10.1248/CPB.45.1498
53035 - Ricciocarpos natans: 10.1016/S0031-9422(00)97567-8
75704 - Salix alba:
395313 - Salix arctica: 10.1016/S0031-9422(00)88609-4
1004002 - Salix atrocinerea:
75706 - Salix babylonica:
75707 - Salix bebbiana:
1087216 - Salix candida: 10.1016/S0031-9422(00)88609-4
172267 - Salix caprea:
470278 - Salix cinerea:
470274 - Salix daphnoides: 10.1016/S0031-9422(00)88609-4
77063 - Salix fragilis:
77064 - Salix herbacea: 10.1016/S0031-9422(00)85563-6
75712 - Salix interior:
470272 - Salix lapponum:
339964 - Salix myrsinifolia:
75715 - Salix pentandra:
470269 - Salix phylicifolia:
77065 - Salix purpurea:
77069 - Salix triandra:
40686 - Salix viminalis:
50506 - Sargentodoxa cuneata: 10.3987/COM-03-9777
1357594 - Scrophularia alpestris: 10.1016/0031-9422(93)85028-P
942083 - Scrophularia umbrosa: 10.1016/0031-9422(93)85028-P
65409 - Scutellaria baicalensis: 10.1016/S0031-9422(96)00443-8
180010 - Stachys byzantina: 10.1021/NP8001805
28545 - Strychnos nux-vomica: 10.1016/S0031-9422(00)97792-6
28545 - Strychnos nux-vomica L.: -
126367 - Syringa reticulata: 10.1016/J.BMCL.2011.08.089
34270 - Syringa vulgaris:
2822952 - Tecoma stans var. sambucifolia: 10.1016/S0031-9422(00)90799-4
237933 - Viburnum dilatatum: 10.1016/0031-9422(91)85058-8
49994 - Volkameria inermis: 10.1016/S0031-9422(01)00208-4
33090 - 大血藤: -
33090 - 天葵子: -
33090 - 女贞子: -
33090 - 木蝴蝶: -
33090 - 肉苁蓉: -
33090 - 连翘: -
33090 - 马钱子: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	14	ANG, CASP1, GSDMD, IL18, MAP2, NOS2, NOS3, PPARG, PRKAA2, PTGS2, SIRT1, STAT3, TXNIP, VEGFA
Peripheral membrane protein	1	PTGS2
Endoplasmic reticulum membrane	2	HMOX1, PTGS2
Mitochondrion membrane	1	GSDMD
Nucleus	10	ANG, HMOX1, NOS2, NOS3, PPARG, PPARGC1A, PRKAA2, SIRT1, STAT3, VEGFA
cytosol	14	ANG, CASP1, GSDMD, HMOX1, IL18, MAP2, NOS2, NOS3, PPARG, PPARGC1A, PRKAA2, SIRT1, STAT3, TXNIP
dendrite	2	MAP2, PRKAA2
mitochondrial membrane	1	GSDMD
nucleoplasm	9	GSDMD, HMOX1, NOS2, NOS3, PPARG, PPARGC1A, PRKAA2, SIRT1, STAT3
RNA polymerase II transcription regulator complex	2	PPARG, STAT3
Cell membrane	3	CASP1, CD8A, GSDMD
Cytoplasmic side	1	HMOX1
Multi-pass membrane protein	1	GSDMD
cell surface	1	VEGFA
dendritic shaft	1	MAP2
Golgi apparatus	3	NOS3, PRKAA2, VEGFA
Golgi membrane	2	INS, NOS3
growth cone	1	ANG
neuronal cell body	3	ANG, MAP2, PRKAA2
Cytoplasm, cytosol	2	IL18, NOS2
plasma membrane	6	CASP1, CD8A, GSDMD, NOS2, NOS3, STAT3
Membrane	4	GSDMD, HMOX1, PRKAA2, VEGFA
axon	1	PRKAA2
caveola	2	NOS3, PTGS2
endoplasmic reticulum	3	HMOX1, PTGS2, VEGFA
extracellular space	8	ANG, GSDMD, HMOX1, IL17A, IL18, IL5, INS, VEGFA
perinuclear region of cytoplasm	4	HMOX1, NOS2, NOS3, PPARG
adherens junction	1	VEGFA
mitochondrion	1	SIRT1
protein-containing complex	2	CASP1, PTGS2
intracellular membrane-bounded organelle	1	PPARG
Microsome membrane	1	PTGS2
chromatin silencing complex	1	SIRT1
Single-pass type I membrane protein	1	CD8A
Secreted	7	ANG, GSDMD, IL17A, IL18, IL5, INS, VEGFA
extracellular region	8	ANG, CD8A, GSDMD, IL17A, IL18, IL5, INS, VEGFA
mitochondrial outer membrane	1	HMOX1
[Isoform 2]: Secreted	1	CD8A
transcription regulator complex	1	STAT3
external side of plasma membrane	2	CD8A, IL17A
Secreted, extracellular space, extracellular matrix	1	VEGFA
actin cytoskeleton	1	ANG
nucleolus	3	ANG, CASP1, SIRT1
Cytoplasm, P-body	2	NOS2, NOS3
P-body	2	NOS2, NOS3
Cytoplasm, perinuclear region	1	NOS2
heterochromatin	1	SIRT1
Cytoplasm, cytoskeleton	1	MAP2
microtubule	2	CASP1, MAP2
extracellular matrix	1	VEGFA
Peroxisome	1	NOS2
basement membrane	1	ANG
peroxisomal matrix	1	NOS2
Nucleus, PML body	2	PPARGC1A, SIRT1
PML body	2	PPARGC1A, SIRT1
secretory granule	1	VEGFA
nuclear speck	1	PRKAA2
Inflammasome	1	GSDMD
NLRP3 inflammasome complex	2	CASP1, GSDMD
Nucleus inner membrane	1	PTGS2
Nucleus outer membrane	1	PTGS2
nuclear inner membrane	2	PTGS2, SIRT1
nuclear outer membrane	1	PTGS2
dendrite cytoplasm	1	MAP2
receptor complex	2	CD8A, PPARG
neuron projection	2	MAP2, PTGS2
chromatin	4	PPARG, PPARGC1A, SIRT1, STAT3
microtubule associated complex	1	MAP2
Chromosome	1	ANG
cytoskeleton	1	NOS3
Nucleus, nucleolus	1	ANG
fibrillar center	1	SIRT1
nuclear envelope	1	SIRT1
Endomembrane system	1	GSDMD
endosome lumen	1	INS
axon initial segment	1	MAP2
Cell projection, dendrite	1	MAP2
Cytoplasm, Stress granule	2	ANG, NOS3
cytoplasmic stress granule	3	ANG, NOS3, PRKAA2
euchromatin	1	SIRT1
dendritic growth cone	1	MAP2
plasma membrane raft	1	CD8A
ficolin-1-rich granule lumen	1	GSDMD
secretory granule lumen	1	INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	2	INS, PTGS2
platelet alpha granule lumen	1	VEGFA
specific granule lumen	1	GSDMD
tertiary granule lumen	1	GSDMD
endocytic vesicle membrane	1	NOS3
proximal neuron projection	1	MAP2
endocytic vesicle	1	ANG
transport vesicle	1	INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
Single-pass type IV membrane protein	1	HMOX1
AIM2 inflammasome complex	1	CASP1
axon hillock	1	MAP2
[Isoform 1]: Nucleus	1	PPARGC1A
basal dendrite	1	MAP2
canonical inflammasome complex	1	CASP1
[Isoform 1]: Cell membrane	1	CD8A
eNoSc complex	1	SIRT1
rDNA heterochromatin	1	SIRT1
nucleotide-activated protein kinase complex	1	PRKAA2
T cell receptor complex	1	CD8A
cortical cytoskeleton	1	NOS2
angiogenin-PRI complex	1	ANG
apical distal dendrite	1	MAP2
dendritic branch	1	MAP2
dendritic filopodium	1	MAP2
distal dendrite	1	MAP2
primary dendrite	1	MAP2
proximal dendrite	1	MAP2
[N-VEGF]: Cytoplasm	1	VEGFA
[VEGFA]: Secreted	1	VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum	1	VEGFA
[Isoform VEGF121]: Secreted	1	VEGFA
[Isoform VEGF165]: Secreted	1	VEGFA
VEGF-A complex	1	VEGFA
IPAF inflammasome complex	1	CASP1
NLRP1 inflammasome complex	1	CASP1
protease inhibitor complex	1	CASP1
[Gasdermin-D]: Cytoplasm, cytosol	1	GSDMD
[Gasdermin-D, N-terminal]: Cell membrane	1	GSDMD
[Gasdermin-D, N-terminal]: Cytoplasm, cytosol	1	GSDMD
[Gasdermin-D, p13]: Nucleus	1	GSDMD
[Gasdermin-D, C-terminal]: Cytoplasm, cytosol	1	GSDMD
[SirtT1 75 kDa fragment]: Cytoplasm	1	SIRT1
[Isoform B4]: Nucleus	1	PPARGC1A
[Isoform B4-8a]: Cytoplasm	1	PPARGC1A
[Isoform B5]: Nucleus	1	PPARGC1A
[Isoform 9]: Nucleus	1	PPARGC1A

文献列表

Zehui Li, Jiashan Li, Yuan Li, Li Guo, Panyu Xu, Hanqian Du, Na Lin, Ying Xu. The role of Cistanches Herba and its ingredients in improving reproductive outcomes: A comprehensive review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155681. doi: 10.1016/j.phymed.2024.155681. [PMID: 38718638]
Bin Yang, Ying Xu, Jingzhi Yu, Qihao Wang, Qigui Fan, Xiaoyu Zhao, Yang Qiao, Zeyu Zhang, Qing Zhou, Dong Yin, Ming He, Huan He. Salidroside pretreatment alleviates ferroptosis induced by myocardial ischemia/reperfusion through mitochondrial superoxide-dependent AMPKα2 activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155365. doi: 10.1016/j.phymed.2024.155365. [PMID: 38552436]
Ya Hou, Fuhan Fan, Na Xie, Yi Zhang, Xiaobo Wang, Xianli Meng. Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155529. doi: 10.1016/j.phymed.2024.155529. [PMID: 38503156]
Lirong Huang, Jiaxin Xu, Kun Jia, Yulin Wu, Wei Yuan, Zhipeng Liao, Bo Cheng, Qiang Luo, Guiyou Tian, Huiqiang Lu. Butylparaben induced zebrafish (Danio rerio) kidney injury by down-regulating the PI3K-AKT pathway. Journal of hazardous materials. 2024 May; 470(?):134129. doi: 10.1016/j.jhazmat.2024.134129. [PMID: 38565019]
Suxin You, Zhouyun Ma, Pei Zhang, Wenwen Xu, Changsen Zhan, Nina Sang, Jiazhen Xu, Feiyun Wang, Jiange Zhang. Neuroprotective effects of the salidroside derivative SHPL-49 via the BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116460. doi: 10.1016/j.biopha.2024.116460. [PMID: 38520864]
Xianqi Zhang, Mengdi Zhang, Ziyan Zhang, Shengbo Zhou. Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production. Experimental cell research. 2024 May; 438(1):114034. doi: 10.1016/j.yexcr.2024.114034. [PMID: 38588875]
Guosi Li, Wei Wang, Heng Guo, Shanyong Yi, Fang Wang, Shiping Huang, Nan Hu, Qilin Xu, Yongjun Zang, Bangxing Han, Xinjian Yin. Mutability landscape guided engineering of a promiscuous microbial glycosyltransferase for regioselective synthesis of salidroside and icariside D2. International journal of biological macromolecules. 2024 Apr; 263(Pt 1):130229. doi: 10.1016/j.ijbiomac.2024.130229. [PMID: 38378110]
Guosi Li, Qilin Xu, Nan Hu, Xinyang Liu, Yiqi Jiang, Hailong Xue, Yongjun Zang, Fucheng Zhu. Highly efficient biosynthesis of salidroside by a UDP-glucosyltransferase-catalyzed cascade reaction. Biotechnology letters. 2024 Jan; ?(?):. doi: 10.1007/s10529-023-03453-0. [PMID: 38184486]
Qiao Liu, Qingman Luo, Bin Zhong, Kecheng Tang, Xueling Chen, Shengqian Yang, Xiaohui Li. Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways. European journal of pharmacology. 2024 Jan; 962(?):176236. doi: 10.1016/j.ejphar.2023.176236. [PMID: 38048979]
Dan-Qing Zhang, Xiao-Ying Liu, Lin-Feng Qiu, Zhao-Rui Liu, Ya-Peng Yang, Long Huang, Shi-Yu Wang, Jian-Qiang Zhang. Two chromosome-level genome assemblies of Rhodiola shed new light on genome evolution in rapid radiation and evolution of the biosynthetic pathway of salidroside. The Plant journal : for cell and molecular biology. 2024 Jan; 117(2):464-482. doi: 10.1111/tpj.16501. [PMID: 37872890]
Ting Zhu, Hui Liu, Shiman Gao, Ning Jiang, Shuai Chen, Weijie Xie. Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):115999. doi: 10.1016/j.biopha.2023.115999. [PMID: 38091637]
Liu Shuyuan, Chen Haoyu. Mechanism of Nardostachyos Radix et Rhizoma-Salidroside in the treatment of premature ventricular beats based on network pharmacology and molecular docking. Scientific reports. 2023 11; 13(1):20741. doi: 10.1038/s41598-023-48277-0. [PMID: 38007574]
Bing Jiang, Yangyang Cui, Xinxin Ma, Yanmei Zhang, Xin Feng, Tao Yang, Longfei Feng, Wenjing Guo, Yangyang Li, Tao Wang, Huan Guo, Haining Li, Ying Duan, Haixiang Su. Crosstalk between autophagy inhibitor and salidroside-induced apoptosis: A novel strategy for autophagy-based treatment of hepatocellular cancer. International immunopharmacology. 2023 Nov; 124(Pt B):111040. doi: 10.1016/j.intimp.2023.111040. [PMID: 37839277]
Mu-Han Chen, Xin-Ze Liu, Xiu-Wu Qu, Rui-Bo Guo, Lu Zhang, Liang Kong, Yang Yu, Yang Liu, Juan Zang, Xiu-Ying Li, Xue-Tao Li. ApoE-modified liposomes encapsulating resveratrol and salidroside alleviate manifestations of Alzheimer's disease in APP/PS-1 mice. Drug development and industrial pharmacy. 2023 Sep; ?(?):1-13. doi: 10.1080/03639045.2023.2252062. [PMID: 37649422]
Feng Chen, Yi Hong Chai, Fa Zhang, Yong Qiang Liu, Yan Zhang, Ya Jing Shi, Jian Ming Zhang, Yu-Fang Leng. Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion. Bioscience reports. 2023 Aug; ?(?):. doi: 10.1042/bsr20230539. [PMID: 37530723]
Edward J Calabrese, Gaurav Dhawan, Rachna Kapoor, Evgenios Agathokleous, Vittorio Calabrese. Rhodiola rosea and salidroside commonly induce hormesis, with particular focus on longevity and neuroprotection. Chemico-biological interactions. 2023 Aug; 380(?):110540. doi: 10.1016/j.cbi.2023.110540. [PMID: 37169278]
Zexin Wen, Tong Liu, Yanli Zhang, Qiujuan Yue, Hang Meng, Yijie He, Yi Yang, Minghao Li, Jianwen Zheng, Wei Lin. Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs. BMC cancer. 2023 Aug; 23(1):717. doi: 10.1186/s12885-023-11036-5. [PMID: 37528345]
Jie Ma, Yujie Li, Xiaodi Ji, Anqi Wang, Yue Lan, Lihong Ma. Integrating network pharmacology and experimental verification to explore the mechanisms of salidroside against myocardial fibrosis. Biochemical and biophysical research communications. 2023 Aug; 677(?):38-44. doi: 10.1016/j.bbrc.2023.07.059. [PMID: 37544102]
Xue-Hua Wang, Zhong-Fu Zuo, Lu Meng, Qi Yang, Pan Lv, Li-Pan Zhao, Xiao-Bai Wang, Yu-Fei Wang, Ying Huang, Cong Fu, Wen-Qiang Liu, Xue-Zheng Liu, De-Yu Zheng. Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway. Psychopharmacology. 2023 Jul; ?(?):. doi: 10.1007/s00213-023-06373-z. [PMID: 37490132]
Ru-Han Liu, Teng-Fei Ma, Qin Yang, Wen-Chang Xiao, Lu Yin, Miao Yin, Jin-Song Zhang, Chi-Hua Wang. Salidroside suppresses proliferation and migration in prostate cancer via the PI3K/AKT pathway. Cancer biomarkers : section A of Disease markers. 2023 Jul; ?(?):. doi: 10.3233/cbm-220454. [PMID: 37545219]
Pei Zhang, Jiazhen Xu, Qianfei Cui, Guoqiang Lin, Feiyun Wang, Xinyue Ding, Suxin You, Nina Sang, Junchao Tan, Wenwen Xu, Changsen Zhan, Yuying Zhu, Jiange Zhang. Multi-pathway neuroprotective effects of a novel salidroside derivative SHPL-49 against acute cerebral ischemic injury. European journal of pharmacology. 2023 Jun; 949(?):175716. doi: 10.1016/j.ejphar.2023.175716. [PMID: 37059375]
Lin Tao, Zhi-Fang Liang, Liu Miao, Yu-Jie Guo, Ye Li, Yan-Li Liu, Dong-Ming Fang, Zhi-Jie Yang. Mechanism of salidroside against coronary artery disease by network pharmacology analysis. BMC complementary medicine and therapies. 2023 Jun; 23(1):194. doi: 10.1186/s12906-023-04027-3. [PMID: 37308900]
Yushiro Fuji, Kai Uchida, Tomoyoshi Akashi, Takashi Ohtsuki, Hiroshi Matsufuji, Masami Yokota Hirai. Molecular Identification of UDP-Sugar Dependent Glycosyltransferase and Acyltransferase Involved in the Phenylethanoid Glycoside Biosynthesis Induced by Methyl Jasmonate in Sesamum indicum L. Plant & cell physiology. 2023 May; ?(?):. doi: 10.1093/pcp/pcad053. [PMID: 37233612]
Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao. Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6'/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability. Journal of agricultural and food chemistry. 2023 May; 71(20):7689-7702. doi: 10.1021/acs.jafc.3c00527. [PMID: 37167604]
Shihua Shi, Demei Huang, Yongcan Wu, Caixia Pei, Yilan Wang, Zherui Shen, Sijing Zhao, Nan Jia, Xiaomin Wang, Bonan Chen, Jie Pan, Fei Wang, Zhenxing Wang. Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 Inflammasome. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 May; 177(?):113858. doi: 10.1016/j.fct.2023.113858. [PMID: 37236293]
Jiuxi Liu, Jiapei Cai, Peng Fan, Xue Dong, Naisheng Zhang, Jiandong Tai, Yongguo Cao. Salidroside protects mice from high-fat diet-induced obesity by modulating the gut microbiota. International immunopharmacology. 2023 May; 120(?):110278. doi: 10.1016/j.intimp.2023.110278. [PMID: 37192552]
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, Yuliang Cheng, Yahui Guo, He Qian, Yu Liu. Reshaped Gut Microbial Composition and Functions Associated with the Antifatigue Effect of Salidroside in Exercise Mice. Molecular nutrition & food research. 2023 Apr; ?(?):e2300015. doi: 10.1002/mnfr.202300015. [PMID: 37082899]
Lingling Xiao, Liang Li, Jingcong Huang, Yuting Luan, Jiaying Pan, Yun Gai, Zhenyu Xu. Salidroside attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in septic encephalopathy mice. International immunopharmacology. 2023 Apr; 117(?):109975. doi: 10.1016/j.intimp.2023.109975. [PMID: 36948107]
Hanna Nikolaichuk, Irena M Choma, Gertrud E Morlock. Effect-Directed Profiling of Akebia quinata and Clitoria ternatea via High-Performance Thin-Layer Chromatography, Planar Assays and High-Resolution Mass Spectrometry. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28072893. [PMID: 37049655]
Yihan Yang, Daoyi Xi, Yanan Wu, Tao Liu. Complete Biosynthesis of Phenylethanoid Glycoside Verbascoside. Plant communications. 2023 Mar; ?(?):100592. doi: 10.1016/j.xplc.2023.100592. [PMID: 36935606]
Sixia Yang, Linshuang Wang, Yi Zeng, Yong Wang, Tingting Pei, Zeping Xie, Qiaowu Xiong, Hui Wei, Wenxu Li, Jiaqi Li, Qian Su, Dongfeng Wei, Weidong Cheng. Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154762. doi: 10.1016/j.phymed.2023.154762. [PMID: 36965372]
Bing Jiang, Longfei Feng, Tao Yang, Wenjing Guo, Yangyang Li, Tao Wang, Chengguang Liu, Haixiang Su. Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy. Molecular medicine reports. 2023 Feb; 27(2):. doi: 10.3892/mmr.2022.12924. [PMID: 36579660]
Yun Wang, Zhe Chen, Jing Luo, Jing Zhang, A-Ming Sang, Zhen-Shun Cheng, Xin-Yi Li. Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis. International immunopharmacology. 2023 Feb; 115(?):109731. doi: 10.1016/j.intimp.2023.109731. [PMID: 36907990]
Yihong Chai, Feng Chen, Zijian Li, Panpan Yang, Qi Zhou, Wenling Liu, Yaming Xi. Mechanism of salidroside in the treatment of chronic myeloid leukemia based on the network pharmacology and molecular docking. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2023 Feb; 25(2):384-395. doi: 10.1007/s12094-022-02990-w. [PMID: 36369630]
Kun Wang, Li Wang, Guojing Zhao, Yong Liu, Fengchan Wang, Huan Song, Yin Sun, Zhaoshan Zhou, Xuechao Lu, Haibo Hu, Huantian Cui. Mechanistic study of salidroside on ovalbumin-induced asthmatic model mice based on untargeted metabolomics analysis. Food & function. 2023 Jan; 14(1):413-426. doi: 10.1039/d2fo02225g. [PMID: 36515134]
Jun Zhou, Shan Yan, Xu Guo, Yanguo Gao, Shiqi Chen, Xiaohan Li, Yonghong Zhang, Qibin Wang, Tao Zheng, Li Chen. Salidroside protects pancreatic β-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions. International immunopharmacology. 2023 Jan; 114(?):109543. doi: 10.1016/j.intimp.2022.109543. [PMID: 36508922]
Jiaying Pan, Jie Zhu, Liang Li, Tao Zhang, Zhenyu Xu. Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway. Human & experimental toxicology. 2023 Jan; 42(?):9603271231169520. doi: 10.1177/09603271231169520. [PMID: 37078094]
Ya Hou, Yating Zhang, Shengnan Jiang, Na Xie, Yi Zhang, Xianli Meng, Xiaobo Wang. Salidroside intensifies mitochondrial function of CoCl2-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154568. doi: 10.1016/j.phymed.2022.154568. [PMID: 36610162]
Baocheng Xie, Huan Zhou, Hongyu Liu, Shiyi Liao, Chenhui Zhou, Daohua Xu. Salidroside alleviates dexamethasone-induced inhibition of bone formation via transforming growth factor-beta/Smad2/3 signaling pathway. Phytotherapy research : PTR. 2022 Dec; ?(?):. doi: 10.1002/ptr.7711. [PMID: 36567454]
Baozhen Qu, Xuemao Liu, Yanjiao Liang, Keke Zheng, Chunling Zhang, Linlin Lu. Salidroside in the Treatment of NAFLD/NASH. Chemistry & biodiversity. 2022 Dec; 19(12):e202200401. doi: 10.1002/cbdv.202200401. [PMID: 36210339]
Hanna Nikolaichuk, Marek Studziński, Marek Stankevič, Irena M Choma. Qualitative and Quantitative Evaluation of Rosavin, Salidroside, and p-Tyrosol in Artic Root Products via TLC-Screening, HPLC-DAD, and NMR Spectroscopy. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238299. [PMID: 36500392]
Sixia Yang, Tingting Pei, Linshuang Wang, Yi Zeng, Wenxu Li, Shihua Yan, Wei Xiao, Weidong Cheng. Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27228039. [PMID: 36432138]
Qinyun Du, Qingxiu He, Fengming Zhang, Jiao Mi, Yuying Li, Shaohui Wang, Yi Zhang. An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules. Journal of visualized experiments : JoVE. 2022 11; ?(189):. doi: 10.3791/64670. [PMID: 36408988]
Nazym K Korbozova, Nataliya O Kudrina, Nataliya A Zhukova, Alexander E Grazhdannikov, Irina V Blavachinskaya, Gulnaz A Seitimova, Timur E Kulmanov, Tatyana G Tolstikova, Nina V Terletskaya. Antihypothyroid Effect of Salidroside. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217487. [PMID: 36364314]
Jie Liu, Dezhao Li, Yaoshan Dun, Hui Li, Jeffrey W Ripley-Gonzalez, Jie Zhang, Ling Qiu, Baiyang You, Suixin Liu. Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease. Life sciences. 2022 Nov; 308(?):120949. doi: 10.1016/j.lfs.2022.120949. [PMID: 36096243]
Jiannan Li, Ruibin Wang, Qiang Chen, Yiqi Tian, Leilei Gao, Anmin Lei. Salidroside improves porcine oocyte maturation and subsequent embryonic development by promoting lipid metabolism. Theriogenology. 2022 Oct; 192(?):89-96. doi: 10.1016/j.theriogenology.2022.08.028. [PMID: 36084388]
Lu Jiang, Liying Xu, Lanzhi Zheng, Yuan Wang, Mingyang Zhuang, Dongdong Yang. Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition. Bioorganic & medicinal chemistry. 2022 10; 71(?):116865. doi: 10.1016/j.bmc.2022.116865. [PMID: 35985062]
Zhifu Cui, Ningning Jin, Felix Kwame Amevor, Gang Shu, Xiaxia Du, Xincheng Kang, Zifan Ning, Xun Deng, Yaofu Tian, Qing Zhu, Yan Wang, Diyan Li, Yao Zhang, Xiaoqi Wang, Xue Han, Jing Feng, Xiaoling Zhao. Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3-β pathway. Poultry science. 2022 Sep; 101(9):102034. doi: 10.1016/j.psj.2022.102034. [PMID: 35926351]
Tingxu Yan, Xu Li, Tingting Nian, Xiaozhuo Zhang, Bosai He, Kaishun Bi, Zhenzhong Wang. Salidroside Inhibits Ischemia/Reperfusion-Induced Myocardial Apoptosis by Targeting Mir-378a-3p Via the Igf1r/Pi3k/Akt Signaling Pathway. Transplantation proceedings. 2022 Sep; 54(7):1970-1983. doi: 10.1016/j.transproceed.2022.05.017. [PMID: 35927086]
Cai-Long Pan, Guo-Liang Dai, Hui-Wen Zhang, Chen-Yang Zhang, Qing-Hai Meng, Lu Xu, Ning Xu, Yong Zhang, Qi-Lian Tan, Xiao-Liang Wang, Zhi-Yuan Zhang. Salidroside ameliorates orthopedic surgery-induced cognitive dysfunction by activating adenosine 5'-monophosphate-activated protein kinase signaling in mice. European journal of pharmacology. 2022 Aug; 929(?):175148. doi: 10.1016/j.ejphar.2022.175148. [PMID: 35834964]
Xin Tian, Ye Huang, Xiaofeng Zhang, Rong Fang, Yi Feng, Wanfang Zhang, Ling Li, Tian Li. Salidroside attenuates myocardial ischemia/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission. Toxicology and applied pharmacology. 2022 08; 448(?):116093. doi: 10.1016/j.taap.2022.116093. [PMID: 35659894]
Xiaobo Wang, Yan Tang, Na Xie, Jinrong Bai, Shengnan Jiang, Yi Zhang, Ya Hou, Xianli Meng. Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1/p53/Drp1 signaling. Journal of ethnopharmacology. 2022 Jul; 293(?):115278. doi: 10.1016/j.jep.2022.115278. [PMID: 35439546]
Shengnan Jiang, Fangfang Fan, Lu Yang, Ke Chen, Zhihao Sun, Yi Zhang, Nanjia Cairang, Xiaobo Wang, Xianli Meng. Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-κB/NLRP3 pathway. European journal of pharmacology. 2022 Jun; 925(?):175015. doi: 10.1016/j.ejphar.2022.175015. [PMID: 35561751]
Philip G Kasprzyk, Christopher Vickery, Mingli Ye, Magdalena Sewastianik, Wei Gong, Sheng Ding, Margitta Dziwenka, Amy Mozingo, Kaiti Valm, Holly Schachner, Jing-Ke Weng. Safety of a Sustainably Produced, Bioengineered, Nature-Identical Salidroside Compound. Nutrients. 2022 Jun; 14(11):. doi: 10.3390/nu14112330. [PMID: 35684130]
Xing-Mei Shu, Yang Hu, Xin Fang, Jing Wang, Xiao-Yan Qin, Rongfeng Lan. Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2022 Jun; 71(5-6):615-626. doi: 10.1007/s00011-022-01580-4. [PMID: 35583558]
Fangfang Fan, Ning Xu, Yucheng Sun, Xuanhao Li, Xinchang Gao, Xizhen Yi, Yi Zhang, Xianli Meng, Jin-Ming Lin. Uncovering the Metabolic Mechanism of Salidroside Alleviating Microglial Hypoxia Inflammation Based on Microfluidic Chip-Mass Spectrometry. Journal of proteome research. 2022 04; 21(4):921-929. doi: 10.1021/acs.jproteome.1c00647. [PMID: 34851127]
Jia-Qi Mao, Chuan-Chuan Liu, Yu-Wei Zhang, Qing-Qing Zhang, Hong Liu, Lan Ma. [Salidroside inhibits phenotypic transformation of rat pulmonary artery smooth muscle cells induced by hypoxia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Feb; 47(4):1024-1030. doi: 10.19540/j.cnki.cjcmm.20211103.706. [PMID: 35285203]
Jing Qian, Xiao-Hong Wang, Ben-Zhong Wei, Guo-Xiong Zhou, Shun-Xing Zhu, Chun Liu. Therapeutic effects of salidroside vs pyrrolidine dithiocarbamate against severe acute pancreatitis in rat. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 02; 42(1):49-57. doi: 10.19852/j.cnki.jtcm.20210707.002. [PMID: 35322632]
Yanjia Che, Yuanyang Chen, Zhiwei Wang, Sihao Zheng, Kai Xing, Shun Yuan, Xiaohan Zhong. The Combination of Rhodosin and MMF Prolongs Cardiac Allograft Survival by Inhibiting DC Maturation by Promoting Mitochondrial Fusion. Oxidative medicine and cellular longevity. 2022; 2022(?):7260305. doi: 10.1155/2022/7260305. [PMID: 35855862]
Yanjiao Hao, Zhiyu Li, Mingzhi Chang, Xiaoli Zhang. Effects of Salidroside Combined with Paclitaxel on Proliferation, Migration, and Epithelial Mesenchyme of Colorectal Cancer Cells. Drug design, development and therapy. 2022; 16(?):4079-4089. doi: 10.2147/dddt.s384151. [PMID: 36465266]
Jing Shi, Qin Zhao, Dou Dou Hao, Hong Xia Miao, Sha Wan, Chao Hua Zhou, Si Yu Wang, Si Yuan Chen, Jin Shang, Tian Hang Feng. Gut microbiota profiling revealed the regulating effects of salidroside on iron metabolism in diabetic mice. Frontiers in endocrinology. 2022; 13(?):1014577. doi: 10.3389/fendo.2022.1014577. [PMID: 36213297]
Heng Fan, Bin-Jie Su, Jian-Wei Le, Jian-Hua Zhu. Salidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting Inflammation and Apoptosis. Drug design, development and therapy. 2022; 16(?):899-907. doi: 10.2147/dddt.s361972. [PMID: 35386851]
Fei Yao, Xinyi Jiang, Ling Qiu, Zixuan Peng, Wei Zheng, Lexi Ding, Xiaobo Xia. Long-Term Oral Administration of Salidroside Alleviates Diabetic Retinopathy in db/db Mice. Frontiers in endocrinology. 2022; 13(?):861452. doi: 10.3389/fendo.2022.861452. [PMID: 35370972]
Xi Ming, Xingzhu Yu, Jijun Li, Junyu Wang, Jialin Zheng, Lei Xiong. Salidroside Attenuates Airway Inflammation and Remodeling via the miR-323-3p/SOCS5 Axis in Asthmatic Mice. International archives of allergy and immunology. 2022; 183(4):424-434. doi: 10.1159/000520444. [PMID: 34856542]
Yan Tang, Ya Hou, Yong Zeng, Yao Hu, Yi Zhang, Xiaobo Wang, Xianli Meng. Salidroside attenuates CoCl2-simulated hypoxia injury in PC12 cells partly by mitochondrial protection. European journal of pharmacology. 2021 Dec; 912(?):174617. doi: 10.1016/j.ejphar.2021.174617. [PMID: 34748770]
Manli Hu, Dingran Zhang, Hongyang Xu, Yan Zhang, Hongjie Shi, Xiaoli Huang, Xinhui Wang, Yan Wu, Zhili Qi. Salidroside Activates the AMP-Activated Protein Kinase Pathway to Suppress Nonalcoholic Steatohepatitis in Mice. Hepatology (Baltimore, Md.). 2021 12; 74(6):3056-3073. doi: 10.1002/hep.32066. [PMID: 34292604]
Ziying Dai, Xuan Zhang, Wuyan Li, Junxia Tang, Tingting Pan, Chenru Ma, Quanlin Guan. Salidroside Induces Apoptosis in Human Gastric Cancer Cells via the Downregulation of ENO1/PKM2/GLUT1 Expression. Biological & pharmaceutical bulletin. 2021 Nov; 44(11):1724-1731. doi: 10.1248/bpb.b21-00443. [PMID: 34471002]
Ya-Wen Hsiao, Yung-Nan Tsai, Yu-Ting Huang, Shuen-Hsin Liu, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Shien-Fong Lin, Shih-Lin Chang, Satoshi Higa, Shih-Ann Chen. Rhodiola crenulata reduces ventricular arrhythmia through mitigating the activation of IL-17 and inhibiting the MAPK signaling pathway. Cardiovascular drugs and therapy. 2021 10; 35(5):889-900. doi: 10.1007/s10557-020-07072-z. [PMID: 32946036]
Miaoyong Ye, Fan Zhao, Ke Ma, Kang Zhou, Jianxiong Ma, Huiying Fu, Zengbao Xu, Wenjie Huang, Wenzhi Wang, Jianfeng Zhao, Bodong Lv. Enhanced effects of salidroside on erectile function and corpora cavernosa autophagy in a cavernous nerve injury rat model. Andrologia. 2021 Jul; 53(6):e14044. doi: 10.1111/and.14044. [PMID: 33709426]
Cheng-Cheng Zhao, Xin-Yue Wu, Huan Yi, Rong Chen, Gang Fan. The Therapeutic Effects and Mechanisms of Salidroside on Cardiovascular and Metabolic Diseases: An Updated Review. Chemistry & biodiversity. 2021 Jul; 18(7):e2100033. doi: 10.1002/cbdv.202100033. [PMID: 33991395]
Qian-Nan Ye, Chang-Qing Zhao, Jian Ping, Lie-Ming Xu. [Study on mechanism of salidroside against liver fibrosis by regulating CXCL16]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Jun; 46(11):2865-2870. doi: 10.19540/j.cnki.cjcmm.20201224.401. [PMID: 34296587]
Marc-Sebastian F Straka, Noha Abdullah Al-Otaibi, Philip D Whitfield, Mary K Doherty, Bruno F E Matarèse, Nigel K H Slater, Hassan Rahmoune. Disaccahrides-Based Cryo-Formulant Effect on Modulating Phospho/Mitochondrial Lipids and Biological Profiles of Human Leukaemia Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2021 Apr; 55(2):206-221. doi: 10.33594/000000360. [PMID: 33914444]
Xumin Zhang, Long Xie, Jiaying Long, Qingxuan Xie, Yu Zheng, Kai Liu, Xiaofang Li. Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties. Chemico-biological interactions. 2021 Apr; 339(?):109268. doi: 10.1016/j.cbi.2020.109268. [PMID: 33617801]
Tao Zheng, Qibin Wang, Fang Bian, Yan Zhao, Weidong Ma, Yonghong Zhang, Wei Lu, Pan Lei, Lulu Zhang, Xincai Hao, Li Chen. Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis. Toxicology and applied pharmacology. 2021 04; 416(?):115468. doi: 10.1016/j.taap.2021.115468. [PMID: 33639149]
Chun-Xia Liang, Dong-Li Qi, Li-Na Zhang, Peng Lu, Zhi-Dong Liu. Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside. Chinese journal of natural medicines. 2021 Mar; 19(3):231-240. doi: 10.1016/s1875-5364(21)60025-0. [PMID: 33781457]
Tongxin Song, Pengli Wang, Chenyang Li, Li Jia, Qianqian Liang, Yuanlin Cao, Pengzhi Dong, Hong Shi, Miaomiao Jiang. Salidroside simultaneously reduces de novo lipogenesis and cholesterol biosynthesis to attenuate atherosclerosis in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Feb; 134(?):111137. doi: 10.1016/j.biopha.2020.111137. [PMID: 33341055]
Ping Jin, Liang-Hai Li, Yan Shi, Nan-Bin Hu. Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury. Gene. 2021 Jan; 767(?):145075. doi: 10.1016/j.gene.2020.145075. [PMID: 32858179]
Zelin Yang, Xin Huang, Wenfang Lai, Yuheng Tang, Junjie Liu, Yingzheng Wang, Kedan Chu, John Brown, Guizhu Hong. Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. European journal of medicinal chemistry. 2021 Jan; 209(?):112935. doi: 10.1016/j.ejmech.2020.112935. [PMID: 33097301]
Attalla F El-Kott, Eman R ElBealy, Ali S Alshehri, Ayman E El-Kenawy, Heba S Khalifa, Amira M AlRamlawy. Salidroside induces cell apoptosis and inhibits the invasiveness of HT29 colorectal cells by regulating protein kinase R, NF-κB and STAT3. Cancer biomarkers : section A of Disease markers. 2021; 31(1):13-25. doi: 10.3233/cbm-203257. [PMID: 33749640]
Weidong Ma, Ziyuan Wang, Yan Zhao, Qibin Wang, Yonghong Zhang, Pan Lei, Wei Lu, Shan Yan, Jun Zhou, Xiaojiao Li, Wenjun Yu, Yaoxin Zhong, Li Chen, Tao Zheng. Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation. Oxidative medicine and cellular longevity. 2021; 2021(?):6614574. doi: 10.1155/2021/6614574. [PMID: 34457117]
Xia Zhang, Jinglin Zhu, Jiangna Yan, Yue Xiao, Ruijie Yang, Ruifei Huang, Jun Zhou, Zhenzhong Wang, Wei Xiao, Chunli Zheng, Yonghua Wang. Systems pharmacology unravels the synergic target space and therapeutic potential of Rhodiola rosea L. for non-small cell lung cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153326. doi: 10.1016/j.phymed.2020.153326. [PMID: 32992083]
Limin Yang, Lin Zhou, Xiaohui Wang, Wang Wang, Jin Wang. Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice. International immunopharmacology. 2020 Dec; 89(Pt A):106987. doi: 10.1016/j.intimp.2020.106987. [PMID: 33217691]
Tingxu Yan, Tingting Nian, Fuyuan Li, Bosai He, Ying Jia, Kaishun Bi, Zhenzhong Wang. Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. 2020 11; 44(11):e13446. doi: 10.1111/jfbc.13446. [PMID: 32910486]
Kechen Yang, Xiaozhou Qi, Maosheng He, Kaige Song, Fei Luo, Xiangyu Qu, Gaoxue Wang, Fei Ling. Dietary supplementation of salidroside increases immune response and disease resistance of crucian carp (Carassius auratus) against Aeromonas hydrophila. Fish & shellfish immunology. 2020 Nov; 106(?):1-7. doi: 10.1016/j.fsi.2020.07.054. [PMID: 32731013]
Qiaoyun Guo, Jing Yang, Yumeng Chen, Xin Jin, Zongmin Li, Xiaochang Wen, Qun Xia, Yue Wang. Salidroside improves angiogenesis-osteogenesis coupling by regulating the HIF-1α/VEGF signalling pathway in the bone environment. European journal of pharmacology. 2020 Oct; 884(?):173394. doi: 10.1016/j.ejphar.2020.173394. [PMID: 32730833]
Kateryna Khokhlova, Oleksandr Zdoryk. Authentication of Rhodiola rosea, Rhodiola quadrifida and Rhodiola rosea liquid extract from the Ukrainian market using HPTLC chromatographic profiles. Natural product research. 2020 Oct; 34(19):2842-2846. doi: 10.1080/14786419.2019.1591398. [PMID: 30919667]
Jia Shou-Ning, Zhang Qing-Guang, M A Chun-Hua, L I Xin, Wang Shuang-Xi, Chen Wen-Juan, Dou Xuan, G E Guang-Bo. [Proteomics analysis of erythrocyte membrane in rats with high altitude polycythemia before and after intervention with salidroside]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Oct; 45(19):4719-4724. doi: 10.19540/j.cnki.cjcmm.20200323.402. [PMID: 33164438]
Ali A Shati, Mohammad Y Alfaifi. Salidroside protects against diabetes mellitus-induced kidney injury and renal fibrosis by attenuating TGF-β1 and Wnt1/3a/β-catenin signalling. Clinical and experimental pharmacology & physiology. 2020 10; 47(10):1692-1704. doi: 10.1111/1440-1681.13355. [PMID: 32472701]
Shao-Hua Xu, Hai-Lan Chen, Ze-Lin Yang, Li-Wei Lyu, Yong Fan, Mei Sha, Jian Zhang, Wei Xu, Yu Lin. New 30-norlupane derivatives through chemical-microbial semi-synthesis of betulinic acid and their neuroprotective effect. Bioorganic & medicinal chemistry letters. 2020 09; 30(17):127407. doi: 10.1016/j.bmcl.2020.127407. [PMID: 32738992]
Bao Xiao-Qiang, W U Hai-Nan. [Study on pharmacokinetics and tissue distribution characteristics of salidroside in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Sep; 45(18):4466-4471. doi: 10.19540/j.cnki.cjcmm.202000623.202. [PMID: 33164377]
Fangfang Fan, Lu Yang, Rui Li, Xuemei Zou, Ning Li, Xianli Meng, Yi Zhang, Xiaobo Wang. Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110458. doi: 10.1016/j.biopha.2020.110458. [PMID: 32603893]
Li Yuetong, Li Shangzhu, Hu Qinglin, Huang Pingping. Salidroside inhibits proliferation, migration and invasion of human pancreatic cancer PANC1 and SW1990 cells through the AKT and ERK signaling pathway. Die Pharmazie. 2020 08; 75(8):385-388. doi: 10.1691/ph.2020.0556. [PMID: 32758338]
Xue Zhang, Ge Kuang, Jingyuan Wan, Rong Jiang, Li Ma, Xia Gong, Xing Liu. Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation. International immunopharmacology. 2020 Aug; 85(?):106662. doi: 10.1016/j.intimp.2020.106662. [PMID: 32544869]
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