alpha-Mangostin (BioDeep_00000003601)

 

Secondary id: BioDeep_00000398565

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


9H-Xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-

化学式: C24H26O6 (410.17292960000003)
中文名称: α-倒捻子素, 山竺提取物
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.23%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc1c(c2=O)c(c(c(c1)O)OC)CC=C(C)C)O)CC=C(C)C)O
InChI: InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3

描述信息

Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antineoplastic agent, an antimicrobial agent, an antioxidant and a plant metabolite. It is a member of xanthones, a member of phenols and an aromatic ether.
Mangostin is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
alpha-Mangostin is a natural product found in Garcinia merguensis, Garcinia cowa, and other organisms with data available.
See also: Garcinia mangostana fruit rind (part of).
A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.
alpha-Mangostin is found in fruits. alpha-Mangostin is a pigment from Garcinia mangostana (mangosteen
Pigment from Garcinia mangostana (mangosteen). alpha-Mangostin is found in fruits.
alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.

同义名列表

56 个代谢物同义名

9H-Xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-; 1,3,6-TRIHYDROXY-7-METHOXY-2,8-BIS-(3-METHYL-2-BUTEN-1-YL)-9H-XANTHEN-9-ONE; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one; 9H-Xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-; 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2- butenyl)-9H-xanthen-9-one; 9H-Xanthen-9-one,1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-; 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one; 2-methoxy-1,7-bis(3-methylbut-2-enyl)-3,6,8-tris(oxidanyl)xanthen-9-one; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one; 9H-Xanthen-9-one,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-; 1,3,6-Trihydroxy-7-methoxy-2,8-bis-(3-methyl-but-2-enyl)-xanthen-9-one; Xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-; 3,6,8-trihydroxy-2-methoxy-1,7-bis(3-methylbut-2-enyl)xanthen-9-one; Xanthen-9-one,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-; 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9-xanthenone; 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one; 1,7-bis(3-methylbut-2-enyl)-3,6,8-trihydroxy-2-methoxyxanthen-9-one; 1,3,6,7-tetrahydroxy-2,5-bis(3-methyl-2-butenyl)-9H-xanthen-9-one; 1,3,6-Trihydroxy-7-methoxy-2,8-di(3-methyl-2-butenyl)xanthone; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3,3-dimethylallyl)xanthone; 1,3,6-trihydroxy-7-methoxy-2,8-diprenylxanthone; alpha-Mangostin, >=98\\% (HPLC); 7-o-methyl-4-desprenylcostatin; 7-o-methyl-.gamma.-mangostin; 7-O-methyl-gamma-mangostin; 7-O-Methyl-γ-mangostin; Alpha-Mangostin, 95\\%; .Alpha.-mangostin; .Alpha.-mangosten; Spectrum3_001297; Spectrum5_000622; MANGOSTIN [INCI]; Spectrum2_001620; Spectrum4_001911; gamma-mangostin; delta-mangostin; alpha-mangosten; alpha-mangostin; UNII-U6RIV93RU1; alfa-mangostin; MANGOSTIN [MI]; DivK1c_006670; KBio2_002206; KBio3_002153; KBio1_001614; KBio2_004774; KBio2_007342; ?-MANGOSTIN; α-Mangosten; Α-mangostin; a-Mangostin; Mangostine; U6RIV93RU1; Mangostin; α-MANGOSTIN



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zi-Jie Long, Jun-Dan Wang, Sheng-Xiang Qiu, Yi Zhang, Si-Jin Wu, Xin-Xing Lei, Ze-Wei Huang, Jia-Jie Chen, Yong-Liang Yang, Xiang-Zhong Zhang, Quentin Liu. Dietary γ-mangostin triggers immunogenic cell death and activates cGAS signaling in acute myeloid leukemia. Pharmacological research. 2023 Nov; 197(?):106973. doi: 10.1016/j.phrs.2023.106973. [PMID: 37898441]
  • Sandar Naing, Nichawadee Sandech, Arnatchai Maiuthed, Sumet Chongruchiroj, Jaturong Pratuangdejkul, Pattamapan Lomarat. Garcinia mangostana L. Pericarp Extract and Its Active Compound α-Mangostin as Potential Inhibitors of Immune Checkpoint Programmed Death Ligand-1. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196991. [PMID: 37836835]
  • Cecep Suhandi, Gofarana Wilar, Ronny Lesmana, Felix Zulhendri, Ine Suharyani, Nurhasni Hasan, Nasrul Wathoni. Propolis-Based Nanostructured Lipid Carriers for α-Mangostin Delivery: Formulation, Characterization, and In Vitro Antioxidant Activity Evaluation. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28166057. [PMID: 37630309]
  • Mohamed Yousif Ibrahim, Najihah Mohd Hashim, Fatima Abdelmutaal Ahmed Omer, Muhammad Salisu Abubakar, Hoyam Adam Mohammed, Suzy Munir Salama, Soher Nagi Jayash. Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210283. [PMID: 37373429]
  • Muchtaridi Muchtaridi, Dian Triwahyuningtyas, Taufik Muhammad Fakih, Sandra Megantara, Sy Bing Choi. Mechanistic insight of α-mangostin encapsulation in 2-hydroxypropyl-β-cyclodextrin for solubility enhancement. Journal of biomolecular structure & dynamics. 2023 Jun; ?(?):1-10. doi: 10.1080/07391102.2023.2214237. [PMID: 37286382]
  • Heba M Eltahir, Hossein M Elbadawy, Ali Alalawi, Ahmed J Aldhafiri, Sabrin R M Ibrahim, Gamal A Mohamed, Abdel-Gawad S Shalkami, Mohannad A Almikhlafi, Muayad Albadrani, Yaser Alahmadi, Mekky M Abouzied, Maiiada H Nazmy. Alpha-Mangostin ameliorates acute kidney injury via modifying levels of circulating TNF-α and IL-6 in glycerol-induced rhabdomyolysis animal model. Acta biochimica Polonica. 2023 04; ?(?):. doi: 10.18388/abp.2020_6509. [PMID: 37068203]
  • Maan T Khayat, Khadijah A Mohammad, Gamal A Mohamed, Dina S El-Agamy, Wael M Elsaed, Sabrin R M Ibrahim. γ-Mangostin abrogates AINT-induced cholestatic liver injury: Impact on Nrf2/NF-κB/NLRP3/Caspase-1/IL-1β/GSDMD signalling. Life sciences. 2023 Apr; 322(?):121663. doi: 10.1016/j.lfs.2023.121663. [PMID: 37023956]
  • Yanfen Niu, Qiang Li, Caixia Tu, Na Li, Lihui Gao, Hua Lin, Zhenyu Wang, Zhihong Zhou, Ling Li. Hypouricemic Actions of the Pericarp of Mangosteen in Vitro and in Vivo. Journal of natural products. 2023 01; 86(1):24-33. doi: 10.1021/acs.jnatprod.2c00531. [PMID: 36634312]
  • Yi-Jin Wu, Sa-Sa Zhang, Qin Yin, Ming Lei, Qi-Hai Wang, Wen-Gang Chen, Ting-Ting Luo, Peng Zhou, Cong-Lan Ji. α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously. Drug design, development and therapy. 2023; 17(?):563-577. doi: 10.2147/dddt.s397914. [PMID: 36860800]
  • Qirou Wang, Ruilin Li, Nannan Li, Yanan Jia, Yajie Wang, Yue Chen, Pharkphoom Panichayupakaranant, Haixia Chen. The antioxidant activities, inhibitory effects, kinetics, and mechanisms of artocarpin and α-mangostin on α-glucosidase and α-amylase. International journal of biological macromolecules. 2022 Jul; 213(?):880-891. doi: 10.1016/j.ijbiomac.2022.06.017. [PMID: 35688278]
  • Romgase Sakamula, Teerapong Yata, Wachiryah Thong-Asa. Nanostructure lipid carriers enhance alpha-mangostin neuroprotective efficacy in mice with rotenone-induced neurodegeneration. Metabolic brain disease. 2022 06; 37(5):1465-1476. doi: 10.1007/s11011-022-00967-w. [PMID: 35353275]
  • Rubén Estrada-Valencia, María Ester Hurtado-Díaz, Edgar Rangel-López, Socorro Retana-Márquez, Isaac Túnez, Alexey Tinkov, Cimen Karasu, Beatriz Ferrer, José Pedraza-Chaverri, Michael Aschner, Abel Santamaría. Alpha-Mangostin Alleviates the Short-term 6-Hydroxydopamine-Induced Neurotoxicity and Oxidative Damage in Rat Cortical Slices and in Caenorhabditis elegans. Neurotoxicity research. 2022 Apr; 40(2):573-584. doi: 10.1007/s12640-022-00493-8. [PMID: 35380367]
  • Xiaojia Liu, Jianzhong Shen, Kui Zhu. Antibacterial activities of plant-derived xanthones. RSC medicinal chemistry. 2022 Feb; 13(2):107-116. doi: 10.1039/d1md00351h. [PMID: 35308024]
  • Wen-Gang Chen, Sa-Sa Zhang, Shu Pan, Zhong-Fang Wang, Jin-Ying Xu, Xue-He Sheng, Qin Yin, Yi-Jin Wu. α-Mangostin Treats Early-Stage Adjuvant-Induced Arthritis of Rat by Regulating the CAP-SIRT1 Pathway in Macrophages. Drug design, development and therapy. 2022; 16(?):509-520. doi: 10.2147/dddt.s348836. [PMID: 35250263]
  • Naroeporn Nopwinyoowong, Waranya Chatuphonprasert, Nitima Tatiya-Aphiradee, Kanokwan Jarukamjorn. Garcinia mangostana and α-Mangostin Revive Ulcerative Colitis-Modified Hepatic Cytochrome P450 Profiles in Mice. Pakistan journal of biological sciences : PJBS. 2022 Jan; 25(9):843-851. doi: 10.3923/pjbs.2022.843.851. [PMID: 36098087]
  • Alexander Th Wu, Yuan-Chieh Yeh, Yan-Jiun Huang, Ntlotlang Mokgautsi, Bashir Lawal, Tse-Hung Huang. Gamma-mangostin isolated from garcinia mangostana suppresses colon carcinogenesis and stemness by downregulating the GSK3β/β-catenin/CDK6 cancer stem pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153797. doi: 10.1016/j.phymed.2021.153797. [PMID: 34802869]
  • Intouch Sakpakdeejaroen, Patcharaporn Muanrit, Sumalee Panthong, Srisopa Ruangnoo. Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery. TheScientificWorldJournal. 2022; 2022(?):9217268. doi: 10.1155/2022/9217268. [PMID: 36081606]
  • Julalak Chuprom, Suthinee Sangkanu, Watcharapong Mitsuwan, Rachasak Boonhok, Wilawan Mahabusarakam, L Ravithej Singh, Ekachai Dumkliang, Kritamorn Jitrangsri, Alok K Paul, Sirirat Surinkaew, Polrat Wilairatana, Maria de Lourdes Pereira, Mohammed Rahmatullah, Christophe Wiart, Sonia Marlene Rodrigues Oliveira, Veeranoot Nissapatorn. Anti-Acanthamoeba activity of a semi-synthetic mangostin derivative and its ability in removal of Acanthamoeba triangularis WU19001 on contact lens. PeerJ. 2022; 10(?):e14468. doi: 10.7717/peerj.14468. [PMID: 36523474]
  • Sih-Pei Chen, Shian-Ren Lin, Ting-Hsu Chen, Hui-Suan Ng, Hip-Seng Yim, Max K Leong, Ching-Feng Weng. Mangosteen xanthone γ-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK/PPARγ. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Dec; 144(?):112333. doi: 10.1016/j.biopha.2021.112333. [PMID: 34678724]
  • Faisal Usman, Hamid Saeed Shah, Sumera Zaib, Sirikhwan Manee, Jahanzeb Mudassir, Ajmal Khan, Gaber El-Saber Batiha, Khamael M Abualnaja, Dalal Alhashmialameer, Imtiaz Khan. Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies. Molecules (Basel, Switzerland). 2021 Nov; 26(21):. doi: 10.3390/molecules26216633. [PMID: 34771042]
  • Piyawat Tangsuksan, Jureeporn Chuerduangphui, Chutha Takahashi Yupanqui, Teerapol Srichana, Ekarat Hitakomate, Chamsai Pientong, Tipaya Ekalaksananan, Wipawee Nittayananta. Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment. BMC oral health. 2021 10; 21(1):512. doi: 10.1186/s12903-021-01845-0. [PMID: 34629065]
  • Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi. α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175119. [PMID: 34500560]
  • N Tatiya-Aphiradee, W Chatuphonprasert, K Jarukamjorn. Garcinia mangostana Linn. pericarp and alpha-mangostin ameliorate dextran sulfate sodium-induced hepatic injury in mice. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2021 06; 72(3):. doi: 10.26402/jpp.2021.3.11. [PMID: 34873066]
  • Nargis Jamila, Naeem Khan, Nousheen Bibi, Muhammad Waqas, Sadiq Noor Khan, Amir Atlas, Farhat Amin, Faryal Khan, Malka Saba. Hg(II) sensing, catalytic, antioxidant, antimicrobial, and anticancer potential of Garcinia mangostana and α-mangostin mediated silver nanoparticles. Chemosphere. 2021 Jun; 272(?):129794. doi: 10.1016/j.chemosphere.2021.129794. [PMID: 35534954]
  • Aihong Yang, Chang Liu, Jiarui Wu, Xiaodi Kou, Rui Shen. A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease. European journal of pharmacology. 2021 Apr; 897(?):173950. doi: 10.1016/j.ejphar.2021.173950. [PMID: 33607107]
  • Tanpong Chaiwarit, Nutthapong Kantrong, Sarana Rose Sommano, Pornchai Rachtanapun, Taepin Junmahasathien, Mont Kumpugdee-Vollrath, Pensak Jantrawut. Extraction of Tropical Fruit Peels and Development of HPMC Film Containing the Extracts as an Active Antibacterial Packaging Material. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082265. [PMID: 33919710]
  • Mulyadi Tanjung, Tjitjik Srie Tjahjandarie, Ratih Dewi Saputri, Baharrani Dwi Kurnia, Muhammad Faisal Rachman, Yana Maolana Syah. Calotetrapterins A-C, three new pyranoxanthones and their cytotoxicity from the stem bark of Calophyllum tetrapterum Miq. Natural product research. 2021 Feb; 35(3):407-412. doi: 10.1080/14786419.2019.1634714. [PMID: 31305138]
  • Nitima Tatiya-Aphiradee, Waranya Chatuphonprasert, Kanokwan Jarukamjorn. Ethanolic Garcinia mangostana extract and α-mangostin improve dextran sulfate sodium-induced ulcerative colitis via the suppression of inflammatory and oxidative responses in ICR mice. Journal of ethnopharmacology. 2021 Jan; 265(?):113384. doi: 10.1016/j.jep.2020.113384. [PMID: 32927006]
  • Oliver D John, Peter Mouatt, Sunil K Panchal, Lindsay Brown. Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats. Nutrients. 2021 Jan; 13(2):. doi: 10.3390/nu13020319. [PMID: 33499382]
  • Panudda Dechwongya, Songpol Limpisood, Nawong Boonnak, Supachoke Mangmool, Mariko Takeda-Morishita, Thitianan Kulsirirat, Pattarawit Rukthong, Korbtham Sathirakul. The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245877. [PMID: 33322620]
  • P Rukthong, N Sereesongsang, T Kulsirirat, N Boonnak, K Sathirakul. In vitro investigation of metabolic fate of α-mangostin and gartanin via skin permeation by LC-MS/MS and in silico evaluation of the metabolites by ADMET predictor™. BMC complementary medicine and therapies. 2020 Nov; 20(1):359. doi: 10.1186/s12906-020-03144-7. [PMID: 33228689]
  • Huochun Ye, Qin Wang, Fadi Zhu, Gang Feng, Chao Yan, Jing Zhang. Antifungal Activity of Alpha-Mangostin against Colletotrichum gloeosporioides In Vitro and In Vivo. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225335. [PMID: 33207599]
  • Ning Tiang, Mohamad Anuar Ahad, Vikneswaran Murugaiyah, Zurina Hassan. Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats. The Journal of pharmacy and pharmacology. 2020 Nov; 72(11):1629-1644. doi: 10.1111/jphp.13345. [PMID: 32743849]
  • M S Meah, M Lertcanawanichakul, P Pedpradab, W Lin, K Zhu, G Li, P Panichayupakaranant. Synergistic effect on anti-methicillin-resistant Staphylococcus aureus among combinations of α-mangostin-rich extract, lawsone methyl ether and ampicillin. Letters in applied microbiology. 2020 Nov; 71(5):510-519. doi: 10.1111/lam.13369. [PMID: 32770753]
  • Huifeng Guan, Jiabing Li, Xiaofang Tan, Shenying Luo, Yangdan Liu, Yiwen Meng, Baichuan Wu, Yan Zhou, Yang Yang, Hongzhuan Chen, Lina Hou, Yu Qiu, Juan Li. Natural Xanthone α-Mangostin Inhibits LPS-Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF-κB Signaling Pathway. Molecular nutrition & food research. 2020 07; 64(14):e2000096. doi: 10.1002/mnfr.202000096. [PMID: 32506806]
  • Wiparat Hotarat, Bodee Nutho, Peter Wolschann, Thanyada Rungrotmongkol, Supot Hannongbua. Delivery of Alpha-Mangostin Using Cyclodextrins through a Biological Membrane: Molecular Dynamics Simulation. Molecules (Basel, Switzerland). 2020 May; 25(11):. doi: 10.3390/molecules25112532. [PMID: 32485931]
  • Xiao-Qian Chi, Bo Hou, Liu Yang, Cheng-Ting Zi, Yong-Feng Lv, Jin-Yu Li, Fu-Cai Ren, Ming-Yan Yuan, Jiang-Miao Hu, Jun Zhou. Design, synthesis and cholinesterase inhibitory activity of α-mangostin derivatives. Natural product research. 2020 May; 34(10):1380-1388. doi: 10.1080/14786419.2018.1510925. [PMID: 30456989]
  • Jingxian Feng, Minjun Xu, Jiahao Wang, Songlei Zhou, Yipu Liu, Shanshan Liu, Yukun Huang, Yu Chen, Liang Chen, Qingxiang Song, Jingru Gong, Huiping Lu, Xiaoling Gao, Jun Chen. Sequential delivery of nanoformulated α-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer. Biomaterials. 2020 05; 241(?):119907. doi: 10.1016/j.biomaterials.2020.119907. [PMID: 32120315]
  • Yen-Shuo Chiu, Jia-Lin Wu, Chi-Tai Yeh, Vijesh Kumar Yadav, Hsu-Shan Huang, Liang-Shun Wang. γ-Mangostin isolated from Garcinia mangostana L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling. Aging. 2020 04; 12(8):6630-6643. doi: 10.18632/aging.103003. [PMID: 32302289]
  • Thi Kieu Trang Phan, Fahimeh Shahbazzadeh, Takanori Kihara. Alpha-mangostin reduces mechanical stiffness of various cells. Human cell. 2020 Apr; 33(2):347-355. doi: 10.1007/s13577-020-00330-0. [PMID: 32078151]
  • Hai Zhang, Yu-Ping Tan, Lin Zhao, Lun Wang, Nai-Jie Fu, Song-Ping Zheng, Xiao-Fei Shen. Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1. Cell death & disease. 2020 01; 11(1):63. doi: 10.1038/s41419-020-2227-4. [PMID: 31980595]
  • Abhijeet Parkhe, Pathik Parekh, Lakshmi Vineela Nalla, Nishant Sharma, Monika Sharma, Anagha Gadepalli, Abhijeet Kate, Amit Khairnar. Protective effect of alpha mangostin on rotenone induced toxicity in rat model of Parkinson's disease. Neuroscience letters. 2020 01; 716(?):134652. doi: 10.1016/j.neulet.2019.134652. [PMID: 31778768]
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