Liriodenine (BioDeep_00000326798)

Main id: BioDeep_00000000915

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


3,5-dioxa-11-azapentacyclo[10.7.1.0^{2,6.0^{8,20.0^{14,19]icosa-1(20),2(6),7,9,11,14,16,18-octaen-13-one

化学式: C17H9NO3 (275.0582)
中文名称: 鹅掌楸碱
谱图信息: 最多检出来源 Homo sapiens(not specific) 7.55%

分子结构信息

SMILES: c1ccc2c(c1)c1c3c(ccnc3C2=O)cc2c1OCO2
InChI: InChI=1/C17H9NO3/c19-16-11-4-2-1-3-10(11)14-13-9(5-6-18-15(13)16)7-12-17(14)21-8-20-12/h1-7H,8H2

描述信息

Liriodenine is an oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities. It has a role as a metabolite, an antineoplastic agent, an antimicrobial agent, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an EC 3.2.1.20 (alpha-glucosidase) inhibitor and an antifungal agent. It is a cyclic ketone, an oxacycle, an organic heteropentacyclic compound, an alkaloid antibiotic and an oxoaporphine alkaloid. It is functionally related to an aporphine.
Liriodenine is a natural product found in Magnolia mexicana, Annona purpurea, and other organisms with data available.
An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities.

同义名列表

23 个代谢物同义名

3,5-dioxa-11-azapentacyclo[10.7.1.0^{2,6.0^{8,20.0^{14,19]icosa-1(20),2(6),7,9,11,14,16,18-octaen-13-one; 3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,9,11,14,16,18-octaen-13-one; Noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2-(methylenedioxy)-; Noraporphin-7-one,5,6,6a-tetradehydro-1,2-(methylenedioxy)-; 8H-[1,3]Benzodioxolo[6,5,4-de]benzo[g]quinolin-8-one #; 8H-[1,3]Benzodioxolo[6,5,4-de]benzo[g]quinolin-8-one; 8H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-8-one; 8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one; 4-27-00-06585 (Beilstein Handbook Reference); 8H-Benzo[g]-1,5,4-de]quinolin-8-one; Ushinsunine, oxo-; Spermatheridine; Spermatheridin; Oxoushinsunine; Oxoushinsunin; MEGxp0_001521; NCI60_042088; NCI60_001798; Liriodenine; Hiriodenine; Micheline B; 8H-Benzo[g]-1,3benzodioxolo[6,5,4-de]quinolin-8-one; Liriodenine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

497 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ANXA5, BCL2, BIRC5, CASP3, CASP8, CASP9, CCNB1, CCND1, CDK1, DDC, NOS3, TYR, VEGFA
Peripheral membrane protein 2 ANXA5, USO1
Endoplasmic reticulum membrane 3 BCL2, CDK1, RTN4
Nucleus 10 BCL2, BIRC5, CASP3, CASP8, CASP9, CCNB1, CCND1, CDK1, NOS3, VEGFA
cytosol 13 ANXA5, BCL2, BIRC5, CASP3, CASP8, CASP9, CCNB1, CCND1, CDK1, DDC, KCNN4, NOS3, USO1
centrosome 3 CCNB1, CCND1, CDK1
nucleoplasm 7 BIRC5, CASP3, CASP8, CCNB1, CCND1, CDK1, NOS3
Cell membrane 3 KCNN4, PTAFR, RTN4
Cytoplasmic side 1 RTN4
lamellipodium 1 CASP8
ruffle membrane 1 KCNN4
Multi-pass membrane protein 4 CACNA1E, KCNN4, PTAFR, RTN4
Golgi apparatus membrane 1 USO1
Synapse 2 CACNA1E, RTN4
cell junction 1 RTN4
cell surface 1 VEGFA
glutamatergic synapse 2 CASP3, RTN4
Golgi apparatus 3 NOS3, USO1, VEGFA
Golgi membrane 2 NOS3, USO1
lysosomal membrane 1 GAA
neuronal cell body 4 CACNA1E, CASP3, KCNN4, RTN4
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 USO1
Lysosome 2 GAA, TYR
plasma membrane 7 BCHE, CACNA1E, GAA, KCNN4, NOS3, PTAFR, RTN4
Membrane 10 ANXA5, BCL2, CACNA1E, CCNB1, CDK1, GAA, KCNN4, PTAFR, USO1, VEGFA
caveola 1 NOS3
extracellular exosome 4 ANXA5, CDK1, DDC, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 4 BCL2, RTN4, USO1, VEGFA
extracellular space 2 BCHE, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 NOS3, TYR, USO1
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
mitochondrion 4 BCL2, CASP8, CASP9, CDK1
protein-containing complex 4 BCL2, BIRC5, CASP8, CASP9
intracellular membrane-bounded organelle 2 GAA, TYR
postsynaptic density 2 CASP3, RTN4
Single-pass type I membrane protein 1 TYR
Secreted 3 BCHE, GAA, VEGFA
extracellular region 4 ANXA5, BCHE, GAA, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CASP8
mitochondrial matrix 2 CCNB1, CDK1
Extracellular side 1 RTN4
anchoring junction 1 RTN4
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 ANXA5
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 BIRC5
Melanosome membrane 1 TYR
midbody 2 BIRC5, CDK1
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Golgi-associated vesicle 1 TYR
vesicle 1 KCNN4
Cell projection, lamellipodium 1 CASP8
Cell projection, ruffle membrane 1 KCNN4
pore complex 1 BCL2
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 1 ANXA5
microtubule 1 BIRC5
spindle 1 BIRC5
extracellular matrix 1 VEGFA
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
interphase microtubule organizing center 1 BIRC5
Zymogen granule membrane 1 ANXA5
neuron projection 2 KCNN4, RTN4
mitotic spindle 1 CDK1
Chromosome 1 BIRC5
cytoskeleton 2 CASP8, NOS3
centriole 1 BIRC5
spindle pole 1 CCNB1
chromosome, telomeric region 1 CDK1
nuclear chromosome 1 BIRC5
blood microparticle 1 BCHE
fibrillar center 1 USO1
nuclear envelope 1 RTN4
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
microtubule organizing center 1 USO1
monoatomic ion channel complex 1 CACNA1E
tertiary granule membrane 2 GAA, PTAFR
Melanosome 1 TYR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
cell body 1 CASP8
myelin sheath 1 BCL2
voltage-gated potassium channel complex 1 KCNN4
Golgi stack 1 USO1
secretory granule membrane 1 PTAFR
endoplasmic reticulum lumen 1 BCHE
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
voltage-gated calcium channel complex 1 CACNA1E
kinetochore 1 BIRC5
endocytic vesicle membrane 1 NOS3
transport vesicle 1 USO1
azurophil granule membrane 1 GAA
ER to Golgi transport vesicle membrane 1 USO1
nuclear envelope lumen 1 BCHE
apoptosome 1 CASP9
chromosome, centromeric region 1 BIRC5
outer kinetochore 1 CCNB1
vesicle membrane 1 ANXA5
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
ficolin-1-rich granule membrane 1 GAA
spindle microtubule 2 BIRC5, CDK1
survivin complex 1 BIRC5
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDK1
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 2 CCNB1, CDK1
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
caspase complex 1 CASP9
endoplasmic reticulum tubular network 1 RTN4
endoplasmic reticulum tubular network membrane 1 RTN4
[Isoform a]: Endoplasmic reticulum membrane 1 RTN4
[Isoform b]: Endoplasmic reticulum membrane 1 RTN4
[Isoform C]: Endoplasmic reticulum membrane 1 RTN4


文献列表

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