Fosfomycin (BioDeep_00000003243)

 

Secondary id: BioDeep_00001868085

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid

化学式: C3H7O4P (138.0082)
中文名称: 磷霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 55.6%

分子结构信息

SMILES: CC1C(O1)P(=O)(O)O
InChI: InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)

描述信息

Fosfomycin is only found in individuals that have used or taken this drug. It is an antibiotic produced by Streptomyces fradiae. [PubChem]Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall.
S - Sensory organs > S02 - Otologicals > S02A - Antiinfectives > S02AA - Antiinfectives
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use
C254 - Anti-Infective Agent > C255 - Urinary Anti-Infective Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents

同义名列表

32 个代谢物同义名

[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid; (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid; (2R-cis)-(3-Methyloxiranyl)phosphonic acid; (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonate; 1R-cis-(1,2-Epoxypropyl)phosphonic acid; cis-(1R,2S)-Epoxypropylphosphonic acid; (2R-cis)-(3-Methyloxiranyl)phosphonate; (3-Methyloxiran-2-yl)phosphonic acid; L-cis-1,2-Epoxypropylphosphonic acid; 1R-cis-(1,2-Epoxypropyl)phosphonate; (1R,2S)-Epoxypropylphosphonic acid; cis-(1R,2S)-Epoxypropylphosphonate; L-cis-1,2-Epoxypropylphosphonate; (1R,2S)-Epoxypropylphosphonate; Phosphomycin disodium salt; Fosfomycin trometamol salt; Tromethamine, fosfomycin; Fosfomycin disodium salt; Fosfomycin tromethamine; Fosfomycin sodium; Phosphonomycin; Phosphonemycin; Fosfonomycin; Phosphomycin; Fosfomycinum; Fosfomicina; Fosfomycine; Fosfomycin; Fosfocina; Monuril; FCM; Fosfomycin



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

50 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 CAT, HPGDS, MRTFA
Peripheral membrane protein 1 CYP27A1
Endoplasmic reticulum membrane 1 SLC37A1
Mitochondrion membrane 1 CYP27A1
Nucleus 3 FOSB, GLRX, MRTFA
cytosol 9 B2M, CAT, FOSB, GLRX, GPT, HPGDS, LIPE, MRTFA, STX1A
nucleoplasm 3 FOSB, HPGDS, MRTFA
Cell membrane 6 AVPR1B, B2M, LIPE, RECK, STX1A, TNF
lamellipodium 1 STX2
Early endosome membrane 1 B2M
Multi-pass membrane protein 2 AVPR1B, SLC37A1
cell surface 2 B2M, TNF
glutamatergic synapse 1 MRTFA
Golgi apparatus 2 AVPR1B, B2M
Golgi membrane 1 B2M
lysosomal membrane 1 B2M
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 1 TNF
postsynapse 1 MRTFA
synaptic vesicle 2 STX1A, STX2
Cytoplasm, cytosol 1 LIPE
Presynapse 1 MRTFA
endosome 1 AVPR1B
plasma membrane 6 AVPR1B, B2M, RECK, STX1A, STX2, TNF
synaptic vesicle membrane 1 STX1A
Membrane 6 B2M, CAT, LIPE, RECK, SLC37A1, STX2
axon 1 STX1A
basolateral plasma membrane 1 STX2
caveola 1 LIPE
extracellular exosome 4 B2M, CAT, GLRX, GPT
endoplasmic reticulum 1 B2M
extracellular space 7 B2M, CPZ, CRP, CXCL8, IL10, STX2, TNF
mitochondrion 2 CAT, CYP27A1
protein-containing complex 2 CAT, STX2
intracellular membrane-bounded organelle 4 CAT, FOSB, HPGDS, STX2
Secreted 4 B2M, CRP, CXCL8, IL10
extracellular region 8 B2M, CAT, CRP, CXCL8, IL10, RECK, STX1A, TNF
[Isoform 2]: Secreted 1 STX1A
mitochondrial matrix 2 CAT, CYP27A1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 STX1A
nuclear membrane 1 STX1A
external side of plasma membrane 2 B2M, TNF
Secreted, extracellular space, extracellular matrix 1 CPZ
Wnt signalosome 1 RECK
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
presynaptic active zone membrane 2 STX1A, STX2
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 1 TNF
focal adhesion 2 B2M, CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
neuron projection 1 STX1A
chromatin 1 FOSB
Late endosome membrane 1 B2M
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 B2M
Lipid-anchor, GPI-anchor 1 RECK
Recycling endosome membrane 1 B2M
Endomembrane system 2 STX1A, STX2
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
side of membrane 1 RECK
SNARE complex 2 STX1A, STX2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
HFE-transferrin receptor complex 1 B2M
endoplasmic reticulum lumen 1 B2M
specific granule lumen 1 B2M
tertiary granule lumen 1 B2M
Single-pass type IV membrane protein 1 STX1A
ER to Golgi transport vesicle membrane 1 B2M
Synapse, synaptosome 1 STX1A
MHC class I peptide loading complex 1 B2M
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
MHC class I protein complex 1 B2M
MHC class II protein complex 1 B2M
catalase complex 1 CAT
early endosome lumen 1 B2M
synaptobrevin 2-SNAP-25-syntaxin-1a complex 1 STX1A
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xin Wu, Mengwei Bu, Zili Yang, Hongrui Ping, Chunlin Song, Jiang Duan, Aidong Zhang. Design and Synthesis of Fosmidomycin Analogs containing aza-Linkers and Their Biological Activity Evaluation. Pest management science. 2023 Oct; ?(?):. doi: 10.1002/ps.7810. [PMID: 37794283]
  • Oya Güven, Samet Sayılan, Özlem Tataroğlu, Nihat Müjdat Hökenek, Dilek Vural Keleş. Antibiotic versus cranberry in the treatment of uncomplicated urinary infection: a randomized controlled trial. Revista da Associacao Medica Brasileira (1992). 2023; 70(1):e20230799. doi: 10.1590/1806-9282.20230799. [PMID: 38126412]
  • D Busse, P Simon, D Petroff, N El-Najjar, L Schmitt, D Bindellini, A Dietrich, M Zeitlinger, W Huisinga, R Michelet, H Wrigge, C Kloft. High-Dosage Fosfomycin Results in Adequate Plasma and Target-Site Exposure in Morbidly Obese and Nonobese Nonhyperfiltration Patients. Antimicrobial agents and chemotherapy. 2022 06; 66(6):e0230221. doi: 10.1128/aac.02302-21. [PMID: 35603536]
  • David Busse, Jens Markus Borghardt, David Petroff, Alice Pevzner, Christoph Dorn, Nahed El-Najjar, Wilhelm Huisinga, Hermann Wrigge, Philipp Simon, Charlotte Kloft. Evaluating prediction methods for glomerular filtration to optimise drug doses in obese and nonobese patients. British journal of clinical pharmacology. 2022 06; 88(6):2973-2981. doi: 10.1111/bcp.15115. [PMID: 34688225]
  • Shahbaz Ahmad, Farooq Ali, Sadaf Anwar Qureshi, Bibi Uzma, Qismat Shakeela, Muhammad Shehryar Sabir, Sajjad Ahmad, Ijazul Haq, Atia Rasheed, Shehzad Ahmed, Muhammad Farooq. The evaluation of antibiotic susceptibility pattern and associated risk factors of UTI in tertiary care hospital of Peshawar. Pakistan journal of pharmaceutical sciences. 2022 May; 35(3(Special)):897-903. doi: NULL. [PMID: 35791585]
  • Iain J Abbott, Elke van Gorp, Kelly L Wyres, Steven C Wallis, Jason A Roberts, Joseph Meletiadis, Anton Y Peleg. Oral fosfomycin activity against Klebsiella pneumoniae in a dynamic bladder infection in vitro model. The Journal of antimicrobial chemotherapy. 2022 04; 77(5):1324-1333. doi: 10.1093/jac/dkac045. [PMID: 35211736]
  • Virginia Garcia-Fulgueiras, Leticia Caiata, Ines Bado, Gustavo Giachetto, Luciana Robino. Antibiotic susceptibility and fosfomycin resistance characterization in a cohort of children older than 6 years of age with urinary tract infection. Revista Argentina de microbiologia. 2022 Apr; 54(2):120-124. doi: 10.1016/j.ram.2021.04.002. [PMID: 34154873]
  • Şeyma Nigiz, Gülşen Hazırolan, Özgen Köseoglu Eser, Deniz Gür. First Detection of Klebsiella pneumoniae Isolate Co-Harboring Fosfomycin Resistance Gene fosA3 and blactx-m Among Gram Negative Urine Isolates in a Turkish Hospital. Microbial drug resistance (Larchmont, N.Y.). 2022 Mar; 28(3):317-321. doi: 10.1089/mdr.2021.0114. [PMID: 34851744]
  • Timothy F Carroll, Alana L Christie, Bonnie C Prokesch, Philippe E Zimmern. Fosfomycin Prevents Intravenous Antibiotic Therapy in Women With Recurrent Urinary Tract Infections: A Retrospective Review. Female pelvic medicine & reconstructive surgery. 2022 02; 28(2):109-114. doi: 10.1097/spv.0000000000001083. [PMID: 35084371]
  • Sara Baldelli, Matteo Cerea, Davide Mangioni, Laura Alagna, Antonio Muscatello, Alessandra Bandera, Dario Cattaneo. Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples. Journal of chemotherapy (Florence, Italy). 2022 Feb; 34(1):25-34. doi: 10.1080/1120009x.2021.1963617. [PMID: 34410896]
  • Miriam Ortiz-Padilla, Inés Portillo-Calderón, Natalia Maldonado, José Rodríguez-Martínez, Belén de Gregorio-Iaria, Vicente Merino-Bohórquez, Jesús Rodríguez-Baño, Álvaro Pascual, Fernando Docobo-Pérez. Role of inorganic phosphate concentrations in in vitro activity of fosfomycin. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2022 Feb; 28(2):302.e1-302.e4. doi: 10.1016/j.cmi.2021.09.037. [PMID: 34634457]
  • Teresa Gil-Gil, José L Martínez. Fosfomycin Resistance Evolutionary Pathways of Stenotrophomonas maltophilia in Different Growing Conditions. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031132. [PMID: 35163052]
  • Patrice Nordmann, Mustafa Sadek, José Manuel Ortiz de la Rosa, Stefan Pfister, Claudine Fournier, Laurent Poirel. Selective Culture Medium for Screening of Fosfomycin Resistance in Enterobacterales. Journal of clinical microbiology. 2022 01; 60(1):e0206321. doi: 10.1128/jcm.02063-21. [PMID: 34669459]
  • Ann-Sera Manseck, Wolfgang Otto, Marco Schnabel, Stefan Denzinger, Maximilian Burger, Philipp Julian Spachmann. Geriatric Patients and Symptomatic Urinary Tract Infections: Analysis of Bacterial Range and Resistance Rates at a 3rd Level of Care Hospital in Germany. Urologia internationalis. 2022; 106(3):298-303. doi: 10.1159/000516677. [PMID: 34175852]
  • Lingchun Zhang, Fenfen Li, Xiaotian Li. Studies on Virulence and Extended-Spectrum β-Lactamase-Producing Uropathogenic Escherichia coli Isolates and Therapeutic Effect of Fosfomycin in Acute Pyelonephritis Mice. BioMed research international. 2022; 2022(?):8334153. doi: 10.1155/2022/8334153. [PMID: 35141335]
  • Lisa K V Gerecke, Julius J Schmidt, Carsten Hafer, Gabriele Eden, Stefanie M Bode-Böger, Jens Martens-Lobenhoffer, Tobias Welte, Jan T Kielstein. Fosfomycin single- and multiple-dose pharmacokinetics in patients undergoing prolonged intermittent renal replacement therapy. The Journal of antimicrobial chemotherapy. 2021 12; 77(1):169-173. doi: 10.1093/jac/dkab357. [PMID: 34586373]
  • T V Shatylko, S I Gamidov, V M Popkov, Korolev Yu A, N G Gasanov. [The efficiency of combined regimens for the treatment of urinary tract infections in women using the herbal drug Canephron N]. Urologiia (Moscow, Russia : 1999). 2021 12; ?(6):51-56. doi: NULL. [PMID: 34967165]
  • Ana Garcia-Sangenís, Rosa Morros, Mercedes Aguilar-Sánchez, Laura Medina-Perucha, Alfonso Leiva, Joana Ripoll, Mar Martínez-Pecharromán, Cruz B Bartolomé-Moreno, Rosa Magallon Botaya, Jaime Marín-Cañada, José M Molero, Ana Moragas, Amelia Troncoso, Ramon Monfà, Carl Llor. Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical trial. BMJ open. 2021 11; 11(11):e055898. doi: 10.1136/bmjopen-2021-055898. [PMID: 34824124]
  • James A Karlowsky, Melanie R Baxter, Alyssa R Golden, Heather J Adam, Andrew Walkty, Philippe R S Lagacé-Wiens, George G Zhanel. Use of Fosfomycin Etest To Determine In Vitro Susceptibility of Clinical Isolates of Enterobacterales Other than Escherichia coli, Nonfermenting Gram-Negative Bacilli, and Gram-Positive Cocci. Journal of clinical microbiology. 2021 11; 59(12):e0163521. doi: 10.1128/jcm.01635-21. [PMID: 34495708]
  • Iain J Abbott, Johan W Mouton, Anton Y Peleg, Joseph Meletiadis. Pharmacokinetic/pharmacodynamic analysis of oral fosfomycin against Enterobacterales, Pseudomonas aeruginosa and Enterococcus spp. in an in vitro bladder infection model: impact on clinical breakpoints. The Journal of antimicrobial chemotherapy. 2021 11; 76(12):3201-3211. doi: 10.1093/jac/dkab313. [PMID: 34473271]
  • Ildikó Gágyor, Eva Hummers, Guido Schmiemann, Tim Friede, Sebastian Pfeiffer, Kambiz Afshar, Jutta Bleidorn. Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2021 Oct; 27(10):1441-1447. doi: 10.1016/j.cmi.2021.05.032. [PMID: 34111592]
  • Faryal Yunus, Ashfaq Hussain, Irfan Ali Mirza, Faisal Hanif, Wajid Hussain, Luqman Satti, Umar Khursheed. Diagnostic Accuracy Of Rapid Fosfomycin Np Test For Detection Of Fosfomycin Resistance In Escherichia Coli In A Tertiary Care Hospital In Pakistan. Journal of Ayub Medical College, Abbottabad : JAMC. 2021 Oct; 33(4):668-672. doi: NULL. [PMID: 35124928]
  • Rafael C Lima, Carlos A Faria, José C Carraro-Eduardo, Pedro S Morales, Ana Beatriz M Fonseca. Evaluation of sensitivity profiles to fosfomycin in bacterial urine samples from outpatients. European journal of obstetrics, gynecology, and reproductive biology. 2021 Jul; 262(?):184-187. doi: 10.1016/j.ejogrb.2021.05.022. [PMID: 34034198]
  • Zoe Kane, Silke Gastine, Christina Obiero, Phoebe Williams, Sheila Murunga, Johnstone Thitiri, Sally Ellis, Erika Correia, Borna Nyaoke, Karin Kipper, John van den Anker, Mike Sharland, James A Berkley, Joseph F Standing. IV and oral fosfomycin pharmacokinetics in neonates with suspected clinical sepsis. The Journal of antimicrobial chemotherapy. 2021 06; 76(7):1855-1864. doi: 10.1093/jac/dkab083. [PMID: 33855449]
  • Max A Simon, Chayanid Ongpipattanakul, Satish K Nair, Wilfred A van der Donk. Biosynthesis of fosfomycin in pseudomonads reveals an unexpected enzymatic activity in the metallohydrolase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 2021 06; 118(23):. doi: 10.1073/pnas.2019863118. [PMID: 34074759]
  • T Dimski, T Brandenburger, M Janczyk, T Slowinski, C MacKenzie, D Kindgen-Milles. Elimination of fosfomycin during dialysis with the Genius system in septic patients. Scientific reports. 2021 06; 11(1):12032. doi: 10.1038/s41598-021-91423-9. [PMID: 34103579]
  • M I Davidov, M N Meltsina, N E Bunova, A M Metelkin, Prussakov R O, A A Lunev. [Phenazopyridine and fosfomycin for the acute cystitis treatment: results of multicenter randomized study]. Urologiia (Moscow, Russia : 1999). 2021 06; ?(3):20-27. doi: . [PMID: 34251097]
  • Javad Yasbolaghi Sharahi, Ali Hashemi, Abdollah Ardebili, Sara Davoudabadi. Molecular characteristics of antibiotic-resistant Escherichia coli and Klebsiella pneumoniae strains isolated from hospitalized patients in Tehran, Iran. Annals of clinical microbiology and antimicrobials. 2021 Apr; 20(1):32. doi: 10.1186/s12941-021-00437-8. [PMID: 33906654]
  • Toshiki Etani, Minami Asaoka, Shuhei Kondo, Chiharu Wachino, Kaoru Hori, Nobuhiko Shimizu, Yusuke Noda, Takashi Nagai, Satoshi Nozaki, Keitaro Iida, Taku Naiki, Ryosuke Ando, Noriyasu Kawai, Takeshi Yanagita, Atsushi Nakamura, Takahiro Yasui. Efficacy of fosfomycin in the prevention of postoperative infection following transurethral resection of bladder tumor during periods of limited cefazolin, cefotiam, and cefmetazole supply. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2021 Apr; 27(4):625-631. doi: 10.1016/j.jiac.2020.11.025. [PMID: 33309628]
  • Guoan Wang, Wei Yu, Yushan Cui, Qingyi Shi, Chen Huang, Yonghong Xiao. Optimal empiric treatment for KPC-2-producing Klebsiella pneumoniae infections in critically ill patients with normal or decreased renal function using Monte Carlo simulation. BMC infectious diseases. 2021 Mar; 21(1):307. doi: 10.1186/s12879-021-06000-2. [PMID: 33771113]
  • Lin Chen, Bingming Ou, Minyu Zhang, Chung-Hsi Chou, Shao-Kuang Chang, Guoqiang Zhu. Coexistence of Fosfomycin Resistance Determinant fosA and fosA3 in Enterobacter cloacae Isolated from Pets with Urinary Tract Infection in Taiwan. Microbial drug resistance (Larchmont, N.Y.). 2021 Mar; 27(3):415-423. doi: 10.1089/mdr.2020.0077. [PMID: 32667841]
  • Teodora Shopova, Tobias Hüppe, Beate Wolf, Daniel I Sessler, Thomas Volk, Heinrich V Groesdonk, Sascha Kreuer, Felix Maurer. Quantitative Determination of Fosfomycin in 10 μL of Plasma and Dialysate by Hydrophilic Interaction Liquid Chromatography Electrospray Ionization Mass Spectrometry. Journal of chromatographic science. 2021 Jan; 59(2):165-174. doi: 10.1093/chromsci/bmaa092. [PMID: 33302294]
  • Valentin Al Jalali, Peter Matzneller, Beatrix Wulkersdorfer, Scharon Chou, Soma Bahmany, Birgit C P Koch, Markus Zeitlinger. Clinical Pharmacokinetics of Fosfomycin after Continuous Infusion Compared with Intermittent Infusion: a Randomized Crossover Study in Healthy Volunteers. Antimicrobial agents and chemotherapy. 2020 12; 65(1):. doi: 10.1128/aac.01375-20. [PMID: 33106259]
  • Kevin Deemer, Jonathan Grey, Christopher Fronczek, Kerry Marr. Impact of reflex fosfomycin susceptibility testing on the utilization of carbapenems for definitive extended-spectrum β-lactamase Escherichia coli urinary tract infection treatment. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2020 Nov; 77(Supplement_4):S105-S110. doi: 10.1093/ajhp/zxaa174. [PMID: 32840305]
  • Rodrigo Rosado-Canto, Idalia Parra-Avila, Javier Tejeda-Maldonado, Cristopher Kauffman-Ortega, Francisco T Rodriguez-Covarrubias, Mariedel Trujeque-Matos, Rodrigo Cruz-Martínez, Ernesto Maravilla-Franco, Elia Criollo-Mora, José M Arreola-Guerra, Luis E Morales-Buenrostro, José Sifuentes-Osornio. Perioperative fosfomycin disodium prophylaxis against urinary tract infection in renal transplant recipients: a randomized clinical trial. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2020 11; 35(11):1996-2003. doi: 10.1093/ndt/gfz261. [PMID: 31883327]
  • Sander G Kuiper, Anneke C Dijkmans, Erik B Wilms, Ingrid M C Kamerling, Jacobus Burggraaf, Jasper Stevens, Cees van Nieuwkoop. Pharmacokinetics of fosfomycin in patients with prophylactic treatment for recurrent Escherichia coli urinary tract infection. The Journal of antimicrobial chemotherapy. 2020 11; 75(11):3278-3285. doi: 10.1093/jac/dkaa294. [PMID: 32712666]
  • E Farfour, N Degand, E Riverain, V Fihman, C Le Brun, G Péan de Ponfilly, A Muggeo, A Jousset, C Piau, P Lesprit. Fosfomycin, from susceptibility to resistance: Impact of the new guidelines on breakpoints. Medecine et maladies infectieuses. 2020 Oct; 50(7):611-616. doi: 10.1016/j.medmal.2020.07.003. [PMID: 32679342]
  • Jakhongir F Alidjanov, Andre Overesch, Dimitri Abramov-Sommariva, Martina Hoeller, Hubert Steindl, Florian M Wagenlehner, Kurt G Naber. Acute Cystitis Symptom Score questionnaire for measuring patient-reported outcomes in women with acute uncomplicated cystitis: Clinical validation as part of a phase III trial comparing antibiotic and nonantibiotic therapy. Investigative and clinical urology. 2020 09; 61(5):498-507. doi: 10.4111/icu.20200060. [PMID: 32869564]
  • Siv Fonnes, Johan Juhl Weisser, Barbara Juliane Holzknecht, Magnus Arpi, Jacob Rosenberg. The plasma pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration in patients undergoing appendectomy for uncomplicated appendicitis. Fundamental & clinical pharmacology. 2020 Aug; 34(4):504-512. doi: 10.1111/fcp.12535. [PMID: 31944378]
  • Iain J Abbott, Elke van Gorp, Rixt A Wijma, Jordy Dekker, Peter D Croughs, Joseph Meletiadis, Johan W Mouton, Anton Y Peleg. Efficacy of single and multiple oral doses of fosfomycin against Pseudomonas aeruginosa urinary tract infections in a dynamic in vitro bladder infection model. The Journal of antimicrobial chemotherapy. 2020 07; 75(7):1879-1888. doi: 10.1093/jac/dkaa127. [PMID: 32361749]
  • Timothy J Hatlen, Richard Flor, Megan H Nguyen, Grace H Lee, Loren G Miller. Oral fosfomycin use for pyelonephritis and complicated urinary tract infections: a 1 year review of outcomes and prescribing habits in a large municipal healthcare system. The Journal of antimicrobial chemotherapy. 2020 07; 75(7):1993-1997. doi: 10.1093/jac/dkaa126. [PMID: 32303061]
  • Merih Simsek. Sensitivity of extended spectrum of β-lactamase producing Escherichia coli and Klebsiella species to Fosfomycin. JPMA. The Journal of the Pakistan Medical Association. 2020 Jul; 70(7):1187-1192. doi: 10.5455/jpma.32169. [PMID: 32799271]
  • Cristina Loras, Ana Constança Mendes, Luisa Peixe, Ângela Novais, Juan-Ignacio Alós. Escherichia coli resistant to fosfomycin from urinary tract infections: Detection of the fosA3 gene in Spain. Journal of global antimicrobial resistance. 2020 06; 21(?):414-416. doi: 10.1016/j.jgar.2020.01.023. [PMID: 32061811]
  • Iain J Abbott, Elke van Gorp, Aart van der Meijden, Rixt A Wijma, Joseph Meletiadis, Jason A Roberts, Johan W Mouton, Anton Y Peleg. Oral Fosfomycin Treatment for Enterococcal Urinary Tract Infections in a Dynamic In Vitro Model. Antimicrobial agents and chemotherapy. 2020 05; 64(6):. doi: 10.1128/aac.00342-20. [PMID: 32253214]
  • Fei Song, Chuan Liu, Junyong Zhang, Yusheng Lei, Zili Hu. Antibacterial effect of fosfomycin tromethamine on the bacteria inside urinary infection stones. International urology and nephrology. 2020 Apr; 52(4):645-654. doi: 10.1007/s11255-019-02358-0. [PMID: 31832876]
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