Topotecan (BioDeep_00000003185)

   

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs


代谢物信息卡片


(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

化学式: C23H23N3O5 (421.16376280000003)
中文名称: 拓扑替康
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.12%

分子结构信息

SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O
InChI: InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1

描述信息

Topotecan is only found in individuals that have used or taken this drug. It is an antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. [PubChem]Topotecan has the same mechanism of action as irinotecan and is believed to exert its cytotoxic effects during the S-phase of DNA synthesis. Topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks. Topotecan binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. This ternary complex interferes with the moving replication fork, which leads to the induction of replication arrest and lethal double-stranded breaks in DNA. As mammalian cells cannot efficiently repair these double strand breaks, the formation of this ternary complex eventually leads to apoptosis (programmed cell death).Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (−1) and downstream (+1) base pairs. Intercalation displaces the downstream DNA, thus preventing religation of the cleaved strand. By specifically binding to the enzyme–substrate complex, Topotecan acts as an uncompetitive inhibitor.
Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent.
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Topotecan is a Topoisomerase Inhibitor. The mechanism of action of topotecan is as a Topoisomerase Inhibitor.
Topotecan is a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
See also: Topotecan Hydrochloride (active moiety of).
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CE - Topoisomerase 1 (top1) inhibitors
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059004 - Topoisomerase I Inhibitors
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D004791 - Enzyme Inhibitors
Same as: D08618
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

86 个代谢物同义名

(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione; (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0(2),(1)(1).0?,?.0(1)?,(2)?]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride; Nogitecan hydrochloride; Hycamtin; (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione; (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione; (S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; hydrochloride; (S)-11-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; hydrochloride; (S)-10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione; 10-dimethylaminomethyl-4-ethyl-4,9-dihydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14-dione; (4-Ethyl-4,9-dihydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-10-ylmethyl)-dimethyl-ammonium; 10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; hydrochloride; 10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Topotecan); 1H-PYRANO(3,4:6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE, 10-((DIMETHYLAMINO)METHYL)-4-ETHYL-4,9-DIHYDROXY-, (4S)-; 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-; 10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione(Topotecan); 1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-, (S)-; 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-; 1H-Pyrano[3,7]indolizino[1,2-b]quinoline- 3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-; (s)-10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3,4:6,7)indolizino(1,2-b)-quinoline-3,14(4H,12H)-dione; (4S)-10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3,4:6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; (S)-11-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; (S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; 10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; Topotecan hydrochloride hydrate, >=98\\% (HPLC and enzymatic); 10-HYDROXY-9-((DIMETHYLAMINO)METHYL)-(20S)-CAMPTOTHECIN; 9-((dimethylamino)methyl)-10-hydroxy-(20S)-camptothecin; 9-((dimethylamino)methyl)-10-hydroxy-(4S)-camptothecin; 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin; SmithKline beecham brand OF topotecan hydrochloride; dihydroxy(oxo)silane; dioxido(dioxo)molybdenum; 9 Dimethylaminomethyl 10 hydroxycamptothecin; dimethylaminomethyl-ethyl-dihydroxy-[?]dione; 9-Dimethylaminomethyl-10-hydroxycamptothecin; Topotecan Monohydrochloride, (S)-Isomer; Topotecan hydrochloride hydrate; UCFGDBYHRUNTLO-QHCPKHFHSA-N; Hydrochloride, Topotecan; Hydrochloride, Nogitecan; Topotecane (INN-French); Topotecanum (INN-Latin); Topotecan Hydrochloride; Nogitecan hydrochloride; Topotecanum [INN-Latin]; Topotecane [INN-French]; TOPOTECANHYDROCHLORIDE; TOPOTECAN [EMA EPAR]; Topotecan [INN:BAN]; Topotecanum (Latin); TOPOTECAN [WHO-DD]; Topotecan lactone; TOPOTECAN [VANDF]; Topotecan Actavis; SK And F 104864 a; SK And F-104864-a; NCIStruc2_001796; NCIStruc1_001659; TOPOTECAN [INN]; SK And F104864a; UNII-7M7YKX2N15; Topotecan (BAN); TOPOTECAN [MI]; (S)-Topotecan; Hycamtin (TN); NCI60_004771; HSCI1_000228; Hycamptamine; SMP2_000327; Topophore C; Hycamtamine; Topotecanum; SMP2_000312; Topotecane; 7M7YKX2N15; Nogitecan; Hycamptin; Topotecan; CHEMBL84; Hycamtin; TopoCED; Topotecan-d6



数据库引用编号

23 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

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2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ali Rasouli, Qin Yu, Sepehr Dehghani-Ghahnaviyeh, Po-Chao Wen, Julia Kowal, Kaspar P Locher, Emad Tajkhorshid. Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proceedings of the National Academy of Sciences of the United States of America. 2023 01; 120(1):e2213437120. doi: 10.1073/pnas.2213437120. [PMID: 36580587]
  • Qun Niu, Wanxin Hou, Yinjie Yan, Shuzhang Sun, Yanyan Lin, Houshun Fang, Chunshuang Ma, Changsheng Dong, Yixuan Cheng, Yan Xu, Ming Ding, Shuxuan Wang, Zhiyan Cui, Yao Chen, Hegen Li, Hui Li, Ning Xiao. Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1. Biochimica et biophysica acta. Molecular basis of disease. 2022 12; 1868(12):166492. doi: 10.1016/j.bbadis.2022.166492. [PMID: 35850175]
  • Aveek Samanta, Saptadipa Banerjee, Tilak Raj Maity, Jangala Jahnavi, Siraj Datta. Towards establishment of a plant-based model to assess the novel anti-cancerous lead molecule(s): An in silico, in vivo and in vitro assessment of some potential anti-cancerous drugs on Lathyrus sativus L. Protoplasma. 2022 Nov; 259(6):1455-1466. doi: 10.1007/s00709-022-01745-2. [PMID: 35195768]
  • Yin-Peng Bai, Cheng-Jie Yang, Nan Deng, Mi Zhang, Zhi-Jun Zhang, Lei Li, Yong Zhou, Xiong-Fei Luo, Chuan-Rui Xu, Bao-Qi Zhang, Yue Ma, Ying-Qian Liu. Design and synthesis of novel 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives as potential high selectivity and low toxicity topoisomerase I inhibitors for hepatocellular carcinoma. Biochemical pharmacology. 2022 06; 200(?):115049. doi: 10.1016/j.bcp.2022.115049. [PMID: 35469784]
  • M J Del Sole, M Clausse, P Nejamkin, B Cancela, M Del Río, G Lamas, F Lubieniecki, J H Francis, D H Abramson, G Chantada, P Schaiquevich. Ocular and systemic toxicity of high-dose intravitreal topotecan in rabbits: Implications for retinoblastoma treatment. Experimental eye research. 2022 05; 218(?):109026. doi: 10.1016/j.exer.2022.109026. [PMID: 35276184]
  • Xiangyong Hao, Jiedan Deng, Honghua Zhang, Ziyi Liang, Fang Lei, Yuqing Wang, Xiaoyan Yang, Zhen Wang. Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents. Bioorganic & medicinal chemistry. 2022 02; 55(?):116595. doi: 10.1016/j.bmc.2021.116595. [PMID: 34990980]
  • Ziyi Liang, Fang Lei, Jiedan Deng, Honghua Zhang, Yuqing Wang, Junfang Li, Tao Shi, Xiaoyan Yang, Zhen Wang. Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer. European journal of medicinal chemistry. 2022 Jan; 228(?):113960. doi: 10.1016/j.ejmech.2021.113960. [PMID: 34774339]
  • Philip J Kuehl, Christin M Yingling, Devon Dubose, Michael Burke, David A Revelli, Wenshu Chen, Wendy W Dye, Steven A Belinsky, Mathewos Tessema. Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer. Drug delivery. 2021 Dec; 28(1):767-775. doi: 10.1080/10717544.2021.1912209. [PMID: 33860729]
  • Zhiyong Zhang, Yan Pan, Yan Zhao, Mudan Ren, Yarui Li, Guifang Lu, Kaichun Wu, Shuixiang He. Topotecan-loaded thermosensitive nanocargo for tumor therapy: In vitro and in vivo analyses. International journal of pharmaceutics. 2021 Sep; 606(?):120871. doi: 10.1016/j.ijpharm.2021.120871. [PMID: 34246742]
  • Xuan Wang, Jim C Oates, Kristi L Helke, Gary S Gilkeson, Xian K Zhang. Camptothecin and Topotecan, Inhibitors of Transcription Factor Fli-1 and Topoisomerase, Markedly Ameliorate Lupus Nephritis in (NZB × NZW)F1 Mice and Reduce the Production of Inflammatory Mediators in Human Renal Cells. Arthritis & rheumatology (Hoboken, N.J.). 2021 08; 73(8):1478-1488. doi: 10.1002/art.41685. [PMID: 33559345]
  • Tianjiao Zeng, Mingshi Xu, Wanli Zhang, Xiaofan Gu, Fangqing Zhao, Xuan Liu, Xiongwen Zhang. Autophagy inhibition and microRNA‑199a‑5p upregulation in paclitaxel‑resistant A549/T lung cancer cells. Oncology reports. 2021 07; 46(1):. doi: 10.3892/or.2021.8100. [PMID: 34080652]
  • Jessica Sook Yuin Ho, Bobo Wing-Yee Mok, Laura Campisi, Tristan Jordan, Soner Yildiz, Sreeja Parameswaran, Joseph A Wayman, Natasha N Gaudreault, David A Meekins, Sabarish V Indran, Igor Morozov, Jessie D Trujillo, Yesai S Fstkchyan, Raveen Rathnasinghe, Zeyu Zhu, Simin Zheng, Nan Zhao, Kris White, Helen Ray-Jones, Valeriya Malysheva, Michiel J Thiecke, Siu-Ying Lau, Honglian Liu, Anna Junxia Zhang, Andrew Chak-Yiu Lee, Wen-Chun Liu, Sonia Jangra, Alba Escalera, Teresa Aydillo, Betsaida Salom Melo, Ernesto Guccione, Robert Sebra, Elaine Shum, Jan Bakker, David A Kaufman, Andre L Moreira, Mariano Carossino, Udeni B R Balasuriya, Minji Byun, Randy A Albrecht, Michael Schotsaert, Adolfo Garcia-Sastre, Sumit K Chanda, Emily R Miraldi, Anand D Jeyasekharan, Benjamin R TenOever, Mikhail Spivakov, Matthew T Weirauch, Sven Heinz, Honglin Chen, Christopher Benner, Juergen A Richt, Ivan Marazzi. TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. Cell. 2021 05; 184(10):2618-2632.e17. doi: 10.1016/j.cell.2021.03.051. [PMID: 33836156]
  • N S Dyrkheeva, A L Zakharenko, E S Novoselova, A A Chepanova, N A Popova, V P Nikolin, O A Luzina, N F Salakhutdinov, E I Ryabchikova, O I Lavrik. [Antitumor Activity of the Combination of Topotecan and Tyrosyl-DNA-Phosphodiesterase 1 Inhibitor on Model Krebs-2 Mouse Ascite Carcinoma]. Molekuliarnaia biologiia. 2021 Mar; 55(2):312-317. doi: 10.31857/s0026898421020051. [PMID: 33871444]
  • Yang Li, Chuchu Feng, Yantao Chen, Ke Huang, Chunmou Li, Xilin Xiong, Peng Li, Dunhua Zhou, Xiaomin Peng, Wenjun Weng, Xiaogeng Deng, Yaohao Wu, Jianpei Fang. Improved Outcomes with Induction Chemotherapy Combined with Arsenic Trioxide in Stage 4 Neuroblastoma: A Case Series. Technology in cancer research & treatment. 2021 Jan; 20(?):15330338211041454. doi: 10.1177/15330338211041454. [PMID: 34569870]
  • R Xing, O Mustapha, T Ali, M Rehman, S S Zaidi, A Baseer, S Batool, M Mukhtiar, S Shafique, M Malik, S Sohail, Z Ali, F Zahid, A Zeb, F Shah, A Yousaf, F Din. Development, Characterization, and Evaluation of SLN-Loaded Thermoresponsive Hydrogel System of Topotecan as Biological Macromolecule for Colorectal Delivery. BioMed research international. 2021; 2021(?):9968602. doi: 10.1155/2021/9968602. [PMID: 34285920]
  • Esther Hee, Meng Kang Wong, Sheng Hui Tan, Zhang'E Choo, Chik Hong Kuick, Sharon Ling, Min Hwee Yong, Sudhanshi Jain, Derrick W Q Lian, Eileen H Q Ng, Yvonne F L Yong, Mee Hiong Ren, Nurfarhanah Syed Sulaiman, Sharon Y Y Low, Yong Wei Chua, Muhammad Fahmy Syed, Tony K H Lim, Shui Yen Soh, Prasad Iyer, Michaela S F Seng, Joyce C M Lam, Enrica E K Tan, Mei Yoke Chan, Ah Moy Tan, Yong Chen, Zhixiong Chen, Kenneth T E Chang, Amos Hong Pheng Loh. Neuroblastoma patient-derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response. Cancer science. 2020 Oct; 111(10):3780-3792. doi: 10.1111/cas.14610. [PMID: 32777141]
  • Ying Li, Ying Liu, Bin Du, Genyang Cheng. Reshaping Tumor Blood Vessels to Enhance Drug Penetration with a Multistrategy Synergistic Nanosystem. Molecular pharmaceutics. 2020 09; 17(9):3151-3164. doi: 10.1021/acs.molpharmaceut.0c00077. [PMID: 32787273]
  • Yu-Mei Kang, Alexander Lan, Yen-Hua Huang, Kai-Mei Hsu, Yee Chao, Keng-Li Lan. Identification of key genes and pathways associated with topotecan treatment using multiple bioinformatics tools. Journal of the Chinese Medical Association : JCMA. 2020 May; 83(5):446-453. doi: 10.1097/jcma.0000000000000313. [PMID: 32243271]
  • Paramjot Kaur, Sivanesan Dhandayuthapani, Thiagarajan Venkatesan, Miroslav Gantor, Appu Rathinavelu. Molecular mechanism of C-phycocyanin induced apoptosis in LNCaP cells. Bioorganic & medicinal chemistry. 2020 02; 28(3):115272. doi: 10.1016/j.bmc.2019.115272. [PMID: 31883786]
  • Cheng-Jie Yang, Bin Li, Zhi-Jun Zhang, Jian-Mei Gao, Mei-Juan Wang, Xiao-Bo Zhao, Zi-Long Song, Ying-Qian Liu, Hu Li, Yuyuan Chen, Kuo-Hsiung Lee, Susan L Morris-Natschke, Chuanrui Xu. Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin. European journal of medicinal chemistry. 2020 Feb; 187(?):111971. doi: 10.1016/j.ejmech.2019.111971. [PMID: 31881457]
  • Lei Wang, Kun Fang, Junfei Cheng, Yu Li, Yahui Huang, Shuqiang Chen, Guoqiang Dong, Shanchao Wu, Chunquan Sheng. Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer. Journal of medicinal chemistry. 2020 01; 63(2):696-713. doi: 10.1021/acs.jmedchem.9b01626. [PMID: 31880942]
  • Manisha Yadav, Swasti Dhagat, Jujjavarapu S Eswari. Structure Based Drug Design and Molecular Docking Studies of Anticancer Molecules Paclitaxel, Etoposide and Topotecan using Novel Ligands. Current drug discovery technologies. 2020; 17(2):183-190. doi: 10.2174/1570163816666190307102033. [PMID: 30848204]
  • Liting Yan, Xiang Nan, Cunzheng Zhang, Haifang Wang, Xiaoyan Huang, Jun Hu, Yingqian Liu. Development of an enzyme‑linked immunosorbent assay for camptothecin. Molecular medicine reports. 2019 Aug; 20(2):959-966. doi: 10.3892/mmr.2019.10342. [PMID: 31173229]
  • Biswajit Kundu, Subhendu K Das, Srijita Paul Chowdhuri, Sourav Pal, Dipayan Sarkar, Arijit Ghosh, Ayan Mukherjee, Debomita Bhattacharya, Benu Brata Das, Arindam Talukdar. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. Journal of medicinal chemistry. 2019 04; 62(7):3428-3446. doi: 10.1021/acs.jmedchem.8b01938. [PMID: 30897325]
  • Anna Birg Mitchell, Aksana Vasilyeva, Amar Gajjar, Victor M Santana, Clinton F Stewart. Determining success rates of the current pharmacokinetically guided dosing approach of topotecan in pediatric oncology patients. Pediatric blood & cancer. 2019 04; 66(4):e27578. doi: 10.1002/pbc.27578. [PMID: 30548417]
  • Kasirawat Sawangrat, Shugo Yamashita, Akiko Tanaka, Masaki Morishita, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto. Modulation of Intestinal Transport and Absorption of Topotecan, a BCRP Substrate, by Various Pharmaceutical Excipients and Their Inhibitory Mechanisms of BCRP Transporter. Journal of pharmaceutical sciences. 2019 03; 108(3):1315-1325. doi: 10.1016/j.xphs.2018.10.043. [PMID: 30389568]
  • Philip J Kuehl, Marcie J Grimes, Devon Dubose, Michael Burke, David A Revelli, Andrew P Gigliotti, Steven A Belinsky, Mathewos Tessema. Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model. Drug delivery. 2018 Nov; 25(1):1127-1136. doi: 10.1080/10717544.2018.1469688. [PMID: 29779406]
  • Youcef M Rustum, Sreenivasulu Chintala, Farukh A Durrani, Arup Bhattacharya. Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy. International journal of molecular sciences. 2018 Oct; 19(11):. doi: 10.3390/ijms19113378. [PMID: 30380599]
  • José Lopes-de-Araújo, Salette Reis, Cláudia Nunes. Topotecan effect on the structure of normal and cancer plasma membrane lipid models: A multi-model approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Oct; 123(?):515-523. doi: 10.1016/j.ejps.2018.08.006. [PMID: 30086354]
  • Venkatesh Teja Banala, Shweta Sharma, Puja Barnwal, Sandeep Urandur, Ravi P Shukla, Naseer Ahmad, Naresh Mittapelly, Gitu Pandey, Monika Dwivedi, Navodayam Kalleti, Kalyan Mitra, Srikanta Kumar Rath, Ritu Trivedi, Prabhat Ranjan Mishra. Synchronized Ratiometric Codelivery of Metformin and Topotecan through Engineered Nanocarrier Facilitates In Vivo Synergistic Precision Levels at Tumor Site. Advanced healthcare materials. 2018 10; 7(19):e1800300. doi: 10.1002/adhm.201800300. [PMID: 30102470]
  • Yuta Naro, Nicholas Ankenbruck, Meryl Thomas, Yaniv Tivon, Colleen M Connelly, Laura Gardner, Alexander Deiters. Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan. Journal of medicinal chemistry. 2018 Jul; 61(14):5900-5909. doi: 10.1021/acs.jmedchem.7b01891. [PMID: 29993250]
  • Asma Yasmeen Khan, Gopinatha Suresh Kumar. Exploring the binding interaction of potent anticancer drug topotecan with human serum albumin: spectroscopic, calorimetric and fibrillation study. Journal of biomolecular structure & dynamics. 2018 Jul; 36(9):2463-2473. doi: 10.1080/07391102.2017.1359671. [PMID: 28760107]
  • Andrea E Wahner Hendrickson, Michael E Menefee, Lynn C Hartmann, Harry J Long, Donald W Northfelt, Joel M Reid, Felix Boakye-Agyeman, Olumide Kayode, Karen S Flatten, Maria I Harrell, Elizabeth M Swisher, Guy G Poirier, Daniel Satele, Jake Allred, Janet L Lensing, Alice Chen, Jiuping Ji, Yiping Zang, Charles Erlichman, Paul Haluska, Scott H Kaufmann. A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 02; 24(4):744-752. doi: 10.1158/1078-0432.ccr-17-1590. [PMID: 29138343]
  • Emanuelle Jesus Silva, Leonardo Gomes Souza, Luis Antonio Dantas Silva, Stephania Fleury Taveira, Raquel Ciffarello Guilger, Luciano Morais Liao, Luiz Henrique Keng Queiroz Junior, Mabio Joao Santana, Ricardo Neves Marreto. A Novel Polymer-Lipid Hybrid Nanoparticle for the Improvement of Topotecan Hydrochloride Physicochemical Properties. Current drug delivery. 2018; 15(7):979-986. doi: 10.2174/1567201815666171215110026. [PMID: 29243576]
  • Tao Wang, Liao Shen, Zhen Zhang, Haiyan Li, Ri Huang, Yadan Zhang, Dongqin Quan. A novel core-shell lipid nanoparticle for improving oral administration of water soluble chemotherapeutic agents: inhibited intestinal hydrolysis and enhanced lymphatic absorption. Drug delivery. 2017 Nov; 24(1):1565-1573. doi: 10.1080/10717544.2017.1386730. [PMID: 29029577]
  • Sara M Federico, M Beth McCarville, Barry L Shulkin, Paul M Sondel, Jacquelyn A Hank, Paul Hutson, Michael Meagher, Aaron Shafer, Catherine Y Ng, Wing Leung, William E Janssen, Jianrong Wu, Shenghua Mao, Rachel C Brennan, Victor M Santana, Alberto S Pappo, Wayne L Furman. A Pilot Trial of Humanized Anti-GD2 Monoclonal Antibody (hu14.18K322A) with Chemotherapy and Natural Killer Cells in Children with Recurrent/Refractory Neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Nov; 23(21):6441-6449. doi: 10.1158/1078-0432.ccr-17-0379. [PMID: 28939747]
  • Guillem Pascual-Pasto, Nagore G Olaciregui, Javier A W Opezzo, Helena Castillo-Ecija, Maria Cuadrado-Vilanova, Sonia Paco, Ezequiel M Rivero, Monica Vila-Ubach, Camilo A Restrepo-Perdomo, Montserrat Torrebadell, Mariona Suñol, Paula Schaiquevich, Jaume Mora, Guillermo F Bramuglia, Guillermo L Chantada, Angel M Carcaboso. Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier. Journal of controlled release : official journal of the Controlled Release Society. 2017 Oct; 264(?):34-44. doi: 10.1016/j.jconrel.2017.08.018. [PMID: 28830790]
  • Krishnansu S Tewari, Michael W Sill, Richard T Penson, Helen Huang, Lois M Ramondetta, Lisa M Landrum, Ana Oaknin, Thomas J Reid, Mario M Leitao, Helen E Michael, Philip J DiSaia, Larry J Copeland, William T Creasman, Frederick B Stehman, Mark F Brady, Robert A Burger, J Tate Thigpen, Michael J Birrer, Steven E Waggoner, David H Moore, Katherine Y Look, Wui-Jin Koh, Bradley J Monk. Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240). Lancet (London, England). 2017 Oct; 390(10103):1654-1663. doi: 10.1016/s0140-6736(17)31607-0. [PMID: 28756902]
  • João Hélio Venâncio, Lígia Marquez Andrade, Najla Locatelli Santos Esteves, Lara Barroso Brito, Marize Campos Valadares, Gisele Augusto Rodrigues Oliveira, Eliana Martins Lima, Ricardo Neves Marreto, Tais Gratieri, Stephânia Fleury Taveira. Topotecan-loaded lipid nanoparticles as a viable tool for the topical treatment of skin cancers. The Journal of pharmacy and pharmacology. 2017 Oct; 69(10):1318-1326. doi: 10.1111/jphp.12772. [PMID: 28703281]
  • Shailly Mehrotra, Mathangi Gopalakrishnan, Jogarao Gobburu, Jacqueline M Greer, Richard Piekarz, Judith E Karp, Keith Pratz, Michelle A Rudek. Population pharmacokinetics and site of action exposures of veliparib with topotecan plus carboplatin in patients with haematological malignancies. British journal of clinical pharmacology. 2017 08; 83(8):1688-1700. doi: 10.1111/bcp.13253. [PMID: 28156017]
  • Roger Gilabert-Oriol, Lina Chernov, Malathi Anantha, Wieslawa H Dragowska, Marcel B Bally. In vitro assay for measuring real time topotecan release from liposomes: release kinetics and cellular internalization. Drug delivery and translational research. 2017 08; 7(4):544-557. doi: 10.1007/s13346-017-0380-9. [PMID: 28432657]
  • Lina Chernov, Rebecca J Deyell, Malathi Anantha, Nancy Dos Santos, Roger Gilabert-Oriol, Marcel B Bally. Optimization of liposomal topotecan for use in treating neuroblastoma. Cancer medicine. 2017 Jun; 6(6):1240-1254. doi: 10.1002/cam4.1083. [PMID: 28544814]
  • Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher, Sebastian Heikaus. The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling. Cell communication and signaling : CCS. 2017 05; 15(1):16. doi: 10.1186/s12964-017-0170-5. [PMID: 28464919]
  • Kathelijne Cjm Kraal, Elvira C van Dalen, Godelieve Am Tytgat, Berthe Lf Van Eck-Smit. Iodine-131-meta-iodobenzylguanidine therapy for patients with newly diagnosed high-risk neuroblastoma. The Cochrane database of systematic reviews. 2017 Apr; 4(?):CD010349. doi: 10.1002/14651858.cd010349.pub2. [PMID: 28429876]
  • Kieuhoa T Vo, Erin E Karski, Nicole M Nasholm, Shelly Allen, Fabienne Hollinger, W Clay Gustafson, Janel R Long-Boyle, Stephen Shiboski, Katherine K Matthay, Steven G DuBois. Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. Oncotarget. 2017 Apr; 8(14):23851-23861. doi: 10.18632/oncotarget.12904. [PMID: 27793021]
  • Emanuela Martino, Serena Della Volpe, Elisa Terribile, Emanuele Benetti, Mirena Sakaj, Adriana Centamore, Andrea Sala, Simona Collina. The long story of camptothecin: From traditional medicine to drugs. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):701-707. doi: 10.1016/j.bmcl.2016.12.085. [PMID: 28073672]
  • Zhao-Jie Chen, Zhen Zhang, Bei-Bei Xie, Hai-Yan Zhang. Development and evaluation of topotecan loaded solid lipid nanoparticles: A study in cervical cancer cell lines. Journal of photochemistry and photobiology. B, Biology. 2016 Dec; 165(?):182-188. doi: 10.1016/j.jphotobiol.2016.10.019. [PMID: 27816641]
  • Sensen Lin, Xiaodan Lyu, Jun Yu, Li Sun, Danyu Du, Yanqi Lai, Hongyang Li, Ying Wang, Luyong Zhang, Hongping Yin, Shengtao Yuan. MHP-1 inhibits cancer metastasis and restores topotecan sensitivity via regulating epithelial-mesenchymal transition and TGF-β signaling in human breast cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Sep; 23(10):1053-63. doi: 10.1016/j.phymed.2016.06.013. [PMID: 27444351]
  • Zeljko M Prijovich, Pierre-Alain Burnouf, Hua-Cheng Chou, Ping-Ting Huang, Kai-Chuan Chen, Tian-Lu Cheng, Yu-Lin Leu, Steve R Roffler. Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation. Molecular pharmaceutics. 2016 Apr; 13(4):1242-50. doi: 10.1021/acs.molpharmaceut.5b00771. [PMID: 26824303]
  • Paula Taich, Flavio Requejo, Marcelo Asprea, Mariana Sgroi, Pierre Gobin, David H Abramson, Guillermo Chantada, Paula Schaiquevich. Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery. PloS one. 2016; 11(3):e0151343. doi: 10.1371/journal.pone.0151343. [PMID: 26959658]
  • Marie Morfouace, Satish Cheepala, Sadhana Jackson, Yu Fukuda, Yogesh T Patel, Soghra Fatima, Daisuke Kawauchi, Anang A Shelat, Clinton F Stewart, Brian P Sorrentino, John D Schuetz, Martine F Roussel. ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy. Cancer research. 2015 Sep; 75(18):3879-89. doi: 10.1158/0008-5472.can-15-0030. [PMID: 26199091]
  • Lot A Devriese, Petronella Els O Witteveen, Marja Mergui-Roelvink, Deborah A Smith, Lionel D Lewis, David S Mendelson, Yung-Jue Bang, Hyun Choel Chung, Mohammed M Dar, Alwin D R Huitema, Jos H Beijnen, Emile E Voest, Jan H M Schellens. Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function. British journal of clinical pharmacology. 2015 Aug; 80(2):253-66. doi: 10.1111/bcp.12606. [PMID: 25677219]
  • Elena V Rosca, Michael Wright, Roman Gonitel, Wladyslaw Gedroyc, Andrew D Miller, Maya Thanou. Thermosensitive, near-infrared-labeled nanoparticles for topotecan delivery to tumors. Molecular pharmaceutics. 2015 May; 12(5):1335-46. doi: 10.1021/mp5002679. [PMID: 25826624]
  • Christopher Jedeszko, Marta Paez-Ribes, Teresa Di Desidero, Shan Man, Christina R Lee, Ping Xu, Georg A Bjarnason, Guido Bocci, Robert S Kerbel. Postsurgical adjuvant or metastatic renal cell carcinoma therapy models reveal potent antitumor activity of metronomic oral topotecan with pazopanib. Science translational medicine. 2015 Apr; 7(282):282ra50. doi: 10.1126/scitranslmed.3010722. [PMID: 25855496]
  • A M C Mavinkurve-Groothuis, M M van den Heuvel-Eibrink, G A Tytgat, H van Tinteren, G Vujanic, K L P Pritchard-Jones, L Howell, N Graf, C Bergeron, T Acha, S Catania, F Spreafico. Treatment of relapsed Wilms tumour (WT) patients: experience with topotecan. A report from the SIOP Renal Tumour Study Group (RTSG). Pediatric blood & cancer. 2015 Apr; 62(4):598-602. doi: 10.1002/pbc.25357. [PMID: 25546733]
  • Gulsah Congur, Arzum Erdem, Fehmi Mese. Electrochemical investigation of the interaction between topotecan and DNA at disposable graphite electrodes. Bioelectrochemistry (Amsterdam, Netherlands). 2015 Apr; 102(?):21-8. doi: 10.1016/j.bioelechem.2014.11.003. [PMID: 25461757]
  • Kyle D Fugit, Amar Jyoti, Meenakshi Upreti, Bradley D Anderson. Insights into accelerated liposomal release of topotecan in plasma monitored by a non-invasive fluorescence spectroscopic method. Journal of controlled release : official journal of the Controlled Release Society. 2015 Jan; 197(?):10-9. doi: 10.1016/j.jconrel.2014.10.011. [PMID: 25456833]
  • Ming Zhao, Ruth A Gjerset. Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. PloS one. 2015; 10(8):e0134929. doi: 10.1371/journal.pone.0134929. [PMID: 26248194]
  • Qingyong Li, Wenchao Wang, Yuhui Liu, Bolin Lian, Qiaochu Zhu, Liping Yao, Tianyu Liu. The biological characteristics of a novel camptothecin-artesunate conjugate. Bioorganic & medicinal chemistry letters. 2015 Jan; 25(1):148-52. doi: 10.1016/j.bmcl.2014.10.048. [PMID: 25453788]
  • Primo N Lara, James Moon, Mary W Redman, Thomas J Semrad, Karen Kelly, Jeffrey W Allen, Barbara J Gitlitz, Philip C Mack, David R Gandara. Relevance of platinum-sensitivity status in relapsed/refractory extensive-stage small-cell lung cancer in the modern era: a patient-level analysis of southwest oncology group trials. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2015 Jan; 10(1):110-5. doi: 10.1097/jto.0000000000000385. [PMID: 25490004]
  • Hung C Tran, Sharon Gardner, Howard L Weiner, Leonard F Liebes, Jonathan L Finlay. Pilot study assessing a seven-day continuous intrathecal topotecan infusion for recurrent or progressive leptomeningeal metastatic cancer. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2014 Jun; 20(3):229-32. doi: 10.1177/1078155213494940. [PMID: 23929729]
  • Dhaval K Shah, Joseph P Balthasar. PK/TD modeling for prediction of the effects of 8C2, an anti-topotecan mAb, on topotecan-induced toxicity in mice. International journal of pharmaceutics. 2014 Apr; 465(1-2):228-38. doi: 10.1016/j.ijpharm.2014.01.038. [PMID: 24508555]
  • Kyle D Fugit, Bradley D Anderson. Dynamic, nonsink method for the simultaneous determination of drug permeability and binding coefficients in liposomes. Molecular pharmaceutics. 2014 Apr; 11(4):1314-25. doi: 10.1021/mp400765n. [PMID: 24628304]
  • Paula Taich, Alejandro Ceciliano, Emiliano Buitrago, Claudia Sampor, Adriana Fandino, Francisco Villasante, Evandro Lucena, Livia Romero, Guillermo L Chantada, Paula Schaiquevich. Clinical pharmacokinetics of intra-arterial melphalan and topotecan combination in patients with retinoblastoma. Ophthalmology. 2014 Apr; 121(4):889-97. doi: 10.1016/j.ophtha.2013.10.045. [PMID: 24359624]
  • Dhaval K Shah, Joseph P Balthasar. Predicting the effects of 8C2, a monoclonal anti-topotecan antibody, on plasma and tissue disposition of topotecan. Journal of pharmacokinetics and pharmacodynamics. 2014 Feb; 41(1):55-69. doi: 10.1007/s10928-013-9346-9. [PMID: 24368689]
  • Ling Ye, Jian Shi, Shanhe Wan, Xiaoshan Yang, Ying Wang, Jiajie Zhang, Dayong Zheng, Zhongqiu Liu. Development and validation of a liquid chromatography-tandem mass spectrometry method for topotecan determination in beagle dog plasma and its application in a bioequivalence study. Biomedical chromatography : BMC. 2013 Nov; 27(11):1532-9. doi: 10.1002/bmc.2956. [PMID: 23788247]
  • Alessandra Rovida, Vittoria Castiglioni, Alessandra Decio, Valentina Scarlato, Eugenio Scanziani, Raffaella Giavazzi, Marta Cesca. Chemotherapy counteracts metastatic dissemination induced by antiangiogenic treatment in mice. Molecular cancer therapeutics. 2013 Oct; 12(10):2237-47. doi: 10.1158/1535-7163.mct-13-0244. [PMID: 23918831]
  • Corbin Bachmeier, Gary M Levin, David Beaulieu-Abdelahad, Jon Reed, Michael Mullan. Effect of venlafaxine and desvenlafaxine on drug efflux protein expression and biodistribution in vivo. Journal of pharmaceutical sciences. 2013 Oct; 102(10):3838-43. doi: 10.1002/jps.23680. [PMID: 23897419]
  • Ning Li, Yuanyuan Song, Ping Du, Yinchen Shen, Jianliang Yang, Lin Gui, Shuai Wang, Jianfei Wang, Yan Sun, Xiaohong Han, Yuankai Shi. Oral topotecan: Bioavailability, pharmacokinetics and impact of ABCG2 genotyping in Chinese patients with advanced cancers. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2013 Oct; 67(8):801-6. doi: 10.1016/j.biopha.2013.08.002. [PMID: 24074809]
  • Yoshiki Matsuda, Yoshihiro Konno, Takashi Hashimoto, Mika Nagai, Takayuki Taguchi, Masahiro Satsukawa, Shinji Yamashita. In vivo assessment of the impact of efflux transporter on oral drug absorption using portal vein-cannulated rats. Drug metabolism and disposition: the biological fate of chemicals. 2013 Aug; 41(8):1514-21. doi: 10.1124/dmd.113.051680. [PMID: 23686319]
  • Amit K Tiwari, Rong Zhang, James M Gallo. Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models. Molecular cancer therapeutics. 2013 Jul; 12(7):1343-55. doi: 10.1158/1535-7163.mct-13-0100. [PMID: 23635651]
  • Krupa J Patel, Olivier Trédan, Ian F Tannock. Distribution of the anticancer drugs doxorubicin, mitoxantrone and topotecan in tumors and normal tissues. Cancer chemotherapy and pharmacology. 2013 Jul; 72(1):127-38. doi: 10.1007/s00280-013-2176-z. [PMID: 23680920]
  • F Bauer, B Filipiak-Pittroff, A Wawer, I von Luettichau, S Burdach. Escalating topotecan in combination with treosulfan has acceptable toxicity in advanced pediatric sarcomas. Pediatric hematology and oncology. 2013 May; 30(4):263-72. doi: 10.3109/08880018.2013.777948. [PMID: 23509879]
  • Fan Lin, Lisette Hoogendijk, Levi Buil, Jos H Beijnen, Olaf van Tellingen. Sildenafil is not a useful modulator of ABCB1 and ABCG2 mediated drug resistance in vivo. European journal of cancer (Oxford, England : 1990). 2013 May; 49(8):2059-64. doi: 10.1016/j.ejca.2012.12.028. [PMID: 23422148]
  • Ning Li, Xiaohong Han, Jianliang Yang, Lin Gui, Yuanyuan Song, Ping Du, Yuankai Shi. Absolute bioavailability studies of a new oral topotecan formulation in Chinese patients using UHPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2013 Mar; 76(?):252-6. doi: 10.1016/j.jpba.2012.12.033. [PMID: 23354352]
  • Emiliano Buitrago, María José Del Sole, Ana Torbidoni, Adriana Fandino, Marcelo Asprea, J O Croxatto, Guillermo L Chantada, Guillermo F Bramuglia, Paula Schaiquevich. Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma. Experimental eye research. 2013 Mar; 108(?):103-9. doi: 10.1016/j.exer.2013.01.002. [PMID: 23333535]
  • ChunLei Li, Xi Zhao, YaJuan Wang, HanYu Yang, HaiXia Li, Huan Li, Wei Tian, Jian Yang, JingXia Cui. Prolongation of time interval between doses could eliminate accelerated blood clearance phenomenon induced by pegylated liposomal topotecan. International journal of pharmaceutics. 2013 Feb; 443(1-2):17-25. doi: 10.1016/j.ijpharm.2013.01.012. [PMID: 23318366]
  • A Susloparova, D Koppenhöfer, X T Vu, M Weil, S Ingebrandt. Impedance spectroscopy with field-effect transistor arrays for the analysis of anti-cancer drug action on individual cells. Biosensors & bioelectronics. 2013 Feb; 40(1):50-6. doi: 10.1016/j.bios.2012.06.006. [PMID: 22795530]
  • Nilesh A Patankar, Dawn Waterhouse, Dita Strutt, Malathi Anantha, Marcel B Bally. Topophore C: a liposomal nanoparticle formulation of topotecan for treatment of ovarian cancer. Investigational new drugs. 2013 Feb; 31(1):46-58. doi: 10.1007/s10637-012-9832-8. [PMID: 22615060]
  • Denisa Darsova, Pavel Pochop, Jiri Uhlik, Eva Klapkova, Hundie Tesfaye, Daniela Kodetova, Jan Lestak, Josef Malis, Ludek Vajner. Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: alternative retinoblastoma treatment. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2012 Dec; 156(4):318-23. doi: 10.5507/bp.2011.068. [PMID: 22660213]
  • Tomasz Bączek, Lucyna Konieczna, Mariusz Belka, Lucyna Maciejka-Kapuścińska, Jakub Wiśniewski, Maciej Niedźwiecki, Anna Balcerska, Elżbieta Adamkiewicz-Drożyńska, Jacek Wachowiak. Topotecan exposure estimation in pediatric acute myeloid leukemia supported by LC-MS-based drug monitoring and pharmacokinetic analysis. Journal of pharmaceutical and biomedical analysis. 2012 Nov; 70(?):330-6. doi: 10.1016/j.jpba.2012.05.012. [PMID: 22658903]
  • Domenico Alloatti, Giuseppe Giannini, Loredana Vesci, Massimo Castorina, Claudio Pisano, Elena Badaloni, Walter Cabri. Camptothecins in tumor homing via an RGD sequence mimetic. Bioorganic & medicinal chemistry letters. 2012 Oct; 22(20):6509-12. doi: 10.1016/j.bmcl.2012.07.061. [PMID: 22959246]
  • E Chatelut, M L White-Koning, R Hj Mathijssen, F Puisset, S D Baker, A Sparreboom. Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents. British journal of cancer. 2012 Sep; 107(7):1100-6. doi: 10.1038/bjc.2012.357. [PMID: 22929884]
  • Anthony G McCluskey, Robert J Mairs, Mathias Tesson, Sally L Pimlott, John W Babich, Mark N Gaze, Sue Champion, Marie Boyd. Inhibition of poly(ADP-Ribose) polymerase enhances the toxicity of 131I-metaiodobenzylguanidine/topotecan combination therapy to cells and xenografts that express the noradrenaline transporter. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2012 Jul; 53(7):1146-54. doi: 10.2967/jnumed.111.095943. [PMID: 22689924]
  • Paula Schaiquevich, Emiliano Buitrago, Paula Taich, Ana Torbidoni, Alejandro Ceciliano, Adriana Fandino, Marcelo Asprea, Flavio Requejo, David H Abramson, Guillermo F Bramuglia, Guillermo L Chantada. Pharmacokinetic analysis of melphalan after superselective ophthalmic artery infusion in preclinical models and retinoblastoma patients. Investigative ophthalmology & visual science. 2012 Jun; 53(7):4205-12. doi: 10.1167/iovs.12-9501. [PMID: 22628208]
  • Giacomo Allegrini, Teresa Di Desidero, Maria Teresa Barletta, Anna Fioravanti, Paola Orlandi, Bastianina Canu, Silvio Chericoni, Fotios Loupakis, Antonello Di Paolo, Gianluca Masi, Andrea Fontana, Sara Lucchesi, Giada Arrighi, Mario Giusiani, Andrea Ciarlo, Giovanni Brandi, Romano Danesi, Robert S Kerbel, Alfredo Falcone, Guido Bocci. Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers. Angiogenesis. 2012 Jun; 15(2):275-86. doi: 10.1007/s10456-012-9260-6. [PMID: 22382585]
  • Mira Kim, Kwangsu Ock, Keunchang Cho, Sang-Woo Joo, So Yeong Lee. Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media. Chemical communications (Cambridge, England). 2012 May; 48(35):4205-7. doi: 10.1039/c2cc30679d. [PMID: 22441353]
  • Elie Toledano, Vasily Ogryzko, Antoine Danchin, Daniel Ladant, Undine Mechold. 3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo. The Biochemical journal. 2012 Apr; 443(2):485-90. doi: 10.1042/bj20111057. [PMID: 22240080]
  • Chunlei Li, Caixia Wang, Hanyu Yang, Xi Zhao, Na Wei, Jingxia Cui. Liposomal topotecan formulation with a low polyethylene glycol grafting density: pharmacokinetics and antitumour activity. The Journal of pharmacy and pharmacology. 2012 Mar; 64(3):372-82. doi: 10.1111/j.2042-7158.2011.01422.x. [PMID: 22309269]
  • Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda, Yuichi Sugiyama. In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):602-9. doi: 10.1124/dmd.111.042101. [PMID: 22190695]
  • Rajiv Radhakrishnan, Milanduth Kanigere, Jayakumar Menon, Sam Calvin, Krishnamachari Srinivasan. Comparison of three a-priori models in the prediction of serum lithium concentration. Indian journal of pharmacology. 2012 Mar; 44(2):234-7. doi: 10.4103/0253-7613.93856. [PMID: 22529482]
  • Liping Yao, Xiuhua Zhao, Qingyong Li, Yuangang Zu, Yujie Fu, Baishi Zu, Xiangdong Meng, Chen Liu. In vitro and in vivo evaluation of camptothecin nanosuspension: a novel formulation with high antitumor efficacy and low toxicity. International journal of pharmaceutics. 2012 Feb; 423(2):586-8. doi: 10.1016/j.ijpharm.2011.11.031. [PMID: 22193057]
  • William Jacot, Jean-Louis Pujol, Mohammad Chakra, Olivier Molinier, Marie-Cécile Bozonnat, Radj Gervais, Xavier Quantin. Epirubicin and ifosfamide in relapsed or refractory small cell lung cancer patients. Lung cancer (Amsterdam, Netherlands). 2012 Feb; 75(2):213-6. doi: 10.1016/j.lungcan.2011.07.012. [PMID: 21831476]
  • Qingyong Li, Qiaochu Zhu, Xiaoqiu Deng, Wuna He, Tengfei Zhao, Baoyou Zhang. Binding interactions of water-soluble camptothecin derivatives with bovine serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Feb; 86(?):124-30. doi: 10.1016/j.saa.2011.10.017. [PMID: 22051412]
  • Paula Schaiquevich, Emiliano Buitrago, Alejandro Ceciliano, Adriana C Fandino, Marcelo Asprea, Sergio Sierre, David H Abramson, Guillermo F Bramuglia, Guillermo L Chantada. Pharmacokinetic analysis of topotecan after superselective ophthalmic artery infusion and periocular administration in a porcine model. Retina (Philadelphia, Pa.). 2012 Feb; 32(2):387-95. doi: 10.1097/iae.0b013e31821e9f8a. [PMID: 21878842]
  • Puiyan Lee, Ruizhong Zhang, Vincent Li, Xuelai Liu, Raymond W Y Sun, Chi-Ming Che, Kenneth K Y Wong. Enhancement of anticancer efficacy using modified lipophilic nanoparticle drug encapsulation. International journal of nanomedicine. 2012; 7(?):731-7. doi: 10.2147/ijn.s28783. [PMID: 22359452]
  • David P AuCoin, Dana E Reed, Nicole L Marlenee, Richard A Bowen, Peter Thorkildson, Barbara M Judy, Alfredo G Torres, Thomas R Kozel. Polysaccharide specific monoclonal antibodies provide passive protection against intranasal challenge with Burkholderia pseudomallei. PloS one. 2012; 7(4):e35386. doi: 10.1371/journal.pone.0035386. [PMID: 22530013]
  • Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions. Frontiers in pharmacology. 2012; 3(?):69. doi: 10.3389/fphar.2012.00069. [PMID: 22557968]
  • Gregory J Anger, Alex M Cressman, Micheline Piquette-Miller. Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes. PloS one. 2012; 7(4):e35027. doi: 10.1371/journal.pone.0035027. [PMID: 22558111]