Ochratoxin A (BioDeep_00000298194)

Main id: BioDeep_00000001398

 

natural product


代谢物信息卡片


NCGC00162403-05_C20H18ClNO6_L-Phenylalanine, N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-

化学式: C20H18ClNO6 (403.0823)
中文名称: 曲霉素A
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: CC1CC2=C(C=C(C(=C2C(=O)O1)O)C(=O)NC(CC3=CC=CC=C3)C(=O)O)Cl
InChI: InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)

描述信息

A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D009676 - Noxae > D011042 - Poisons > D009793 - Ochratoxins
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D000077264 - Calcium-Regulating Hormones and Agents
D009676 - Noxae > D002273 - Carcinogens
D049990 - Membrane Transport Modulators
CONFIDENCE standard compound; INTERNAL_ID 5966
CONFIDENCE Reference Standard (Level 1)

同义名列表

5 个代谢物同义名

Ochratoxin A; N-[(5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-L-phenylalanine; Antibiotic 9663; NCGC00162403-05_C20H18ClNO6_L-Phenylalanine, N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-; Ochratoxin A



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, ALB, ANXA5, CASP3, DNA2, MAPK14, NFE2L2, PRKAA2, PTGS2, TFPT, TLR4, TP53
Peripheral membrane protein 3 ANXA5, GORASP1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 9 AKT1, ALB, CASP3, DNA2, MAPK14, NFE2L2, PRKAA2, TFPT, TP53
cytosol 9 AKT1, ALB, ANXA5, CASP3, GPT, MAPK14, NFE2L2, PRKAA2, TP53
dendrite 1 PRKAA2
centrosome 3 ALB, NFE2L2, TP53
nucleoplasm 8 AKT1, CASP3, DNA2, MAPK14, NFE2L2, PRKAA2, TFPT, TP53
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 6 AKT1, CD79A, CLDN1, CLDN3, HAVCR1, TLR4
Cytoplasmic side 1 GORASP1
lamellipodium 1 AKT1
Multi-pass membrane protein 4 ABCC2, ABCC3, CLDN1, CLDN3
Golgi apparatus membrane 1 GORASP1
cell cortex 1 AKT1
cell surface 3 ABCC2, HAVCR1, TLR4
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 4 ALB, GORASP1, NFE2L2, PRKAA2
Golgi membrane 1 GORASP1
neuronal cell body 2 CASP3, PRKAA2
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NFE2L2
plasma membrane 9 ABCC2, ABCC3, AKT1, CD79A, CLDN1, CLDN3, HAVCR1, NFE2L2, TLR4
Membrane 9 ABCC2, ABCC3, AKT1, ANXA5, CLDN1, CLDN3, PRKAA2, TLR4, TP53
apical plasma membrane 2 ABCC2, CLDN1
axon 1 PRKAA2
basolateral plasma membrane 2 ABCC3, CLDN1
caveola 1 PTGS2
extracellular exosome 3 ALB, ANXA5, GPT
endoplasmic reticulum 3 ALB, PTGS2, TP53
extracellular space 1 ALB
perinuclear region of cytoplasm 1 TLR4
Cell junction, tight junction 2 CLDN1, CLDN3
apicolateral plasma membrane 1 CLDN3
bicellular tight junction 2 CLDN1, CLDN3
intercellular canaliculus 1 ABCC2
mitochondrion 3 DNA2, MAPK14, TP53
protein-containing complex 6 AKT1, ALB, CLDN1, CLDN3, PTGS2, TP53
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD79A, HAVCR1, TLR4
Secreted 1 ALB
extracellular region 3 ALB, ANXA5, MAPK14
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
anchoring junction 1 ALB
transcription regulator complex 1 TP53
motile cilium 1 HAVCR1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 3 ANXA5, CD79A, TLR4
multivesicular body 1 CD79A
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
Early endosome 1 TLR4
cell-cell junction 2 AKT1, CLDN3
vesicle 1 AKT1
Apical cell membrane 1 ABCC2
Membrane raft 1 CD79A
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 ANXA5
spindle 1 AKT1
cis-Golgi network 1 GORASP1
mitochondrial nucleoid 1 DNA2
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
lateral plasma membrane 2 CLDN1, CLDN3
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, ALB
chromatin 2 NFE2L2, TP53
mediator complex 1 NFE2L2
phagocytic cup 1 TLR4
centriole 1 ALB
spindle pole 2 ALB, MAPK14
chromosome, telomeric region 1 DNA2
actin filament 1 TFPT
blood microparticle 1 ALB
Basolateral cell membrane 2 ABCC3, CLDN1
site of double-strand break 1 TP53
cytoplasmic stress granule 1 PRKAA2
germ cell nucleus 1 TP53
replication fork 1 TP53
basal plasma membrane 1 ABCC3
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 ALB, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 ALB
tight junction 2 CLDN1, CLDN3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
Basal cell membrane 1 ABCC3
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
apical junction complex 1 CLDN3
nucleotide-activated protein kinase complex 1 PRKAA2
Ino80 complex 1 TFPT
IgM B cell receptor complex 1 CD79A
endothelial microparticle 1 ANXA5
B cell receptor complex 1 CD79A
ciliary transition fiber 1 ALB


文献列表

  • Yue Wang, Buda Su, Xingxu Yan, Chenlei Geng, Tingting Lian, Xiaomeng Li, Yanyan Xu, Yubo Li. Studies of Mycotoxins in Medicinal Plants Conducted Worldwide over the Last Decade: A Systematic Review, Meta-Analysis, and Exposure Risk Assessment. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155367. doi: 10.1016/j.phymed.2024.155367. [PMID: 38493720]
  • Bu-Da Su, Xiao-Meng Li, Zhi-Wei Huang, Yue Wang, Jia Shao, Yan-Yan Xu, Le-Xin Shu, Yu-Bo Li. Development and application of the physiologically-based toxicokinetic (PBTK) model for ochratoxin A (OTA) in rats and humans. Ecotoxicology and environmental safety. 2024 May; 276(?):116277. doi: 10.1016/j.ecoenv.2024.116277. [PMID: 38604061]
  • Xuanjun Zhang, Na Li, Han Luo, Yu Zhou. A discussion on N-terminal signal peptide removed ADH3 and the hydrolytic activity on ochratoxin A in the published paper by Dai et al. (2023). Journal of hazardous materials. 2024 Apr; 468(?):133767. doi: 10.1016/j.jhazmat.2024.133767. [PMID: 38377903]
  • Hangbin Yan, Weifan Zhao, Asma Parveen, Ziling Ye, Qingru Fei, Xu Wang, Yu Zhou. Comprehensive and cumulative risk evaluation of dietary exposure to aflatoxins and ochratoxin A on fermented teas worldwide by a new assessment model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 Feb; 184(?):114321. doi: 10.1016/j.fct.2023.114321. [PMID: 38072213]
  • Sen Wang, Hui Ren, Chen Fan, Qian Lin, Man Liu, Jun Tian. Ochratoxin A Induces Renal Cell Ferroptosis by Disrupting Iron Homeostasis and Increasing ROS. Journal of agricultural and food chemistry. 2024 Jan; 72(3):1734-1744. doi: 10.1021/acs.jafc.3c04495. [PMID: 38133486]
  • Yang Yang, Linjie Lv, Shanshan Shi, Gaofeng Cai, Lin Yu, Shuwen Xu, Tianyu Zhu, Xinyue Su, Ningning Mao, Yue Zhang, Song Peng, Jin He, Zhenguang Liu, Deyun Wang. Polysaccharide from walnut green husk alleviates liver inflammation and gluconeogenesis dysfunction by altering gut microbiota in ochratoxin A-induced mice. Carbohydrate polymers. 2023 Dec; 322(?):121362. doi: 10.1016/j.carbpol.2023.121362. [PMID: 37839834]
  • G A Domínguez-Gutiérrez, I Perraud-Gaime, H Escalona-Buendía, N Durand, E I Champion-Martínez, R R Fernández-Soto, G Saucedo-Castañeda, G Rodríguez-Serrano. Inhibition of Aspergillus carbonarius growth and Ochratoxin A production using lactic acid bacteria cultivated in an optimized medium. International journal of food microbiology. 2023 Nov; 404(?):110320. doi: 10.1016/j.ijfoodmicro.2023.110320. [PMID: 37490784]
  • Zhentao Tang, Fang Fang, Tingting Lou, Bakhetgul Manatbai, Cheng Peng, Zhiguo Gong, Jinlin Guo. Determination of ochratoxin A in licorice extract based on modified immunoaffinity column clean-up and HPLC analysis. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2023 Nov; 40(11):1470-1481. doi: 10.1080/19440049.2023.2266042. [PMID: 37862446]
  • Wiem Chtioui, Sandrina Heleno, Quirico Migheli, Paula Rodrigues. Plant extracts as biocontrol agents against Aspergillus carbonarius growth and ochratoxin A production in grapes. International journal of food microbiology. 2023 Oct; 407(?):110425. doi: 10.1016/j.ijfoodmicro.2023.110425. [PMID: 37804776]
  • Jiangyu Tang, Junya Zeng, Li Chen, Mengmeng Wang, Suibin He, Azhar Muhmood, Xingxiang Chen, Kehe Huang, Fang Gan. Farnesoid X Receptor Plays a Key Role in Ochratoxin A-Induced Nephrotoxicity by Targeting Ferroptosis In Vivo and In Vitro. Journal of agricultural and food chemistry. 2023 Oct; 71(39):14365-14378. doi: 10.1021/acs.jafc.3c04560. [PMID: 37750412]
  • Huifeng Xu, Rui Pan, Weihua Huang, Xi Zhu. Label-free dual-mode sensing platform based on target-regulated CRISPR-Cas12a activity for ochratoxin A in Morinda officinalis. Analytical methods : advancing methods and applications. 2023 09; 15(35):4518-4523. doi: 10.1039/d3ay01025b. [PMID: 37622284]
  • Lijuan Ding, Meihua Han, Xiangtao Wang, Yifei Guo. Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods. Toxins. 2023 09; 15(9):. doi: 10.3390/toxins15090565. [PMID: 37755991]
  • Yujiao Hou, Qingbin Xu, Ying Li, Nan Long, Peng Li, Jiabo Wang, Lidong Zhou, Ping Sheng, Weijun Kong. Ultrasensitive electrochemical aptasensor with Nafion-stabilized f-MWCNTs as signal enhancers for OTA detection. Bioelectrochemistry (Amsterdam, Netherlands). 2023 Jun; 151(?):108399. doi: 10.1016/j.bioelechem.2023.108399. [PMID: 36805204]
  • Xinyu Cai, Boqiang Li, Xue Li, Hui Dang, Di Wang, Zhifei Pei, Xuan Feng, Xueyan Ren, Qingjun Kong. Characteristic Structures of Different Stilbenes Distinguish the Impact on Ochratoxin A Biosynthesis Intermediate Pathway and Metabolites of Aspergillus carbonarius. Journal of agricultural and food chemistry. 2023 May; 71(21):7996-8007. doi: 10.1021/acs.jafc.3c00717. [PMID: 37192315]
  • Ying Zhang, Dongmei Wei, Xiaohu Wu, Tingting Duan, Jun Xu, Fengshou Dong, Xinglu Pan, Yongquan Zheng. Occurrence and impact of carbendazim and hymexazol residues on yeast and ochratoxin A contamination during wine production. Journal of the science of food and agriculture. 2023 May; ?(?):. doi: 10.1002/jsfa.12699. [PMID: 37177869]
  • Roua Gabriela Popescu, George Cătălin Marinescu, Andreea Luminița Rădulescu, Daniela Eliza Marin, Ionelia Țăranu, Anca Dinischiotu. Natural Antioxidant By-Product Mixture Counteracts the Effects of Aflatoxin B1 and Ochratoxin A Exposure of Piglets after Weaning: A Proteomic Survey on Liver Microsomal Fraction. Toxins. 2023 04; 15(4):. doi: 10.3390/toxins15040299. [PMID: 37104237]
  • Meilin Wei, Solairaj Dhanasekaran, Qihao Ji, Qiya Yang, Hongyin Zhang. Sustainable and efficient method utilizing N-acetyl-L-cysteine for complete and enhanced ochratoxin A clearance by antagonistic yeast. Journal of hazardous materials. 2023 04; 448(?):130975. doi: 10.1016/j.jhazmat.2023.130975. [PMID: 36860082]
  • Nii Korley Kortei, Peter Oman Ayiku, John Nsor-Atindana, Leslie Owusu Ansah, Michael Wiafe-Kwagyan, Vincent Kyei-Baffour, Isaac Delali Kottoh, George Tawia Odamtten. Toxicogenic fungal profile, Ochratoxin A exposure and cancer risk characterization through maize (Zea mays) consumed by different age populations in the Volta region of Ghana. Toxicon : official journal of the International Society on Toxinology. 2023 Apr; 226(?):107085. doi: 10.1016/j.toxicon.2023.107085. [PMID: 36921906]
  • Yujiao Hou, Nan Long, Qingbin Xu, Ying Li, Pengyue Song, Minghan Yang, Jiabo Wang, Lidong Zhou, Ping Sheng, Weijun Kong. Development of a Nafion-MWCNTs and in-situ generated Au nanopopcorns dual-amplification electrochemical aptasensor for ultrasensitive detection of OTA. Food chemistry. 2023 Mar; 403(?):134375. doi: 10.1016/j.foodchem.2022.134375. [PMID: 36162268]
  • Marcin Bryła, Krzysztof Damaziak, Magdalena Twarużek, Agnieszka Waśkiewicz, Łukasz Stępień, Marek Roszko, Adam Pierzgalski, Ewelina Soszczyńska, Monika Łukasiewicz-Mierzejewska, Marta Chmiel, Wojciech Wójcik. Toxico-pathological effects of ochratoxin A and its diastereoisomer under in ovo conditions and in vitro evaluation of the toxicity of these toxins against the embryo Gallus gallus fibroblast cell line. Poultry science. 2023 Feb; 102(2):102413. doi: 10.1016/j.psj.2022.102413. [PMID: 36566659]
  • Limin Guo, Yun Li, Shichao Gao, Lei Ren. Detection of ochratoxin A using a 'turn-on' fluorescence assay based on guanine quenching of the aptamer. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2023 Jan; 39(1):51-57. doi: 10.1007/s44211-022-00199-z. [PMID: 36242755]
  • Yuanshan Chen, Jiang Chen, Qiujin Zhu, Jing Wan. Ochratoxin A in Dry-Cured Ham: OTA-Producing Fungi, Prevalence, Detection Methods, and Biocontrol Strategies-A Review. Toxins. 2022 10; 14(10):. doi: 10.3390/toxins14100693. [PMID: 36287962]
  • Nan Chen, Qingru Fei, Han Luo, Zemin Fang, Yazhong Xiao, Zhengjun Du, Yu Zhou. Isoenzyme N-Acyl-l-Amino Acid Amidohydrolase NA Increases Ochratoxin A Degradation Efficacy of Stenotrophomonas sp. CW117 by Enhancing Amidohydrolase ADH3 Stability. Microbiology spectrum. 2022 08; 10(4):e0220522. doi: 10.1128/spectrum.02205-22. [PMID: 35924842]
  • Piao Zhao, Xin Liu, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Lu Zhang, Hai-Feng Mi, Sheng-Yao Kuang, Ling Tang, Xiao-Qiu Zhou, Lin Feng. The multiple biotoxicity integrated study in grass carp (Ctenopharyngodon idella) caused by Ochratoxin A: Oxidative damage, apoptosis and immunosuppression. Journal of hazardous materials. 2022 08; 436(?):129268. doi: 10.1016/j.jhazmat.2022.129268. [PMID: 35739783]
  • Wen-Chao Liu, Karthika Pushparaj, Arun Meyyazhagan, Vijaya Anand Arumugam, Manikantan Pappuswamy, Haripriya Kuchi Bhotla, Rathinasamy Baskaran, Utthapon Issara, Balamuralikrishnan Balasubramanian, Amin Mousavi Khaneghah. Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis. Toxicon : official journal of the International Society on Toxinology. 2022 Jul; 213(?):59-75. doi: 10.1016/j.toxicon.2022.04.012. [PMID: 35452686]
  • Raquel Penalva-Olcina, Cristina Juan, Mónica Fernández-Franzón, Ana Juan-García. Effectiveness of beetroot extract in SH-SY5Y neuronal cell protection against Fumonisin B1, Ochratoxin A and its combination. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 Jul; 165(?):113164. doi: 10.1016/j.fct.2022.113164. [PMID: 35605710]
  • Consiglia Longobardi, Gianmarco Ferrara, Emanuela Andretta, Serena Montagnaro, Sara Damiano, Roberto Ciarcia. Ochratoxin A and Kidney Oxidative Stress: The Role of Nutraceuticals in Veterinary Medicine-A Review. Toxins. 2022 06; 14(6):. doi: 10.3390/toxins14060398. [PMID: 35737059]
  • Massimo Frangiamone, Manuel Alonso-Garrido, Guillermina Font, Alessandra Cimbalo, Lara Manyes. Pumpkin extract and fermented whey individually and in combination alleviated AFB1- and OTA-induced alterations on neuronal differentiation invitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 Jun; 164(?):113011. doi: 10.1016/j.fct.2022.113011. [PMID: 35447289]
  • Yin Zhu, Shaomin Wang, Xiaohui Xu, Lingling Wang, Heng Zhou, Xuanyu Ying, Qing Hu, Xinglong Wang, Shen Ji, Qiang Cai. Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China. Ecotoxicology and environmental safety. 2022 Jun; 237(?):113517. doi: 10.1016/j.ecoenv.2022.113517. [PMID: 35429800]
  • Indra Dev, Saurabh Pal, Onila Lugun, Neha Singh, Kausar Mahmood Ansari. Ochratoxin A treated rat derived urinary exosomes enhanced cell growth and extracellular matrix production in normal kidney cells through modulation of TGF-β1/smad2/3 signaling pathway. Life sciences. 2022 Jun; 298(?):120506. doi: 10.1016/j.lfs.2022.120506. [PMID: 35364054]
  • Alexandra Jaus, Peter Rhyn, Max Haldimann, Beat J Brüschweiler, Céline Fragnière Rime, Judith Jenny-Burri, Otmar Zoller. Biomonitoring of ochratoxin A, 2'R-ochratoxin A and citrinin in human blood serum from Switzerland. Mycotoxin research. 2022 May; 38(2):147-161. doi: 10.1007/s12550-022-00456-0. [PMID: 35446004]
  • Muhamed N H Eeza, Narmin Bashirova, Zain Zuberi, Jörg Matysik, John P Berry, A Alia. An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling. Scientific reports. 2022 04; 12(1):6341. doi: 10.1038/s41598-022-09726-4. [PMID: 35428752]
  • Dubravka Rašić, Srđan Stefanović, Dragan Milićević, Marin Mladinić, Davor Želježić, Alica Pizent, Paško Konjevoda, Maja Peraica. Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats. Arhiv za higijenu rada i toksikologiju. 2022 Apr; 73(1):43-47. doi: 10.2478/aiht-2022-73-3605. [PMID: 35390240]
  • Jian Zhang, Linlin Li, Yan Yang, Chaofan Zhao, Jiuju Hu, Xianli Xue, Qiang Gao, Depei Wang, Zhenhong Zhuang, Ying Zhang. Deletion and Overexpression of the AnOTAbzip Gene, a Positive Regulator of Ochratoxin A Biosynthesis in Aspergillus niger. Journal of agricultural and food chemistry. 2022 Feb; 70(7):2169-2178. doi: 10.1021/acs.jafc.1c08160. [PMID: 35143724]
  • Dean Karaica, Vedran Micek, Dubravka Rašić, Maja Peraica, Maja Šegvić Klarić, Davorka Breljak. Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters. Mycotoxin research. 2022 Feb; 38(1):61-70. doi: 10.1007/s12550-022-00450-6. [PMID: 35028911]
  • Han Luo, Gan Wang, Nan Chen, Zemin Fang, Yazhong Xiao, Min Zhang, Khishigjargal Gerelt, Yingying Qian, Ren Lai, Yu Zhou. A Superefficient Ochratoxin A Hydrolase with Promising Potential for Industrial Applications. Applied and environmental microbiology. 2022 01; 88(2):e0196421. doi: 10.1128/aem.01964-21. [PMID: 34788069]
  • Mikela Vlachou, Andreana Pexara, Nikolaos Solomakos, Alexander Govaris. Ochratoxin A in Slaughtered Pigs and Pork Products. Toxins. 2022 01; 14(2):. doi: 10.3390/toxins14020067. [PMID: 35202095]
  • Rehab E Abdelrahman, Abdel Azeim A Khalaf, Mohamed A Elhady, Marwa A Ibrahim, Eman I Hassanen, Peter A Noshy. Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway. Chemico-biological interactions. 2022 Jan; 351(?):109720. doi: 10.1016/j.cbi.2021.109720. [PMID: 34717913]
  • Xinru Mao, Hu Li, Lei Ge, Shuiping Liu, Lili Hou, Dongmei Yue, Heng Du, Cuiling Pan, Fang Gan, Yunhuan Liu, Kehe Huang, Xingxiang Chen. Selenomethionine alleviated Ochratoxin A induced pyroptosis and renal fibrotic factors expressions in MDCK cells. Journal of biochemical and molecular toxicology. 2022 Jan; 36(1):e22933. doi: 10.1002/jbt.22933. [PMID: 34676619]
  • Mingxuan Jia, Boyu Jia, Xiaofang Liao, Linchun Shi, Zheng Zhang, Miao Liu, Lidong Zhou, Donghui Li, Weijun Kong. A CdSe@CdS quantum dots based electrochemiluminescence aptasensor for sensitive detection of ochratoxin A. Chemosphere. 2022 Jan; 287(Pt 1):131994. doi: 10.1016/j.chemosphere.2021.131994. [PMID: 34478969]
  • Guannan Le, Lulu Yang, Heng Du, Lili Hou, Lei Ge, Ardache Sylia, Azhar Muhmood, Xinxiang Chen, Bo Han, Kehe Huang. Combination of zinc and selenium alleviates ochratoxin A-induced fibrosis via blocking ROS-dependent autophagy in HK-2 cells. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2022 Jan; 69(?):126881. doi: 10.1016/j.jtemb.2021.126881. [PMID: 34751137]
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