Malonate (BioDeep_00000002855)

 

Secondary id: BioDeep_00000399871, BioDeep_00000405337

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Malonic acid, disodium salt, 1-(14)C-labeled

化学式: C3H4O4 (104.01095839999999)
中文名称: 丙二酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.04%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Malonate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/malonate (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000002855). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(=O)O)C(=O)O
InChI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

描述信息

Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionised form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acids ethyl ester. The name originates from Latin malum, meaning apple. Malonic acid is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.; Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionised form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acids ethyl ester. The name originates from the Greek word ????? (malon) meaning apple. Propanedioic acid is found in many foods, some of which are green bell pepper, red bell pepper, common beet, and sweet orange.
Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionised form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acids ethyl ester. The name originates from Latin malum, meaning apple. Malonic acid is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associated with malonyl-CoA decarboxylase deficiency, which is an inborn error of metabolism.

Malonic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=141-82-2 (retrieved 2024-07-02) (CAS RN: 141-82-2). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

36 个代谢物同义名

Malonic acid, disodium salt, 1-(14)C-labeled; α,ω-dicarboxylic acid; Propanedioic acid dithallium salt; Malonic acid, 1,3-(14)C2-labeled; Malonic acid, dipotassium salt; Malonic acid, monocalcium salt; Malonic acid, diammonium salt; Malonic acid, 2-(14)C-labeled; alpha,Omega-dicarboxylic acid; Malonic acid, dithallium salt; Malonic acid, monosodium salt; Malonic acid, potassium salt; Malonic acid, disodium salt; Malonate dicarboxylic acid; Kyselina malonova [Czech]; Malonic acid, sodium salt; Metahnedicarboxylic acid; Methanedicarboxylic acid; Methanedicarbonic acid; Monosodium malonate; Dithallium malonate; Propanediolic acid; Carboxyacetic acid; Kyselina malonova; Propanedioic acid; Thallium malonate; Thallous malonate; Dicarboxylic acid; Dicarboxymethane; Propanedioate; HOOC-CH2-COOH; Dicarboxylate; malonic acid; Malonate; H2Malo; Malonic acid



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shubo Zhang, Wenfang Gao, Lina Xie, Guogang Zhang, Zimin Wei, Jie Li, Caihong Song, Mingkai Chang. Malonic acid shapes bacterial community dynamics in compost to promote carbon sequestration and humic substance synthesis. Chemosphere. 2024 Feb; 350(?):141092. doi: 10.1016/j.chemosphere.2023.141092. [PMID: 38169202]
  • Milica N Dimitrijević Stojanović, Andjela A Franich, Milena M Jurišević, Nevena M Gajović, Nebojša N Arsenijević, Ivan P Jovanović, Bojan S Stojanović, Slobodanka Lj Mitrović, Jakob Kljun, Snežana Rajković, Marija D Živković. Platinum(II) complexes with malonic acids: Synthesis, characterization, in vitro and in vivo antitumor activity and interactions with biomolecules. Journal of inorganic biochemistry. 2022 06; 231(?):111773. doi: 10.1016/j.jinorgbio.2022.111773. [PMID: 35279446]
  • Sarah Snanoudj, Stéphanie Torre, Bénédicte Sudrié-Arnaud, Lenaig Abily-Donval, Alice Goldenberg, Gajja S Salomons, Stéphane Marret, Soumeya Bekri, Abdellah Tebani. Heterogenous Clinical Landscape in a Consanguineous Malonic Aciduria Family. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312633. [PMID: 34884438]
  • Randy J Chandler, Leah E Venturoni, Jing Liao, Brandon T Hubbard, Jessica L Schneller, Victoria Hoffmann, Susana Gordo, Shengwen Zang, Chih-Wei Ko, Nelson Chau, Kyle Chiang, Mark A Kay, Adi Barzel, Charles P Venditti. Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia. Hepatology (Baltimore, Md.). 2021 06; 73(6):2223-2237. doi: 10.1002/hep.31570. [PMID: 32976669]
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  • Seung Hoon Lee, Jung Min Ko, Mi-Kyoung Song, Junghan Song, Kyung Sun Park. A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy. Molecular genetics & genomic medicine. 2020 09; 8(9):e1379. doi: 10.1002/mgg3.1379. [PMID: 32602666]
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