Malonate (BioDeep_00000002855)

 

Secondary id: BioDeep_00000399871, BioDeep_00000405337

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


Malonic acid, disodium salt, 1-(14)C-labeled

化学式: C3H4O4 (104.011)
中文名称: 丙二酸, 丙二酸盐
谱图信息: 最多检出来源 Homo sapiens(blood) 30.91%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Malonate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/malonate (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000002855). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(=O)O)C(=O)O
InChI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

描述信息

Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionised form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acids ethyl ester. The name originates from Latin malum, meaning apple. Malonic acid is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.; Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionised form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acids ethyl ester. The name originates from the Greek word ????? (malon) meaning apple. Propanedioic acid is found in many foods, some of which are green bell pepper, red bell pepper, common beet, and sweet orange.
Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionised form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acids ethyl ester. The name originates from Latin malum, meaning apple. Malonic acid is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associated with malonyl-CoA decarboxylase deficiency, which is an inborn error of metabolism.

Malonic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=141-82-2 (retrieved 2024-07-02) (CAS RN: 141-82-2). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

38 个代谢物同义名

Malonic acid, disodium salt, 1-(14)C-labeled; α,ω-dicarboxylic acid; Propanedioic acid dithallium salt; Malonic acid, 1,3-(14)C2-labeled; Malonic acid, dipotassium salt; Malonic acid, monocalcium salt; Malonic acid, diammonium salt; Malonic acid, 2-(14)C-labeled; alpha,Omega-dicarboxylic acid; Malonic acid, dithallium salt; Malonic acid, monosodium salt; Malonic acid, potassium salt; Malonic acid, disodium salt; Malonate dicarboxylic acid; Kyselina malonova [Czech]; Malonic acid, sodium salt; Metahnedicarboxylic acid; Methanedicarboxylic acid; Methanedicarbonic acid; Monosodium malonate; Dithallium malonate; Propanediolic acid; Carboxyacetic acid; Kyselina malonova; Propanedioic acid; Thallium malonate; Thallous malonate; Dicarboxylic acid; Dicarboxymethane; Propanedioate; HOOC-CH2-COOH; Dicarboxylate; malonic acid; Malonate; H2Malo; Malonic acid; Malonic acid; Malonate



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CAT, DCTD, FH, GLUL, HTT, MLYCD, PC, SRR
Peripheral membrane protein 1 HSD17B6
Endosome membrane 1 HTT
Nucleus 5 FH, GLUL, HTT, SLC25A10, SLC25A11
autophagosome 1 HTT
cytosol 8 CAT, DCTD, FH, GLUL, HTT, MLYCD, PC, SRR
dendrite 1 HTT
nucleoplasm 5 ACSF3, ATP2B1, CD2, HTT, SLC25A10
Cell membrane 5 ATP2B1, CD2, GLUL, HTT, SLC13A3
Lipid-anchor 1 GLUL
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 8 ABCC3, ATP2B1, HTT, SLC13A2, SLC13A3, SLC22A6, SLC25A10, SLC25A11
Synapse 2 ATP2B1, HTT
cell surface 1 CD2
glutamatergic synapse 1 ATP2B1
Golgi apparatus 2 CD2, HTT
Golgi membrane 1 INS
mitochondrial inner membrane 2 SLC25A10, SLC25A11
neuronal cell body 1 SRR
presynaptic membrane 2 ATP2B1, HTT
Cytoplasm, cytosol 1 GLUL
plasma membrane 9 ABCC3, ATP2B1, CD2, GLUL, HTT, SLC13A2, SLC13A3, SLC22A6, SLC25A11
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ABCC3, ATP2B1, CAT, SLC13A2, SLC13A3, SLC22A6, SLC25A10, SLC25A11
apical plasma membrane 1 SLC13A2
axon 1 HTT
basolateral plasma membrane 4 ABCC3, ATP2B1, SLC13A3, SLC22A6
caveola 1 SLC22A6
extracellular exosome 7 ATP2B1, CAT, FH, GLUL, SLC13A2, SLC13A3, SLC22A6
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 GLUL, HSD17B6, HTT
extracellular space 2 IL6, INS
perinuclear region of cytoplasm 1 HTT
mitochondrion 8 ACSF3, CAT, FH, GLUL, MLYCD, PC, SLC25A10, SLC25A11
protein-containing complex 4 CAT, CD2, HTT, SLC22A6
intracellular membrane-bounded organelle 3 ATP2B1, CAT, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 1 CD2
Secreted 2 IL6, INS
extracellular region 4 CAT, CD2, IL6, INS
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion matrix 2 MLYCD, PC
mitochondrial matrix 5 ACSF3, CAT, FH, MLYCD, PC
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 CD2
Early endosome 1 HTT
apical part of cell 1 SRR
cell-cell junction 1 CD2
postsynaptic membrane 1 HTT
Apical cell membrane 1 SLC13A2
Mitochondrion inner membrane 1 SLC25A11
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
focal adhesion 2 CAT, HTT
Peroxisome 2 CAT, MLYCD
Peroxisome matrix 2 CAT, MLYCD
peroxisomal matrix 2 CAT, MLYCD
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
Late endosome 1 HTT
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
cell projection 1 ATP2B1
Chromosome 1 FH
centriole 1 HTT
Basolateral cell membrane 3 ABCC3, ATP2B1, SLC22A6
site of double-strand break 1 FH
Endomembrane system 1 HTT
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 HTT
Presynaptic cell membrane 1 ATP2B1
cell body 1 GLUL
basal plasma membrane 2 ABCC3, SLC22A6
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
Basal cell membrane 2 ABCC3, SLC22A6
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
glial cell projection 1 GLUL
catalase complex 1 CAT
inclusion body 1 HTT
interleukin-6 receptor complex 1 IL6
[Isoform Mitochondrial]: Mitochondrion 1 FH
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 FH
photoreceptor ribbon synapse 1 ATP2B1
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT


文献列表

  • Shubo Zhang, Wenfang Gao, Lina Xie, Guogang Zhang, Zimin Wei, Jie Li, Caihong Song, Mingkai Chang. Malonic acid shapes bacterial community dynamics in compost to promote carbon sequestration and humic substance synthesis. Chemosphere. 2024 Feb; 350(?):141092. doi: 10.1016/j.chemosphere.2023.141092. [PMID: 38169202]
  • Milica N Dimitrijević Stojanović, Andjela A Franich, Milena M Jurišević, Nevena M Gajović, Nebojša N Arsenijević, Ivan P Jovanović, Bojan S Stojanović, Slobodanka Lj Mitrović, Jakob Kljun, Snežana Rajković, Marija D Živković. Platinum(II) complexes with malonic acids: Synthesis, characterization, in vitro and in vivo antitumor activity and interactions with biomolecules. Journal of inorganic biochemistry. 2022 06; 231(?):111773. doi: 10.1016/j.jinorgbio.2022.111773. [PMID: 35279446]
  • Sarah Snanoudj, Stéphanie Torre, Bénédicte Sudrié-Arnaud, Lenaig Abily-Donval, Alice Goldenberg, Gajja S Salomons, Stéphane Marret, Soumeya Bekri, Abdellah Tebani. Heterogenous Clinical Landscape in a Consanguineous Malonic Aciduria Family. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312633. [PMID: 34884438]
  • Randy J Chandler, Leah E Venturoni, Jing Liao, Brandon T Hubbard, Jessica L Schneller, Victoria Hoffmann, Susana Gordo, Shengwen Zang, Chih-Wei Ko, Nelson Chau, Kyle Chiang, Mark A Kay, Adi Barzel, Charles P Venditti. Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia. Hepatology (Baltimore, Md.). 2021 06; 73(6):2223-2237. doi: 10.1002/hep.31570. [PMID: 32976669]
  • Gui-Ya Yang, Jun-Na Song, Ya-Qing Chang, Lei Wang, Yu-Guang Zheng, Dan Zhang, Long Guo. Natural Deep Eutectic Solvents for the Extraction of Bioactive Steroidal Saponins from Dioscoreae Nipponicae Rhizoma. Molecules (Basel, Switzerland). 2021 Apr; 26(7):. doi: 10.3390/molecules26072079. [PMID: 33916390]
  • Yanzhou Wang, Siyuan Zhu, Touming Liu, Bing Guo, Fu Li, Xuehua Bai. Identification of the rhizospheric microbe and metabolites that led by the continuous cropping of ramie (Boehmeria nivea L. Gaud). Scientific reports. 2020 11; 10(1):20408. doi: 10.1038/s41598-020-77475-3. [PMID: 33230149]
  • S S Efimova, D A Khaleneva, E V Litasova, L B Piotrovskiy, O S Ostroumova. The mechanisms of action of water-soluble aminohexanoic and malonic adducts of fullerene C60 with hexamethonium on model lipid membranes. Biochimica et biophysica acta. Biomembranes. 2020 11; 1862(11):183433. doi: 10.1016/j.bbamem.2020.183433. [PMID: 32763244]
  • Seung Hoon Lee, Jung Min Ko, Mi-Kyoung Song, Junghan Song, Kyung Sun Park. A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy. Molecular genetics & genomic medicine. 2020 09; 8(9):e1379. doi: 10.1002/mgg3.1379. [PMID: 32602666]
  • Gulsah Gundogdu, Onur Senol, Fatma Demirkaya Miloglu, Yavuzer Koza, Fuat Gundogdu, Ahmet Hacımüftüoğlu, A M Abd El-Aty. Serum metabolite profiling of ST-segment elevation myocardial infarction using liquid chromatography quadrupole time-of-flight mass spectrometry. Biomedical chromatography : BMC. 2020 Feb; 34(2):e4738. doi: 10.1002/bmc.4738. [PMID: 31677392]
  • Boda Zhou, Yipeng Du, Yajun Xue, Guobin Miao, Taotao Wei, Ping Zhang. Identification of Malonylation, Succinylation, and Glutarylation in Serum Proteins of Acute Myocardial Infarction Patients. Proteomics. Clinical applications. 2020 01; 14(1):e1900103. doi: 10.1002/prca.201900103. [PMID: 31532912]
  • José Luiz Portela, Matheus Chimelo Bianchini, Aline Augusti Boligon, Murilo Ricardo Sigal Carriço, Rafael Roehrs, Félix Alexandre Antunes Soares, Marcelo Gomes de Gomes, Waseem Hassan, Robson Luiz Puntel. Ilex paraguariensis Attenuates Changes in Mortality, Behavioral and Biochemical Parameters Associated to Methyl Malonate or Malonate Exposure in Drosophila melanogaster. Neurochemical research. 2019 Sep; 44(9):2202-2214. doi: 10.1007/s11064-019-02862-w. [PMID: 31422521]
  • Elizabeth Mary Mathew, Leslie Lewis, Pragna Rao, K Nalini, Asha Kamath, Sudheer Moorkoth. Novel HILIC-ESI-MS method for urinary profiling of MSUD and methylmalonic aciduria biomarkers. Journal of chromatographic science. 2019 Aug; 57(8):715-723. doi: 10.1093/chromsci/bmz045. [PMID: 31251316]
  • Alina Levtova, Paula J Waters, Daniela Buhas, Sébastien Lévesque, Christiane Auray-Blais, Joe T R Clarke, Rachel Laframboise, Bruno Maranda, Grant A Mitchell, Catherine Brunel-Guitton, Nancy E Braverman. Combined malonic and methylmalonic aciduria due to ACSF3 mutations: Benign clinical course in an unselected cohort. Journal of inherited metabolic disease. 2019 01; 42(1):107-116. doi: 10.1002/jimd.12032. [PMID: 30740739]
  • Bao-Zhong Du, Gui-Yue Zhang, Hua Fan, Wei Yu. [Electrochemical fingerprint of traditional Chinese medicines based on BrO⁻₃-Ce⁴⁺-H⁺-malonic acid/tartaric acid chemical oscillating system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Nov; 43(21):4288-4294. doi: 10.19540/j.cnki.cjcmm.2018.0115. [PMID: 30583631]
  • Ben Zhao, Yafei Li, Changling Li, Hailin Yang, Wu Wang. Enhancement of Schizochytrium DHA synthesis by plasma mutagenesis aided with malonic acid and zeocin screening. Applied microbiology and biotechnology. 2018 Mar; 102(5):2351-2361. doi: 10.1007/s00253-018-8756-4. [PMID: 29356868]
  • Sanjay K Mohanty, Cedric Gonneau, Ashkan Salamatipour, Ralph A Pietrofesa, Brenda Casper, Melpo Christofidou-Solomidou, Jane K Willenbring. Siderophore-mediated iron removal from chrysotile: Implications for asbestos toxicity reduction and bioremediation. Journal of hazardous materials. 2018 Jan; 341(?):290-296. doi: 10.1016/j.jhazmat.2017.07.033. [PMID: 28797944]
  • Christian Wölk, Christopher Janich, Udo Bakowsky, Andreas Langner, Gerald Brezesinski. Malonic acid based cationic lipids - The way to highly efficient DNA-carriers. Advances in colloid and interface science. 2017 Oct; 248(?):20-34. doi: 10.1016/j.cis.2017.08.003. [PMID: 28842122]
  • Wataru Nabeyama, Kenji Ishihara, Hyun Seung Ban, Hiroshi Wada, Hiroyuki Nakamura. Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells. Bioorganic & medicinal chemistry. 2017 05; 25(9):2601-2608. doi: 10.1016/j.bmc.2017.03.024. [PMID: 28341401]
  • Chandra Shekar R Ambati, Furong Yuan, Lutfi A Abu-Elheiga, Yiqing Zhang, Vivekananda Shetty. Identification and Quantitation of Malonic Acid Biomarkers of In-Born Error Metabolism by Targeted Metabolomics. Journal of the American Society for Mass Spectrometry. 2017 05; 28(5):929-938. doi: 10.1007/s13361-017-1631-1. [PMID: 28315235]
  • Ben Fan, Yu-Long Li, Lei Li, Xiao-Jun Peng, Chen Bu, Xiao-Qin Wu, Rainer Borriss. Malonylome analysis of rhizobacterium Bacillus amyloliquefaciens FZB42 reveals involvement of lysine malonylation in polyketide synthesis and plant-bacteria interactions. Journal of proteomics. 2017 02; 154(?):1-12. doi: 10.1016/j.jprot.2016.11.022. [PMID: 27939684]
  • Guoju Chen, Heping Liu, Qian Wei, Huina Zhao, Juanxu Liu, Yixun Yu. The acyl-activating enzyme PhAAE13 is an alternative enzymatic source of precursors for anthocyanin biosynthesis in petunia flowers. Journal of experimental botany. 2017 01; 68(3):457-467. doi: 10.1093/jxb/erw426. [PMID: 28204578]
  • Bibi Rafeiza Khan, Daniel J Wherritt, David Huhman, Lloyd W Sumner, Kent D Chapman, Elison B Blancaflor. Malonylation of Glucosylated N-Lauroylethanolamine: A NEW PATHWAY THAT DETERMINES N-ACYLETHANOLAMINE METABOLIC FATE IN PLANTS. The Journal of biological chemistry. 2016 12; 291(53):27112-27121. doi: 10.1074/jbc.m116.751065. [PMID: 27856641]
  • Rajesh K Harijan, Muriel Mazet, Tiila R Kiema, Guillaume Bouyssou, Stefan E H Alexson, Ulrich Bergmann, Patrick Moreau, Paul A M Michels, Frédéric Bringaud, Rik K Wierenga. The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism. Proteins. 2016 08; 84(8):1075-96. doi: 10.1002/prot.25054. [PMID: 27093562]
  • Tiyakhon Chatnaparat, Sutruedee Prathuangwong, Steven E Lindow. Global Pattern of Gene Expression of Xanthomonas axonopodis pv. glycines Within Soybean Leaves. Molecular plant-microbe interactions : MPMI. 2016 Jun; 29(6):508-22. doi: 10.1094/mpmi-01-16-0007-r. [PMID: 27003800]
  • Huan Liu, Dongqiong Tan, Lianshu Han, Jun Ye, Wenjuan Qiu, Xuefan Gu, Huiwen Zhang. A new case of malonyl-CoA decarboxylase deficiency with mild clinical features. American journal of medical genetics. Part A. 2016 May; 170A(5):1347-51. doi: 10.1002/ajmg.a.37590. [PMID: 26858006]
  • Xin Guan, Basil J Nikolau. AAE13 encodes a dual-localized malonyl-CoA synthetase that is crucial for mitochondrial fatty acid biosynthesis. The Plant journal : for cell and molecular biology. 2016 Mar; 85(5):581-93. doi: 10.1111/tpj.13130. [PMID: 26836315]
  • Yingjie Zhang, Stephen A Boyd, Brian J Teppen, James M Tiedje, Hui Li. Organic acids enhance bioavailability of tetracycline in water to Escherichia coli for uptake and expression of antibiotic resistance. Water research. 2014 Nov; 65(?):98-106. doi: 10.1016/j.watres.2014.07.021. [PMID: 25100186]
  • Leonardo Di Donna, Fabio Mazzotti, Domenico Taverna, Anna Napoli, Giovanni Sindona. Structural characterisation of malonyl flavonols in leek (Allium porrum L.) using high-performance liquid chromatography and mass spectrometry. Phytochemical analysis : PCA. 2014 May; 25(3):207-12. doi: 10.1002/pca.2493. [PMID: 24375682]
  • R Fernández, D Fernández-Fuego, A Bertrand, A González. Strategies for Cd accumulation in Dittrichia viscosa (L.) Greuter: role of the cell wall, non-protein thiols and organic acids. Plant physiology and biochemistry : PPB. 2014 May; 78(?):63-70. doi: 10.1016/j.plaphy.2014.02.021. [PMID: 24636908]
  • Yun Wang, Yi-Gang Wang, Teng-Fei Ma, Mei Li, Shu-Ling Gu. Dynamic metabolites profile of cerebral ischemia/reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers. International journal of clinical and experimental pathology. 2014; 7(7):4067-75. doi: NULL. [PMID: 25120785]
  • Xuejie Zhang, Qiaoling Liu, Tie Xia, Nan Li, Kangmin He, Chunru Wang, Weihong Tan, Xiaohong Fang. Atomic force microscopy study of the effects of water-soluble fullerenes on the elasticity of living plant cells. Chemistry, an Asian journal. 2013 Oct; 8(10):2388-94. doi: 10.1002/asia.201300522. [PMID: 23929723]
  • Wei Ning Chen, Kee Yang Tan. "Malonate uptake and metabolism in Saccharomyces cerevisiae". Applied biochemistry and biotechnology. 2013 Sep; 171(1):44-62. doi: 10.1007/s12010-013-0334-8. [PMID: 23813405]
  • Ramakrishnan Karunakaran, Alison K East, Philip S Poole. Malonate catabolism does not drive N2 fixation in legume nodules. Applied and environmental microbiology. 2013 Jul; 79(14):4496-8. doi: 10.1128/aem.00919-13. [PMID: 23666330]
  • Peng Zheng, Ying Wang, Liang Chen, Deyu Yang, Huaqing Meng, Dezhi Zhou, Jiaju Zhong, Yang Lei, N D Melgiri, Peng Xie. Identification and validation of urinary metabolite biomarkers for major depressive disorder. Molecular & cellular proteomics : MCP. 2013 Jan; 12(1):207-14. doi: 10.1074/mcp.m112.021816. [PMID: 23111923]
  • Neusa Martins, Sandra Gonçalves, Paula B Andrade, Patrícia Valentão, Anabela Romano. Changes on organic acid secretion and accumulation in Plantago almogravensis Franco and Plantago algarbiensis Samp. under aluminum stress. Plant science : an international journal of experimental plant biology. 2013 Jan; 198(?):1-6. doi: 10.1016/j.plantsci.2012.09.001. [PMID: 23199681]
  • Trina Ghosh Dastidar, Anil N Netravali. 'Green' crosslinking of native starches with malonic acid and their properties. Carbohydrate polymers. 2012 Nov; 90(4):1620-8. doi: 10.1016/j.carbpol.2012.07.041. [PMID: 22944425]
  • Alaa A Salem, Ibrahim M Abdou, Habiba A Saleh. Application of quantitative nuclear magnetic resonance spectroscopy for the determination ofamantadine and acyclovir in plasma and pharmaceutical samples. Journal of AOAC International. 2012 Nov; 95(6):1644-51. doi: 10.5740/jaoacint.11-165. [PMID: 23451380]
  • André Macherius, Trine Eggen, Wilhelm Lorenz, Monika Moeder, Jelka Ondruschka, Thorsten Reemtsma. Metabolization of the bacteriostatic agent triclosan in edible plants and its consequences for plant uptake assessment. Environmental science & technology. 2012 Oct; 46(19):10797-804. doi: 10.1021/es3028378. [PMID: 22989227]
  • Damien L Callahan, Ute Roessner, Vincent Dumontet, Alysha M De Livera, Augustine Doronila, Alan J M Baker, Spas D Kolev. Elemental and metabolite profiling of nickel hyperaccumulators from New Caledonia. Phytochemistry. 2012 Sep; 81(?):80-9. doi: 10.1016/j.phytochem.2012.06.010. [PMID: 22795763]
  • Juan Huang, Yan Liu, Tao Ding, Xiaoyan Zhang, Huilan Chen, Chongyu Shen, Bin Wu, Wen Niu. [Determination of kojic acid in foods using high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2012 Jun; 30(6):578-83. doi: 10.3724/sp.j.1123.2012.02002. [PMID: 23016291]
  • Sara Valdeolivas, Valentina Satta, Roger G Pertwee, Javier Fernández-Ruiz, Onintza Sagredo. Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors. ACS chemical neuroscience. 2012 May; 3(5):400-6. doi: 10.1021/cn200114w. [PMID: 22860209]
  • Atsuki Ikeda, Shin Nishiumi, Masakazu Shinohara, Tomoo Yoshie, Naoya Hatano, Tatsuya Okuno, Takeshi Bamba, Eiichiro Fukusaki, Tadaomi Takenawa, Takeshi Azuma, Masaru Yoshida. Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomedical chromatography : BMC. 2012 May; 26(5):548-58. doi: 10.1002/bmc.1671. [PMID: 21773981]
  • Zhi Liu, Yu Li, Xiang Li, Chang-Chun Ruan, Li-Juan Wang, Guang-Zhi Sun. The effects of dynamic changes of malonyl ginsenosides on evaluation and quality control of Panax ginseng C.A. Meyer. Journal of pharmaceutical and biomedical analysis. 2012 May; 64-65(?):56-63. doi: 10.1016/j.jpba.2012.02.005. [PMID: 22387101]
  • Yan Gu, Cheng Lu, Qinglin Zha, Hongwei Kong, Xin Lu, Aiping Lu, Guowang Xu. Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry. Molecular bioSystems. 2012 Apr; 8(5):1535-43. doi: 10.1039/c2mb25022e. [PMID: 22419152]
  • Mamtimin Batur, Upur Halmurat, Fu-Hua Hao, Rena Aiziz, Matsidik Aynur. Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2012 Mar; 32(1):119-24. doi: 10.1016/s0254-6272(12)60044-2. [PMID: 22594115]
  • Pratibha Yadav, V K Singh, Meera Yadav, Sunil Kumar Singh, Sudha Yadava, K D S Yadav. Purification and characterization of Mn-peroxidase from Musa paradisiaca (banana) stem juice. Indian journal of biochemistry & biophysics. 2012 Feb; 49(1):42-8. doi: ". [PMID: 22435143]
  • Emily B Merewitz, Hongmei Du, Wenjuan Yu, Yimin Liu, Thomas Gianfagna, Bingru Huang. Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation. Journal of experimental botany. 2012 Feb; 63(3):1315-28. doi: 10.1093/jxb/err372. [PMID: 22131157]
  • Noriyoshi Iriyama, Yuta Yoshino, Bo Yuan, Akira Horikoshi, Yukio Hirabayashi, Yoshihiro Hatta, Hiroo Toyoda, Jin Takeuchi. Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient. Journal of hematology & oncology. 2012 Jan; 5(?):1. doi: 10.1186/1756-8722-5-1. [PMID: 22272800]
  • Xiang Tao, Ying-Hong Gu, Hai-Yan Wang, Wen Zheng, Xiao Li, Chuan-Wu Zhao, Yi-Zheng Zhang. Digital gene expression analysis based on integrated de novo transcriptome assembly of sweet potato [Ipomoea batatas (L.) Lam]. PloS one. 2012; 7(4):e36234. doi: 10.1371/journal.pone.0036234. [PMID: 22558397]
  • Alessandra Ferramosca, Annalea Conte, Lena Burri, Kjetil Berge, Francesco De Nuccio, Anna Maria Giudetti, Vincenzo Zara. A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. PloS one. 2012; 7(6):e38797. doi: 10.1371/journal.pone.0038797. [PMID: 22685607]
  • Stewart Frankel, Blanka Rogina. Indy mutants: live long and prosper. Frontiers in genetics. 2012; 3(?):13. doi: 10.3389/fgene.2012.00013. [PMID: 22363340]
  • Lihong Xiao, Liechi Zhang, Ge Yang, Honglin Zhu, Yikun He. Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. PloS one. 2012; 7(4):e35961. doi: 10.1371/journal.pone.0035961. [PMID: 22545152]
  • Nan Wang, Wajahatullah Khan, Donald L Smith. Changes in soybean global gene expression after application of lipo-chitooligosaccharide from Bradyrhizobium japonicum under sub-optimal temperature. PloS one. 2012; 7(2):e31571. doi: 10.1371/journal.pone.0031571. [PMID: 22348109]
  • Ana Carolina Ariza, Peter Meinardus T Deen, Joris Hubertus Robben. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. Frontiers in endocrinology. 2012; 3(?):22. doi: 10.3389/fendo.2012.00022. [PMID: 22649411]
  • Marcus Thein, Mari Bonde, Ignas Bunikis, Katrin Denker, Albert Sickmann, Sven Bergström, Roland Benz. DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. PloS one. 2012; 7(5):e36523. doi: 10.1371/journal.pone.0036523. [PMID: 22590556]
  • Patrick M Finnegan, Weihua Chen. Arsenic toxicity: the effects on plant metabolism. Frontiers in physiology. 2012; 3(?):182. doi: 10.3389/fphys.2012.00182. [PMID: 22685440]
  • Gabriel Scalliet, Judith Bowler, Torsten Luksch, Lucy Kirchhofer-Allan, Diana Steinhauer, Keith Ward, Michael Niklaus, Andreas Verras, Michael Csukai, Antoine Daina, Raymonde Fonné-Pfister. Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola. PloS one. 2012; 7(4):e35429. doi: 10.1371/journal.pone.0035429. [PMID: 22536383]
  • Irene Russo Krauss, Filomena Sica, Carlo Andrea Mattia, Antonello Merlino. Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data. International journal of molecular sciences. 2012; 13(3):3782-800. doi: 10.3390/ijms13033782. [PMID: 22489183]
  • Ilka Haferkamp, Stephan Schmitz-Esser. The plant mitochondrial carrier family: functional and evolutionary aspects. Frontiers in plant science. 2012; 3(?):2. doi: 10.3389/fpls.2012.00002. [PMID: 22639632]
  • Hendrik Führs, André Specht, Alexander Erban, Joachim Kopka, Walter J Horst. Functional associations between the metabolome and manganese tolerance in Vigna unguiculata. Journal of experimental botany. 2012 Jan; 63(1):329-40. doi: 10.1093/jxb/err276. [PMID: 21934118]
  • Mario Chojkier, Hisham Elkhayat, Dina Sabry, Michael Donohue, Martina Buck. Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. PloS one. 2012; 7(3):e31516. doi: 10.1371/journal.pone.0031516. [PMID: 22412837]
  • Kanchan Anand, Kenji Maeda, Anne-Claude Gavin. Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. PloS one. 2012; 7(5):e36526. doi: 10.1371/journal.pone.0036526. [PMID: 22574179]
  • Fabiola G Zuno-Floriano, Marion G Miller, Maria L Aldana-Madrid, Matt J Hengel, Nilesh W Gaikwad, Vladimir Tolstikov, Ana G Contreras-Cortés. Effect of Acinetobacter sp on metalaxyl degradation and metabolite profile of potato seedlings (Solanum tuberosum L.) alpha variety. PloS one. 2012; 7(2):e31221. doi: 10.1371/journal.pone.0031221. [PMID: 22363586]
  • Sarah Engeham, Kennedy Mdaki, Kirsty Jewell, Ruth Austin, Alexander N Lehner, Simon C Langley-Evans. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet. Journal of nutrition and metabolism. 2012; 2012(?):989037. doi: 10.1155/2012/989037. [PMID: 22536494]
  • Jon K Pittman. Multiple Transport Pathways for Mediating Intracellular pH Homeostasis: The Contribution of H(+)/ion Exchangers. Frontiers in plant science. 2012; 3(?):11. doi: 10.3389/fpls.2012.00011. [PMID: 22645567]
  • Sharon E Miller, Daniela A Sahlender, Stephen C Graham, Stefan Höning, Margaret S Robinson, Andrew A Peden, David J Owen. The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell. 2011 Nov; 147(5):1118-31. doi: 10.1016/j.cell.2011.10.038. [PMID: 22118466]
  • Vikas S Padalkar, Vikas S Patil, N Sekar. Synthesis and characterization of novel 2, 2'-bipyrimidine fluorescent derivative for protein binding. Chemistry Central journal. 2011 Nov; 5(?):72. doi: 10.1186/1752-153x-5-72. [PMID: 22067202]
  • Sung Ryeol Park, Mi Sun Ahn, Ah Reum Han, Je Won Park, Yeo Joon Yoon. Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. Journal of microbiology and biotechnology. 2011 Nov; 21(11):1143-6. doi: 10.4014/jmb.1108.08012. [PMID: 22127124]
  • Vinoy K Ramachandran, Alison K East, Ramakrishnan Karunakaran, J Allan Downie, Philip S Poole. Adaptation of Rhizobium leguminosarum to pea, alfalfa and sugar beet rhizospheres investigated by comparative transcriptomics. Genome biology. 2011 Oct; 12(10):R106. doi: 10.1186/gb-2011-12-10-r106. [PMID: 22018401]
  • Isabel Bondia-Pons, Emilia Nordlund, Ismo Mattila, Kati Katina, Anna-Marja Aura, Marjukka Kolehmainen, Matej Orešič, Hannu Mykkänen, Kaisa Poutanen. Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread. Nutrition journal. 2011 Oct; 10(?):116. doi: 10.1186/1475-2891-10-116. [PMID: 22011443]
  • Sheila Alves, Cristina Nabais, Maria de Lurdes Simões Gonçalves, Margarida M Correia Dos Santos. Nickel speciation in the xylem sap of the hyperaccumulator Alyssum serpyllifolium ssp. lusitanicum growing on serpentine soils of northeast Portugal. Journal of plant physiology. 2011 Oct; 168(15):1715-22. doi: 10.1016/j.jplph.2011.04.004. [PMID: 21664714]
  • Jason W Holder, Jil C Ulrich, Anthony C DeBono, Paul A Godfrey, Christopher A Desjardins, Jeremy Zucker, Qiandong Zeng, Alex L B Leach, Ion Ghiviriga, Christine Dancel, Thomas Abeel, Dirk Gevers, Chinnappa D Kodira, Brian Desany, Jason P Affourtit, Bruce W Birren, Anthony J Sinskey. Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development. PLoS genetics. 2011 Sep; 7(9):e1002219. doi: 10.1371/journal.pgen.1002219. [PMID: 21931557]
  • Ahmed Alfares, Laura Dempsey Nunez, Khalid Al-Thihli, John Mitchell, Serge Melançon, Natascia Anastasio, Kevin C H Ha, Jacek Majewski, David S Rosenblatt, Nancy Braverman. Combined malonic and methylmalonic aciduria: exome sequencing reveals mutations in the ACSF3 gene in patients with a non-classic phenotype. Journal of medical genetics. 2011 Sep; 48(9):602-5. doi: 10.1136/jmedgenet-2011-100230. [PMID: 21785126]
  • Elena A Kotova, Alexey V Kuzevanov, Alina A Pashkovskaya, Yuri N Antonenko. Selective permeabilization of lipid membranes by photodynamic action via formation of hydrophobic defects or pre-pores. Biochimica et biophysica acta. 2011 Sep; 1808(9):2252-7. doi: 10.1016/j.bbamem.2011.05.018. [PMID: 21663731]
  • Hyun S Lillehoj, Duk K Kim, David M Bravo, Sung H Lee. Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens. BMC proceedings. 2011 Jun; 5 Suppl 4(?):S34. doi: 10.1186/1753-6561-5-s4-s34. [PMID: 21645315]
  • Leonhard Jaitz, Bernhard Mueller, Gunda Koellensperger, Daniela Huber, Eva Oburger, Markus Puschenreiter, Stephan Hann. LC-MS analysis of low molecular weight organic acids derived from root exudation. Analytical and bioanalytical chemistry. 2011 Jun; 400(8):2587-96. doi: 10.1007/s00216-010-4090-0. [PMID: 20711769]
  • Hui Chen, Hyun Uk Kim, Hua Weng, John Browse. Malonyl-CoA synthetase, encoded by ACYL ACTIVATING ENZYME13, is essential for growth and development of Arabidopsis. The Plant cell. 2011 Jun; 23(6):2247-62. doi: 10.1105/tpc.111.086140. [PMID: 21642549]
  • Xianping Fang, Huasheng Ma, Dezhao Lu, Hong Yu, Wenguo Lai, Songlin Ruan. Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons. Proteome science. 2011 May; 9(?):26. doi: 10.1186/1477-5956-9-26. [PMID: 21569547]
  • Ya-Yun Wang, Yi-Fang Tsay. Arabidopsis nitrate transporter NRT1.9 is important in phloem nitrate transport. The Plant cell. 2011 May; 23(5):1945-57. doi: 10.1105/tpc.111.083618. [PMID: 21571952]
  • M Flint Beal. Neuroprotective effects of creatine. Amino acids. 2011 May; 40(5):1305-13. doi: 10.1007/s00726-011-0851-0. [PMID: 21448659]
  • So-Hyun Kim, Somi K Cho, Tae-Sun Min, Yujin Kim, Seung-Ok Yang, Hee-Su Kim, Sun-Hee Hyun, Hana Kim, Young-Suk Kim, Hyung-Kyoon Choi. Ameliorating effects of Mango (Mangifera indica L.) fruit on plasma ethanol level in a mouse model assessed with H-NMR based metabolic profiling. Journal of clinical biochemistry and nutrition. 2011 May; 48(3):214-21. doi: 10.3164/jcbn.10-96. [PMID: 21562641]
  • Hong Lin, Binghai Lou, Jonathan M Glynn, Harshavardhan Doddapaneni, Edwin L Civerolo, Chuanwu Chen, Yongping Duan, Lijuan Zhou, Cheryl M Vahling. The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease. PloS one. 2011 Apr; 6(4):e19135. doi: 10.1371/journal.pone.0019135. [PMID: 21552483]
  • Jian Zhao, David Huhman, Gail Shadle, Xian-Zhi He, Lloyd W Sumner, Yuhong Tang, Richard A Dixon. MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. The Plant cell. 2011 Apr; 23(4):1536-55. doi: 10.1105/tpc.110.080804. [PMID: 21467581]
  • Batur Mamtimin, Halmurat Upur. [Plasma metabonomics analysis of tumor patients of phlegm-stasis syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2011 Apr; 31(4):492-5. doi: . [PMID: 21608220]
  • Scott M Damrauer, Peter Studer, Cleide G da Silva, Christopher R Longo, Haley E Ramsey, Eva Csizmadia, Gautam V Shrikhande, Salvatore T Scali, Towia A Libermann, Manoj K Bhasin, Christiane Ferran. A20 modulates lipid metabolism and energy production to promote liver regeneration. PloS one. 2011 Mar; 6(3):e17715. doi: 10.1371/journal.pone.0017715. [PMID: 21437236]
  • Nikolaos Psychogios, David D Hau, Jun Peng, An Chi Guo, Rupasri Mandal, Souhaila Bouatra, Igor Sinelnikov, Ramanarayan Krishnamurthy, Roman Eisner, Bijaya Gautam, Nelson Young, Jianguo Xia, Craig Knox, Edison Dong, Paul Huang, Zsuzsanna Hollander, Theresa L Pedersen, Steven R Smith, Fiona Bamforth, Russ Greiner, Bruce McManus, John W Newman, Theodore Goodfriend, David S Wishart. The human serum metabolome. PloS one. 2011 Feb; 6(2):e16957. doi: 10.1371/journal.pone.0016957. [PMID: 21359215]
  • Pamela Strazzer, Flavia Guzzo, Marisa Levi. Correlated accumulation of anthocyanins and rosmarinic acid in mechanically stressed red cell suspensions of basil (Ocimum basilicum). Journal of plant physiology. 2011 Feb; 168(3):288-93. doi: 10.1016/j.jplph.2010.07.020. [PMID: 20943285]
  • Ali Ghasemzadeh, Hawa Z E Jaafar. Effect of CO(2) enrichment on synthesis of some primary and secondary metabolites in ginger (Zingiber officinale Roscoe). International journal of molecular sciences. 2011 Feb; 12(2):1101-14. doi: 10.3390/ijms12021101. [PMID: 21541046]
  • Valeria Boeris, Cecilia Cassane, Jorge Wagner, Guillermo Picó. The formation of non-soluble complexes between polyethyleneimine-anions and their potential use to isolate enzymes. Colloids and surfaces. B, Biointerfaces. 2011 Feb; 82(2):354-8. doi: 10.1016/j.colsurfb.2010.09.008. [PMID: 20932724]
  • Kathleen S Hering-Smith, Faith R Schiro, Ana M Pajor, L Lee Hamm. Calcium sensitivity of dicarboxylate transport in cultured proximal tubule cells. American journal of physiology. Renal physiology. 2011 Feb; 300(2):F425-32. doi: 10.1152/ajprenal.00036.2010. [PMID: 21123491]
  • Wagner L Araújo, Adriano Nunes-Nesi, Sonia Osorio, Björn Usadel, Daniela Fuentes, Réka Nagy, Ilse Balbo, Martin Lehmann, Claudia Studart-Witkowski, Takayuki Tohge, Enrico Martinoia, Xavier Jordana, Fábio M Damatta, Alisdair R Fernie. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. The Plant cell. 2011 Feb; 23(2):600-27. doi: 10.1105/tpc.110.081224. [PMID: 21307286]
  • Batur Mamtimin, Halmurat Upur, Fu-Hua Hao, Aynur Matsidik, Rena Rahim. Plasma metabonomic analysis with ¹H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional Uyghur medicine. Chinese journal of integrative medicine. 2011 Feb; 17(2):111-5. doi: 10.1007/s11655-011-0638-x. [PMID: 21390577]
  • Bimlesh Ojha, Gopal Das. Role of hydrophobic and polar interactions for BSA-amphiphile composites. Chemistry and physics of lipids. 2011 Feb; 164(2):144-50. doi: 10.1016/j.chemphyslip.2010.12.004. [PMID: 21185815]
  • Mingsheng Qi, Dongping Wang, Carl A Bradley, Youfu Zhao. Genome sequence analyses of Pseudomonas savastanoi pv. glycinea and subtractive hybridization-based comparative genomics with nine pseudomonads. PloS one. 2011 Jan; 6(1):e16451. doi: 10.1371/journal.pone.0016451. [PMID: 21304594]
  • Lothar Wissler, Francisco M Codoñer, Jenny Gu, Thorsten B H Reusch, Jeanine L Olsen, Gabriele Procaccini, Erich Bornberg-Bauer. Back to the sea twice: identifying candidate plant genes for molecular evolution to marine life. BMC evolutionary biology. 2011 Jan; 11(?):8. doi: 10.1186/1471-2148-11-8. [PMID: 21226908]
  • Hideki Takahashi, Peter Buchner, Naoko Yoshimoto, Malcolm J Hawkesford, Shin-Han Shiu. Evolutionary relationships and functional diversity of plant sulfate transporters. Frontiers in plant science. 2011; 2(?):119. doi: 10.3389/fpls.2011.00119. [PMID: 22629272]
  • Fabio Facchinelli, Andreas P M Weber. The metabolite transporters of the plastid envelope: an update. Frontiers in plant science. 2011; 2(?):50. doi: 10.3389/fpls.2011.00050. [PMID: 22645538]
  • Nafiseh Darandeh, Ebrahim Hadavi. Effect of Pre-Harvest Foliar Application of Citric Acid and Malic Acid on Chlorophyll Content and Post-Harvest Vase Life of Lilium cv. Brunello. Frontiers in plant science. 2011; 2(?):106. doi: 10.3389/fpls.2011.00106. [PMID: 22639626]
  • Andrea Bräutigam, Kaisa Kajala, Julia Wullenweber, Manuel Sommer, David Gagneul, Katrin L Weber, Kevin M Carr, Udo Gowik, Janina Mass, Martin J Lercher, Peter Westhoff, Julian M Hibberd, Andreas P M Weber. An mRNA blueprint for C4 photosynthesis derived from comparative transcriptomics of closely related C3 and C4 species. Plant physiology. 2011 Jan; 155(1):142-56. doi: 10.1104/pp.110.159442. [PMID: 20543093]