Senna (BioDeep_00000276357)

Main id: BioDeep_00000003612

 

PANOMIX_OTCML-2023


代谢物信息卡片


Senna, Cassia obovata, ext.

化学式: C42H38O20 (862.1956348000001)
中文名称: 番泻叶提取物, 番泻叶苷A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(=O)C4=C(C2C5C6=C(C(=CC=C6)OC7C(C(C(C(O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
InChI: InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1

描述信息

D005765 - Gastrointestinal Agents > D054368 - Laxatives
Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia)[1]. Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication[2].
Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia)[1]. Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication[2].

同义名列表

4 个代谢物同义名

Senna, Cassia obovata, ext.; Sennoside A; sennosides; Senna



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Khushali Thaker, Jaimini Patoliya, Khushbu Rabadiya, Dhaval Patel, Manivel Ponnuchamy, Nagaraja Reddy Rama Reddy, Rushikesh Joshi. An in-silico approach to unravel the structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS): a critical enzyme for sennoside biosynthesis in Cassia angustifolia Vahl. Journal of biomolecular structure & dynamics. 2024 May; 42(8):3848-3861. doi: 10.1080/07391102.2023.2216300. [PMID: 37243697]
  • Nadja Meier, Beat Meier, Alexander Schenk, Le Nhung Ziegler, Samuel Peter, Evelyn Wolfram. Photostability of sennosides and their aglycones in solution. Phytochemical analysis : PCA. 2024 Jan; ?(?):. doi: 10.1002/pca.3308. [PMID: 38198752]
  • Adrienne B Narrowe, Johanna M S Lemons, Karley K Mahalak, Jenni Firrman, Pieter Van den Abbeele, Aurélien Baudot, Stef Deyaert, Yanfang Li, Liangli Lucy Yu, LinShu Liu. Targeted remodeling of the human gut microbiome using Juemingzi (Senna seed extracts). Frontiers in cellular and infection microbiology. 2024; 14(?):1296619. doi: 10.3389/fcimb.2024.1296619. [PMID: 38638830]
  • Kohei Takagi, Takashi Sugihira, Miho Kitamura, Mami Kawai, Yoko Mitsuguchi, Kosei Tsukamoto, Hirofumi Nakanishi, Toshiaki Makino. Inhibitory effect of Bofutsushosan (Fangfengtongshengsan) extract on the absorption of fructose in rats and mice. Journal of natural medicines. 2023 Apr; ?(?):. doi: 10.1007/s11418-023-01697-8. [PMID: 37040005]
  • Mei-Mei Zhang, Zhi-Cheng Gong, Qi Zhao, Ding-Qiao Xu, Rui-Jia Fu, Yu-Ping Tang, Yan-Yan Chen. Time-dependent laxative effect of sennoside A, the core functional component of rhubarb, is attributed to gut microbiota and aquaporins. Journal of ethnopharmacology. 2023 Mar; ?(?):116431. doi: 10.1016/j.jep.2023.116431. [PMID: 37003403]
  • Rohini Verma, S M Jachak. Isolation and biological evaluation of demethylcassiarin B from Senna siamea Lam. Natural product research. 2023 Jan; ?(?):1-4. doi: 10.1080/14786419.2023.2165075. [PMID: 36630172]
  • Haoua Nacambo, Nerbéwendé Sawadogo, Teyiouê Benoit Joseph Batieno, Mahamadi Hamed Ouedraogo, Abdoul Kader Congo, Wend-Pagnagde Felicien Marie Serge Zida, Kiswendsida Romaric Nanema, Mahamadou Sawadogo. Assessment of Genetic Diversity of a Collection of Senna obtusifolia (L.) Irwin and Barneby Using SSRs Markers in Burkina Faso. TheScientificWorldJournal. 2023; 2023(?):3761799. doi: 10.1155/2023/3761799. [PMID: 37313353]
  • Serhat Sezai Çiçek, Calisto Moreno Cardenas, Ulrich Girreser. Determination of Total Sennosides and Sennosides A, B, and A1 in Senna Leaflets, Pods, and Tablets by Two-Dimensional qNMR. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217349. [PMID: 36364175]
  • Xiaoya Li, Xinxin Peng, Bo Qiao, Maijiao Peng, Na Deng, Rong Yu, Zhoujin Tan. Gut-Kidney Impairment Process of Adenine Combined with Folium sennae-Induced Diarrhea: Association with Interactions between Lactobacillus intestinalis, Bacteroides acidifaciens and Acetic Acid, Inflammation, and Kidney Function. Cells. 2022 10; 11(20):. doi: 10.3390/cells11203261. [PMID: 36291135]
  • Jiasi Wu, Yuejia Lan, Xiaoke Shi, Wenge Huang, Sheng Li, Jizhou Zhang, Huan Wang, Fei Wang, Xianli Meng. Sennoside A is a novel inhibitor targeting caspase-1. Food & function. 2022 Oct; 13(19):9782-9795. doi: 10.1039/d2fo01730j. [PMID: 36097956]
  • Caifeng Li, Zhiyong Li, Hongwei Wu, Shihuan Tang, Yi Zhang, Bin Yang, Hongjun Yang, Luqi Huang. Therapeutic effect of Moringa oleifera leaves on constipation mice based on pharmacodynamics and serum metabonomics. Journal of ethnopharmacology. 2022 Jan; 282(?):114644. doi: 10.1016/j.jep.2021.114644. [PMID: 34534599]
  • Perwez Alam, Omar M Noman, Rashed N Herqash, Omer M Almarfadi, Ali Akhtar, Ali S Alqahtani. Response Surface Methodology (RSM)-Based Optimization of Ultrasound-Assisted Extraction of Sennoside A, Sennoside B, Aloe-Emodin, Emodin, and Chrysophanol from Senna alexandrina (Aerial Parts): HPLC-UV and Antioxidant Analysis. Molecules (Basel, Switzerland). 2022 Jan; 27(1):. doi: 10.3390/molecules27010298. [PMID: 35011528]
  • Qinge Ma, Chong-Zhi Wang, Wamtinga R Sawadogo, Zhao-Xiang Bian, Chun-Su Yuan. Herbal Medicines for Constipation and Phytochemical Comparison of Active Components. The American journal of Chinese medicine. 2022; 50(3):723-732. doi: 10.1142/s0192415x2250029x. [PMID: 35331086]
  • Naila Zaman, Nousheen Parvaiz, Rabia Farid, Afifa Navid, Ghulam Abbas, Syed Sikander Azam. Senna makki and other active phytochemicals: Myths and realities behind covid19 therapeutic interventions. PloS one. 2022; 17(6):e0268454. doi: 10.1371/journal.pone.0268454. [PMID: 35700199]
  • Zhaoyang Wang, Ying Cheng, Wenting Su, Hongxia Zhang, Chu Li, Michael N Routledge, Yunyun Gong, Boling Qiao. Organ Specific Differences in Alteration of Aquaporin Expression in Rats Treated with Sennoside A, Senna Anthraquinones and Rhubarb Anthraquinones. International journal of molecular sciences. 2021 Jul; 22(15):. doi: 10.3390/ijms22158026. [PMID: 34360801]
  • Athicha Kittiwattanokhun, Siritron Samosorn, Sukanda Innajak, Ramida Watanapokasin. Inhibitory effects on chondrosarcoma cell metastasis by Senna alata extract. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111337. doi: 10.1016/j.biopha.2021.111337. [PMID: 33582453]
  • Ying Cheng, Huiqin Zhang, Lejing Qu, Ying He, Michael N Routledge, Yun Yun Gong, Boling Qiao. Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones. Food chemistry. 2020 Nov; 331(?):127363. doi: 10.1016/j.foodchem.2020.127363. [PMID: 32590269]
  • Li Ma, Xinyu Cao, Xiaotong Ye, Youke Qi, Yawen Zhu, Jianping Ye, Yongning Sun. Sennoside A restores colonic barrier function through protecting colon enterocytes from ROS-induced mitochondrial damage in diet-induced obese mice. Biochemical and biophysical research communications. 2020 05; 526(2):519-524. doi: 10.1016/j.bbrc.2020.03.117. [PMID: 32245617]
  • Tomasz Kowalczyk, Przemysław Sitarek, Monika Toma, Laurent Picot, Marzena Wielanek, Ewa Skała, Tomasz Śliwiński. An Extract of Transgenic Senna obtusifolia L. Hairy Roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line. Biomolecules. 2020 03; 10(4):. doi: 10.3390/biom10040510. [PMID: 32230928]
  • Hongyu Wu, Feng Feng, Xiunan Jiang, Binchuan Hu, Jieying Qiu, CaiHong Wang, Zheng Xiang. Pharmacokinetic and metabolic profiling studies of sennoside B by UPLC-MS/MS and UPLC-Q-TOF-MS. Journal of pharmaceutical and biomedical analysis. 2020 Feb; 179(?):112938. doi: 10.1016/j.jpba.2019.112938. [PMID: 31816471]
  • Xianbin Wang, Ting Wang, Tingting Pan, Mei Huang, Weihua Ren, Geliang Xu, Hatem K Amin, Rami B Kassab, Ahmed E Abdel Moneim. Senna alexandrina extract supplementation reverses hepatic oxidative, inflammatory, and apoptotic effects of cadmium chloride administration in rats. Environmental science and pollution research international. 2020 Feb; 27(6):5981-5992. doi: 10.1007/s11356-019-07117-3. [PMID: 31863371]
  • Gadah Albasher, Tarfa Albrahim, Nada Aljarba, Raedah I Alharbi, Nouf Alsultan, Jawaher Alsaiari, Humaira Rizwana. Involvement of redox status and the nuclear-related factor 2 in protecting against cadmium-induced renal injury with Sana Makki (Cassia senna L.) pre-treatment in male rats. Anais da Academia Brasileira de Ciencias. 2020; 92(2):e20191237. doi: 10.1590/0001-3765202020191237. [PMID: 32638872]
  • Zhonghong Wei, Peiliang Shen, Peng Cheng, Yin Lu, Aiyun Wang, Zhiguang Sun. Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2 Diabetes and Obesity Traits. Oxidative medicine and cellular longevity. 2020; 2020(?):2375676. doi: 10.1155/2020/2375676. [PMID: 32685087]
  • Jurairat Boonruab, Phiyaphon Poonsuk, Watchara Damjuti. Effect of Court-Type Thai Traditional Massage Versus Senokot Treatment on Chronic Constipation: A Randomized Controlled Trial. Journal of evidence-based integrative medicine. 2020 Jan; 25(?):2515690X20960644. doi: 10.1177/2515690x20960644. [PMID: 32993359]
  • Sang-Ho Kang, Woo-Haeng Lee, Chang-Muk Lee, Joon-Soo Sim, So Youn Won, So-Ra Han, Soo-Jin Kwon, Jung Sun Kim, Chang-Kug Kim, Tae-Jin Oh. De novo transcriptome sequence of Senna tora provides insights into anthraquinone biosynthesis. PloS one. 2020; 15(5):e0225564. doi: 10.1371/journal.pone.0225564. [PMID: 32380515]
  • Bukola Christianah Adebayo-Tayo, Samuel O Borode, Olusola Ademola Olaniyi. Phytosynthesis of zinc oxide nanoparticles using methanol extract of Senna alata leaf: Characterization, optimization, antimicrobial properties, and its application in cold cream formulation. Polimery w medycynie. 2020 Jan; 50(1):5-19. doi: 10.17219/pim/122901. [PMID: 32716148]
  • Basiru Olaitan Ajiboye, Oluwafemi Adeleke Ojo, Bamidele Fatoba, Olakunke Bamikole Afolabi, Israel Olayide, Mary Abiola Okesola, Babatunji Emmanuel Oyinloye. In vitro antioxidant and enzyme inhibitory properties of the n-butanol fraction of Senna podocarpa (Guill. and Perr.) leaf. Journal of basic and clinical physiology and pharmacology. 2019 Dec; 31(1):. doi: 10.1515/jbcpp-2019-0123. [PMID: 31874099]
  • Jinlan Yang, An Zhu, Shuo Xiao, Tao Zhang, Liming Wang, Qi Wang, Lifeng Han. Anthraquinones in the aqueous extract of Cassiae semen cause liver injury in rats through lipid metabolism disorder. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Nov; 64(?):153059. doi: 10.1016/j.phymed.2019.153059. [PMID: 31401496]
  • Julalak C Ontong, Supakit Paosen, Shiv Shankar, Supayang P Voravuthikunchai. Eco-friendly synthesis of silver nanoparticles using Senna alata bark extract and its antimicrobial mechanism through enhancement of bacterial membrane degradation. Journal of microbiological methods. 2019 10; 165(?):105692. doi: 10.1016/j.mimet.2019.105692. [PMID: 31437555]
  • Mohamed A Farag, Amira S El Senousy, Sherweit H El-Ahmady, Andrea Porzel, Ludger A Wessjohann. Comparative metabolome-based classification of Senna drugs: a prospect for phyto-equivalency of its different commercial products. Metabolomics : Official journal of the Metabolomic Society. 2019 05; 15(5):80. doi: 10.1007/s11306-019-1538-x. [PMID: 31087208]
  • Mohanasundaram Sugumar, Victor Arokia Doss, Prasad Maddisetty, Magesh Rangaraju, Sivakumar Kandhasamy, Subathra Munuswamy. Pharmacological analysis of hydroethanolic extract of Senna alata (L.) for in vitro free radical scavenging and cytotoxic activities against HepG2 cancer cell line. Pakistan journal of pharmaceutical sciences. 2019 May; 32(3):933-936. doi: ". [PMID: 31278702]
  • Siriwan Ongchai, Chatchadawalai Chokchaitaweesuk, Patiwat Kongdang, Siriwadee Chomdej, Kittisak Buddhachat. In vitro chondroprotective potential of Senna alata and Senna tora in porcine cartilage explants and their species differentiation by DNA barcoding-high resolution melting (Bar-HRM) analysis. PloS one. 2019; 14(4):e0215664. doi: 10.1371/journal.pone.0215664. [PMID: 31002692]
  • L Carneiro-Leão, L Amaral, D Silva, B Bartolomé, M Miranda. Exploring a rare case of occupational senna allergy. Occupational medicine (Oxford, England). 2018 Dec; 68(9):641-643. doi: 10.1093/occmed/kqy159. [PMID: 30496499]
  • Yixin Cao, Ying He, Cong Wei, Jing Li, Lejing Qu, Huiqin Zhang, Ying Cheng, Boling Qiao. Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats. International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103210. [PMID: 30336596]
  • Kira-Isabel Zier, Wulf Schultze, Claudia S Leopold. Factors influencing the properties and the stability of spray-dried Sennae fructus extracts. Drug development and industrial pharmacy. 2018 Oct; 44(10):1659-1667. doi: 10.1080/03639045.2018.1483397. [PMID: 29954227]
  • Jiawei Tan, Mengcheng Zheng, Susu Duan, Yanling Zeng, Ziwei Zhang, Qingyu Cui, Jiamei Zhang, Tingting Hong, Jie Bai, Shouying Du. Chemical Profiling and Screening of the Marker Components in the Fruit of Cassia fistula by HPLC and UHPLC/LTQ-Orbitrap MSn with Chemometrics. Molecules (Basel, Switzerland). 2018 06; 23(7):. doi: 10.3390/molecules23071501. [PMID: 29933591]
  • Jiamei Le, Weiping Jia, Yongning Sun. Sennoside A protects mitochondrial structure and function to improve high-fat diet-induced hepatic steatosis by targeting VDAC1. Biochemical and biophysical research communications. 2018 06; 500(2):484-489. doi: 10.1016/j.bbrc.2018.04.108. [PMID: 29673597]
  • Marwa Magdy Saad Abbass, Dalia Abdel-Hameed El-Baz. The effect of daily intake of green coffee bean extract as compared to Agiolax® on the alveolar bone of albino rats. Dental and medical problems. 2018 Apr; 55(2):125-131. doi: 10.17219/dmp/90983. [PMID: 30152614]
  • Alejandra Vilanova-Sanchez, Alessandra C Gasior, Nicole Toocheck, Laura Weaver, Richard J Wood, Carlos A Reck, Andrea Wagner, Erin Hoover, Renae Gagnon, Jordon Jaggers, Tassiana Maloof, Onnalisa Nash, Charae Williams, Marc A Levitt. Are Senna based laxatives safe when used as long term treatment for constipation in children?. Journal of pediatric surgery. 2018 Apr; 53(4):722-727. doi: 10.1016/j.jpedsurg.2018.01.002. [PMID: 29429768]
  • Zhiqi Yin, Lidan Sun, Qiaomei Jin, Shaoli Song, Yuanbo Feng, Hong Liao, Yicheng Ni, Jian Zhang, Wei Liu. Excretion and toxicity evaluation of 131I-Sennoside A as a necrosis-avid agent. Xenobiotica; the fate of foreign compounds in biological systems. 2017 Nov; 47(11):980-988. doi: 10.1080/00498254.2016.1258740. [PMID: 27830982]
  • Yue Zhang, Jiaojiao Li, Xiuying Wen. Jueming prescription and its ingredients, semen cassiae and Rhizoma Curcumae Longae, stimulate lipolysis and enhance the phosphorylation of hormone‑sensitive lipase in cultured rat white adipose tissue. Molecular medicine reports. 2017 Nov; 16(5):6200-6207. doi: 10.3892/mmr.2017.7317. [PMID: 28849212]
  • Tushar Dhanani, Raghuraj Singh, Nagaraja Reddy, A Trivedi, Satyanshu Kumar. Comparison on extraction yield of sennoside A and sennoside B from senna (Cassia angustifolia) using conventional and non conventional extraction techniques and their quantification using a validated HPLC-PDA detection method. Natural product research. 2017 May; 31(9):1097-1101. doi: 10.1080/14786419.2016.1258562. [PMID: 27855501]
  • Ling Li, Dongjian Zhang, Shengwei Yang, Shaoli Song, Jindian Li, Qin Wang, Cong Wang, Yuanbo Feng, Yicheng Ni, Jian Zhang, Wei Liu, Zhiqi Yin. Effects of Glycosylation on Biodistribution and Imaging Quality of Necrotic Myocardium of Iodine-131-Labeled Sennidins. Molecular imaging and biology. 2016 12; 18(6):877-886. doi: 10.1007/s11307-016-0961-x. [PMID: 27172937]
  • Francesca Esposito, Ilaria Carli, Claudia Del Vecchio, Lijia Xu, Angela Corona, Nicole Grandi, Dario Piano, Elias Maccioni, Simona Distinto, Cristina Parolin, Enzo Tramontano. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Nov; 23(12):1383-1391. doi: 10.1016/j.phymed.2016.08.001. [PMID: 27765358]
  • Saptarshi Roy, Suman Kundu, Larisha M Lyndem. Senna leaf extracts induced Ca(+2) homeostasis in a zoonotic tapeworm Hymenolepis diminuta. Pharmaceutical biology. 2016 Oct; 54(10):2353-7. doi: 10.3109/13880209.2016.1139600. [PMID: 26878612]
  • Vandana Tripathy, Ajoy Saha, Dilipkumar J Patel, B B Basak, Paresh G Shah, Jitendra Kumar. Validation of a QuEChERS-based gas chromatographic method for analysis of pesticide residues in Cassia angustifolia (senna). Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2016 Aug; 51(8):508-18. doi: 10.1080/03601234.2016.1170544. [PMID: 27153296]
  • Yu-Zhi Jin, Yue Yu, Lu Fu, Yan-Dong Ma. [Preliminary study of history of senna be used in China--On phenomenon about 'reign medicine localized']. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Jun; 41(12):2371-2375. doi: 10.4268/cjcmm20161232. [PMID: 28901087]
  • Makoto Arai, Yoshinobu Nakada, Kagemasa Kajiwara, Minoru Kimura, Naoaki Ishii. Preparation of Clinically Useful Sennoside-reduced Rhubarb. The Tokai journal of experimental and clinical medicine. 2016 Mar; 41(1):24-9. doi: NULL. [PMID: 27050892]
  • Kento Takayama, Norihiko Tabuchi, Masahito Fukunaga, Nobuyuki Okamura. Rhein 8-O-β-D-Glucopyranoside Elicited the Purgative Action of Daiokanzoto (Da-Huang-Gan-Cao-Tang), Despite Dysbiosis by Ampicillin. Biological & pharmaceutical bulletin. 2016; 39(3):378-83. doi: 10.1248/bpb.b15-00815. [PMID: 26934929]
  • Jeruto P, Arama P F, Anyango B, Akenga T, Nyunja R, Khasabuli D. IN VITRO ANTIFUNGAL ACTIVITY OF METHANOLIC EXTRACTS OF DIFFERENT Senna didymobotrya (FRESEN.) H.S. IRWIN & BARNEBY PLANT PARTS. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2016; 13(6):168-174. doi: 10.21010/ajtcam.v13i6.24. [PMID: 28480375]
  • Yeomoon Sim, Hyein Oh, Dal-Seok Oh, Namkwon Kim, Pil Sung Gu, Jin Gyu Choi, Hyo Geun Kim, Tong Ho Kang, Myung Sook Oh. An experimental study on providing a scientific evidence for seven-time alcohol-steaming of Rhei Rhizoma when clinically used. BMC complementary and alternative medicine. 2015 Oct; 15(?):388. doi: 10.1186/s12906-015-0922-y. [PMID: 26506837]
  • Sait Byul Park, Yeong Shik Kim. Simultaneous separation of three isomeric sennosides from senna leaf (Cassia acutifolia) using counter-current chromatography. Journal of separation science. 2015 Oct; 38(20):3502-7. doi: 10.1002/jssc.201500672. [PMID: 26255810]
  • Dongjian Zhang, Dejian Huang, Yun Ji, Cuihua Jiang, Yue Li, Meng Gao, Nan Yao, Xuejiao Liu, Haibo Shao, Su Jing, Yicheng Ni, Zhiqi Yin, Jian Zhang. Experimental evaluation of radioiodinated sennoside B as a necrosis-avid tracer agent. Journal of drug targeting. 2015 Feb; 23(2):180-90. doi: 10.3109/1061186x.2014.971328. [PMID: 25330022]
  • Nagaraja Reddy Rama Reddy, Rucha Harishbhai Mehta, Palak Harendrabhai Soni, Jayanti Makasana, Narendra Athamaram Gajbhiye, Manivel Ponnuchamy, Jitendra Kumar. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PloS one. 2015; 10(6):e0129422. doi: 10.1371/journal.pone.0129422. [PMID: 26098898]
  • F L Brighenti, M J Salvador, Alberto Carlos Botazzo Delbem, Ádina Cleia Bottazzo Delbem, M A C Oliveira, C P Soares, L S F Freitas, C Y Koga-Ito. Systematic screening of plant extracts from the Brazilian Pantanal with antimicrobial activity against bacteria with cariogenic relevance. Caries research. 2014; 48(5):353-60. doi: 10.1159/000357225. [PMID: 24603299]
  • Immanuel Rosenthal, Evelyn Wolfram, Beat Meier. An HPLC method to determine sennoside A and sennoside B in Sennae fructus and Sennae folium. Pharmeuropa bio & scientific notes. 2014; 2014(?):92-102. doi: . [PMID: 25655246]
  • Osamu Norisugi, Yoko Yoshihisa, Kyoko Shimizu, Tadamichi Shimizu. In vitro cytokine expression by peripheral mononuclear cells in herbal drug-induced skin eruption. Acta dermato-venereologica. 2014 Jan; 94(1):58-62. doi: 10.2340/00015555-1631. [PMID: 23817527]
  • Linda L D Zhong, Chung Wah Cheng, Yawen Chan, King Hong Chan, Ting Wa Lam, Xiao Rui Chen, Chi Tak Wong, Justin C Y Wu, Zhao Xiang Bian. Chinese herbal medicine (Ma Zi Ren Wan) for functional constipation: study protocol for a prospective, double-blinded, double-dummy, randomized controlled trial. Trials. 2013 Nov; 14(?):366. doi: 10.1186/1745-6215-14-366. [PMID: 24180235]
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