(+)-Sesamin (BioDeep_00000002674)

 

Secondary id: BioDeep_00000171568, BioDeep_00000230030, BioDeep_00000231021

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


1,3-BENZODIOXOLE, 5,5-(TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS-, (1S-(1.ALPHA.,3A .ALPHA.,4.ALPHA.,6A .ALPHA.))-

化学式: C20H18O6 (354.1103)
中文名称: 芝麻素
谱图信息: 最多检出来源 Viridiplantae(plant) 18.16%

分子结构信息

SMILES: C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6
InChI: InChI=1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2

描述信息

(+)-Sesamin, also known as fagarol or sezamin, belongs to the class of organic compounds known as furanoid lignans. These are lignans with a structure that contains either a tetrahydrofuran ring, a furan ring, or a furofuan ring system, that arises from the joining of the two phenylpropanoid units. (+)-Sesamin is an extremely weak basic (essentially neutral) compound (based on its pKa). (+)-Sesamin is found, on average, in the highest concentration within sesames. (+)-Sesamin has also been detected, but not quantified in, several different foods, such as fats and oils, flaxseeds, ginkgo nuts, and ucuhuba. This could make (+)-sesamin a potential biomarker for the consumption of these foods.
(+)-sesamin is a lignan that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR stereoisomer). Isolated from Cinnamomum camphora, it exhibits cytotoxic activity. It has a role as an antineoplastic agent, a neuroprotective agent and a plant metabolite. It is a lignan, a member of benzodioxoles and a furofuran.
Sesamin is a natural product found in Pandanus boninensis, Podolepis rugata, and other organisms with data available.
See also: Sesame Oil (part of).
A lignan that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR stereoisomer). Isolated from Cinnamomum camphora, it exhibits cytotoxic activity.
Constituent of sesame oil. (+)-Sesamin is found in many foods, some of which are ginkgo nuts, sesame, flaxseed, and fats and oils.
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D020011 - Protective Agents > D000975 - Antioxidants
D009676 - Noxae > D000963 - Antimetabolites
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].

同义名列表

64 个代谢物同义名

1,3-BENZODIOXOLE, 5,5-(TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS-, (1S-(1.ALPHA.,3A .ALPHA.,4.ALPHA.,6A .ALPHA.))-; 1,3-BENZODIOXOLE, 5,5-(TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS-, (1.ALPHA.,3A.ALPHA.,4.ALPHA.,6A.ALPHA.)-(+/-)-; 1,3-BENZODIOXOLE, 5,5-(TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS-, (1.ALPHA.,3A.ALPHA.,4.ALPHA.,6A.ALPHA.)-; 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis-, (1S-(1alpha,3a alpha,4alpha,6a alpha))-; 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3h-furo(3,4-c)furan-1,4-diyl)bis-, (1alpha,3aalpha,4alpha,6aalpha)-(+/-)-; 5-[(3S,3aR,6S,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole; 5-[(3S,3aR,6S,6aR)-6-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole; 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3h-furo(3,4-c)furan-1,4-diyl)bis-, (1alpha,3aalpha,4alpha,6aalpha)-; 5-[(1S,3aR,4S,6aR)-4-(2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-1-yl]-2H-1,3-benzodioxole; 1,3-Benzodioxole, 5,5-((1R,3as,4R,6as)-tetrahydro-1H,3h-furo(3,4-c)furan-1,4-diyl)bis-, rel-; 1H,3H-Furo(3,4-c)furan, tetrahydro-1,4-bis(3,4-(methylenedioxy)phenyl)-, (1S,3aR,4S,6aR)-; 1,3-Benzodioxole, 5,5-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, (1S,3aR,4S,6aR)-; 5,5-(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole); 5,5-(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diylbis(1,3-benzodioxole); 5,5-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxol); (1S,3aR,4S,6aR)-1,4-bis(benzo[d][1,3]dioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan; (1S,3aR,4S,6aR)-1,4-Bis(benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan; (1S,3aR,4S,6aR)-1,4-di(benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan; TETRAHYDRO-1,4-BIS(3,4-(METHYLENEDIOXY)PHENYL)-1H,3H-FURO(3,4-C)FURAN; Tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-1H,3H-furo[3,4-c]furan; 5,5-(TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS-1,3-BENZODIOXOLE; sesamin, (1R-(1alpha,3aalpha,4alpha,6aalpha))-isomer; sesamin, (1R-(1alpha,3aalpha,4beta,6aalpha))-isomer; dioxol-5-yl)hexahydrofuro[3,4-c]furan; (1S,3aR,4S,6aR)-1,4-di(benzo[d][1,3]; Sesamin, >=95\\%, crystalline; Sesamin, analytical standard; REL-(7S,7S,8R,8R)-SESAMIN; Rel-(7S,7S8R,8R)-Sesamin; Sesamin, >=98\\% (HPLC); Sesamin dl-form [MI]; SESAMIN D-FORM [MI]; Sesamin (Fagarol); SESAMIN [WHO-DD]; UNII-FY3S29JVC9; Sesamin, (+/-)-; PSEUDO CUBEBIN; SESAMIN D-FORM; Sesamin, (+)-; D-(+)-Sesamin; pseudocubebin; (+/-)-Sesamin; delta-Sesamin; ACon0_000323; ACon1_002421; SESAMIN [MI]; Sesamin,(S); epi-sesamin; (+)-Segamin; (+)-Sesamin; FY3S29JVC9; episesamin; d-Sesamin; AI3-00811; δ-Sesamin; l-sesamin; asarinin; Fsesamin; sesamin; Fagarol; Sezamin; [1S-(1α,3aα,4α,6aα)]-5,5-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole; (-)-Asarinin; Sesamin



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

92 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(90)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

194 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 ANG, BCL2, CASP3, CAT, CCND1, CYP2E1, MAPK8, NFE2L2, NOS2, NOS3, PIK3CA, RELA, SIRT1, TH, TP53, VEGFA
Peripheral membrane protein 1 CYP2E1
Endoplasmic reticulum membrane 3 BCL2, CYP2E1, HMOX1
Nucleus 14 ANG, BCL2, CASP3, CCND1, HMOX1, MAPK8, NFE2L2, NOS2, NOS3, RELA, SIRT1, TH, TP53, VEGFA
cytosol 16 ANG, BCL2, CASP3, CAT, CCND1, GPT, HMOX1, MAPK8, NFE2L2, NOS2, NOS3, PIK3CA, RELA, SIRT1, TH, TP53
dendrite 1 TH
centrosome 3 CCND1, NFE2L2, TP53
nucleoplasm 10 CASP3, CCND1, HMOX1, MAPK8, NFE2L2, NOS2, NOS3, RELA, SIRT1, TP53
RNA polymerase II transcription regulator complex 1 NFE2L2
Cytoplasmic side 1 HMOX1
lamellipodium 1 PIK3CA
Cell projection, axon 1 TH
Synapse 1 MAPK8
cell surface 1 VEGFA
glutamatergic synapse 2 CASP3, RELA
Golgi apparatus 3 NFE2L2, NOS3, VEGFA
Golgi membrane 2 INS, NOS3
growth cone 1 ANG
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 2 ANG, CASP3
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Cytoplasm, cytosol 2 NFE2L2, NOS2
plasma membrane 4 NFE2L2, NOS2, NOS3, PIK3CA
terminal bouton 1 TH
Membrane 5 BCL2, CAT, HMOX1, TP53, VEGFA
axon 2 MAPK8, TH
caveola 1 NOS3
extracellular exosome 2 CAT, GPT
endoplasmic reticulum 4 BCL2, HMOX1, TP53, VEGFA
extracellular space 5 ANG, HMOX1, IL6, INS, VEGFA
perinuclear region of cytoplasm 5 HMOX1, NOS2, NOS3, PIK3CA, TH
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CAT, SIRT1, TH, TP53
protein-containing complex 3 BCL2, CAT, TP53
intracellular membrane-bounded organelle 2 CAT, CYP2E1
Microsome membrane 1 CYP2E1
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Secreted 4 ANG, IL6, INS, VEGFA
extracellular region 5 ANG, CAT, IL6, INS, VEGFA
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 2 RELA, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
perikaryon 1 TH
cytoplasmic vesicle 1 TH
nucleolus 3 ANG, SIRT1, TP53
Melanosome membrane 1 TH
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Cytoplasm, perinuclear region 2 NOS2, TH
Mitochondrion inner membrane 1 CYP2E1
heterochromatin 1 SIRT1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
extracellular matrix 1 VEGFA
Peroxisome 2 CAT, NOS2
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 2 SIRT1, TP53
PML body 2 SIRT1, TP53
secretory granule 1 VEGFA
nuclear inner membrane 1 SIRT1
neuron projection 1 TH
chromatin 4 NFE2L2, RELA, SIRT1, TP53
mediator complex 1 NFE2L2
Chromosome 1 ANG
cytoskeleton 1 NOS3
Nucleus, nucleolus 1 ANG
site of double-strand break 1 TP53
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
endosome lumen 1 INS
Cytoplasm, Stress granule 2 ANG, NOS3
cytoplasmic stress granule 2 ANG, NOS3
euchromatin 1 SIRT1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 NOS3
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Ya-Ping Bai, Teng Zhang, Zheng-Yan Hu, Yan Zhang, De-Guo Wang, Meng-Yun Zhou, Ying Zhang, Fang Zhang, Xiang Kong. Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo. Biochemical pharmacology. 2024 Jun; 224(?):116240. doi: 10.1016/j.bcp.2024.116240. [PMID: 38679210]
  • Mengyun Dong, Tianliang Zhang, Xueli Liang, Xinyi Cheng, Fuyan Shi, Hang Yuan, Fengxiang Zhang, Qiqi Jiang, Xia Wang. Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells. Biochemical and biophysical research communications. 2024 May; 708(?):149815. doi: 10.1016/j.bbrc.2024.149815. [PMID: 38531220]
  • Maoyuan Zhao, Yueqiang Wen, Yi Yang, Huafeng Pan, Shunkai Xie, Caifei Shen, Wenhao Liao, Nianzhi Chen, Qiao Zheng, Gang Zhang, Yuchen Li, Daoyin Gong, Jianyuan Tang, Ziyi Zhao, Jinhao Zeng. (-)-Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155348. doi: 10.1016/j.phymed.2024.155348. [PMID: 38335913]
  • Baining Zhang, Zhiwei He, Jialin Guo, Feng Li, Zhi Huang, Wenkai Zheng, Wenhua Xing, Manglai Li, Yong Zhu, Xuejun Yang. Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation. Aging. 2024 Jan; 16(2):1145-1160. doi: 10.18632/aging.205386. [PMID: 38284902]
  • Shahab Ghaderi, Masome Rashno, Alireza Sarkaki, Seyed Esmaeil Khoshnam. Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress. Brain research bulletin. 2024 Jan; 206(?):110852. doi: 10.1016/j.brainresbull.2023.110852. [PMID: 38141790]
  • Nelma Nyvonne Tiqu Gina, Jui-Ling Kuo, Mei-Li Wu, Show-Mei Chuang. Sesamin and sesamolin potentially inhibit adipogenesis through downregulating the peroxisome proliferator-activated receptor γ protein expression and activity in 3T3-L1 cells. Nutrition research (New York, N.Y.). 2023 Dec; 123(?):4-17. doi: 10.1016/j.nutres.2023.12.011. [PMID: 38228077]
  • Shu-Ming Huang, Cheng-Hung Chuang, Christine Joyce F Rejano, Lemmuel L Tayo, Cheng-Yang Hsieh, Steven Kuan-Hua Huang, Po-Wei Tsai. Sesamin: A Promising Therapeutic Agent for Ameliorating Symptoms of Diabetes. Molecules (Basel, Switzerland). 2023 Oct; 28(21):. doi: 10.3390/molecules28217255. [PMID: 37959677]
  • Qian Zeng, Ting-Ting Zhou, Wen-Jie Huang, Xiao-Ting Huang, Lei Huang, Xiao-Hua Zhang, Xiao-Xue Sang, Yu-Yang Luo, Yu-Mei Tian, Bin Wu, Lin Liu, Zi-Qiang Luo, Bin He, Wei Liu, Si-Yuan Tang. Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ. Scientific reports. 2023 09; 13(1):14706. doi: 10.1038/s41598-023-41933-5. [PMID: 37679587]
  • Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Chul Yung Choi, Gil-Saeng Jeong, Sang Ki Lee, Hyung Sik Kim, Hye Gwang Jeong. Sesamin ameliorates lipotoxicity and lipid accumulation through the activation of the estrogen receptor alpha signaling pathway. Biochemical pharmacology. 2023 Aug; 216(?):115768. doi: 10.1016/j.bcp.2023.115768. [PMID: 37652106]
  • Elham Ramazani, Faeze Ebrahimpour, Seyed Ahmad Emami, Abolfazl Shakeri, Behjat Javadi, Amirhossein Sahebkar, Zahra Tayarani-Najaran. Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells. Recent advances in food, nutrition & agriculture. 2023 Aug; ?(?):. doi: 10.2174/2772574x14666230804151124. [PMID: 37539928]
  • Zhao-Jie Wang, Yi-Chi Chen, Feng-Cai Zou, Yan Qin, Yan-Yan Zhu, Xia Xiao, Tian-Zhen Xie, Ying-Jie He, Yun-Li Zhao, Xiao-Dong Luo. Phytochemical Analysis and Anti-Ascaris suum Activity of Different Zanthoxylum Species In Vitro and In Vivo. Journal of agricultural and food chemistry. 2023 Apr; 71(13):5219-5229. doi: 10.1021/acs.jafc.2c08949. [PMID: 36971186]
  • Chao Liang, Chi Ndi, Louise Kjaerulff, Susan Semple, Bevan Buirchell, Sonia Coriani, Birger Lindberg Møller, Dan Staerk. Characterization of Serrulatane Diterpenoids in Eremophila phyllopoda subsp. phyllopoda by Triple High-Resolution α-Glucosidase/PTP1B/Radical Scavenging Profiling, NMR Spectroscopy, DFT-GIAO NMR, and Electronic Circular Dichroism Calculations. Journal of natural products. 2023 Mar; ?(?):. doi: 10.1021/acs.jnatprod.2c00692. [PMID: 36880726]
  • Hui Du, Shiwen Tong, Ge Kuang, Xia Gong, Ningman Jiang, Xian Yang, Hao Liu, Nana Li, Yao Xie, Yang Xiang, Jiashi Guo, Zhenhan Li, Yinglin Yuan, Shengwang Wu, Jingyuan Wan. Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice. Journal of immunology research. 2023; 2023(?):1116841. doi: 10.1155/2023/1116841. [PMID: 37663051]
  • Satoshi Morita, Hideyuki Sasaki, Yoshihisa Kaneda, Tomohiro Rogi, Takayuki Izumo, Masaaki Nakai. Effects of Combining Docosahexaenoic Acid and Eicosapentaenoic Acid with Sesame Lignan on Vascular Endothelial Function. Journal of nutritional science and vitaminology. 2023; 69(5):370-376. doi: 10.3177/jnsv.69.370. [PMID: 37940577]
  • Jun Yamada, Shoichiro Maeda, Mariko Soya, Hidefumi Nishida, Kyoko M Iinuma, Shozo Jinno. Alleviation of cognitive deficits via upregulation of chondroitin sulfate biosynthesis by lignan sesamin in a mouse model of neuroinflammation. The Journal of nutritional biochemistry. 2022 10; 108(?):109093. doi: 10.1016/j.jnutbio.2022.109093. [PMID: 35724814]
  • Longkai Shi, Emad Karrar, Ruijie Liu, Ming Chang, Xingguo Wang. Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells. Journal of food biochemistry. 2022 08; 46(8):e14180. doi: 10.1111/jfbc.14180. [PMID: 35396857]
  • Qiaoyun Bai, Zhiguang Wang, Yihua Piao, Xiao Zhou, Qinji Piao, Jingzhi Jiang, Hanye Liu, Hongmei Piao, Liangchang Li, Yilan Song, Guanghai Yan. Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis. Journal of agricultural and food chemistry. 2022 Apr; 70(16):4921-4933. doi: 10.1021/acs.jafc.1c07877. [PMID: 35420033]
  • Daiki Oikawa, Satoshi Yamashita, Seiji Takahashi, Toshiyuki Waki, Koichi Kikuchi, Takaaki Abe, Takane Katayama, Toru Nakayama. (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis. Biochemical and biophysical research communications. 2022 01; 590(?):158-162. doi: 10.1016/j.bbrc.2021.12.088. [PMID: 34974305]
  • Sayeh Mottaghi, Hassan Abbaszadeh. A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives. Critical reviews in food science and nutrition. 2022; 62(26):7301-7318. doi: 10.1080/10408398.2021.1913568. [PMID: 33905270]
  • Yiting Sun, Jingyi Ren, Siqi Zhu, Zhenao Zhang, Zihao Guo, Jiaqi An, Bowen Yin, Yuxia Ma. The Effects of Sesamin Supplementation on Obesity, Blood Pressure, and Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in endocrinology. 2022; 13(?):842152. doi: 10.3389/fendo.2022.842152. [PMID: 35311241]
  • Haiping He, Tonghua Yang, Fan Li, Lihua Zhang, Xiaosui Ling. A novel study on the immunomodulatory effect of umbilical cord derived mesenchymal stem cells pretreated with traditional Chinese medicine Asarinin. International immunopharmacology. 2021 Nov; 100(?):108054. doi: 10.1016/j.intimp.2021.108054. [PMID: 34492537]
  • Chen Chen, Xinwei Shi, Tao Zhou, Weimin Li, Sifeng Li, Guoqing Bai. Full-length transcriptome analysis and identification of genes involved in asarinin and aristolochic acid biosynthesis in medicinal plant Asarum sieboldii. Genome. 2021 Jun; 64(6):639-653. doi: 10.1139/gen-2020-0095. [PMID: 33320770]
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