Daunorubicin (BioDeep_00000002594)

 

Secondary id: BioDeep_00000398422

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(8S,10S)-8-acetyl-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione

化学式: C27H29NO10 (527.1791374000001)
中文名称: 柔红霉素
谱图信息: 最多检出来源 Macaca mulatta(otcml) 3.18%

分子结构信息

SMILES: CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O
InChI: InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3

描述信息

Daunorubicin is only found in individuals that have used or taken this drug. It is a very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. [PubChem]Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances > L01DB - Anthracyclines and related substances
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D004791 - Enzyme Inhibitors
KEIO_ID D106

同义名列表

22 个代谢物同义名

(8S,10S)-8-acetyl-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; Daunorubicin mixt. with native calf thymus DNA; Hydrochloride, Daunorubicin; Daunorubicin Hydrochloride; Dauno Rubidomycine; Dauno-Rubidomycine; Acetyladriamycin; Leukaemomycin C; (+)-Daunomycin; Daunorubicinum; Daunoblastine; Daunorubicin; Daunoblastin; Rubidomycin; Daunomycin; Cerubidine; Rubomycin; DaunoXome; DM



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ioannis Isaioglou, Gloria Lopez-Madrigal, Jasmeen S Merzaban. A fast, easy, cost-free method to remove excess dye or drug from small extracellular vesicle solution. PloS one. 2024; 19(5):e0301761. doi: 10.1371/journal.pone.0301761. [PMID: 38718025]
  • Qi Liu, Lijun Luo, Xiaofeng Gao, Di Zhang, Xinqian Feng, Peng Yang, Hui Li, Shengjun Mao. Co-Delivery of Daunorubicin and Homoharringtonine in Folic Acid Modified-Liposomes for Enhancing Therapeutic Effect on Acute Myeloid Leukemia. Journal of pharmaceutical sciences. 2023 01; 112(1):123-131. doi: 10.1016/j.xphs.2022.04.014. [PMID: 35469834]
  • Yuanyuan Zhu, Wei Zhang, Jing Chen. Binary Nanodrug-Delivery System Designed for Leukemia Therapy: Aptamer- and Transferrin-Codecorated Daunorubicin- and Luteolin-Coloaded Nanoparticles. Drug design, development and therapy. 2023; 17(?):1-13. doi: 10.2147/dddt.s387246. [PMID: 36636745]
  • Angelina Subeska, Jan Althaus, Theresa Hake, Walburga Hanekamp, Dominik Bettenworth, Dennis Mulac, Klaus Langer, Matthias Lehr. Synthesis and pharmacokinetic properties of novel cPLA2α inhibitors with 1-(carboxyalkylpyrrolyl)-3-aryloxypropan-2-one structure. Bioorganic & medicinal chemistry. 2023 01; 77(?):117110. doi: 10.1016/j.bmc.2022.117110. [PMID: 36495814]
  • Hamad Alrbyawi, Sai H S Boddu, Ishwor Poudel, Manjusha Annaji, Nur Mita, Robert D Arnold, Amit K Tiwari, R Jayachandra Babu. Cardiolipin for Enhanced Cellular Uptake and Cytotoxicity of Thermosensitive Liposome-Encapsulated Daunorubicin toward Breast Cancer Cell Lines. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911763. [PMID: 36233061]
  • Emmanuel Gyan, Arnaud Pigneux, Mathilde Hunault, Pierre Peterlin, Martin Carré, Jacques-Olivier Bay, Caroline Bonmati, Maria-Pilar Gallego-Hernanz, Bruno Lioure, Philippe Bertrand, Nicolas Vallet, David Ternant, François Darrouzain, Frédéric Picou, Marie-Christine Béné, Christian Récher, Olivier Hérault. Adjunction of a fish oil emulsion to cytarabine and daunorubicin induction chemotherapy in high-risk AML. Scientific reports. 2022 06; 12(1):9748. doi: 10.1038/s41598-022-13626-y. [PMID: 35697729]
  • Sha Li, Shi Zeng, Bo-Ping Wei, Qiang Wu, Chang Liu, Pei-Ying Song. Determination of free and encapsulated cytarabine and daunorubicin in rat plasma after intravenous administration of liposomal formulation using ultra-high performance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jun; 1200(?):123275. doi: 10.1016/j.jchromb.2022.123275. [PMID: 35551041]
  • Riya Sinha, Arunavo Chatterjee, Pradipta Purkayastha. Graphene Quantum Dot Assisted Translocation of Daunomycin through an Ordered Lipid Membrane: A Study by Fluorescence Lifetime Imaging Microscopy and Resonance Energy Transfer. The journal of physical chemistry. B. 2022 02; 126(6):1232-1241. doi: 10.1021/acs.jpcb.1c09376. [PMID: 35129981]
  • Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba. Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up. Clinical science (London, England : 1979). 2022 01; 136(1):139-161. doi: 10.1042/cs20210836. [PMID: 34878093]
  • Claire Amaris Hobson, Lucile Vigué, Mélanie Magnan, Benoit Chassaing, Sabrine Naimi, Benoit Gachet, Pauline Claraz, Thomas Storme, Stephane Bonacorsi, Olivier Tenaillon, André Birgy. A Microbiota-Dependent Response to Anticancer Treatment in an In Vitro Human Microbiota Model: A Pilot Study With Hydroxycarbamide and Daunorubicin. Frontiers in cellular and infection microbiology. 2022; 12(?):886447. doi: 10.3389/fcimb.2022.886447. [PMID: 35719352]
  • Mélanie Donnette, Mourad Hamimed, Joseph Ciccolini, Yael Berda-Haddad, Elise Kaspi, Geoffroy Venton, Bruno Lacarelle, Regis Costello, L''Houcine Ouafik, Laure Farnault, Raphaelle Fanciullino. Pharmacokinetics and pharmacogenetics of liposomal cytarabine in AML patients treated with CPX-351. Journal of controlled release : official journal of the Controlled Release Society. 2021 10; 338(?):244-252. doi: 10.1016/j.jconrel.2021.08.023. [PMID: 34416320]
  • Danyang Wu, Xiaoxuan Lu, Xiaojing Yan, Ran Gao. Case report: Rare myeloid sarcoma development following renal transplantation with KRAS and DNMT3A gene mutations. Diagnostic pathology. 2021 Aug; 16(1):82. doi: 10.1186/s13000-021-01141-z. [PMID: 34465355]
  • Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba. Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo. Clinical science (London, England : 1979). 2021 08; 135(15):1897-1914. doi: 10.1042/cs20210311. [PMID: 34318878]
  • Satya Prakash Yadav, Teena Wadhwa, Dhwanee Thakkar, Rohit Kapoor, Neha Rastogi, Smita Sarma. COVID-19 reinfection in two children with cancer. Pediatric hematology and oncology. 2021 05; 38(4):403-405. doi: 10.1080/08880018.2020.1855276. [PMID: 33625290]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Annette Demmer, Hubert Thole, Manfred Raida, Burkhard Tümmler. Lysine 268 adjacent to transmembrane helix 5 of hamster P-glycoprotein is the major photobinding site of iodomycin in CHO B30 cells. FEBS open bio. 2021 04; 11(4):1084-1092. doi: 10.1002/2211-5463.13112. [PMID: 33565718]
  • W-Y Chen, Z-X Fang, X-D Lv, Q-H Zhou, M Yao, M Deng. Prediction of potential therapeutic drugs against SARS-CoV-2 by using Connectivity Map based on transcriptome data. European review for medical and pharmacological sciences. 2021 04; 25(7):3122-3131. doi: 10.26355/eurrev_202104_25567. [PMID: 33877681]
  • Kumuda C Das, Harish Muniyappa, Venkatesh Kundumani-Sridharan, Jaganathan Subramani. Thioredoxin Decreases Anthracycline Cardiotoxicity, But Sensitizes Cancer Cell Apoptosis. Cardiovascular toxicology. 2021 02; 21(2):142-151. doi: 10.1007/s12012-020-09605-2. [PMID: 32880787]
  • Olga Maliszewska, Natalia Treder, IIona Olędzka, Piotr Kowalski, Natalia Miękus, Tomasz Bączek, Wojciech Rodzaj, Ewa Bień, Małgorzata Anna Krawczyk, Alina Plenis. Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: An Application in Drug Monitoring. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245799. [PMID: 33316898]
  • Milena Locci de Oliveira, Adriana Rocha, Glauco Henrique Balthazar Nardotto, Leandro Francisco Pippa, Belinda Pinto Simões, Vera Lucia Lanchote. Analysis of daunorubicin and its metabolite daunorubicinol in plasma and urine with application in the evaluation of total, renal and metabolic formation clearances in patients with acute myeloid leukemia. Journal of pharmaceutical and biomedical analysis. 2020 Nov; 191(?):113576. doi: 10.1016/j.jpba.2020.113576. [PMID: 32889347]
  • Jiaoyang Zhang, Lingli Zhou, Yu Zhang, Haibing He, Tian Yin, Jingxin Gou, Yanjiao Wang, Xing Tang. Contrastive Studies of Cytarabine/Daunorubicin Dual-Loaded Liposomes Prepared by pH Gradient and Cu2+ Gradient Method. AAPS PharmSciTech. 2020 Nov; 21(8):325. doi: 10.1208/s12249-020-01867-x. [PMID: 33206247]
  • Qi Wang, Paul Tardi, Nicole Sadowski, Sherwin Xie, Dennis Heller, Lawrence Mayer. Pharmacokinetics, drug metabolism, and tissue distribution of CPX-351 in animals. Nanomedicine : nanotechnology, biology, and medicine. 2020 11; 30(?):102275. doi: 10.1016/j.nano.2020.102275. [PMID: 32750494]
  • Huan Zhou, Li-Xiang Fu, Li Li, Yan-Yan Chen, Hong-Qing Zhu, Jin-Ling Zhou, Mei-Xian Lv, Ri-Zhi Gan, Xuan-Xuan Zhang, Gang Liang. The epigallocatechin gallate derivative Y6 reduces the cardiotoxicity and enhances the efficacy of daunorubicin against human hepatocellular carcinoma by inhibiting carbonyl reductase 1 expression. Journal of ethnopharmacology. 2020 Oct; 261(?):113118. doi: 10.1016/j.jep.2020.113118. [PMID: 32621953]
  • Lia Phillips, Jovana Pavisic, Dominder Kaur, N Valerio Dorrello, Larisa Broglie, Nobuko Hijiya. Successful management of SARS-CoV-2 acute respiratory distress syndrome and newly diagnosed acute lymphoblastic leukemia. Blood advances. 2020 09; 4(18):4358-4361. doi: 10.1182/bloodadvances.2020002745. [PMID: 32926122]
  • Fereidoon Rahmani, Mohammad-Reza Milani Hosseini, Ali Es-Haghi, Afsaneh Mollahosseini. A 96-Monolithic inorganic hollow fiber array as a new geometry for high throughput solid-phase microextraction of doxorubicin in water and human urine samples coupled with liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2020 Sep; 1627(?):461413. doi: 10.1016/j.chroma.2020.461413. [PMID: 32823111]
  • Qiu-Jin Yang, Jie Zheng, Fu-Tao Dang, Yue-Meng Wan, Jing Yang. Acute pancreatitis induced by combination chemotherapy used for the treatment of acute myeloid leukemia: A case report. Medicine. 2020 Aug; 99(35):e21848. doi: 10.1097/md.0000000000021848. [PMID: 32871908]
  • Wencheng Xu, Xiaoqin Wang, Shuhe Chen, Hongguang Wu, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Tetrandrine enhances glucocorticoid receptor translocation possibly via inhibition of P-glycoprotein in daunorubicin-resistant human T lymphoblastoid leukemia cells. European journal of pharmacology. 2020 Aug; 881(?):173232. doi: 10.1016/j.ejphar.2020.173232. [PMID: 32525004]
  • Qingwei Nong, Cong Zhang, Qinghao Liu, Rui Xie, Min Dong. Effect of daunorubicin on acute promyelocytic leukemia cells using nuclear magnetic resonance spectroscopy-based metabolomics. Environmental toxicology and pharmacology. 2020 Aug; 78(?):103382. doi: 10.1016/j.etap.2020.103382. [PMID: 32344291]
  • Nadine Farah, Richard Burt, Amr R Ibrahim, Robert Baker, Panagiotis D Kottaridis. Concerns about how to use established minimal residual disease monitoring in the treatment of NPM1-mutant acute myeloid leukaemia (AML) following reduced intensity chemotherapy protocols for AML given as a result of the COVID-19 pandemic. British journal of haematology. 2020 08; 190(4):e208-e210. doi: 10.1111/bjh.16985. [PMID: 32609881]
  • Masuho Saburi, Masao Ogata, Yasuhiro Soga, Kazuhito Itani, Kazuhiro Kohno, Toshiyuki Nakayama. L-asparaginase-induced Parotitis in an Elderly Patient with Acute Lymphoblastic Leukemia. Internal medicine (Tokyo, Japan). 2020 Jul; 59(14):1745-1748. doi: 10.2169/internalmedicine.4335-19. [PMID: 32296003]
  • Andrea Angelo Pierluigi Tripodi, Ivan Ranđelović, Beáta Biri-Kovács, Bálint Szeder, Gábor Mező, József Tóvári. In Vivo Tumor Growth Inhibition and Antiangiogenic Effect of Cyclic NGR Peptide-Daunorubicin Conjugates Developed for Targeted Drug Delivery. Pathology oncology research : POR. 2020 Jul; 26(3):1879-1892. doi: 10.1007/s12253-019-00773-3. [PMID: 31820302]
  • Xue-Min Yao, Feng-Ju Niu, Liang Kong, Fu-Yi Cai, Ming Jing, Min Fu, Jing-Jing Liu, Si-Yu He, Lu Zhang, Xin-Ze Liu, Rui-Jun Ju, Xue-Tao Li. GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial-mesenchymal transition. Drug development and industrial pharmacy. 2020 Jun; 46(6):916-930. doi: 10.1080/03639045.2020.1763397. [PMID: 32362146]
  • Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Caleb A Class, Koji Sasaki, Farhad Ravandi, Jorge E Cortes, Naval Daver, Koichi Takahashi, Nicholas J Short, Courtney D DiNardo, Elias Jabbour, Gautam Borthakur, Kiran Naqvi, Ghayas C Issa, Marina Konopleva, Joseph D Khoury, Mark Routbort, Sherry Pierce, Kim-Anh Do, Carlos Bueso-Ramos, Keyur Patel, Hagop Kantarjian, Guillermo Garcia-Manero, Tapan M Kadia. Outcomes of acute myeloid leukemia with myelodysplasia related changes depend on diagnostic criteria and therapy. American journal of hematology. 2020 06; 95(6):612-622. doi: 10.1002/ajh.25769. [PMID: 32112433]
  • Mirza Muhammad Faran Ashraf Baig, Wing-Fu Lai, Reyaj Mikrani, Mehreen Jabeen, Muhammad Naveed, Muhammad Abbas, Muhammad Asim Farooq, Anam Ahsan, Said Abasse Kassim, Ghulam Jilany Khan, Muhammad Tayyab Ansari. Synthetic NRG-1 functionalized DNA nanospindels towards HER2/neu targets for in vitro anti-cancer activity assessment against breast cancer MCF-7 cells. Journal of pharmaceutical and biomedical analysis. 2020 Apr; 182(?):113133. doi: 10.1016/j.jpba.2020.113133. [PMID: 32004770]
  • P H Nguyen, K P Sigdel, K G Schaefer, G A K Mensah, G M King, A G Roberts. The effects of anthracycline drugs on the conformational distribution of mouse P-glycoprotein explains their transport rate differences. Biochemical pharmacology. 2020 04; 174(?):113813. doi: 10.1016/j.bcp.2020.113813. [PMID: 31954717]
  • Min Fu, Wei Tang, Jing-Jing Liu, Xiao-Qing Gong, Liang Kong, Xue-Min Yao, Ming Jing, Fu-Yi Cai, Xue-Tao Li, Rui-Jun Ju. Combination of targeted daunorubicin liposomes and targeted emodin liposomes for treatment of invasive breast cancer. Journal of drug targeting. 2020 03; 28(3):245-258. doi: 10.1080/1061186x.2019.1656725. [PMID: 31462111]
  • Xin Zeng, Jie Sun, Suping Li, Jiyun Shi, Han Gao, Wei Sun Leong, Yiqi Wu, Minghui Li, Chengxin Liu, Ping Li, Jing Kong, Yi-Zhou Wu, Guangjun Nie, Yuming Fu, Gen Zhang. Blood-triggered generation of platinum nanoparticle functions as an anti-cancer agent. Nature communications. 2020 Jan; 11(1):567. doi: 10.1038/s41467-019-14131-z. [PMID: 31992692]
  • Erfaneh Firouzi Niaki, Thibaut Van Acker, László Imre, Péter Nánási, Szabolcs Tarapcsák, Zsolt Bacsó, Frank Vanhaecke, Gábor Szabó. Interactions of Cisplatin and Daunorubicin at the Chromatin Level. Scientific reports. 2020 01; 10(1):1107. doi: 10.1038/s41598-020-57702-7. [PMID: 31980698]
  • Wooil Choi, Mi Young Heo, Sang Yong Kim, Ji-Hyang Wee, Yang-Hoon Kim, Jiho Min. Encapsulation of daunorubicin into Saccharomyces cerevisiae-derived lysosome as drug delivery vehicles for acute myeloid leukemia (AML) treatment. Journal of biotechnology. 2020 Jan; 308(?):118-123. doi: 10.1016/j.jbiotec.2019.12.008. [PMID: 31846628]
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  • Zuzana Pokorna, Eduard Jirkovsky, Marketa Hlavackova, Hana Jansova, Anna Jirkovska, Olga Lencova-Popelova, Petra Brazdova, Jan Kubes, Dita Sotakova-Kasparova, Yvona Mazurova, Michaela Adamcova, Lucie Vostatkova, Kristyna Holzerova, Frantisek Kolar, Tomas Simunek, Martin Sterba. In vitro and in vivo investigation of cardiotoxicity associated with anticancer proteasome inhibitors and their combination with anthracycline. Clinical science (London, England : 1979). 2019 08; 133(16):1827-1844. doi: 10.1042/cs20190139. [PMID: 31409729]
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