Oleandrin (BioDeep_00000000245)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


[(3S,5R,8R,9S,10S,13R,14S,16S,17R)-14-hydroxy-3-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] acetate

化学式: C32H48O9 (576.3298)
中文名称: 欧夹竹桃甙丙, 欧夹竹桃苷, 夹竹桃育齐墩果君欧莲素, 欧夹竹桃苷丙
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 90.76%

分子结构信息

SMILES: C1[C@@]2(C)[C@]([H])(CC[C@]3([H])[C@]2([H])CC[C@]2(C)[C@@]([H])(C4COC(=O)C=4)[C@@H](OC(=O)C)C[C@]32O)C[C@@H](O[C@H]2C[C@H](OC)[C@@H](O)[C@H](C)O2)C1
InChI: InChI=1S/C32H48O9/c1-17-29(35)24(37-5)14-27(39-17)41-21-8-10-30(3)20(13-21)6-7-23-22(30)9-11-31(4)28(19-12-26(34)38-16-19)25(40-18(2)33)15-32(23,31)36/h12,17,20-25,27-29,35-36H,6-11,13-16H2,1-5H3/t17-,20+,21-,22-,23+,24-,25-,27-,28-,29-,30-,31+,32-/m0/s1

描述信息

Oleandrin is a steroid saponin that consists of oleandrigenin having a 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl residue attached to the oxygen function at position 3. It is a cardenolide glycoside, a 14beta-hydroxy steroid, a steroid ester and a steroid saponin. It is functionally related to an oleandrigenin.
Oleandrin has been used in trials studying the treatment of Lung Cancer and Chemotherapeutic Agent Toxicity.
Oleandrin is a natural product found in Daphnis nerii, Plumeria, and other organisms with data available.
Oleandrin is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically binds to and inhibits the alpha3 subunit of the Na/K-ATPase pump in human cancer cells. This may inhibit the phosphorylation of Akt, upregulate MAPK, inhibit NF-kb activation and inhibit FGF-2 export and may downregulate mTOR thereby inhibiting p70S6K and S6 protein expression. All of this may lead to an induction of apoptosis. As cancer cells with relatively higher expression of the alpha3 subunit and with limited expression of the alpha1 subunit are more sensitive to oleandrin, one may predict the tumor response to treatment with lipid-soluble cardiac glycosides such as oleandrin based on the tumors Na/K-ATPase pump protein subunit expression. Overexpression of the alpha3 subunit in tumor cells correlates with tumor proliferation.
See also: Nerium oleander leaf (part of).
A steroid saponin that consists of oleandrigenin having a 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl residue attached to the oxygen function at position 3.
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2262
Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.
Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.

同义名列表

34 个代谢物同义名

[(3S,5R,8R,9S,10S,13R,14S,16S,17R)-14-hydroxy-3-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] acetate; [(3S,8R,9S,10S,13R,14S,16S,17R)-14-Hydroxy-3-[(4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] acetate; CARD-20(22)-ENOLIDE, 16-(ACETYLOXY)-3-((2,6-DIDEOXY-3-O-METHYL-.ALPHA.-L-ARABINO-HEXOPYRANOSYL)OXY)-14-HYDROXY-, (3.BETA.,5.BETA.,16.BETA.)-; Card-20(22)-enolide, 16-(acetyloxy)-3-((2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy)-14-hydroxy-, (3-beta,5-beta,16-beta)-; Card-20(22)-enolide, 16-(acetyloxy)-3-((2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta,16beta)-; (3beta,5beta,16beta)-16-(acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide; (3beta,5beta,16beta)-16-acetoxy-3-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide; (3beta,5beta,16beta)-16-acetoxy-3-((2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide; (3 beta,16 beta)-16-(acetyloxy)-3-((2,6-dideoxy-3-O-methyl-L-arabino-hexopyranosyl)oxy)-14-hydroxy card-20(22)-enolide; (3beta,16beta)-16-(Acetyloxy)-3-((2,6-dideoxy-3-O-methyl-L-arabino-hexopyranosyl)oxy)-14-hydroxy card-20(22)-enolide; 16beta-(Acetyloxy)-3beta-((2,6-dideoxy-3-O-methyl-L-arabino-hexopyranosyl)oxy)-14-hydroxycard-20-(22)-enolide; 16beta-Acetoxy-3beta-(2,6-dideoxy-3-O-methyl-L-arabino-hexopyranosyloxy)-14-hydroxycard-20(22)-enolide; (3beta,5beta,16beta)-16-(Acetyloxy)-3-; Oleandrigenin oleandroside; Oleandrin, >=98\\% (HPLC); Oleandrina [Spanish]; OLEANDRIN [WHO-DD]; UNII-II95UDU7I4; OLEANDRIN [MI]; II95UDU7I4; Oleandrina; Foliandrin; Neriostene; Oleandrine; Folinevin; Oleandrin; Folinerin; Neriolin; Corrigen; Anvirzel; Neriol; NSC254670; PBI-05204; Oleandrin



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ABCB1, ANXA5, ATF4, BCL2, BDNF, CALR, CASP3, CTNNB1, FGF2, FOXO1, HMGB1, MTOR, NFKB1, NTRK2, PIK3CA
Peripheral membrane protein 3 ANXA5, HMGB1, MTOR
Endosome membrane 1 NTRK2
Endoplasmic reticulum membrane 3 BCL2, CALR, MTOR
Nucleus 11 ATF4, BCL2, CALR, CASP3, CTNNB1, FGF2, FOXO1, HMGB1, JUND, MTOR, NFKB1
cytosol 11 ANXA5, ATF4, BCL2, CALR, CASP3, CTNNB1, FOXO1, MTOR, NFKB1, NTRK2, PIK3CA
dendrite 3 BDNF, MTOR, NTRK2
phagocytic vesicle 1 MTOR
centrosome 2 ATF4, CTNNB1
nucleoplasm 9 ATF4, ATP2B1, CASP3, CTNNB1, FOXO1, HMGB1, JUND, MTOR, NFKB1
RNA polymerase II transcription regulator complex 2 ATF4, JUND
Cell membrane 7 ABCB1, ATF4, ATP2B1, CTNNB1, HMGB1, NTRK2, TNF
Cytoplasmic side 1 MTOR
lamellipodium 2 CTNNB1, PIK3CA
Cell projection, axon 1 NTRK2
Early endosome membrane 1 NTRK2
Multi-pass membrane protein 2 ABCB1, ATP2B1
Golgi apparatus membrane 1 MTOR
Synapse 2 ATP2B1, CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 4 ABCB1, CALR, HMGB1, TNF
glutamatergic synapse 4 ATP2B1, CALR, CASP3, CTNNB1
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
postsynapse 1 CALR
presynaptic membrane 2 ATP2B1, CTNNB1
sarcolemma 1 ANXA5
smooth endoplasmic reticulum 1 CALR
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 CALR
Lysosome 1 MTOR
acrosomal vesicle 1 CALR
endosome 1 HMGB1
plasma membrane 7 ABCB1, ATP2B1, CTNNB1, HMGB1, NTRK2, PIK3CA, TNF
synaptic vesicle membrane 1 ATP2B1
terminal bouton 1 NTRK2
Membrane 9 ABCB1, ANXA5, ATP2B1, BCL2, BDNF, CALR, CTNNB1, MTOR, NTRK2
apical plasma membrane 1 ABCB1
axon 2 BDNF, NTRK2
basolateral plasma membrane 2 ATP2B1, CTNNB1
extracellular exosome 5 ABCB1, ANXA5, ATP2B1, CALR, CTNNB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, CALR, HMGB1
extracellular space 6 BDNF, CALR, CXCL8, FGF2, HMGB1, TNF
perinuclear region of cytoplasm 5 BDNF, CALR, CTNNB1, NTRK2, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, FOXO1, NFKB1
protein-containing complex 3 ATF4, BCL2, CTNNB1
intracellular membrane-bounded organelle 1 ATP2B1
Microsome membrane 1 MTOR
postsynaptic density 2 CASP3, NTRK2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 NTRK2
Secreted 5 BDNF, CXCL8, FGF2, HMGB1, SMR3A
extracellular region 9 ANXA5, BDNF, CALR, CXCL8, FGF2, HMGB1, NFKB1, SMR3A, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Extracellular side 1 HMGB1
transcription regulator complex 3 CTNNB1, JUND, NFKB1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 ATF4
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 ANXA5, CALR, TNF
Secreted, extracellular space, extracellular matrix 1 CALR
dendritic spine 1 NTRK2
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
Early endosome 1 NTRK2
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 NTRK2
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 3 ANXA5, CALR, CTNNB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 2 ANXA5, CALR
fascia adherens 1 CTNNB1
lateral plasma membrane 2 ATP2B1, CTNNB1
nuclear speck 1 ATF4
receptor complex 1 NTRK2
Zymogen granule membrane 1 ANXA5
neuron projection 1 ATF4
chromatin 4 ATF4, FOXO1, JUND, NFKB1
cell projection 1 ATP2B1
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 CALR
cell periphery 1 CTNNB1
Chromosome 1 HMGB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 ATP2B1
microvillus membrane 1 CTNNB1
nuclear envelope 2 CALR, MTOR
Endomembrane system 2 CTNNB1, MTOR
Cell projection, dendrite 1 NTRK2
Nucleus speckle 1 ATF4
euchromatin 1 CTNNB1
Presynaptic cell membrane 1 ATP2B1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 HMGB1
secretory granule lumen 2 HMGB1, NFKB1
endoplasmic reticulum quality control compartment 1 CALR
endoplasmic reticulum lumen 2 BDNF, CALR
transcription repressor complex 2 HMGB1, JUND
axon terminus 1 NTRK2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 CALR
immunological synapse 1 ATP2B1
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
Sarcoplasmic reticulum lumen 1 CALR
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
protein-DNA complex 1 CTNNB1
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
lumenal side of endoplasmic reticulum membrane 1 CALR
MHC class I peptide loading complex 1 CALR
dendrite membrane 1 ATF4
condensed chromosome 1 HMGB1
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
nuclear periphery 1 ATF4
endocytic vesicle lumen 1 CALR
ribosome 1 CALR
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
Cytoplasmic vesicle, secretory vesicle, Cortical granule 1 CALR
cortical granule 1 CALR
endothelial microparticle 1 ANXA5
Cytolytic granule 1 CALR
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
beta-catenin-TCF7L2 complex 1 CTNNB1
ATF4-CREB1 transcription factor complex 1 ATF4
ATF1-ATF4 transcription factor complex 1 ATF4
CHOP-ATF4 complex 1 ATF4
Lewy body core 1 ATF4
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Canan Eroğlu Güneş, Fatma Seçer Çelik, Mücahit Seçme, Levent Elmas, Yavuz Dodurga, Ercan Kurar. Glycoside oleandrin downregulates toll-like receptor pathway genes and associated miRNAs in human melanoma cells. Gene. 2022 Nov; 843(?):146805. doi: 10.1016/j.gene.2022.146805. [PMID: 35964872]
  • Robert A Newman, Christopher C L Chase, Jose R Matos, Karim Abdelsalam, Robin Buterbaugh, Sonja Van Holland, Hadia Abdelaal, Amelia Woolum, K Jagannadha Sastry. Efficacy of oleandrin and PBI-05204 against bovine viruses of importance to commercial cattle health. Antiviral chemistry & chemotherapy. 2022 Jan; 30(?):20402066221103960. doi: 10.1177/20402066221103960. [PMID: 35611441]
  • C Combe, J Guitton, A Daudé, T Le Bricon, N Guibert, C Bosset, T Girardot. [Multidisciplinary management of voluntary pink oleander poisoning: How to estimate the quantities ingested?]. Annales pharmaceutiques francaises. 2022 Jan; 80(1):76-80. doi: 10.1016/j.pharma.2021.04.003. [PMID: 33878309]
  • Kenneth S Plante, Varun Dwivedi, Jessica A Plante, Diana Fernandez, Divya Mirchandani, Nathen Bopp, Patricia V Aguilar, Jun-Gyu Park, Paula Pino Tamayo, Jennifer Delgado, Vinay Shivanna, Jordi B Torrelles, Luis Martinez-Sobrido, Rick Matos, Scott C Weaver, K Jagannadha Sastry, Robert A Newman. Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111457. doi: 10.1016/j.biopha.2021.111457. [PMID: 33721754]
  • Anna Carfora, Raffaella Petrella, Renata Borriello, Lucia Aventaggiato, Roberto Gagliano-Candela, Carlo Pietro Campobasso. Fatal poisoning by ingestion of a self-prepared oleander leaf infusion. Forensic science, medicine, and pathology. 2021 Mar; 17(1):120-125. doi: 10.1007/s12024-020-00338-w. [PMID: 33237522]
  • Jeffrey Suchard, Alexandra Greb. Negligible Oleandrin Content of Hot Dogs Cooked on Nerium oleander Skewers. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2021 01; 17(1):57-60. doi: 10.1007/s13181-020-00805-4. [PMID: 32803693]
  • Ana F M Botelho, Ana L S Miranda, Thalita G Freitas, Paula F Milani, Tatiane Barreto, Jáder S Cruz, Marília M Melo. Comparative Cardiotoxicity of Low Doses of Digoxin, Ouabain, and Oleandrin. Cardiovascular toxicology. 2020 12; 20(6):539-547. doi: 10.1007/s12012-020-09579-1. [PMID: 32488807]
  • Marc T Roth, Dana Backlund Cardin, Erkut Hasan Borazanci, Margaux Steinbach, Vincent J Picozzi, Alexander Rosemury, Raymond Couric Wadlow, Robert A Newman, Jordan Berlin. A Phase II, Single-Arm, Open-Label, Bayesian Adaptive Efficacy and Safety Study of PBI-05204 in Patients with Stage IV Metastatic Pancreatic Adenocarcinoma. The oncologist. 2020 10; 25(10):e1446-e1450. doi: 10.1634/theoncologist.2020-0440. [PMID: 32452588]
  • Lavinia L Ruta, Claudia V Popa, Ileana C Farcasanu. Cytotoxicity of Oleandrin Is Mediated by Calcium Influx and by Increased Manganese Uptake in Saccharomyces cerevisiae Cells. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184259. [PMID: 32957533]
  • Nazia Kanwal, Azhar Rasul, Ghulam Hussain, Haseeb Anwar, Muhammad Ajmal Shah, Iqra Sarfraz, Ammara Riaz, Rabia Batool, Muhammad Shahbaz, Arif Hussain, Zeliha Selamoglu. Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Sep; 143(?):111570. doi: 10.1016/j.fct.2020.111570. [PMID: 32640345]
  • Luigi Ceci, Flavia Girolami, Maria Teresa Capucchio, Elena Colombino, Carlo Nebbia, Fabio Gosetti, Emilio Marengo, Fabrizio Iarussi, Grazia Carelli. Outbreak of Oleander (Nerium oleander) Poisoning in Dairy Cattle: Clinical and Food Safety Implications. Toxins. 2020 07; 12(8):. doi: 10.3390/toxins12080471. [PMID: 32722138]
  • Yanzhi Zhang, Xubing Chen, Yang Zhou, Jinjun Hou, Huali Long, Zijia Zhang, Min Lei, Wanying Wu. Synthesis of oleandrin derivatives and their cytotoxic activity. Steroids. 2020 07; 159(?):108650. doi: 10.1016/j.steroids.2020.108650. [PMID: 32360418]
  • Svetlana V Malysheva, Patrick P J Mulder, Julien Masquelier. Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market. Toxins. 2020 04; 12(4):. doi: 10.3390/toxins12040243. [PMID: 32283845]
  • Giorgia Montrucchio, Stefano Bosso, Martina Scanu, Andrea Mina, Maria R Imeneo, Luca Brazzi. Oleander poisoning: an old toxic in the modern era. Minerva anestesiologica. 2020 03; 86(3):355-356. doi: 10.23736/s0375-9393.19.14066-7. [PMID: 31818086]
  • Cui Zhou, Fangjun Yu, Peng Zeng, Tianpeng Zhang, Hao Huang, Wenying Chen, Baojian Wu. Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression. Biochemical pharmacology. 2019 11; 169(?):113622. doi: 10.1016/j.bcp.2019.08.024. [PMID: 31472126]
  • Silva Rubini, Sabina Strano Rossi, Serena Mestria, Sara Odoardi, Sara Chendi, Andrea Poli, Giuseppe Merialdi, Giuseppina Andreoli, Paolo Frisoni, Rosa Maria Gaudio, Anna Baldisserotto, Piergiacomo Buso, Stefano Manfredini, Guido Govoni, Stefania Barbieri, Cinzia Centelleghe, Giorgia Corazzola, Sandro Mazzariol, Carlo Alessandro Locatelli. A Probable Fatal Case of Oleander (Nerium oleander) Poisoning on a Cattle Farm: A New Method of Detection and Quantification of the Oleandrin Toxin in Rumen. Toxins. 2019 07; 11(8):. doi: 10.3390/toxins11080442. [PMID: 31349685]
  • Elena Azzalini, Marzia Bernini, Sara Vezzoli, Anna Antonietti, Andrea Verzeletti. A fatal case of self-poisoning through the ingestion of oleander leaves. Journal of forensic and legal medicine. 2019 Jul; 65(?):133-136. doi: 10.1016/j.jflm.2019.05.016. [PMID: 31153008]
  • J X Zhai, H Yan, M Shen, B H Shen, W Liu. Determination of Oleandrin in Blood and Liver Samples by LC-MS/MS. Fa yi xue za zhi. 2018 Jun; 34(6):585-589. doi: 10.12116/j.issn.1004-5619.2018.06.002. [PMID: 30896093]
  • Midori A Arai, Ryuta Akamine, Narumi Hayashi, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi. The Notch Inhibitors Isolated from Nerium indicum. Journal of natural products. 2018 05; 81(5):1235-1240. doi: 10.1021/acs.jnatprod.7b01031. [PMID: 29693393]
  • Michael J Van Kanegan, Denise E Dunn, Linda S Kaltenbach, Bijal Shah, Dong Ning He, Daniel D McCoy, Peiying Yang, Jiangnan Peng, Li Shen, Lin Du, Robert H Cichewicz, Robert A Newman, Donald C Lo. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. Scientific reports. 2016 05; 6(?):25626. doi: 10.1038/srep25626. [PMID: 27172999]
  • José Manuel Calderón-Montaño, Estefanía Burgos-Morón, Emilio Guillén-Mancina, Miguel López-Lázaro. Does the Nerium oleander extract PBI-05204 have potential for pancreatic cancer therapy?. Investigational new drugs. 2015 Jun; 33(3):787. doi: 10.1007/s10637-014-0204-4. [PMID: 25698441]
  • D S Hong, H Henary, G S Falchook, A Naing, S Fu, S Moulder, J J Wheler, A Tsimberidou, J B Durand, R Khan, P Yang, M Johansen, R A Newman, R Kurzrock. First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors. Investigational new drugs. 2014 Dec; 32(6):1204-12. doi: 10.1007/s10637-014-0127-0. [PMID: 24919855]
  • S L Fink, T E Robey, A F Tarabar, M E Hodsdon. Rapid detection of convallatoxin using five digoxin immunoassays. Clinical toxicology (Philadelphia, Pa.). 2014 Aug; 52(7):659-63. doi: 10.3109/15563650.2014.932366. [PMID: 24980812]
  • Nune Raviprakash, Sunil Kumar Manna. Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors. British journal of pharmacology. 2014 Jul; 171(14):3339-51. doi: 10.1111/bph.12493. [PMID: 24172227]
  • Michael J Van Kanegan, Dong Ning He, Denise E Dunn, Peiying Yang, Robert A Newman, Anne E West, Donald C Lo. BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Jan; 34(3):963-8. doi: 10.1523/jneurosci.2700-13.2014. [PMID: 24431454]
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