Benzamide (BioDeep_00000002325)

 

Secondary id: BioDeep_00000405587

human metabolite Endogenous PANOMIX_OTCML-2023


代谢物信息卡片


Trimethobenzamide hydrochloride

化学式: C7H7NO (121.0527612)
中文名称: 苯甲酰胺, 苯甲酰胺
谱图信息: 最多检出来源 Homo sapiens(blood) 0.19%

分子结构信息

SMILES: C1=CC=C(C=C1)C(=O)N
InChI: InChI=1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)

描述信息

Benzamide is an intermediate in the Benzoate degradation via CoA ligation. Benzamides are a class of chemical compounds derived from Benzamid, the carbonic acid amide of benzoic acid. In psychiatry some substituted benzamides are therapeutically used as neuroleptics and/or antipsychotics (wikipedia).
Benzamide is an intermediate in the Benzoate degradation via CoA ligation.
CONFIDENCE standard compound; INTERNAL_ID 8080
KEIO_ID B009
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].

同义名列表

18 个代谢物同义名

Trimethobenzamide hydrochloride; Benzamide (acd/name 4.0); Amid kyseliny benzoove; Phenyl carboxyamide; Benzoic acid amide; Benzenecarboxamide; Phenylcarboxyamide; Phenylcarboxamide; Benzoate amide; Benzoylamide; Benzoic Acid; PHC(=O)NH2; PHC(O)NH2; Benzamide; benzoate; Tigan; Benzamide; Phenylamide



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yi-Dan Ma, Huan Zhou, Guo-Tai Lin, Ke-Huan Wu, Gong Xu, Xili Liu, Dan Xu. Design, Synthesis, and Fungicidal Activities of Novel N-(Pyrazol-5-yl)benzamide Derivatives Containing a Diphenylamine Moiety. Journal of agricultural and food chemistry. 2024 Mar; 72(12):6691-6701. doi: 10.1021/acs.jafc.3c07567. [PMID: 38498985]
  • Tan Dai, Jikun Yang, Chuang Zhao, Jinzhu Chen, Can Zhang, Zhiwen Wang, Qin Peng, Pengfei Liu, Jianqiang Miao, Xili Liu. Unveiling Vacuolar H+-ATPase Subunit a as the Primary Target of the Pyridinylmethyl-Benzamide Fungicide, Fluopicolide. Journal of agricultural and food chemistry. 2024 Jan; 72(3):1527-1538. doi: 10.1021/acs.jafc.3c08485. [PMID: 38193425]
  • Tingting Wang, Pengfei Xu, Jianyang Fang, Cijuan Li, Xinying Zeng, Jia Liu, Lingxin Meng, Rongqiang Zhuang, Xianzhong Zhang, Xinhui Su, Zhide Guo. Synthesis and Preclinical Evaluation of a 68Ga-Labeled Pyridine-Based Benzamide Dimer for Malignant Melanoma Imaging. Molecular pharmaceutics. 2023 Feb; 20(2):1015-1024. doi: 10.1021/acs.molpharmaceut.2c00745. [PMID: 36562303]
  • Bashir Lawal, Yu-Cheng Kuo, Sung-Ling Tang, Feng-Cheng Liu, Alexander T H Wu, Hung-Yun Lin, Hsu-Shan Huang. Transcriptomic-Based Identification of the Immuno-Oncogenic Signature of Cholangiocarcinoma for HLC-018 Multi-Target Therapy Exploration. Cells. 2021 10; 10(11):. doi: 10.3390/cells10112873. [PMID: 34831096]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Huajian Zhu, Wenlong Li, Wen Shuai, Yang Liu, Limei Yang, Yuchen Tan, Tiandong Zheng, Hong Yao, Jinyi Xu, Zheying Zhu, Dong-Hua Yang, Zhe-Sheng Chen, Shengtao Xu. Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. European journal of medicinal chemistry. 2021 Apr; 216(?):113316. doi: 10.1016/j.ejmech.2021.113316. [PMID: 33676300]
  • Jelena Lazarević, Andrija Šmelcerović, Jelena Zvezdanović, Denitsa Yancheva, Silvana Casati, Roberta Ottria, Pierangela Ciuffreda. Lipid peroxidation inhibition study: A promising case of 1,3-di([1,1'-biphenyl]-3-yl)urea. Chemico-biological interactions. 2020 Aug; 326(?):109137. doi: 10.1016/j.cbi.2020.109137. [PMID: 32442417]
  • Agnieszka Niemczynowicz, Iwona Budziak, Sławomir Kulesza, Andrzej Górecki, Marcin Makowski, Dariusz Karcz, Karolina Starzak, Bożena Gładyszewska, Janusz Podleśny, Agnieszka I Piotrowicz-Cieślak, Arkadiusz Matwijczuk. Spectroscopic and theoretical studies of fluorescence effects induced by the ESIPT process in a new derivative 2-Hydroxy-N-(2-phenylethyl)benzamide - Study on the effects of pH and medium polarity changes. PloS one. 2020; 15(2):e0229149. doi: 10.1371/journal.pone.0229149. [PMID: 32097423]
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  • Nehaben A Gujarati, Leli Zeng, Pranav Gupta, Zhe-Sheng Chen, Vijaya L Korlipara. Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors. Bioorganic & medicinal chemistry letters. 2017 10; 27(20):4698-4704. doi: 10.1016/j.bmcl.2017.09.009. [PMID: 28916341]
  • Chen Hu, Shi-Wen Zhou, Fang Chen, Xin-Heng Zheng, Hui-Fang Shen, Bi-Run Lin, Guang-Xiong Zhou. Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15. Molecules (Basel, Switzerland). 2017 Mar; 22(4):. doi: 10.3390/molecules22040557. [PMID: 28358337]
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  • Liping Wang, Huajun Fan, Kunhong Wu, Xiaosheng Peng, Zitao Jiang, Linquan Zang. [Chiral separation of benzamide antipsychotics and determination of their enantiomers by high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2012 Dec; 30(12):1265-70. doi: 10.3724/sp.j.1123.2012.07035. [PMID: 23593884]
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