Indolin-2-one (BioDeep_00000002320)

 

Secondary id: BioDeep_00000173063, BioDeep_00000397445

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


1,3-dihydro-(2H)-indol-2-One

化学式: C8H7NO (133.0528)
中文名称: 2-吲哚酮, 羟吲哚
谱图信息: 最多检出来源 Homo sapiens(feces) 23.02%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Indolin-2-one. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/indolin-2-one (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000002320). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C2=CC=CC=C2NC1=O
InChI: InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10)

描述信息

1,3-Dihydro-(2H)-indol-2-one, also known as 2-oxindole or 2-indolinone, belongs to the class of organic compounds known as indolines. Indolines are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
CONFIDENCE standard compound; INTERNAL_ID 2508
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

同义名列表

15 个代谢物同义名

1,3-dihydro-(2H)-indol-2-One; 2,3-dihydro-1H-indol-2-one; 1,3-dihydro-2h-indol-2-one; 2-oxo-2,3-Dihydroindole; 1,3-dihydroindol-2-one; indol-2(3h)-one; indoline-2-one; 2-Oxoindoline; 2-indolinone; 2-OXOINDOLE; 2-oxindole; 2-Indolone; Oxindole; Oxindol; Oxindole



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(2)

PlantCyc(2)

代谢反应

153 个相关的代谢反应过程信息。

Reactome(65)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(86)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, AKT1, ANXA5, BCL2, CASP3, CDK1, CDK2, MDM2, MSMP, PDGFRB, TNK1, TUBB4B, TYR, VEGFA
Peripheral membrane protein 3 ACHE, ANXA5, TNK1
Endosome membrane 1 FLT3
Endoplasmic reticulum membrane 2 BCL2, CDK1
Nucleus 11 ACHE, AKT1, BCL2, CASP3, CDK1, CDK2, KDR, MDM2, PDGFRB, TUBB4B, VEGFA
cytosol 8 AKT1, ANXA5, BCL2, CASP3, CDK1, CDK2, MDM2, TUBB4B
centrosome 2 CDK1, CDK2
nucleoplasm 5 AKT1, CASP3, CDK1, CDK2, MDM2
Cell membrane 6 ABCB1, ACHE, AKT1, KDR, KIT, PROKR2
lamellipodium 1 AKT1
Multi-pass membrane protein 2 ABCB1, PROKR2
Synapse 1 ACHE
cell cortex 1 AKT1
cell junction 1 KDR
cell surface 3 ABCB1, ACHE, VEGFA
glutamatergic synapse 3 AKT1, CASP3, MDM2
Golgi apparatus 4 ACHE, KDR, PDGFRB, VEGFA
neuromuscular junction 1 ACHE
neuronal cell body 1 CASP3
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Lysosome 1 TYR
acrosomal vesicle 1 KIT
endosome 2 CDK2, KDR
plasma membrane 11 ABCB1, ACHE, AKT1, BCHE, FLT3, KDR, KIT, MDM2, PDGFRB, PROKR2, TNK1
Membrane 11 ABCB1, ACHE, AKT1, ANXA5, BCL2, CDK1, FLT3, KIT, PDGFRB, TNK1, VEGFA
apical plasma membrane 2 ABCB1, PDGFRB
extracellular exosome 4 ABCB1, ANXA5, CDK1, TUBB4B
endoplasmic reticulum 4 BCL2, FLT3, KDR, VEGFA
extracellular space 5 ACHE, BCHE, KIT, MSMP, VEGFA
lysosomal lumen 1 PDGFRB
perinuclear region of cytoplasm 2 ACHE, TYR
adherens junction 1 VEGFA
mitochondrion 2 BCL2, CDK1
protein-containing complex 3 AKT1, BCL2, MDM2
intracellular membrane-bounded organelle 2 PDGFRB, TYR
postsynaptic density 2 CASP3, MDM2
Single-pass type I membrane protein 3 FLT3, KIT, TYR
Secreted 4 ACHE, BCHE, MSMP, VEGFA
extracellular region 6 ACHE, ANXA5, BCHE, KDR, TUBB4B, VEGFA
cytoplasmic side of plasma membrane 1 KIT
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 CDK1
Extracellular side 1 ACHE
anchoring junction 1 KDR
transcription regulator complex 1 CDK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK1, CDK2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 ANXA5, KDR, KIT
Extracellular vesicle 1 TUBB4B
Secreted, extracellular space, extracellular matrix 1 VEGFA
cytoplasmic vesicle 1 PDGFRB
microtubule cytoskeleton 2 AKT1, TUBB4B
nucleolus 1 MDM2
Melanosome membrane 1 TYR
midbody 1 CDK1
Early endosome 1 KDR
cell-cell junction 2 AKT1, KIT
Golgi-associated vesicle 1 TYR
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Membrane raft 1 KDR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TUBB4B
focal adhesion 2 ANXA5, PDGFRB
microtubule 1 TUBB4B
spindle 1 AKT1
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
receptor complex 4 FLT3, KDR, KIT, PDGFRB
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 AKT1
mitotic spindle 2 CDK1, TUBB4B
cytoskeleton 1 TUBB4B
Nucleus, nucleolus 1 MDM2
chromosome, telomeric region 2 CDK1, CDK2
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
fibrillar center 1 KIT
nuclear envelope 1 CDK2
sorting endosome 1 KDR
axonemal microtubule 1 TUBB4B
Nucleus, nucleoplasm 1 MDM2
Melanosome 1 TYR
side of membrane 1 ACHE
myelin sheath 1 BCL2
[Isoform 3]: Cytoplasm 1 KIT
endoplasmic reticulum lumen 2 BCHE, FLT3
transcription repressor complex 1 MDM2
male germ cell nucleus 1 CDK2
platelet alpha granule lumen 1 VEGFA
endocytic vesicle membrane 1 MDM2
azurophil granule lumen 1 TUBB4B
nuclear envelope lumen 1 BCHE
vesicle membrane 1 ANXA5
Cajal body 1 CDK2
synaptic cleft 1 ACHE
spindle microtubule 1 CDK1
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
condensed chromosome 1 CDK2
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 2 CDK1, CDK2
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin A2-CDK2 complex 1 CDK2
[Isoform H]: Cell membrane 1 ACHE
cyclin A1-CDK2 complex 1 CDK2


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