Tetrahydrocoptisine (BioDeep_00000229954)

 

Secondary id: BioDeep_00000184276

PANOMIX_OTCML-2023


代谢物信息卡片


5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaene

化学式: C19H17NO4 (323.11575220000003)
中文名称: 四氢黄连碱, 四氢可的松, 人血草鹼
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.61%

分子结构信息

SMILES: C1(C(CCN2CC3=C4OCOC4=CC=C3CC21)=C5)=CC6=C5OCO6
InChI: InChI=1S/C19H17NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,6-7,15H,3-5,8-10H2

描述信息

Stylopine is a natural product found in Fumaria capreolata, Fumaria muralis, and other organisms with data available.
(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities[1][2].
(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities[1][2].

同义名列表

38 个代谢物同义名

5,7,17,19-tetraoxa-13-azahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaene; 6,7,12b,13-Tetrahydro-4H-[1,3]dioxolo[4,5:7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinoline; 6,7,12b,13-Tetrahydro-4H-[1,3]dioxolo[4,5-g][1,3]dioxolo[4,5:7,8]isoquino[3,2-a]isoquinoline #; 4H-(1,3)benzodioxolo(5,6-a)-1,3-benzodioxolo(4,5-g)quinolizine, 6,7,12b,13-tetrahydro-; 4H-Bis[1,3]benzodioxolo[5,6-a:4,5-g]quinolizine, 6,7,12b,13-tetrahydro-, (.+/-.)-; (12bS)-6,7,12b,13-Tetrahydro-4H-bis(1,3)benzodioxolo(5,6-a:4,5-g)quinolizine; 6,7,12b,13-Tetrahydro-4H-bis(1,3)benzodioxolo(5,6-a:4,5-g)quinolizine; 4H-Bis[1,6-a:4,5-g]quinolizine, 6,7,12b,13-tetrahydro-, (.+-.)-; 4H-Bis[1,6-a:4,5-g]quinolizine, 6,7,12b,13-tetrahydro-; Berbine, 2,3:9,10-bis(methylenedioxy)-, (.+/-.)-; Berbine,3:9,10-bis(methylenedioxy)-, (.+-.)-; ( inverted exclamation markA)-Stylopine; stylopine, 14C-labeled, (+,-)-isomer; TETRAHYDROCOPTISINE;(-)-STYLOPINE; Stylopine (Trahydocoptisine); (.+/-.)-Tetrahydrocoptisine; UXYJCYXWJGAKQY-UHFFFAOYSA-N; (.+-.)-Tetrahydrocoptisine; STYLOPINE, (-)-(RG)(CALL); (+-)-tetrahydrocoptisine; (-)-tetrahydrocoptisine; Coptisine, tetrahydro-; stylopine, (S)-isomer; Tetrahydrocoptisine; Stylopine, (.+/-.)-; Stylopine, (.+-.)-; (.+/-.)-Stylopine; (.+-.)-Stylopine; (R,S)-Stylopine; (RS)-Stylopine; Oprea1_614048; (S)-stylopine; (±)-Stylopine; (+-)stylopine; (-)-stylopine; dl-Stylopine; stylopine; stylopin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Meng-Ting Zuo, Sha-Sha Liu, Li Lin, Zi-Yuan Wang, Xia Bai, Zhi-Liang Sun, Zhao-Ying Liu. Characterization of N-methylcanadine and N-methylstylopine metabolites in rat liver S9 by high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM. 2018 Dec; 32(23):2047-2054. doi: 10.1002/rcm.8286. [PMID: 30252168]
  • Jae Woo Han, Sang Hee Shim, Kyoung Soo Jang, Yong Ho Choi, Hun Kim, Gyung Ja Choi. In Vivo Disease Control Efficacy of Isoquinoline Alkaloids Isolated from Corydalis ternata against Wheat Leaf Rust and Pepper Anthracnose. Journal of microbiology and biotechnology. 2018 Feb; 28(2):262-266. doi: 10.4014/jmb.1707.07009. [PMID: 29141127]
  • Mahdi Yahyazadeh, Purwanto Ratmoyo, Florian Bittner, Fumihiko Sato, Dirk Selmar. Cloning and Characterization of Cheilanthifoline and Stylopine Synthase Genes from Chelidonium majus. Plant & cell physiology. 2017 Aug; 58(8):1421-1430. doi: 10.1093/pcp/pcx077. [PMID: 28633475]
  • A D Bozhadze, V Iu Vachnadze, M S Dzhokhadze, D T Berashvili, A Dzh Bakuridze. [Study on the separation process of pharmacological active total alkaloids from Chelidonium majus L. growing in Georgia]. Georgian medical news. 2013 Apr; ?(217):61-5. doi: . [PMID: 23676491]
  • Shuping Wang, Lei Liu, Lingling Wang, Peng Jiang, Li Xiang, Weidong Zhang, Runhui Liu. Development and validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of four tertiary alkaloids in rat plasma and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2013 Jan; 72(?):80-8. doi: 10.1016/j.jpba.2012.09.001. [PMID: 23146230]
  • Zhong-Ze Ma, Wei Xu, Niels H Jensen, Bryan L Roth, Lee-Yuan Liu-Chen, David Y W Lee. Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. Molecules (Basel, Switzerland). 2008 Sep; 13(9):2303-12. doi: 10.3390/molecules13092303. [PMID: 18830156]
  • David K Liscombe, Peter J Facchini. Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy. The Journal of biological chemistry. 2007 May; 282(20):14741-51. doi: 10.1074/jbc.m611908200. [PMID: 17389594]
  • Seon Il Jang, Byung Hee Kim, Woo-Yiel Lee, Sang Jin An, Han Gil Choi, Byung Hun Jeon, Hun-Taeg Chung, Jung-Rae Rho, Young-Jun Kim, Kyu-Yun Chai. Stylopine from Chelidonium majus inhibits LPS-induced inflammatory mediators in RAW 264.7 cells. Archives of pharmacal research. 2004 Sep; 27(9):923-9. doi: 10.1007/bf02975845. [PMID: 15473662]
  • R Suau, B Cabezudo, R Rico, F Nájera, J M López-Romero. Direct determination of alkaloid contents in Fumaria species by GC-MS. Phytochemical analysis : PCA. 2002 Nov; 13(6):363-7. doi: 10.1002/pca.669. [PMID: 12494757]
  • F J BANDELIN, W MALESH. Alkaloids of Chelidonium majus, L., leaves and stems. I. dl-Tetrahydrocoptisine. Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 1956 Oct; 45(10):702-4. doi: 10.1002/jps.3030451014. [PMID: 13366815]
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