Acephate (BioDeep_00000002229)
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
化学式: C4H10NO3PS (183.0119)
中文名称: 乙酰甲胺磷, 乙酰胆碱酯酶
谱图信息:
最多检出来源 Homo sapiens(blood) 58.25%
分子结构信息
SMILES: CC(=O)NP(=O)(OC)SC
InChI: InChI=1S/C4H10NO3PS/c1-4(6)5-9(7,8-2)10-3/h1-3H3,(H,5,6,7)
描述信息
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1493; ORIGINAL_PRECURSOR_SCAN_NO 1491
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3008; ORIGINAL_PRECURSOR_SCAN_NO 3003
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1469; ORIGINAL_PRECURSOR_SCAN_NO 1467
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1489; ORIGINAL_PRECURSOR_SCAN_NO 1488
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3023; ORIGINAL_PRECURSOR_SCAN_NO 3020
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3022; ORIGINAL_PRECURSOR_SCAN_NO 3018
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3000; ORIGINAL_PRECURSOR_SCAN_NO 2996
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1491; ORIGINAL_PRECURSOR_SCAN_NO 1488
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1478; ORIGINAL_PRECURSOR_SCAN_NO 1476
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3021; ORIGINAL_PRECURSOR_SCAN_NO 3018
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3035; ORIGINAL_PRECURSOR_SCAN_NO 3030
CONFIDENCE standard compound; INTERNAL_ID 702; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1488; ORIGINAL_PRECURSOR_SCAN_NO 1486
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
CONFIDENCE standard compound; INTERNAL_ID 3111
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
同义名列表
15 个代谢物同义名
N-[methoxy(methylsulfanyl)phosphoryl]ethanimidic acid; Acetylphosphoramidothioic acid O,S-dimethyl ester; Acetylphosphoramidothioate O,S-dimethyl ester; N-(Methoxy(methylthio)phosphinoyl)acetamide; O,S-Dimethylacetylphosphoroamidothioic acid; O,S-Dimethyl acetylamidothiophosphoric acid; O,S-Dimethyl N-acetyl phosphoramidothioate; O,S-Dimethylacetylphosphoroamidothioate; O,S-Dimethyl acetylamidothiophosphate; Acetamidophos; Acephic acid; acephate; Orthene; Acephate; Acephate
数据库引用编号
32 个数据库交叉引用编号
- ChEBI: CHEBI:34520
- KEGG: C14426
- PubChem: 1982
- HMDB: HMDB0247901
- Metlin: METLIN44455
- ChEMBL: CHEMBL2133249
- Wikipedia: Acephate
- chemspider: 1905
- CAS: 30560-19-1
- MoNA: AU311104
- MoNA: LU070253
- MoNA: LU070203
- MoNA: LU070256
- MoNA: LU070204
- MoNA: AU311105
- MoNA: AU311102
- MoNA: AU311103
- MoNA: AU311151
- MoNA: LU070201
- MoNA: LU070206
- MoNA: LU070205
- MoNA: LU070254
- MoNA: LU070255
- MoNA: AU311101
- MoNA: LU070202
- MoNA: LU070252
- MoNA: LU070251
- PMhub: MS000002178
- PubChem: 17395426
- NIKKAJI: J4.532B
- RefMet: Acephate
- KNApSAcK: 34520
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Xiaozhen Wu, Wen-Juan Chen, Ziqiu Lin, Yaohua Huang, Talaat N-M El Sebai, Nasser Alansary, Dalia E El-Hefny, Sandhya Mishra, Pankaj Bhatt, Huixiong Lü, Shaohua Chen. Rapid Biodegradation of the Organophosphorus Insecticide Acephate by a Novel Strain Burkholderia sp. A11 and Its Impact on the Structure of the Indigenous Microbial Community.
Journal of agricultural and food chemistry.
2023 Apr; 71(13):5261-5274. doi:
10.1021/acs.jafc.2c07861
. [PMID: 36962004] - Nuo Xu, Yang Sun, Yuru Wang, Yidi Cui, Yuanjin Jiang, Chao Zhang. Hormesis effects in tomato plant growth and photosynthesis due to acephate exposure based on physiology and transcriptomic analysis.
Pest management science.
2023 Jan; ?(?):. doi:
10.1002/ps.7381
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Journal of economic entomology.
2022 10; 115(5):1693-1702. doi:
10.1093/jee/toac136
. [PMID: 36099406] - Weiting Jiao, Ruyan Hou, Jianchao Li, Guoqin Ge, Pei Lv, Tiejun Ling, Taozhong Shi, Zhaoxian Zhang, Qing X Li, Rimao Hua. Enantiomer metabolism of acephate and its metabolite methamidophos in in vitro tea (Camellia sinensis L.) systems: Comparison between cell suspensions and excised tissues.
The Science of the total environment.
2022 Feb; 806(Pt 4):150863. doi:
10.1016/j.scitotenv.2021.150863
. [PMID: 34626633] - Toshiko Tanaka, Hiroaki Sato, Kosho Yoshida, Kentaro Kasai. The Role of Brain Methamidophos in Acephate Poisoning in Mice.
Journal of UOEH.
2021; 43(2):197-203. doi:
10.7888/juoeh.43.197
. [PMID: 34092764] - Mostafa R AbuKhadra, Aya S Mohamed, Ahmed M El-Sherbeeny, Mohammed A Elmeligy. Enhanced photocatalytic degradation of acephate pesticide over MCM-41/Co3O4 nanocomposite synthesized from rice husk silica gel and Peach leaves.
Journal of hazardous materials.
2020 05; 389(?):122129. doi:
10.1016/j.jhazmat.2020.122129
. [PMID: 31972525] - Yanhua Wang, Yu Cheng Zhu, Wenhong Li. Comparative examination on synergistic toxicities of chlorpyrifos, acephate, or tetraconazole mixed with pyrethroid insecticides to honey bees (Apis mellifera L.).
Environmental science and pollution research international.
2020 Mar; 27(7):6971-6980. doi:
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Forensic science international.
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Scientific reports.
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Journal of insect science (Online).
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Pesticide biochemistry and physiology.
2015 Jul; 122(?):15-21. doi:
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. [PMID: 26071802] - Susan L Clauson, James M Sylvia, Thomas A Arcury, Phillip Summers, Kevin M Spencer. Detection of Pesticides and Metabolites Using Surface-Enhanced Raman Spectroscopy (SERS): Acephate.
Applied spectroscopy.
2015 Jul; 69(7):785-93. doi:
10.1366/14-07594
. [PMID: 26036870] - Yurong Hou, Can Cao, Wei Bao, Shuang Yang, Haidan Shi, Dongfang Hao, Xiujuan Zhao, Yonghui Wu. The plasma metabolic profiling of chronic acephate exposure in rats via an ultra-performance liquid chromatography-mass spectrometry based metabonomic method.
Molecular bioSystems.
2015 Feb; 11(2):506-15. doi:
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Toxicology and industrial health.
2015 Jan; 31(1):9-17. doi:
10.1177/0748233712468017
. [PMID: 23211677] - Xiangying Liu, Lifeng Wang, Xiaomao Zhou, Kailin Liu, Lianyang Bai, Xuguo Zhou. Photocatalytic degradation of acephate in pak choi, Brassica chinensis, with Ce-doped TiO2.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2015; 50(5):331-7. doi:
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. [PMID: 25826101] - Qinghua Tang, Xiujuan Shi, Xiaolin Hou, Jie Zhou, Zhixiang Xu. Development of molecularly imprinted electrochemical sensors based on Fe3O4@MWNT-COOH/CS nanocomposite layers for detecting traces of acephate and trichlorfon.
The Analyst.
2014 Dec; 139(24):6406-13. doi:
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. [PMID: 25325612] - Hiroshi Suemizu, Shigeto Sota, Miyuki Kuronuma, Makiko Shimizu, Hiroshi Yamazaki. Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes.
Regulatory toxicology and pharmacology : RTP.
2014 Nov; 70(2):468-73. doi:
10.1016/j.yrtph.2014.08.010
. [PMID: 25158275] - Carmine Inês Acker, Cristina Wayne Nogueira. Diphenyl diselenide protects against metabolic disorders induced by acephate acute exposure in rats.
Environmental toxicology.
2014 Jun; 29(6):665-71. doi:
10.1002/tox.21793
. [PMID: 22778074] - Xue Qing Yang, Ji Yuan Liu, Xian Chun Li, Mao Hua Chen, Ya Lin Zhang. Key amino acid associated with acephate detoxification by Cydia pomonella carboxylesterase based on molecular dynamics with alanine scanning and site-directed mutagenesis.
Journal of chemical information and modeling.
2014 May; 54(5):1356-70. doi:
10.1021/ci500159q
. [PMID: 24749772] - Shoji Sonoda, Xueyan Shi, Dunlun Song, Pei Liang, Xiwu Gao, Youjun Zhang, Jianhong Li, Yong Liu, Ming Li, Masaya Matsumura, Sachiyo Sanada-Morimura, Chieka Minakuchi, Toshiharu Tanaka, Tadashi Miyata. Duplication of acetylcholinesterase gene in diamondback moth strains with different sensitivities to acephate.
Insect biochemistry and molecular biology.
2014 May; 48(?):83-90. doi:
10.1016/j.ibmb.2014.02.008
. [PMID: 24632376] - Peter Asiimwe, Steven E Naranjo, Peter C Ellsworth. Effects of irrigation levels on interactions among Lygus hesperus (Hemiptera: Miridae), insecticides, and predators in cotton.
Environmental entomology.
2014 Apr; 43(2):263-73. doi:
10.1603/en12328
. [PMID: 24533912] - Peter Asiimwe, Steven E Naranjo, Peter C Ellsworth. Relative influence of plant quality and natural enemies on the seasonal dynamics of Bemisia tabaci (Hemiptera: Aleyrodidae) in cotton.
Journal of economic entomology.
2013 Jun; 106(3):1260-73. doi:
10.1603/ec12182
. [PMID: 23865191] - Yan Yao, Ping Zhang, Qi-Jie Chen, Wen-Feng Liu, Juan Zeng, Jian-Jun Xie, Li-Li Sun, Xiaro-Lan Wang. [Characterization of pesticide residual dynamics by in situ attenuated total reflection FTIR].
Guang pu xue yu guang pu fen xi = Guang pu.
2012 Dec; 32(12):3217-9. doi:
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- Dong-Fang Hao, Wei Xu, Hong Wang, Long-Fei Du, Jin-Dan Yang, Xiu-Juan Zhao, Chang-Hao Sun. Metabolomic analysis of the toxic effect of chronic low-dose exposure to acephate on rats using ultra-performance liquid chromatography/mass spectrometry.
Ecotoxicology and environmental safety.
2012 Sep; 83(?):25-33. doi:
10.1016/j.ecoenv.2012.06.006
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Environmental toxicology and pharmacology.
2012 Sep; 34(2):192-199. doi:
10.1016/j.etap.2012.04.002
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Pest management science.
2012 May; 68(5):811-7. doi:
10.1002/ps.2337
. [PMID: 22396314] - Laxmi N Sankhala, Syamantak M Tripathi, S K Bhavsar, Aswin M Thaker, Pramod Sharma. Hematological and Immunological Changes Due to Short-term Oral Administration of Acephate.
Toxicology international.
2012 May; 19(2):162-6. doi:
10.4103/0971-6580.97217
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Environmental health perspectives.
2012 Apr; 120(4):521-5. doi:
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Environmental health perspectives.
2012 Apr; 120(4):487-93. doi:
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Cell biochemistry and function.
2012 Mar; 30(2):122-8. doi:
10.1002/cbf.1825
. [PMID: 22034174] - Yu Cheng Zhu, Zibiao Guo, Yueping He, Randall Luttrell. Microarray analysis of gene regulations and potential association with acephate-resistance and fitness cost in Lygus lineolaris.
PloS one.
2012; 7(5):e37586. doi:
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. [PMID: 22655059] - Nayana K Jayatilaka, M Angela Montesano, Ralph D Whitehead, Sara J Schloth, Larry L Needham, Dana Boyd Barr. High-throughput sample preparation for the quantitation of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea, and propylenethiourea in human urine using 96-well-plate automated extraction and high-performance liquid chromatography-tandem mass spectrometry.
Archives of environmental contamination and toxicology.
2011 Jul; 61(1):59-67. doi:
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International journal of environmental research and public health.
2011 04; 8(4):1061-83. doi:
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Environmental health perspectives.
2011 Mar; 119(3):351-6. doi:
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Journal of visualized experiments : JoVE.
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2010 Dec; 36(12):1363-74. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Oct; 48(10):2766-71. doi:
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American journal of industrial medicine.
2010 Aug; 53(8):802-13. doi:
10.1002/ajim.20856
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Environmental health perspectives.
2010 Jun; 118(6):856-63. doi:
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Environmental health perspectives.
2010 May; 118(5):635-9. doi:
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Journal of AOAC International.
2009 Jul; 92(4):1184-9. doi:
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Journal of chromatography. A.
2009 Jun; 1216(23):4798-808. doi:
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Journal of separation science.
2009 Jun; 32(12):2132-8. doi:
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. [PMID: 19479754] - Arthur Chang, M Angela Montesano, Dana Barr, Jerry Thomas, Robert Geller. Urinary elimination kinetics of acephate and its metabolite, methamidophos, in urine after acute ingestion.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
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