Camptothecin (BioDeep_00000000207)

 

Secondary id: BioDeep_00000173673, BioDeep_00000398548

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

化学式: C20H16N2O4 (348.111)
中文名称: 喜树碱
谱图信息: 最多检出来源 Viridiplantae(plant) 13.45%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Camptothecin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/camptothecin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000207). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
InChI: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3

描述信息

Camptothecin is a pyranoindolizinoquinoline that is pyrano[3,4:6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer). It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an antineoplastic agent, a genotoxin and a plant metabolite. It is a pyranoindolizinoquinoline, a tertiary alcohol, a delta-lactone and a quinoline alkaloid.
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Camptothecin is a natural product found in Archidendron lucidum, Merrilliodendron megacarpum, and other organisms with data available.
Camptothecin is an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
A pyranoindolizinoquinoline that is pyrano[3,4:6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].

同义名列表

76 个代谢物同义名

(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione; (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione; (S)-4-Ethyl-4-hydroxy-1H-pyrano[3 inverted exclamation mark ,4 inverted exclamation mark :6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione; (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione; (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-(+)-Camptothecin; 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT); 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin); 4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14-dione; 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin); 1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-; 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-; 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; 1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione; (4S)-4-ETHYL-4-HYDROXY-1H-PYRANO(3,4:6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE; (S)-4-Ethyl-4-hydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione; 4(S)-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; (S)-4-ethyl-4-hydroxy-1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (S)-4-ethyl-4-hydroxy-1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 4-Ethyl-4-hydroxy-1H-pyrano-[3[,4[:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE; 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-(+)-Camptothecin, >=90\\% (HPLC), powder; 21,22-Secocamptothecin-21-oic acid lactone; CAMPTOTHECIN [WHO-DD]; (S)-(+)-Camptothecin; Camptothecine (S,+); 20(S)-Camptothecine; Camptothecine (8CI); 20(S)-Camptothecin; Prestwick2_000200; (+)-Camptothecine; Prestwick3_000200; Prestwick0_000200; CAMPTOTHECIN [MI]; (s)-camptothecine; (+)-Camptothecin;; Prestwick1_000200; Camptothecin,(S); Spectrum2_000903; (+)-Camptothecin; Spectrum3_001203; (S)-Camptothecin; Spectrum4_000738; Spectrum5_001126; UNII-XT3Z54Z28A; d-camptothecine; d-Camptothecin; Camptothecine; DivK1c_000826; Lopac0_000341; DivK1c_006808; BPBio1_000175; KBio1_000826; KBio1_001752; KBio2_000779; KBio2_003347; NCI60_042105; KBio3_002086; KBio2_005915; Tox21_500341; Camptothecin; Campathecin; Bio1_001378; Bio1_000889; IDI1_000826; Bio1_000400; XT3Z54Z28A; AI3-62475; CHEMBL65; CPT; Camptothecin



数据库引用编号

50 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

91 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ATM, BCL2, BRCA1, CDK1, CDKN1A, CHEK2, EGFR, MAPK8, MCL1, PRKX, TDP1, TP53, TUBB4B, WRN
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 BCL2, CDK1, EGFR
Mitochondrion membrane 1 ABCG2
Nucleus 17 ATM, BCL2, BRCA1, CDK1, CDKN1A, CHEK2, EGFR, H2AX, MAPK8, MCL1, PARP1, PRKDC, PRKX, TDP1, TP53, TUBB4B, WRN
cytosol 10 ATM, BCL2, CDK1, CDKN1A, MAPK8, MCL1, PARP1, PRKDC, TP53, TUBB4B
mitochondrial membrane 1 ABCG2
nuclear body 3 BRCA1, CDKN1A, PARP1
centrosome 5 ATM, CDK1, H2AX, TP53, WRN
nucleoplasm 16 ABCG2, ATM, BRCA1, CDK1, CDKN1A, CHEK2, H2AX, MAPK8, MCL1, PARP1, PRKDC, PRKX, TDP1, TOP1MT, TP53, WRN
Cell membrane 3 ABCG2, EGFR, TNF
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCG2
Synapse 1 MAPK8
cell junction 1 EGFR
cell surface 2 EGFR, TNF
glutamatergic synapse 1 EGFR
Golgi apparatus 1 CHEK2
Golgi membrane 1 EGFR
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 PARP1
endosome 1 EGFR
plasma membrane 5 ABCG2, BRCA1, EGFR, TDP1, TNF
Membrane 9 ABCG2, BCL2, BRCA1, CDK1, EGFR, MCL1, PARP1, PRKDC, TP53
apical plasma membrane 2 ABCG2, EGFR
axon 1 MAPK8
basolateral plasma membrane 1 EGFR
extracellular exosome 3 CDK1, H2AX, TUBB4B
endoplasmic reticulum 2 BCL2, TP53
extracellular space 2 EGFR, TNF
perinuclear region of cytoplasm 2 CDKN1A, EGFR
mitochondrion 6 BCL2, CDK1, MCL1, PARP1, TOP1MT, TP53
protein-containing complex 7 BCL2, BRCA1, CDKN1A, EGFR, PARP1, PRKDC, TP53
intracellular membrane-bounded organelle 2 ATM, TDP1
Single-pass type I membrane protein 1 EGFR
extracellular region 2 TNF, TUBB4B
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, MCL1
mitochondrial outer membrane 2 BCL2, MCL1
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CDK1, TP53
transcription regulator complex 3 PARP1, PRKDC, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 ATM, CDK1, TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 2 BCL2, MCL1
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 TNF
Extracellular vesicle 1 TUBB4B
cytoplasmic vesicle 1 ATM
microtubule cytoskeleton 1 TUBB4B
nucleolus 6 ATM, CDKN1A, PARP1, PRKDC, TP53, WRN
midbody 1 CDK1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCG2
Membrane raft 3 ABCG2, EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 TP53, TUBB4B
focal adhesion 1 EGFR
microtubule 1 TUBB4B
spindle 1 ATM
mitochondrial nucleoid 1 TOP1MT
intracellular vesicle 1 EGFR
Peroxisome matrix 1 ATM
peroxisomal matrix 1 ATM
Nucleus, PML body 1 TP53
PML body 2 CHEK2, TP53
nuclear speck 2 H2AX, WRN
receptor complex 1 EGFR
chromatin 3 PARP1, PRKDC, TP53
phagocytic cup 1 TNF
mitotic spindle 2 CDK1, TUBB4B
Chromosome 5 BRCA1, H2AX, PARP1, TOP1MT, WRN
cytoskeleton 1 TUBB4B
[Isoform 5]: Cytoplasm 1 BRCA1
brush border membrane 1 ABCG2
Nucleus, nucleolus 3 PARP1, PRKDC, WRN
nuclear replication fork 1 PARP1
chromosome, telomeric region 4 CDK1, PARP1, PRKDC, WRN
site of double-strand break 4 ATM, H2AX, PARP1, TP53
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 1 PARP1
axonemal microtubule 1 TUBB4B
lateral element 1 BRCA1
myosin complex 1 MCL1
Nucleus, nucleoplasm 2 MCL1, WRN
germ cell nucleus 1 TP53
replication fork 3 H2AX, TP53, WRN
myelin sheath 1 BCL2
ubiquitin ligase complex 1 BRCA1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
male germ cell nucleus 2 BRCA1, H2AX
XY body 2 BRCA1, H2AX
extrinsic component of synaptic vesicle membrane 1 ATM
azurophil granule lumen 1 TUBB4B
small-subunit processome 1 PRKDC
condensed nuclear chromosome 1 H2AX
clathrin-coated endocytic vesicle membrane 1 EGFR
ribonucleoprotein complex 1 BRCA1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 2 PARP1, PRKDC
spindle microtubule 1 CDK1
external side of apical plasma membrane 1 ABCG2
basal dendrite 1 MAPK8
nucleosome 1 H2AX
intracellular non-membrane-bounded organelle 1 BRCA1
DNA repair complex 2 ATM, BRCA1
BRCA1-C complex 1 BRCA1
site of DNA damage 2 H2AX, PARP1
cyclin-dependent protein kinase holoenzyme complex 2 CDK1, CDKN1A
DNA-dependent protein kinase complex 1 PRKDC
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
DNA-dependent protein kinase-DNA ligase 4 complex 1 PRKDC
nonhomologous end joining complex 1 PRKDC
BRCA1-A complex 1 BRCA1
BRCA1-B complex 1 BRCA1
BRCA1-BARD1 complex 1 BRCA1
gamma-tubulin ring complex 1 BRCA1
nuclear ubiquitin ligase complex 1 BRCA1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Wanlong Lin, Jiabing Xu, Yufang Liao, Xiuxian Lin, Jianhui Yang, Wei Zhuang. Assessing safety concerns of interstitial lung disease associated with antibody-drug conjugates: a real-world pharmacovigilance evaluation of the FDA adverse event reporting system. International journal of clinical pharmacy. 2024 Jun; 46(3):614-622. doi: 10.1007/s11096-023-01673-y. [PMID: 38100054]
  • Ya-Xuan Liang, Xue-Yi Sun, De-Zhong Xu, Yi-Nan Gao, Quan Tang, Zhong-Lin Lu, Yang Liu. Codelivery of CPT and siPHB1 with GSH/ROS Dual-Responsive Hybrid Nanoparticles Based on a [12]aneN3-Derived Lipid for Synergistic Lung Cancer Therapy. ACS applied bio materials. 2024 May; 7(5):3202-3214. doi: 10.1021/acsabm.4c00206. [PMID: 38651918]
  • Lei Xie, Qian Zhang, Qian Zhu, Yang Wang, Shuijiao Niu, Xinyue Zhang, Yuting Huang, Jiayao Li, Xiaoxue Liu, Zhiyuan Xue, Xia Zhao, Yaxin Zheng. The Effect of Lipid Composition on the Liposomal Delivery of Camptothecin Developed by Active Click Loading. Molecular pharmaceutics. 2024 May; 21(5):2327-2339. doi: 10.1021/acs.molpharmaceut.3c01140. [PMID: 38576375]
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  • Can Xie, Yongbo Peng, Zhen Zhang, Kun Luo, Qiaomei Yang, Libin Tan, Liyi Zhou. Tumor Microenvironment Activatable Nanoprodrug System for In Situ Fluorescence Imaging and Therapy of Liver Cancer. Analytical chemistry. 2024 Mar; 96(12):5006-5013. doi: 10.1021/acs.analchem.4c00317. [PMID: 38484040]
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  • Di-Zao Li, Zhao-Di Fu, Hong-Yan Liu, Xian-Dao Pan. Facile synthesis and cytotoxicity of substituted uracil-1'(N)-acetic acid and 4-pyridone-1'(N)-acetic acid esters of 20(S)-camptothecins. Journal of Asian natural products research. 2024 Feb; 26(2):259-268. doi: 10.1080/10286020.2023.2300374. [PMID: 38347748]
  • Jingya Wang, Jiangli Xu, Shuhui Yang, Liu He, Wenhuai Xu, Yan'e Liu, Baoshan Cao, Siwang Yu. SN-38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2-related factor 2 and enhances drug sensitivity of colorectal cancer cells. Molecular carcinogenesis. 2024 Jan; ?(?):. doi: 10.1002/mc.23685. [PMID: 38270247]
  • Zhaochen Wu, Yue Bi, Junting Zhang, Tuqiang Gao, Xueming Li, Jianjun Hao, Guihua Li, Pengfei Liu, Xili Liu. Multidrug resistance of Botrytis cinerea associated with its adaptation to plant secondary metabolites. mBio. 2024 Jan; ?(?):e0223723. doi: 10.1128/mbio.02237-23. [PMID: 38259067]
  • Qing-Rui Qi, Huan Tian, Bao-Sen Yue, Bing-Tao Zhai, Feng Zhao. Research Progress of SN38 Drug Delivery System in Cancer Treatment. International journal of nanomedicine. 2024; 19(?):945-964. doi: 10.2147/ijn.s435407. [PMID: 38293612]
  • Junheng Li, Yin Chen, Lei Wu, Xiaotao Tuo, Li Wang, Guanglian Zhou, Sheng-Xiong Huang, Wei Xiong, Jian-Ping Huang. Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants. Planta medica. 2023 Oct; 89(13):1250-1258. doi: 10.1055/a-2072-2177. [PMID: 37044129]
  • Xue-Yi Sun, Ya-Xuan Liang, Yi-Nan Gao, Xi Zhang, Rui Liu, Quan Tang, Zhong-Lin Lu, Yang Liu. [12]aneN3-modified camptothecin and PEGylated AIEgens co-assembly into core-shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy. Journal of materials chemistry. B. 2023 09; 11(37):8943-8955. doi: 10.1039/d3tb01282d. [PMID: 37727888]
  • Shakunthala Natarajan, Boas Pucker, Smita Srivastava. Genomic and transcriptomic analysis of camptothecin producing novel fungal endophyte: Alternaria burnsii NCIM 1409. Scientific reports. 2023 09; 13(1):14614. doi: 10.1038/s41598-023-41738-6. [PMID: 37670002]
  • Xiang Pu, Minji Wang, Menghan Chen, Xinyu Lin, Ming Lei, Jiahua Zhang, Shengnan Yang, Hanguang Wang, Jinqiu Liao, Li Zhang, Qianming Huang. Proteomics-Guided Mining and Characterization of Epoxidase Involved in Camptothecin Biosynthesis from Camptotheca acuminata. ACS chemical biology. 2023 08; 18(8):1772-1785. doi: 10.1021/acschembio.3c00222. [PMID: 37523250]
  • Abeer Eldeghidy, Gamal Abdel-Fattah, Ashraf S A El-Sayed, Ghada G Abdel-Fattah. Production, bioprocessing and antiproliferative activity of camptothecin from Aspergillus terreus, endophyte of Cinnamomum camphora: restoring their biosynthesis by indigenous microbiome of C. camphora. Microbial cell factories. 2023 Aug; 22(1):143. doi: 10.1186/s12934-023-02158-3. [PMID: 37533061]
  • Aparna Raj, Riju K Thomas, L Vidya, V M Aparna, S Neelima, C Sudarsanakumar. Exploring the cytotoxicity on human lung cancer cells and DNA binding stratagem of camptothecin functionalised silver nanoparticles through multi-spectroscopic, and calorimetric approach. Scientific reports. 2023 Jun; 13(1):9045. doi: 10.1038/s41598-023-34997-w. [PMID: 37270606]
  • Kamalapani Darshani Degambada, Amila Saman Prasad Kumara Peramune Arachchilage, Nazeera Salim, Udumalagala Gamage Chandrika, Ajita Mahendra Abeysekera. Cellular localisation and quantification of Camptothecin in different plant parts of Nothapodytes nimmoniana (J. Graham) Mabberley of Sri Lankan origin. Phytochemical analysis : PCA. 2023 Jun; 34(4):453-460. doi: 10.1002/pca.3226. [PMID: 37015831]
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  • Qi Chen, Jiabao Huang, Yulin Ye, Azhen Hu, Bingxuan Xu, Die Hu, Linlin Wang, Lijun Xing, Shuting Chen, Xingang Gui, Weizhao Tong, Yiming Gan, Tingting Zheng, Jie Zheng, Li Liu, Guoxin Hu. Delivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis. Journal of controlled release : official journal of the Controlled Release Society. 2023 May; ?(?):. doi: 10.1016/j.jconrel.2023.05.002. [PMID: 37149150]
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