Camptothecin (BioDeep_00000000207)

 

Secondary id: BioDeep_00000398548

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

化学式: C20H16N2O4 (348.1110016)
中文名称: 喜树碱
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.03%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Camptothecin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/camptothecin (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000000207). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
InChI: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3

描述信息

Camptothecin is a pyranoindolizinoquinoline that is pyrano[3,4:6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer). It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an antineoplastic agent, a genotoxin and a plant metabolite. It is a pyranoindolizinoquinoline, a tertiary alcohol, a delta-lactone and a quinoline alkaloid.
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Camptothecin is a natural product found in Archidendron lucidum, Merrilliodendron megacarpum, and other organisms with data available.
Camptothecin is an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
A pyranoindolizinoquinoline that is pyrano[3,4:6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].

同义名列表

75 个代谢物同义名

(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione; (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione; (S)-4-Ethyl-4-hydroxy-1H-pyrano[3 inverted exclamation mark ,4 inverted exclamation mark :6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione; (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione; (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-(+)-Camptothecin; 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT); 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin); 4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14-dione; 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin); 1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-; 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-; 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; 1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione; (4S)-4-ETHYL-4-HYDROXY-1H-PYRANO(3,4:6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE; (S)-4-Ethyl-4-hydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione; 4(S)-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-; (S)-4-ethyl-4-hydroxy-1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (S)-4-ethyl-4-hydroxy-1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 4-Ethyl-4-hydroxy-1H-pyrano-[3[,4[:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE; 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-(+)-Camptothecin, >=90\\% (HPLC), powder; 21,22-Secocamptothecin-21-oic acid lactone; CAMPTOTHECIN [WHO-DD]; (S)-(+)-Camptothecin; Camptothecine (S,+); 20(S)-Camptothecine; Camptothecine (8CI); 20(S)-Camptothecin; Prestwick2_000200; (+)-Camptothecine; Prestwick3_000200; Prestwick0_000200; CAMPTOTHECIN [MI]; (s)-camptothecine; (+)-Camptothecin;; Prestwick1_000200; Camptothecin,(S); Spectrum2_000903; (+)-Camptothecin; Spectrum3_001203; (S)-Camptothecin; Spectrum4_000738; Spectrum5_001126; UNII-XT3Z54Z28A; d-camptothecine; d-Camptothecin; Camptothecine; DivK1c_000826; Lopac0_000341; DivK1c_006808; BPBio1_000175; KBio1_000826; KBio1_001752; KBio2_000779; KBio2_003347; NCI60_042105; KBio3_002086; KBio2_005915; Tox21_500341; Camptothecin; Campathecin; Bio1_001378; Bio1_000889; IDI1_000826; Bio1_000400; XT3Z54Z28A; AI3-62475; CHEMBL65; CPT



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wanlong Lin, Jiabing Xu, Yufang Liao, Xiuxian Lin, Jianhui Yang, Wei Zhuang. Assessing safety concerns of interstitial lung disease associated with antibody-drug conjugates: a real-world pharmacovigilance evaluation of the FDA adverse event reporting system. International journal of clinical pharmacy. 2024 Jun; 46(3):614-622. doi: 10.1007/s11096-023-01673-y. [PMID: 38100054]
  • Ya-Xuan Liang, Xue-Yi Sun, De-Zhong Xu, Yi-Nan Gao, Quan Tang, Zhong-Lin Lu, Yang Liu. Codelivery of CPT and siPHB1 with GSH/ROS Dual-Responsive Hybrid Nanoparticles Based on a [12]aneN3-Derived Lipid for Synergistic Lung Cancer Therapy. ACS applied bio materials. 2024 May; 7(5):3202-3214. doi: 10.1021/acsabm.4c00206. [PMID: 38651918]
  • Lei Xie, Qian Zhang, Qian Zhu, Yang Wang, Shuijiao Niu, Xinyue Zhang, Yuting Huang, Jiayao Li, Xiaoxue Liu, Zhiyuan Xue, Xia Zhao, Yaxin Zheng. The Effect of Lipid Composition on the Liposomal Delivery of Camptothecin Developed by Active Click Loading. Molecular pharmaceutics. 2024 May; 21(5):2327-2339. doi: 10.1021/acs.molpharmaceut.3c01140. [PMID: 38576375]
  • Rui Ma, Yixun Shi, Ruijuan Yan, Shiqing Yin, Huanen Bu, Jie Huang. Efficacy and safety of trastuzumab deruxtecan in treating human epidermal growth factor receptor 2-low/positive advanced breast cancer:A meta-analysis of randomized controlled trials. Critical reviews in oncology/hematology. 2024 Apr; 196(?):104305. doi: 10.1016/j.critrevonc.2024.104305. [PMID: 38442809]
  • Can Xie, Yongbo Peng, Zhen Zhang, Kun Luo, Qiaomei Yang, Libin Tan, Liyi Zhou. Tumor Microenvironment Activatable Nanoprodrug System for In Situ Fluorescence Imaging and Therapy of Liver Cancer. Analytical chemistry. 2024 Mar; 96(12):5006-5013. doi: 10.1021/acs.analchem.4c00317. [PMID: 38484040]
  • Zheng Chen, Maoyu Liu, Ningyu Wang, Wenjing Xiao, Jianyou Shi. Unleashing the Potential of Camptothecin: Exploring Innovative Strategies for Structural Modification and Therapeutic Advancements. Journal of medicinal chemistry. 2024 Mar; 67(5):3244-3273. doi: 10.1021/acs.jmedchem.3c02115. [PMID: 38421819]
  • Di-Zao Li, Zhao-Di Fu, Hong-Yan Liu, Xian-Dao Pan. Facile synthesis and cytotoxicity of substituted uracil-1'(N)-acetic acid and 4-pyridone-1'(N)-acetic acid esters of 20(S)-camptothecins. Journal of Asian natural products research. 2024 Feb; 26(2):259-268. doi: 10.1080/10286020.2023.2300374. [PMID: 38347748]
  • Jingya Wang, Jiangli Xu, Shuhui Yang, Liu He, Wenhuai Xu, Yan'e Liu, Baoshan Cao, Siwang Yu. SN-38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2-related factor 2 and enhances drug sensitivity of colorectal cancer cells. Molecular carcinogenesis. 2024 Jan; ?(?):. doi: 10.1002/mc.23685. [PMID: 38270247]
  • Zhaochen Wu, Yue Bi, Junting Zhang, Tuqiang Gao, Xueming Li, Jianjun Hao, Guihua Li, Pengfei Liu, Xili Liu. Multidrug resistance of Botrytis cinerea associated with its adaptation to plant secondary metabolites. mBio. 2024 Jan; ?(?):e0223723. doi: 10.1128/mbio.02237-23. [PMID: 38259067]
  • Qing-Rui Qi, Huan Tian, Bao-Sen Yue, Bing-Tao Zhai, Feng Zhao. Research Progress of SN38 Drug Delivery System in Cancer Treatment. International journal of nanomedicine. 2024; 19(?):945-964. doi: 10.2147/ijn.s435407. [PMID: 38293612]
  • Junheng Li, Yin Chen, Lei Wu, Xiaotao Tuo, Li Wang, Guanglian Zhou, Sheng-Xiong Huang, Wei Xiong, Jian-Ping Huang. Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants. Planta medica. 2023 Oct; 89(13):1250-1258. doi: 10.1055/a-2072-2177. [PMID: 37044129]
  • Xue-Yi Sun, Ya-Xuan Liang, Yi-Nan Gao, Xi Zhang, Rui Liu, Quan Tang, Zhong-Lin Lu, Yang Liu. [12]aneN3-modified camptothecin and PEGylated AIEgens co-assembly into core-shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy. Journal of materials chemistry. B. 2023 09; 11(37):8943-8955. doi: 10.1039/d3tb01282d. [PMID: 37727888]
  • Shakunthala Natarajan, Boas Pucker, Smita Srivastava. Genomic and transcriptomic analysis of camptothecin producing novel fungal endophyte: Alternaria burnsii NCIM 1409. Scientific reports. 2023 09; 13(1):14614. doi: 10.1038/s41598-023-41738-6. [PMID: 37670002]
  • Xiang Pu, Minji Wang, Menghan Chen, Xinyu Lin, Ming Lei, Jiahua Zhang, Shengnan Yang, Hanguang Wang, Jinqiu Liao, Li Zhang, Qianming Huang. Proteomics-Guided Mining and Characterization of Epoxidase Involved in Camptothecin Biosynthesis from Camptotheca acuminata. ACS chemical biology. 2023 08; 18(8):1772-1785. doi: 10.1021/acschembio.3c00222. [PMID: 37523250]
  • Abeer Eldeghidy, Gamal Abdel-Fattah, Ashraf S A El-Sayed, Ghada G Abdel-Fattah. Production, bioprocessing and antiproliferative activity of camptothecin from Aspergillus terreus, endophyte of Cinnamomum camphora: restoring their biosynthesis by indigenous microbiome of C. camphora. Microbial cell factories. 2023 Aug; 22(1):143. doi: 10.1186/s12934-023-02158-3. [PMID: 37533061]
  • Aparna Raj, Riju K Thomas, L Vidya, V M Aparna, S Neelima, C Sudarsanakumar. Exploring the cytotoxicity on human lung cancer cells and DNA binding stratagem of camptothecin functionalised silver nanoparticles through multi-spectroscopic, and calorimetric approach. Scientific reports. 2023 Jun; 13(1):9045. doi: 10.1038/s41598-023-34997-w. [PMID: 37270606]
  • Kamalapani Darshani Degambada, Amila Saman Prasad Kumara Peramune Arachchilage, Nazeera Salim, Udumalagala Gamage Chandrika, Ajita Mahendra Abeysekera. Cellular localisation and quantification of Camptothecin in different plant parts of Nothapodytes nimmoniana (J. Graham) Mabberley of Sri Lankan origin. Phytochemical analysis : PCA. 2023 Jun; 34(4):453-460. doi: 10.1002/pca.3226. [PMID: 37015831]
  • Ahmed S Elkateb, Shahira Nofal, Sahar A Ali, Hanaa B Atya. Camptothecin Sensitizes Hepatocellular Carcinoma Cells to Sorafenib- Induced Ferroptosis Via Suppression of Nrf2. Inflammation. 2023 May; ?(?):. doi: 10.1007/s10753-023-01823-4. [PMID: 37171695]
  • Qi Chen, Jiabao Huang, Yulin Ye, Azhen Hu, Bingxuan Xu, Die Hu, Linlin Wang, Lijun Xing, Shuting Chen, Xingang Gui, Weizhao Tong, Yiming Gan, Tingting Zheng, Jie Zheng, Li Liu, Guoxin Hu. Delivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis. Journal of controlled release : official journal of the Controlled Release Society. 2023 May; ?(?):. doi: 10.1016/j.jconrel.2023.05.002. [PMID: 37149150]
  • Huibo Zhang, Xiaofeng Shen, Sijie Sun, Ying Li, Shu Wang, Jianhe Wei, Baolin Guo, Chao Sun. Integrated transcriptome and proteome analysis provides new insights into camptothecin biosynthesis and regulation in Camptotheca acuminata. Physiologia plantarum. 2023 May; 175(3):e13916. doi: 10.1111/ppl.13916. [PMID: 37093159]
  • Liqiu Kou, Xiu Chen, Xiaolu Xie, Qinglian Wen, Jun Li, Yaling Li. The efficacy and safety of trastuzumab deruxtecan (T-DXd) in HER2-expressing solid tumours: a single-arm meta-analysis. Japanese journal of clinical oncology. 2023 Apr; ?(?):. doi: 10.1093/jjco/hyad036. [PMID: 37114934]
  • Zedong Cai, Meng-Lei Huan, Yao-Wen Zhang, Ting-Ting Zhao, Tian-Yan Han, Wei He, Si-Yuan Zhou, Bang-Le Zhang. Tumor targeted combination therapeutic system for the effective treatment of drug resistant triple negative breast cancer. International journal of pharmaceutics. 2023 Apr; 636(?):122821. doi: 10.1016/j.ijpharm.2023.122821. [PMID: 36914017]
  • Binbin Liang, Yuhang Miao, Liying Zhao, Lan Fang, Dawei Deng. A dandelion-like nanomedicine via hierarchical self-assembly for synergistic chemotherapy and photo-dynamic cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. 2023 04; 49(?):102660. doi: 10.1016/j.nano.2023.102660. [PMID: 36746273]
  • Xin-Liang Xu, Jin-Xia Lan, Hao Huang, Wei Dai, Xiao-Peng Peng, Sheng-Lan Liu, Wei-Ming Chen, Le-Jun Huang, Jun Liu, Xiao-Jun Li, Jun-Lin Zeng, Xian-Hua Huang, Guan-Nan Zhao, Wen Hou. Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents. Bioorganic & medicinal chemistry. 2023 03; 82(?):117234. doi: 10.1016/j.bmc.2023.117234. [PMID: 36906964]
  • Fernanda Isadora Boni, Natália Noronha Ferreira, Camila Fernanda Rodero, Aline Franciane Leão, Beatriz Stringhetti Ferreira Cury, Maria Palmira Daflon Gremião. MULTILAYERED POLYMER COATING MODULATES MUCOADHESIVE AND BIOLOGICAL PROPERTIES OF CAMPTOTHECIN-LOADED LIPID NANOCAPSULES. International journal of pharmaceutics. 2023 Feb; ?(?):122792. doi: 10.1016/j.ijpharm.2023.122792. [PMID: 36863543]
  • Xiaolong Hao, Can Wang, Wei Zhou, Qingyan Ruan, Chenhong Xie, Yinkai Yang, Chengyu Xiao, Yan Cai, Jingyi Wang, Yao Wang, Xuebin Zhang, Itay Maoz, Guoyin Kai. OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila. Journal of integrative plant biology. 2023 Jan; 65(1):133-149. doi: 10.1111/jipb.13377. [PMID: 36194508]
  • Pallavi Karanje, Vishwajeet Ghorpade, Ajay Namdeo, Rajendra Doijad, Abhijit Karanje. Comparison of techniques for the extraction of Camptothecin from Tabernaemontana species. Natural product research. 2023 Jan; 37(2):322-327. doi: 10.1080/14786419.2021.1957886. [PMID: 34319175]
  • Yanyan Wang, Yang Wang, Hefei Bai, Yuqian Han, Fang Yu. An ABCG-Type Transporter Facilitates ABA Influx and Regulates Camptothecin Biosynthesis in Camptotheca acuminata. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232416120. [PMID: 36555760]
  • Wei Li, Yin-Nan Chen, Yue-Yue Chen, Zhe Wang, Zhen Wang, Li-Li Jiang, Hong-Can Shi, Yong Liu. Inhibition of UGT1A1*1 and UGT1A1*6 catalyzed glucuronidation of SN-38 by silybins. Chemico-biological interactions. 2022 Dec; 368(?):110248. doi: 10.1016/j.cbi.2022.110248. [PMID: 36343684]
  • Zhaoxia Jin, Qiyao Zhu, Yangyang Guo, Ronglian Xing, Yanyan Wang, Yue Zhang, Xiaoxiao Gao, Fang Yu. Functional characterization of secologanin synthase-like homologous genes suggests their involvement in the biosynthesis of diverse metabolites in the secoiridoid biosynthetic pathway of Camptotheca acuminata Decne. International journal of biological macromolecules. 2022 Dec; 222(Pt B):2594-2602. doi: 10.1016/j.ijbiomac.2022.10.042. [PMID: 36257366]
  • Pooja Ravi, Prathap Somu, Diptikanta Acharya, Levin Anbu Gomez, Jesse Joel Thathapudi, Yerappa Lakshmikanth Ramachandra, Sunitha Bommanahalli Rudraiah, Mona Isaq, Chetan Shekhar Karua, Mohammed Arifullah, Chandrappa Chinna Poojari, Yong Rok Lee. Isolation and Phytochemical Screening of Endophytic Fungi Isolated from Medicinal Plant Mappia foetida and Evaluation of Its In Vitro Cytotoxicity in Cancer. Applied biochemistry and biotechnology. 2022 Oct; 194(10):4570-4586. doi: 10.1007/s12010-022-03929-1. [PMID: 35536539]
  • Ji-Yoon Lee, Eiji Goto, Hideo Yoshida, Shoko Hikosaka. Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light. Journal of natural medicines. 2022 Sep; 76(4):865-872. doi: 10.1007/s11418-022-01634-1. [PMID: 35788957]
  • Matthew Ng, Sylvia Chen, Whee Sze Ong, Akhila Balachander, Amanda Seet, Joe Yeong, Natalia Sutiman, Tony Kiat Hon Lim, Bernett Lee, Yu Amanda Guo, Wai Fook Leong, Sze Sing Lee, Justina Lam, Su Pin Choo, Anders Jacobsen Skanderup, Subhra Kumar Biswas, David Tai, Balram Chowbay. A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects. International journal of cancer. 2022 08; 151(3):435-449. doi: 10.1002/ijc.34021. [PMID: 35415893]
  • Liangjie Shi, Yong Jin, Shuangquan Lai, Long Bai, Rong Zhou, Yutang Zhou, Xiang Shang. Redox-responsive carrier based on fluorinated gemini amphiphilic polymer for combinational cancer therapy. Colloids and surfaces. B, Biointerfaces. 2022 Aug; 216(?):112551. doi: 10.1016/j.colsurfb.2022.112551. [PMID: 35567807]
  • Ukhyun Jo, Yasuhisa Murai, Keli K Agama, Yilun Sun, Liton Kumar Saha, Xi Yang, Yasuhiro Arakawa, Sophia Gayle, Kelli Jones, Vishwas Paralkar, Ranjini K Sundaram, Jinny Van Doorn, Juan C Vasquez, Ranjit S Bindra, Woo Suk Choi, Yves Pommier. TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor. Molecular cancer therapeutics. 2022 07; 21(7):1090-1102. doi: 10.1158/1535-7163.mct-21-1000. [PMID: 35439320]
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