Mefloquine (BioDeep_00000002025)
Secondary id: BioDeep_00000408948
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol
化学式: C17H16F6N2O (378.1166758)
中文名称: 氟甲喹羟哌啶
谱图信息:
最多检出来源 Homo sapiens(blood) 20%
分子结构信息
SMILES: C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O
InChI: InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2
描述信息
Mefloquine is only found in individuals that have used or taken this drug. It is a phospholipid-interacting antimalarial drug (antimalarials). It is very effective against plasmodium falciparum with very few side effects. [PubChem]Mefloquine has been found to produce swelling of the Plasmodium falciparum food vacuoles. It may act by forming toxic complexes with free heme that damage membranes and interact with other plasmodial components.
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BC - Methanolquinolines
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
COVID info from clinicaltrials, clinicaltrial
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
12 个代谢物同义名
alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol; [2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol; Α-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol; a-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol; Hoffmann la roche brand OF mefloquine hydrochloride; Hoffmann-la roche brand OF mefloquine hydrochloride; Roche brand OF mefloquine hydrochloride; Mefloquine hydrochloride; Mefloquinone; Mephloquine; mefloquine; Lariam
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:63609
- ChEBI: CHEBI:63687
- ChEBI: CHEBI:63681
- KEGG: C07633
- KEGGdrug: D04895
- PubChem: 40692
- PubChem: 4046
- HMDB: HMDB0014502
- Metlin: METLIN1104
- DrugBank: DB00358
- ChEMBL: CHEMBL416956
- ChEMBL: CHEMBL172
- Wikipedia: Mefloquine
- MeSH: Mefloquine
- chemspider: 3906
- CAS: 147368-41-0
- CAS: 53230-10-7
- CAS: 49752-90-1
- CAS: 51742-87-1
- PMhub: MS000001700
- PubChem: 9835
- NIKKAJI: J244.888B
- RefMet: Mefloquine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qian Tao, Nian Liu, Jie Wu, Jing Chen, Xiang Chen, Cong Peng. Mefloquine enhances the efficacy of anti-PD-1 immunotherapy via IFN-γ-STAT1-IRF1-LPCAT3-induced ferroptosis in tumors.
Journal for immunotherapy of cancer.
2024 Mar; 12(3):. doi:
10.1136/jitc-2023-008554. [PMID: 38471712] - Xiang Wang, Jinxiu Chen, Jing Gong, Ying Wu, Xiang-Hao Liu. JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient.
BMC neurology.
2022 Dec; 22(1):462. doi:
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Viruses.
2022 02; 14(2):. doi:
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2022 Feb; 146(?):112454. doi:
10.1016/j.biopha.2021.112454. [PMID: 34894518] - Bing Wan, Zhenghong Wu, Xiulan Zhang, Birun Huang. Mefloquine as a dual inhibitor of glioblastoma angiogenesis and glioblastoma via disrupting lysosomal function.
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Journal of medicinal chemistry.
2015 Apr; 58(7):2958-2966. doi:
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The Journal of antimicrobial chemotherapy.
2015 Mar; 70(3):868-76. doi:
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European journal of drug metabolism and pharmacokinetics.
2014 Dec; 39(4):231-6. doi:
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Journal of medicinal chemistry.
2014 Oct; 57(19):7971-6. doi:
10.1021/jm500811p. [PMID: 25195945] - Thiago Eichi Goto, Luciano Caseli. The interaction of mefloquine hydrochloride with cell membrane models at the air-water interface is modulated by the monolayer lipid composition.
Journal of colloid and interface science.
2014 Oct; 431(?):24-30. doi:
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Experimental parasitology.
2014 Oct; 145(?):80-6. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Oct; 968(?):32-9. doi:
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The Journal of antimicrobial chemotherapy.
2014 Sep; 69(9):2499-507. doi:
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The Cochrane database of systematic reviews.
2014 Aug; ?(8):CD000053. doi:
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Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4745-54. doi:
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The American journal of tropical medicine and hygiene.
2014 Aug; 91(2):361-6. doi:
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PLoS neglected tropical diseases.
2014 Jul; 8(7):e2975. doi:
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Psychopharmacology.
2014 Jul; 231(14):2771-83. doi:
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Malaria journal.
2014 May; 13(?):187. doi:
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Journal of medicinal chemistry.
2014 Mar; 57(6):2789-98. doi:
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The Journal of pharmacy and pharmacology.
2014 Jan; 66(1):14-22. doi:
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Malaria journal.
2013 Dec; 12(?):443. doi:
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Bioorganic & medicinal chemistry.
2013 Dec; 21(23):7250-6. doi:
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The American journal of tropical medicine and hygiene.
2013 Oct; 89(4):737-41. doi:
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Antimicrobial agents and chemotherapy.
2013 Sep; 57(9):4506-11. doi:
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Malaria journal.
2013 Jul; 12(?):263. doi:
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Journal of natural products.
2013 Jul; 76(7):1358-64. doi:
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Malaria journal.
2013 Jul; 12(?):235. doi:
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Journal of neurovirology.
2013 Jun; 19(3):274-9. doi:
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Bioorganic & medicinal chemistry letters.
2013 May; 23(10):3088-95. doi:
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Acta tropica.
2013 May; 126(2):150-5. doi:
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2013 Mar; 56(6):e68-75. doi:
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Malaria journal.
2012 Aug; 11(?):303. doi:
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Journal of natural products.
2012 Jul; 75(7):1299-304. doi:
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2012 Mar; 110(3):1239-48. doi:
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Malaria journal.
2012 Feb; 11(?):59. doi:
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ACS medicinal chemistry letters.
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Biological & pharmaceutical bulletin.
2012; 35(1):29-33. doi:
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Malaria journal.
2011 Oct; 10(?):292. doi:
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Malaria journal.
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The Journal of infectious diseases.
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Malaria journal.
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