Kanamycin (BioDeep_00000002010)

 

Secondary id: BioDeep_00000398040

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol

化学式: C18H36N4O11 (484.238)
中文名称: 卡那霉素A, 卡那霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 44.75%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N
InChI: InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1

描述信息

Kanamycin is only found in individuals that have used or taken this drug. It is an antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. [PubChem]Aminoglycosides like kanamycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Kanamycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

19 个代谢物同义名

(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine; O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-a-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-α-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine; 4,6-Diamino-2-hydroxy-1,3-cyclohexylene 3,6-diamino-3,6-dideoxydi-D-glucopyranoside; 4,6-Diamino-2-hydroxy-1,3-cyclohexane 3,6diamino-3,6-dideoxydi-alpha-D-glucoside; 4,6-Diamino-2-hydroxy-1,3-cyclohexane 3,6diamino-3,6-dideoxydi-α-D-glucoside; 4,6-Diamino-2-hydroxy-1,3-cyclohexane 3,6diamino-3,6-dideoxydi-a-D-glucoside; Kanamycin A monosulfate; Aminodeoxykanamycin; Nebramycin factor 5; KANAMYCIN SULFATE; Kanamycin base; Kanamycin a; kanamycin; Kantrex; KAN; Kanamycin; Kanamycin A



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

64 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 BDNF, CAT, DHFR, DNA2, ODC1
Peripheral membrane protein 1 CYP27A1
Endoplasmic reticulum membrane 1 ZDHHC16
Mitochondrion membrane 1 CYP27A1
Nucleus 1 DNA2
cytosol 6 CAT, DHFR, GOLPH3, LIPE, ODC1, STX1A
dendrite 1 BDNF
trans-Golgi network 1 GOLPH3
nucleoplasm 2 CD2, DNA2
Cell membrane 4 CD2, GOLPH3, LIPE, STX1A
lamellipodium 1 STX2
Multi-pass membrane protein 2 RHO, ZDHHC16
cell surface 2 CD2, STRC
Golgi apparatus 4 CD2, GOLPH3, RHO, ZDHHC16
Golgi membrane 2 GOLPH3, RHO
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 1 INHA
synaptic vesicle 3 BDNF, STX1A, STX2
Cytoplasm, cytosol 1 LIPE
endosome 1 GOLPH3
plasma membrane 6 CD2, F2, GOLPH3, RHO, STX1A, STX2
synaptic vesicle membrane 1 STX1A
Membrane 7 BDNF, CAT, GOLPH3, LIPE, RHO, STX2, ZDHHC16
axon 2 BDNF, STX1A
basolateral plasma membrane 1 STX2
caveola 1 LIPE
extracellular exosome 4 CAT, F2, LYZ, SPINK1
extracellular space 6 BDNF, CCL7, F2, INHA, LYZ, STX2
perinuclear region of cytoplasm 1 BDNF
mitochondrion 5 CAT, CYP27A1, DHFR, DNA2, GOLPH3
protein-containing complex 3 CAT, CD2, STX2
intracellular membrane-bounded organelle 3 CAT, GOLPH3, STX2
Single-pass type I membrane protein 1 CD2
Secreted 5 BDNF, CCL7, F2, INHA, SPINK1
extracellular region 8 BDNF, CAT, CCL7, CD2, F2, INHA, LYZ, STX1A
cytoplasmic side of plasma membrane 1 CD2
[Isoform 2]: Secreted 1 STX1A
mitochondrial matrix 2 CAT, CYP27A1
ciliary membrane 1 RHO
photoreceptor inner segment 2 INHA, RHO
photoreceptor outer segment 2 INHA, RHO
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 STX1A
nuclear membrane 1 STX1A
external side of plasma membrane 1 CD2
cell-cell junction 2 CD2, RHO
presynaptic active zone membrane 2 STX1A, STX2
Mitochondrion inner membrane 1 CYP27A1
focal adhesion 1 CAT
mitochondrial nucleoid 1 DNA2
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
mitochondrial intermembrane space 1 GOLPH3
collagen-containing extracellular matrix 1 F2
neuron projection 1 STX1A
Cell projection, cilium, photoreceptor outer segment 1 RHO
inhibin A complex 1 INHA
chromosome, telomeric region 1 DNA2
blood microparticle 1 F2
sperm midpiece 1 RHO
Endomembrane system 2 STX1A, STX2
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cell projection, stereocilium 1 STRC
Cell projection, kinocilium 1 STRC
kinocilium 1 STRC
stereocilium tip 1 STRC
Golgi cisterna membrane 1 GOLPH3
Golgi-associated vesicle membrane 1 RHO
SNARE complex 2 STX1A, STX2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 BDNF, F2
Photoreceptor inner segment membrane 1 RHO
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
azurophil granule lumen 1 LYZ
Single-pass type IV membrane protein 1 STX1A
Golgi cisterna 1 GOLPH3
Synapse, synaptosome 1 STX1A
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
photoreceptor disc membrane 1 RHO
catalase complex 1 CAT
inhibin B complex 1 INHA
inhibin-betaglycan-ActRII complex 1 INHA
rod photoreceptor outer segment 1 RHO
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
synaptobrevin 2-SNAP-25-syntaxin-1a complex 1 STX1A


文献列表

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