Cirsilineol (BioDeep_00001867535)

Main id: BioDeep_00000000645

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-

化学式: C18H16O7 (344.0896)
中文名称: 3′-甲氧基蓟黄素, 甲基条叶蓟素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(OC)=CC2OC(C3C=CC(O)=C(OC)C=3)=CC(=O)C=2C(O)=C1OC
InChI: InChI=1S/C18H16O7/c1-22-13-6-9(4-5-10(13)19)12-7-11(20)16-14(25-12)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3

描述信息

Cirsilineol is a trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7 and 3 and hydroxy groups at positions 5 and 4 respectively. It has a role as a plant metabolite and an antineoplastic agent. It is a trimethoxyflavone and a dihydroxyflavone. It is functionally related to a flavone.
Cirsilineol is a natural product found in Thymus herba-barona, Salvia tomentosa, and other organisms with data available.
See also: Tangerine peel (part of).
A trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7 and 3 and hydroxy groups at positions 5 and 4 respectively.

同义名列表

21 个代谢物同义名

4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-; 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one; 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one #; 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one; 5-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-chromen-4-one; 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one; Cirsilineol (5,4-dihydroxy-6,7,3-trimethoxyflavone); 4,5-dihydroxy-3,6,7-trimethoxy-flavone; 4,5-dihydroxy-3,6,7-trimethoxyflavone; 4,5-Dihydroxy-3,6,7-trimethoxyflavone; 5,4-Dihydroxy-6,7,3-trimethoxyflavone; Cirsilineol, analytical standard; VKOSQMWSWLZQPA-UHFFFAOYSA-N; UNII-08DZZ529FE; Cirsilineol; Cirsileneol; Fastigenin; Anisomelin; 08DZZ529FE; Eupatrin; Cirsilineol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

176 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, ANXA5, BCL2, CASP9, DHFR, EDN1, MTOR, MYD88, PTGS2, TLR2, TLR4
Peripheral membrane protein 3 ANXA5, MTOR, PTGS2
Endosome membrane 2 MYD88, TLR4
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 8 ALB, BCL2, CASP9, GABPA, HMOX1, MPO, MTOR, MYD88
cytosol 9 ALB, ANXA5, BCL2, CASP9, DHFR, HMOX1, IL1B, MTOR, MYD88
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 ALB
nucleoplasm 4 GABPA, HMOX1, MPO, MTOR
Cell membrane 4 CYSLTR2, SELP, TLR4, TNF
Cytoplasmic side 2 HMOX1, MTOR
Multi-pass membrane protein 1 CYSLTR2
Golgi apparatus membrane 1 MTOR
cell surface 4 MYD88, TLR2, TLR4, TNF
Golgi apparatus 2 ALB, TLR2
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 TNF
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 IL1B
Lysosome 3 IL1B, MPO, MTOR
plasma membrane 6 CYSLTR2, MYD88, SELP, TLR2, TLR4, TNF
Membrane 6 ANXA5, BCL2, HMOX1, MTOR, TLR2, TLR4
caveola 1 PTGS2
extracellular exosome 4 ALB, ANXA5, MPO, SELP
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 ALB, BCL2, HMOX1, PTGS2
extracellular space 9 ALB, EDN1, HMOX1, IL1B, IL4, IL5, MPO, SELP, TNF
perinuclear region of cytoplasm 2 HMOX1, TLR4
mitochondrion 3 BCL2, CASP9, DHFR
protein-containing complex 5 ALB, BCL2, CASP9, MYD88, PTGS2
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 SELP, TLR2, TLR4
Secreted 6 ALB, EDN1, IL1B, IL4, IL5, SELP
extracellular region 9 ALB, ANXA5, EDN1, IL1B, IL4, IL5, MPO, SELP, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
basal part of cell 1 EDN1
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 4 ANXA5, SELP, TLR4, TNF
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 TLR2, TNF
pore complex 1 BCL2
focal adhesion 1 ANXA5
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA5
secretory granule 2 IL1B, MPO
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 TLR2, TLR4
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 1 GABPA
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 2 TLR4, TNF
phagocytic vesicle membrane 1 TLR2
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
cell body 1 TLR2
myelin sheath 1 BCL2
azurophil granule 1 MPO
platelet dense granule membrane 1 SELP
lipopolysaccharide receptor complex 1 TLR4
secretory granule membrane 1 TLR2
endoplasmic reticulum lumen 2 ALB, PTGS2
platelet alpha granule lumen 1 ALB
transport vesicle 1 EDN1
Secreted, extracellular exosome 1 IL1B
azurophil granule lumen 1 MPO
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
phagocytic vesicle lumen 1 MPO
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
Cytoplasmic vesicle, phagosome 1 MTOR
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
extrinsic component of plasma membrane 1 MYD88
platelet alpha granule membrane 1 SELP
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
platelet dense granule lumen 1 SELP
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
ciliary transition fiber 1 ALB
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Dinesh Kumar Patel. Health Benefits, Therapeutic Applications, and Recent Advances of Cirsilineol in the Medicine: Potential Bioactive Natural Flavonoids of Genus Artemisia. Endocrine, metabolic & immune disorders drug targets. 2022 Nov; ?(?):. doi: 10.2174/1871530323666221122123456. [PMID: 36415094]
  • Meimei Ai, Shusheng Lin, Meixia Zhang, Tieli Wu, Nan Yang, Yu Li, Li Li. Cirsilineol attenuates LPS-induced inflammation in both in vivo and in vitro models via inhibiting TLR-4/NFkB/IKK signaling pathway. Journal of biochemical and molecular toxicology. 2021 Aug; 35(8):e22799. doi: 10.1002/jbt.22799. [PMID: 33949057]
  • Mahmoud A Al-Qudah, Hasan I Tashtoush, Ethar F Khlaifat, Sahar O Ibrahim, Ayman M Saleh, Hala I Al-Jaber, Musa H Abu Zarga, Sultan T Abu Orabi. Chemical constituents of the aerial parts of Salvia judaica Boiss. from Jordan. Natural product research. 2020 Oct; 34(20):2981-2985. doi: 10.1080/14786419.2019.1597349. [PMID: 31161797]
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  • Gjoshe Stefkov, Svetlana Kulevanova, Biljana Miova, Suzana Dinevska-Kjovkarovska, Per Mølgaard, Anna K Jäger, Knud Josefsen. Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats. Pharmaceutical biology. 2011 Sep; 49(9):885-92. doi: 10.3109/13880209.2011.552187. [PMID: 21619454]
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  • Ye Yin, Fang-Yuan Gong, Xing-Xin Wu, Yang Sun, Yi-Hua Li, Ting Chen, Qiang Xu. Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. Journal of ethnopharmacology. 2008 Oct; 120(1):1-6. doi: 10.1016/j.jep.2008.07.029. [PMID: 18721870]
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