Sulfanilamide (BioDeep_00000001853)

 

Secondary id: BioDeep_00000411024

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


4-Aminobenzene sulphonic acid amide

化学式: C6H8N2O2S (172.0306468)
中文名称: 磺胺
谱图信息: 最多检出来源 Homo sapiens(blood) 22.21%

分子结构信息

SMILES: C1=CC(=CC=C1N)S(=O)(=O)N
InChI: InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)

描述信息

Sulfanilamide is only found in individuals that have used or taken this drug. It is a molecule containing the sulfonamide functional group attached to an aniline. [Wikipedia]Sulfanilamide is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. This enzyme normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid. The inhibited reaction is normally necessary in these organisms for the synthesis of folic acid. Without it, bacteria cannot replicate.
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BA - Sulfonamides
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EB - Short-acting sulfonamides
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
CONFIDENCE standard compound; INTERNAL_ID 1022
KEIO_ID S016

同义名列表

47 个代谢物同义名

4-Aminobenzene sulphonic acid amide; 4-Aminobenzene sulfonic acid amide; 4-Aminobenzene sulphonate amide; 4-Aminobenzene sulfonate amide; Para-aminobenzenesulphonamide; Sulfanilamide magnesium salt; 4-aminobenzene-1-sulfonamide; Para-aminobenzenesulfonamide; Sulfanilamide strontium salt; p-Aminobenzenesulfonylamide; Sulfanilamide hydrochloride; 4-Azanylbenzenesulphonamide; Sulfanilamide cadmium salt; Sulfanilamide lithium salt; p-Aminobenzenesulphonamide; 4-Azanylbenzenesulfonamide; Sulfanilamide barium salt; 4-Aminobenzenesulfonamide; 4 Aminobenzenesulfonamide; p-Aminobenzenesulfonamide; Sulfanilamide sodium salt; Sulfanilamide silver salt; Sulfanilamide monohydrate; p-Aminobenzensulfonamide; p-Aminobenzenesulphamide; p-Aminophenylsulfonamide; Sulfanilamide zinc salt; p-Aminobenzenesulfamide; Sulfanilamide sodium; p-Anilinesulfonamide; Sulfanilimidic acid; p-Sulfamoylaniline; p-Sulfamidoaniline; Prontosil album; Sulphanilamide; sulfanilamide; Sulfonylamide; Sulphonamide; Streptocide; Azol polvo; Sulphamine; Streptocid; Sulfamine; PABS; AVC; SA; Sulfanilamide



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaohu Xu, Azadeh Nilghaz, Xiaofang Wan, Shan Liu, Meigui Xue, Wan Guo, Junfei Tian. A novel premixing strategy for highly sensitive detection of nitrite on paper-based analytical devices. Analytica chimica acta. 2024 Apr; 1299(?):342417. doi: 10.1016/j.aca.2024.342417. [PMID: 38499414]
  • Tong Zhou, Ziyue Yu, Ling Zhang, Chunming Gong, Changzhou Yan. Removal of sulfonamides from water by wetland plants: Performance, microbial response and mechanism. The Science of the total environment. 2024 Mar; 916(?):170181. doi: 10.1016/j.scitotenv.2024.170181. [PMID: 38244623]
  • Yuzhe He, Lei Liu, Qi Wang, Xiaoqi Dong, Jingfei Huang, Xiaoshan Jia, Xingxing Peng. Bio-degraded of sulfamethoxazole by microbial consortia without addition nutrients: Mineralization, nitrogen removal, and proteomic characterization. Journal of hazardous materials. 2024 Jan; 466(?):133558. doi: 10.1016/j.jhazmat.2024.133558. [PMID: 38262313]
  • Yaning Li, Xinlong An, Gang Liu, Guodong Li, Yanyan Yin. The fate of sulfonamides in microenvironments of rape and hot pepper rhizosphere soil system. International journal of phytoremediation. 2024; 26(2):159-168. doi: 10.1080/15226514.2023.2231552. [PMID: 37424147]
  • Jung-Sheng Chen, Bing-Mu Hsu, Wen-Chien Ko, Jiun-Ling Wang. Comparison of antibiotic-resistant Escherichia coli and extra-intestinal pathogenic E. coli from main river basins under different levels of the sewer system development. Ecotoxicology and environmental safety. 2023 Aug; 263(?):115372. doi: 10.1016/j.ecoenv.2023.115372. [PMID: 37619401]
  • Ruonan Ma, Jiani Wang, Yan Liu, Guoying Wang, Yan Yang, Ying Liu, Yilin Kong, Jiacong Lin, Qinfen Li, Guoxue Li, Jing Yuan. Dynamics of antibiotic resistance genes and bacterial community during pig manure, kitchen waste, and sewage sludge composting. Journal of environmental management. 2023 Jul; 345(?):118651. doi: 10.1016/j.jenvman.2023.118651. [PMID: 37499413]
  • Zongwen Wang, Xiating Li, Feng Zhang, Yu Gao, Jintian Cheng, FengFu Fu. Regulating the Growth Rate of Gold Nanobipyramids via a HCl-NADH-Ascorbic Acid System toward a Dual-Channel Multicolor Colorimetric Immunoassay for Simultaneously Screening and Detecting Multiple Sulfonamides. Analytical chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.analchem.3c01928. [PMID: 37382204]
  • Bo Zhao, Jiali Wang, Na Sun, Chunguang Liu. Low concentration of bromide ions improves sulfadiazine phytoremoval and attenuates its phytotoxicity. The Science of the total environment. 2023 Jun; ?(?):164857. doi: 10.1016/j.scitotenv.2023.164857. [PMID: 37321499]
  • Qian Chen, Yuquan Pan, Chaochen Sun, Zongwen Wang, Yongning Wu, FengFu Fu. A multicolor immunosensor for the visual detection of six sulfonamides based on manganese dioxide nanosheet-mediated etching of gold nanobipyramids. Talanta. 2023 Jun; 258(?):124449. doi: 10.1016/j.talanta.2023.124449. [PMID: 36924640]
  • Yuyuan Yang, Runjiang Song, Limin Yin, Kelei Han, Fei Yan, Baoan Song. Inactivating Activities and Mechanism of Imidazo[1,2-c]pyrimidin-5(6H)-one Nucleoside Derivatives Incorporating a Sulfonamide Scaffold. Journal of agricultural and food chemistry. 2023 May; 71(21):7977-7987. doi: 10.1021/acs.jafc.2c08129. [PMID: 37204296]
  • Hong Wen, Yufeng Jiang, Xueru Deng, Zhijiang Nan, Xinru Liang, Jingru Diao. Potential output and risk of commonly administered veterinary antibiotics from small-scale livestock farms to surrounding areas in Northwest China. Journal of environmental management. 2023 May; 333(?):117468. doi: 10.1016/j.jenvman.2023.117468. [PMID: 36758397]
  • Jiao Xie, Zhou-Qing Long, Ai-Qun Chen, Ying-Guo Ding, Shi-Tao Liu, Xiang Zhou, Li-Wei Liu, Song Yang. Novel Sulfonamide Derivatives Containing a Piperidine Moiety as New Bactericide Leads for Managing Plant Bacterial Diseases. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065861. [PMID: 36982936]
  • Lin Huang, Jie Feng, Jiaoyang Zhu, Jing Yang, Wei Xiong, Xuanyi Lu, Sijin Chen, Sugeun Yang, Yan Li, Yikai Xu, Zheyu Shen. A Strategy of Fenton Reaction Cycloacceleration for High-Performance Ferroptosis Therapy Initiated by Tumor Microenvironment Remodeling. Advanced healthcare materials. 2023 Mar; ?(?):e2203362. doi: 10.1002/adhm.202203362. [PMID: 36893770]
  • Agnieszka Zajda, Joanna Sikora, Mira Hynninen, Janne Tampio, Kristiina M Huttunen, Magdalena Markowicz-Piasecka. Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation. Chemico-biological interactions. 2023 Mar; 373(?):110381. doi: 10.1016/j.cbi.2023.110381. [PMID: 36746201]
  • Mohamed Bedair M Ahmed, Amro Ahmed Taha, Fathy Mohamed Saber Mehaya. Method validation and risk assessment for sulfonamides and tetracyclines in bees' honey from Egypt, Libya and Saudi Arabia. Environmental geochemistry and health. 2023 Mar; 45(3):997-1011. doi: 10.1007/s10653-022-01258-0. [PMID: 35416609]
  • Shengyan Cui, Yuwen Qi, Qing Zhu, Cuiping Wang, Hongwen Sun. A review of the influence of soil minerals and organic matter on the migration and transformation of sulfonamides. The Science of the total environment. 2023 Feb; 861(?):160584. doi: 10.1016/j.scitotenv.2022.160584. [PMID: 36455724]
  • Xinyue Zhao, Mengjie Zhang, Zhilin Sun, Huabao Zheng, Qifa Zhou. Anaerobic Storage Completely Removes Suspected Fungal Pathogens but Increases Antibiotic Resistance Gene Levels in Swine Wastewater High in Sulfonamides. International journal of environmental research and public health. 2023 Feb; 20(4):. doi: 10.3390/ijerph20043135. [PMID: 36833839]
  • Pascaline Sanga, Juanjuan Wang, Xin Li, Jia Chen, Hongdeng Qiu. Effective Removal of Sulfonamides Using Recyclable MXene-Decorated Bismuth Ferrite Nanocomposites Prepared via Hydrothermal Method. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041541. [PMID: 36838529]
  • Xiaofang Luan, Wen Nie, Xinxin Tian, Jinglei Xu, Wenqiang Fang, Shuang Liu, Xinyu Lan, Wenxuan Jia, Yongming Liu, Zhenbo Liu. Synthesis of hierarchical porous zirconium dioxide and its application in the detection of sulfonamides in animal-derived food. Analytical methods : advancing methods and applications. 2022 12; 14(46):4893-4902. doi: 10.1039/d2ay01635d. [PMID: 36420616]
  • V Matamoros, M Escolà Casas, E Pastor, Đ Tadić, N Cañameras, N Carazo, J M Bayona. Effects of tetracycline, sulfonamide, fluoroquinolone, and lincosamide load in pig slurry on lettuce: Agricultural and human health implications. Environmental research. 2022 12; 215(Pt 1):114237. doi: 10.1016/j.envres.2022.114237. [PMID: 36084673]
  • Ruyi Xu, Chen Yang, Lin Huang, Wenchao Lv, Weijuan Yang, Yongning Wu, FengFu Fu. Broad-Specificity Aptamer of Sulfonamides: Isolation and Its Application in Simultaneous Detection of Multiple Sulfonamides in Fish Sample. Journal of agricultural and food chemistry. 2022 Sep; 70(37):11804-11812. doi: 10.1021/acs.jafc.2c03423. [PMID: 36070569]
  • Thalles Pedrosa Lisboa, Guilherme Figueira Alves, Lucas Vinícius de Faria, Cassiano Cunha de Souza, Maria Auxiliadora Costa Matos, Renato Camargo Matos. 3D-printed electrode an affordable sensor for sulfanilamide monitoring in breast milk, synthetic urine, and pharmaceutical formulation samples. Talanta. 2022 Sep; 247(?):123610. doi: 10.1016/j.talanta.2022.123610. [PMID: 35649326]
  • Weifeng Ruan, Jiaxi Wang, Jie Huang, Yiping Tai, Rui Wang, Weipeng Zhu, Yang Yang. The in vivo and vitro degradation of sulfonamides in wetland plants reducing phytotoxicity and environmental pollution. Environmental science and pollution research international. 2022 Sep; 29(43):64972-64982. doi: 10.1007/s11356-022-20395-8. [PMID: 35482241]
  • Chaojie Liu, Xiaofang Xiang, Ying Wan, Jia Yang, Yufei Li, Xinchen Zhang, Zhiqiu Qi, Lu He, Wei Liu, Xinghai Li. Design, Synthesis and Structure-Activity Relationship of Novel Pinacolone Sulfonamide Derivatives against Botrytis cinerea as Potent Antifungal Agents. Molecules (Basel, Switzerland). 2022 Aug; 27(17):. doi: 10.3390/molecules27175468. [PMID: 36080238]
  • Shideng Yuan, Heng Zhang, Shiling Yuan. Theoretical insights into the uptake of sulfonamides onto phospholipid bilayers: Mechanisms, interaction and toxicity evaluation. Journal of hazardous materials. 2022 08; 435(?):129033. doi: 10.1016/j.jhazmat.2022.129033. [PMID: 35525012]
  • Jie Wu, Yihe Zhang, Mengyuan Huang, Ziheng Zou, Shumin Guo, Jinyang Wang, Jianwen Zou. Sulfonamide antibiotics alter gaseous nitrogen emissions in the soil-plant system: A mesocosm experiment and meta-analysis. The Science of the total environment. 2022 Jul; 828(?):154230. doi: 10.1016/j.scitotenv.2022.154230. [PMID: 35271923]
  • Huanting Zhao, Liping Yang, Xiaojing Yang, Shuyan Zhao. Behaviors of 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB) in wheat seedlings: Bioaccumulation, biotransformation and ecotoxicity. Ecotoxicology and environmental safety. 2022 Jun; 238(?):113585. doi: 10.1016/j.ecoenv.2022.113585. [PMID: 35525114]
  • Ying Man, Wanxuan Li, Jiaxi Wang, Nora Fung-Yee Tam, Yiping Tai, Ran Tao, Yang Yang. Plants inhibit the relative abundance of sulfonamide resistance genes and class 1 integron by influencing bacterial community in rhizosphere of constructed wetlands. The Science of the total environment. 2022 Jun; 824(?):153977. doi: 10.1016/j.scitotenv.2022.153977. [PMID: 35181368]
  • Yue Wang, Jinghua Li, Yao Lei, Xiaoqiang Li, Dillirani Nagarajan, Duu-Jong Lee, Jo-Shu Chang. Bioremediation of sulfonamides by a microalgae-bacteria consortium - Analysis of pollutants removal efficiency, cellular composition, and bacterial community. Bioresource technology. 2022 May; 351(?):126964. doi: 10.1016/j.biortech.2022.126964. [PMID: 35272036]
  • Bo Wang, Qin Peng, Rui Wang, Shuhua Yu, Qi Li, Chunping Huang. Efficient Microcystis removal and sulfonamide-resistance gene propagation mitigation by constructed wetlands and functional genes analysis. Chemosphere. 2022 Apr; 292(?):133481. doi: 10.1016/j.chemosphere.2021.133481. [PMID: 34990722]
  • Tiantian Xu, Jiangkun Du, Jian Zhang, Werner David, Peng Liu, Muhammed Faheem, Xiaowei Zhu, Jiawei Yang, Jianguo Bao. Microbially-mediated synthesis of activated carbon derived from cottonseed husks for enhanced sulfanilamide removal. Journal of hazardous materials. 2022 03; 426(?):127811. doi: 10.1016/j.jhazmat.2021.127811. [PMID: 34844799]
  • Lulu Xu, Ruimei Wu, Xiang Geng, Xiaoyu Zhu, Yao Xiong, Tao Chen, Shirong Ai. Rapid detection of sulfonamide antibiotics residues in swine urine by surface-enhanced Raman spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Feb; 267(Pt 2):120570. doi: 10.1016/j.saa.2021.120570. [PMID: 34753705]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ameer Khusro, Chirom Aarti, German Buendía-Rodriguez, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Alberto Barbabosa-Pliego. Adverse Effect of Antibiotics Administration on Horse Health: An Overview. Journal of equine veterinary science. 2021 02; 97(?):103339. doi: 10.1016/j.jevs.2020.103339. [PMID: 33478757]
  • Meilan Xu, Helian Li, Shiwei Li, Cheng Li, Jinyang Li, Yibing Ma. The presence of tetracyclines and sulfonamides in swine feeds and feces: dependence on the antibiotic type and swine growth stages. Environmental science and pollution research international. 2020 Dec; 27(34):43093-43102. doi: 10.1007/s11356-020-10266-5. [PMID: 32729042]
  • M Conde-Cid, D Fernández-Calviño, M J Fernández-Sanjurjo, A Núñez-Delgado, E Álvarez-Rodríguez, M Arias-Estévez. Effects of pine bark amendment on the transport of sulfonamide antibiotics in soils. Chemosphere. 2020 Jun; 248(?):126041. doi: 10.1016/j.chemosphere.2020.126041. [PMID: 32028162]
  • Yan-Fei Sui, Di Li, Juan Wang, Rammohan R Yadav Bheemanaboina, Mohammad Fawad Ansari, Lin-Ling Gan, Cheng-He Zhou. Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. Bioorganic & medicinal chemistry letters. 2020 03; 30(6):126982. doi: 10.1016/j.bmcl.2020.126982. [PMID: 32001137]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Tian-Yu Feng, Fa Ren, Qian Fang, Gui-Chao Dai, Yu Li, Qian Li, Hua-Ming Xi, Hao Li, Yang-Yi Hao, Jian-Hong Hu. Effects of sulfanilamide on boar sperm quality, bacterial composition, and fertility during liquid storage at 17°C. Animal science journal = Nihon chikusan Gakkaiho. 2019 Sep; 90(9):1161-1169. doi: 10.1111/asj.13281. [PMID: 31381235]
  • Anwar E M Noreljaleel, A Wilhelm, S L Bonnet, J H van der Westhuizen. Synthesis and Bioactivity of Reduced Chalcones Containing Sulfonamide Side Chains. Journal of natural products. 2018 01; 81(1):41-48. doi: 10.1021/acs.jnatprod.7b00570. [PMID: 29309141]
  • Magdalena Markowicz-Piasecka, Kristiina M Huttunen, Elżbieta Mikiciuk-Olasik, Joanna Sikora. Biocompatible sulfenamide and sulfonamide derivatives of metformin can exert beneficial effects on plasma haemostasis. Chemico-biological interactions. 2018 Jan; 280(?):15-27. doi: 10.1016/j.cbi.2017.12.005. [PMID: 29217384]
  • Anabel Brandoni, Adriana Mónica Torres. Pharmacokinetics of the antimicrobial drug Sulfanilamide is altered in a preclinical model of vascular calcification. Clinical and experimental pharmacology & physiology. 2017 12; 44 Suppl 1(?):99-106. doi: 10.1111/1440-1681.12722. [PMID: 28042884]
  • Lili Li, Lei Ye, Sen Zhang, Hecheng Meng. Isolation and Identification of Aerobic Bacteria Carrying Tetracycline and Sulfonamide Resistance Genes Obtained from a Meat Processing Plant. Journal of food science. 2016 Jun; 81(6):M1480-4. doi: 10.1111/1750-3841.13318. [PMID: 27100915]
  • Xinrui Yuan, Peng Lu, Xiaojian Xue, Hui Qin, Chen Fan, Yubin Wang, Qi Zhang. Discovery of 2-azetidinone and 1H-pyrrole-2,5-dione derivatives containing sulfonamide group at the side chain as potential cholesterol absorption inhibitors. Bioorganic & medicinal chemistry letters. 2016 Feb; 26(3):849-853. doi: 10.1016/j.bmcl.2015.12.077. [PMID: 26783178]
  • N Rajendiran, J Thulasidhasan. Interaction of sulfanilamide and sulfamethoxazole with bovine serum albumin and adenine: spectroscopic and molecular docking investigations. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015 Jun; 144(?):183-91. doi: 10.1016/j.saa.2015.01.127. [PMID: 25754395]
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  • Abdellatif El-Ghenymy, Pere Lluís Cabot, Francesc Centellas, José Antonio Garrido, Rosa María Rodríguez, Conchita Arias, Enric Brillas. Mineralization of sulfanilamide by electro-Fenton and solar photoelectro-Fenton in a pre-pilot plant with a Pt/air-diffusion cell. Chemosphere. 2013 May; 91(9):1324-31. doi: 10.1016/j.chemosphere.2013.03.005. [PMID: 23561569]
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